Loading…
Noninvasive Continuous Arterial Blood Pressure Monitoring with Nexfin
If invasive measurement of arterial blood pressure is not warranted, finger cuff technology can provide continuous and noninvasive monitoring. Finger and radial artery pressures differ; Nexfin® (BMEYE, Amsterdam, The Netherlands) measures finger arterial pressure and uses physiologic reconstruction...
Saved in:
Published in: | Anesthesiology (Philadelphia) 2012-05, Vol.116 (5), p.1092-1103 |
---|---|
Main Authors: | , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c383t-85844b47abf49e966d3b95926330dea4b9103c13bc02d9fbc3205b87263f60e63 |
---|---|
cites | |
container_end_page | 1103 |
container_issue | 5 |
container_start_page | 1092 |
container_title | Anesthesiology (Philadelphia) |
container_volume | 116 |
creator | MARTINA, Jerson R WESTERHOF, Berend E DE MOL, Bas A. J. M LIESHOUT, Johannes J. Van GOUDOEVER, Jeroen Van DE BEAUMONT, Edouard M. F. H TRUIJEN, Jasper KIM, Yu-Sok IMMINK, Rogier V JÖBSIS, Dorothea A HOLLMANN, Markus W LAHPOR, Jaap R |
description | If invasive measurement of arterial blood pressure is not warranted, finger cuff technology can provide continuous and noninvasive monitoring. Finger and radial artery pressures differ; Nexfin® (BMEYE, Amsterdam, The Netherlands) measures finger arterial pressure and uses physiologic reconstruction methodologies to obtain values comparable to invasive pressures.
Intra-arterial pressure (IAP) and noninvasive Nexfin arterial pressure (NAP) were measured in cardiothoracic surgery patients, because invasive pressures are available. NAP-IAP differences were analyzed during 30 min. Tracking was quantified by within-subject precision (SD of individual NAP-IAP differences) and correlation coefficients. The ranges of pressure change were quantified by within-subject variability (SD of individual averages of NAP and IAP). Accuracy and precision were expressed as group average ± SD of the differences and considered acceptable when smaller than 5 ± 8 mmHg, the Association for the Advancement of Medical Instrumentation criteria.
NAP and IAP were obtained in 50 (34-83 yr, 40 men) patients. For systolic, diastolic, mean arterial, and pulse pressure, median (25-75 percentiles) correlation coefficients were 0.96 (0.91-0.98), 0.93 (0.87-0.96), 0.96 (0.90-0.97), and 0.94 (0.85-0.98), respectively. Within-subject precisions were 4 ± 2, 3 ± 1, 3 ± 2, and 3 ± 2 mmHg, and within-subject variations 13 ± 6, 6 ± 3, 9 ± 4, and 7 ± 4 mmHg, indicating precision over a wide range of pressures. Group average ± SD of the NAP-IAP differences were -1 ± 7, 3 ± 6, 2 ± 6, and -3 ± 4 mmHg, meeting criteria. Differences were not related to mean arterial pressure or heart rate.
Arterial blood pressure can be measured noninvasively and continuously using physiologic pressure reconstruction. Changes in pressure can be followed and values are comparable to invasive monitoring. |
doi_str_mv | 10.1097/ALN.0b013e31824f94ed |
format | article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1018632999</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1018632999</sourcerecordid><originalsourceid>FETCH-LOGICAL-c383t-85844b47abf49e966d3b95926330dea4b9103c13bc02d9fbc3205b87263f60e63</originalsourceid><addsrcrecordid>eNpdkMtOwzAQRS0EgvL4A4SyQWKTYnvsxF6WqjykUljAOrIdB4zSGOykwN9j1AISq5mRzp0ZHYSOCR4TLMvzyXwxxhoTsEAEZY1ktt5CI8KpyAkp-TYaYYwhB0zpHtqP8SWNJQexi_YoZSR15QjNFr5z3UpFt7LZ1He96wY_xGwSehucarOL1vs6uw82xiHY7DbhvQ-ue8reXf-cLexH47pDtNOoNtqjTT1Aj5ezh-l1Pr-7uplO5rkBAX0uuGBMs1Lphkkri6IGLbmkBQCurWJaEgyGgDaY1rLRBijmWpQJaApsCzhAZ-u9r8G_DTb21dJFY9tWdTZ9XRFMRAFUSplQtkZN8DEG21SvwS1V-ExQ9S2wSgKr_wJT7GRzYdBLW_-Gfowl4HQDqGhU2wTVGRf_OC6Ac0LgC4iteZ4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1018632999</pqid></control><display><type>article</type><title>Noninvasive Continuous Arterial Blood Pressure Monitoring with Nexfin</title><source>HEAL-Link subscriptions: Lippincott Williams & Wilkins</source><creator>MARTINA, Jerson R ; WESTERHOF, Berend E ; DE MOL, Bas A. J. M ; LIESHOUT, Johannes J. Van ; GOUDOEVER, Jeroen Van ; DE BEAUMONT, Edouard M. F. H ; TRUIJEN, Jasper ; KIM, Yu-Sok ; IMMINK, Rogier V ; JÖBSIS, Dorothea A ; HOLLMANN, Markus W ; LAHPOR, Jaap R</creator><creatorcontrib>MARTINA, Jerson R ; WESTERHOF, Berend E ; DE MOL, Bas A. J. M ; LIESHOUT, Johannes J. Van ; GOUDOEVER, Jeroen Van ; DE BEAUMONT, Edouard M. F. H ; TRUIJEN, Jasper ; KIM, Yu-Sok ; IMMINK, Rogier V ; JÖBSIS, Dorothea A ; HOLLMANN, Markus W ; LAHPOR, Jaap R</creatorcontrib><description>If invasive measurement of arterial blood pressure is not warranted, finger cuff technology can provide continuous and noninvasive monitoring. Finger and radial artery pressures differ; Nexfin® (BMEYE, Amsterdam, The Netherlands) measures finger arterial pressure and uses physiologic reconstruction methodologies to obtain values comparable to invasive pressures.
Intra-arterial pressure (IAP) and noninvasive Nexfin arterial pressure (NAP) were measured in cardiothoracic surgery patients, because invasive pressures are available. NAP-IAP differences were analyzed during 30 min. Tracking was quantified by within-subject precision (SD of individual NAP-IAP differences) and correlation coefficients. The ranges of pressure change were quantified by within-subject variability (SD of individual averages of NAP and IAP). Accuracy and precision were expressed as group average ± SD of the differences and considered acceptable when smaller than 5 ± 8 mmHg, the Association for the Advancement of Medical Instrumentation criteria.
NAP and IAP were obtained in 50 (34-83 yr, 40 men) patients. For systolic, diastolic, mean arterial, and pulse pressure, median (25-75 percentiles) correlation coefficients were 0.96 (0.91-0.98), 0.93 (0.87-0.96), 0.96 (0.90-0.97), and 0.94 (0.85-0.98), respectively. Within-subject precisions were 4 ± 2, 3 ± 1, 3 ± 2, and 3 ± 2 mmHg, and within-subject variations 13 ± 6, 6 ± 3, 9 ± 4, and 7 ± 4 mmHg, indicating precision over a wide range of pressures. Group average ± SD of the NAP-IAP differences were -1 ± 7, 3 ± 6, 2 ± 6, and -3 ± 4 mmHg, meeting criteria. Differences were not related to mean arterial pressure or heart rate.
Arterial blood pressure can be measured noninvasively and continuously using physiologic pressure reconstruction. Changes in pressure can be followed and values are comparable to invasive monitoring.</description><identifier>ISSN: 0003-3022</identifier><identifier>EISSN: 1528-1175</identifier><identifier>DOI: 10.1097/ALN.0b013e31824f94ed</identifier><identifier>PMID: 22415387</identifier><identifier>CODEN: ANESAV</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Anesthesia ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Arteries - physiology ; Biological and medical sciences ; Blood Pressure Determination - instrumentation ; Blood Pressure Monitors ; Cardiac Surgical Procedures ; Coronary Artery Bypass ; Feasibility Studies ; Female ; Fingers - blood supply ; Heart Valve Prosthesis Implantation ; Humans ; Male ; Medical sciences ; Middle Aged ; Monitoring, Intraoperative - instrumentation ; Regional Blood Flow - physiology ; Reproducibility of Results ; Thoracic Surgical Procedures</subject><ispartof>Anesthesiology (Philadelphia), 2012-05, Vol.116 (5), p.1092-1103</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c383t-85844b47abf49e966d3b95926330dea4b9103c13bc02d9fbc3205b87263f60e63</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=25835511$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22415387$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MARTINA, Jerson R</creatorcontrib><creatorcontrib>WESTERHOF, Berend E</creatorcontrib><creatorcontrib>DE MOL, Bas A. J. M</creatorcontrib><creatorcontrib>LIESHOUT, Johannes J. Van</creatorcontrib><creatorcontrib>GOUDOEVER, Jeroen Van</creatorcontrib><creatorcontrib>DE BEAUMONT, Edouard M. F. H</creatorcontrib><creatorcontrib>TRUIJEN, Jasper</creatorcontrib><creatorcontrib>KIM, Yu-Sok</creatorcontrib><creatorcontrib>IMMINK, Rogier V</creatorcontrib><creatorcontrib>JÖBSIS, Dorothea A</creatorcontrib><creatorcontrib>HOLLMANN, Markus W</creatorcontrib><creatorcontrib>LAHPOR, Jaap R</creatorcontrib><title>Noninvasive Continuous Arterial Blood Pressure Monitoring with Nexfin</title><title>Anesthesiology (Philadelphia)</title><addtitle>Anesthesiology</addtitle><description>If invasive measurement of arterial blood pressure is not warranted, finger cuff technology can provide continuous and noninvasive monitoring. Finger and radial artery pressures differ; Nexfin® (BMEYE, Amsterdam, The Netherlands) measures finger arterial pressure and uses physiologic reconstruction methodologies to obtain values comparable to invasive pressures.
Intra-arterial pressure (IAP) and noninvasive Nexfin arterial pressure (NAP) were measured in cardiothoracic surgery patients, because invasive pressures are available. NAP-IAP differences were analyzed during 30 min. Tracking was quantified by within-subject precision (SD of individual NAP-IAP differences) and correlation coefficients. The ranges of pressure change were quantified by within-subject variability (SD of individual averages of NAP and IAP). Accuracy and precision were expressed as group average ± SD of the differences and considered acceptable when smaller than 5 ± 8 mmHg, the Association for the Advancement of Medical Instrumentation criteria.
NAP and IAP were obtained in 50 (34-83 yr, 40 men) patients. For systolic, diastolic, mean arterial, and pulse pressure, median (25-75 percentiles) correlation coefficients were 0.96 (0.91-0.98), 0.93 (0.87-0.96), 0.96 (0.90-0.97), and 0.94 (0.85-0.98), respectively. Within-subject precisions were 4 ± 2, 3 ± 1, 3 ± 2, and 3 ± 2 mmHg, and within-subject variations 13 ± 6, 6 ± 3, 9 ± 4, and 7 ± 4 mmHg, indicating precision over a wide range of pressures. Group average ± SD of the NAP-IAP differences were -1 ± 7, 3 ± 6, 2 ± 6, and -3 ± 4 mmHg, meeting criteria. Differences were not related to mean arterial pressure or heart rate.
Arterial blood pressure can be measured noninvasively and continuously using physiologic pressure reconstruction. Changes in pressure can be followed and values are comparable to invasive monitoring.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anesthesia</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Arteries - physiology</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure Determination - instrumentation</subject><subject>Blood Pressure Monitors</subject><subject>Cardiac Surgical Procedures</subject><subject>Coronary Artery Bypass</subject><subject>Feasibility Studies</subject><subject>Female</subject><subject>Fingers - blood supply</subject><subject>Heart Valve Prosthesis Implantation</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Monitoring, Intraoperative - instrumentation</subject><subject>Regional Blood Flow - physiology</subject><subject>Reproducibility of Results</subject><subject>Thoracic Surgical Procedures</subject><issn>0003-3022</issn><issn>1528-1175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNpdkMtOwzAQRS0EgvL4A4SyQWKTYnvsxF6WqjykUljAOrIdB4zSGOykwN9j1AISq5mRzp0ZHYSOCR4TLMvzyXwxxhoTsEAEZY1ktt5CI8KpyAkp-TYaYYwhB0zpHtqP8SWNJQexi_YoZSR15QjNFr5z3UpFt7LZ1He96wY_xGwSehucarOL1vs6uw82xiHY7DbhvQ-ue8reXf-cLexH47pDtNOoNtqjTT1Aj5ezh-l1Pr-7uplO5rkBAX0uuGBMs1Lphkkri6IGLbmkBQCurWJaEgyGgDaY1rLRBijmWpQJaApsCzhAZ-u9r8G_DTb21dJFY9tWdTZ9XRFMRAFUSplQtkZN8DEG21SvwS1V-ExQ9S2wSgKr_wJT7GRzYdBLW_-Gfowl4HQDqGhU2wTVGRf_OC6Ac0LgC4iteZ4</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>MARTINA, Jerson R</creator><creator>WESTERHOF, Berend E</creator><creator>DE MOL, Bas A. J. M</creator><creator>LIESHOUT, Johannes J. Van</creator><creator>GOUDOEVER, Jeroen Van</creator><creator>DE BEAUMONT, Edouard M. F. H</creator><creator>TRUIJEN, Jasper</creator><creator>KIM, Yu-Sok</creator><creator>IMMINK, Rogier V</creator><creator>JÖBSIS, Dorothea A</creator><creator>HOLLMANN, Markus W</creator><creator>LAHPOR, Jaap R</creator><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120501</creationdate><title>Noninvasive Continuous Arterial Blood Pressure Monitoring with Nexfin</title><author>MARTINA, Jerson R ; WESTERHOF, Berend E ; DE MOL, Bas A. J. M ; LIESHOUT, Johannes J. Van ; GOUDOEVER, Jeroen Van ; DE BEAUMONT, Edouard M. F. H ; TRUIJEN, Jasper ; KIM, Yu-Sok ; IMMINK, Rogier V ; JÖBSIS, Dorothea A ; HOLLMANN, Markus W ; LAHPOR, Jaap R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c383t-85844b47abf49e966d3b95926330dea4b9103c13bc02d9fbc3205b87263f60e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anesthesia</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Arteries - physiology</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure Determination - instrumentation</topic><topic>Blood Pressure Monitors</topic><topic>Cardiac Surgical Procedures</topic><topic>Coronary Artery Bypass</topic><topic>Feasibility Studies</topic><topic>Female</topic><topic>Fingers - blood supply</topic><topic>Heart Valve Prosthesis Implantation</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Monitoring, Intraoperative - instrumentation</topic><topic>Regional Blood Flow - physiology</topic><topic>Reproducibility of Results</topic><topic>Thoracic Surgical Procedures</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MARTINA, Jerson R</creatorcontrib><creatorcontrib>WESTERHOF, Berend E</creatorcontrib><creatorcontrib>DE MOL, Bas A. J. M</creatorcontrib><creatorcontrib>LIESHOUT, Johannes J. Van</creatorcontrib><creatorcontrib>GOUDOEVER, Jeroen Van</creatorcontrib><creatorcontrib>DE BEAUMONT, Edouard M. F. H</creatorcontrib><creatorcontrib>TRUIJEN, Jasper</creatorcontrib><creatorcontrib>KIM, Yu-Sok</creatorcontrib><creatorcontrib>IMMINK, Rogier V</creatorcontrib><creatorcontrib>JÖBSIS, Dorothea A</creatorcontrib><creatorcontrib>HOLLMANN, Markus W</creatorcontrib><creatorcontrib>LAHPOR, Jaap R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Anesthesiology (Philadelphia)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MARTINA, Jerson R</au><au>WESTERHOF, Berend E</au><au>DE MOL, Bas A. J. M</au><au>LIESHOUT, Johannes J. Van</au><au>GOUDOEVER, Jeroen Van</au><au>DE BEAUMONT, Edouard M. F. H</au><au>TRUIJEN, Jasper</au><au>KIM, Yu-Sok</au><au>IMMINK, Rogier V</au><au>JÖBSIS, Dorothea A</au><au>HOLLMANN, Markus W</au><au>LAHPOR, Jaap R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Noninvasive Continuous Arterial Blood Pressure Monitoring with Nexfin</atitle><jtitle>Anesthesiology (Philadelphia)</jtitle><addtitle>Anesthesiology</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>116</volume><issue>5</issue><spage>1092</spage><epage>1103</epage><pages>1092-1103</pages><issn>0003-3022</issn><eissn>1528-1175</eissn><coden>ANESAV</coden><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>If invasive measurement of arterial blood pressure is not warranted, finger cuff technology can provide continuous and noninvasive monitoring. Finger and radial artery pressures differ; Nexfin® (BMEYE, Amsterdam, The Netherlands) measures finger arterial pressure and uses physiologic reconstruction methodologies to obtain values comparable to invasive pressures.
Intra-arterial pressure (IAP) and noninvasive Nexfin arterial pressure (NAP) were measured in cardiothoracic surgery patients, because invasive pressures are available. NAP-IAP differences were analyzed during 30 min. Tracking was quantified by within-subject precision (SD of individual NAP-IAP differences) and correlation coefficients. The ranges of pressure change were quantified by within-subject variability (SD of individual averages of NAP and IAP). Accuracy and precision were expressed as group average ± SD of the differences and considered acceptable when smaller than 5 ± 8 mmHg, the Association for the Advancement of Medical Instrumentation criteria.
NAP and IAP were obtained in 50 (34-83 yr, 40 men) patients. For systolic, diastolic, mean arterial, and pulse pressure, median (25-75 percentiles) correlation coefficients were 0.96 (0.91-0.98), 0.93 (0.87-0.96), 0.96 (0.90-0.97), and 0.94 (0.85-0.98), respectively. Within-subject precisions were 4 ± 2, 3 ± 1, 3 ± 2, and 3 ± 2 mmHg, and within-subject variations 13 ± 6, 6 ± 3, 9 ± 4, and 7 ± 4 mmHg, indicating precision over a wide range of pressures. Group average ± SD of the NAP-IAP differences were -1 ± 7, 3 ± 6, 2 ± 6, and -3 ± 4 mmHg, meeting criteria. Differences were not related to mean arterial pressure or heart rate.
Arterial blood pressure can be measured noninvasively and continuously using physiologic pressure reconstruction. Changes in pressure can be followed and values are comparable to invasive monitoring.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>22415387</pmid><doi>10.1097/ALN.0b013e31824f94ed</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0003-3022 |
ispartof | Anesthesiology (Philadelphia), 2012-05, Vol.116 (5), p.1092-1103 |
issn | 0003-3022 1528-1175 |
language | eng |
recordid | cdi_proquest_miscellaneous_1018632999 |
source | HEAL-Link subscriptions: Lippincott Williams & Wilkins |
subjects | Adult Aged Aged, 80 and over Anesthesia Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Arteries - physiology Biological and medical sciences Blood Pressure Determination - instrumentation Blood Pressure Monitors Cardiac Surgical Procedures Coronary Artery Bypass Feasibility Studies Female Fingers - blood supply Heart Valve Prosthesis Implantation Humans Male Medical sciences Middle Aged Monitoring, Intraoperative - instrumentation Regional Blood Flow - physiology Reproducibility of Results Thoracic Surgical Procedures |
title | Noninvasive Continuous Arterial Blood Pressure Monitoring with Nexfin |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T18%3A07%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Noninvasive%20Continuous%20Arterial%20Blood%20Pressure%20Monitoring%20with%20Nexfin&rft.jtitle=Anesthesiology%20(Philadelphia)&rft.au=MARTINA,%20Jerson%20R&rft.date=2012-05-01&rft.volume=116&rft.issue=5&rft.spage=1092&rft.epage=1103&rft.pages=1092-1103&rft.issn=0003-3022&rft.eissn=1528-1175&rft.coden=ANESAV&rft_id=info:doi/10.1097/ALN.0b013e31824f94ed&rft_dat=%3Cproquest_cross%3E1018632999%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c383t-85844b47abf49e966d3b95926330dea4b9103c13bc02d9fbc3205b87263f60e63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1018632999&rft_id=info:pmid/22415387&rfr_iscdi=true |