Scintigraphic detection of oral cancer with early bone scintigraphic image

In 117 patients with oral cancer who were examined scintigraphically and histopathologically, the tumor blood flow was estimated scintigraphically immediately after administration of^sup 99m^Tc-Hydroxymethylene-diphosphate (^sup 99m^Tc-HMDP). The radioactivity was measured in the venous phase (30 to...

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Bibliographic Details
Published in:Oral radiology 1997-06, Vol.13 (1), p.1-9
Main Authors: Sato, Tsuyoshi, Hayakawa, Kayoko, Miyahara, Mayumi, Kawashima, Kiyomi, Noikura, Takenori, Sugihara, Kazumasa
Format: Article
Language:English
Subjects:
Cancer
Oral cancer
Tumors
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Summary:In 117 patients with oral cancer who were examined scintigraphically and histopathologically, the tumor blood flow was estimated scintigraphically immediately after administration of^sup 99m^Tc-Hydroxymethylene-diphosphate (^sup 99m^Tc-HMDP). The radioactivity was measured in the venous phase (30 to 40 seconds after administration) and in the blood pool phase (1 to 3 minutes), and the radioactivity ratios of the tumor to the control region in both phases, (venous ratio, VR and blood pool ratio, BPR, respectively) were calculated. The early image with^sup 99m^Tc-HMDP (early image) was obtained 5 minutes after administration, and the image with^sup 67^Ga-citrate (Ga-image) was obtained 3 days after administration. Among the tumor classified histopathologically as showing rich, intermediate and poor vascularity, those with poor vascularity showed small VR (M±SD=0.97±0.08) and BPR (1.02±0.04), whereas those with rich vascularity showed large VR (1.39±0.01) and BPR (1.31±0.16). Early image demonstrating tumor was frequent among tumors with large VR (78%) and with large BPR (100%). Of tumors under 3 cm in diameter, 65% showed intermediate or rich vascularity and positive early image for tumor blood flow. These results suggest that the detection of small soft tissue tumors can be improved by combining the early image with the Ga-image.[PUBLICATION ABSTRACT]
ISSN:0911-6028
1613-9674
DOI:10.1007/BF02489638