Macular and peripapillary microvascular changes in open angle glaucoma and ocular hypertension: A longitudinal study using optical coherence tomography angiography (OCT‐A)

Purpose: To investigate prospectively macular and peripapillary microvascular changes in patients with glaucoma and ocular hypertension. Methods: A 12‐month prospective longitudinal study was performed with 124 open‐angle‐glaucoma‐eyes (GE), 111 ocular‐hypertension‐eyes (OHE) and 98 gender and age m...

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Bibliographic Details
Published in:Acta ophthalmologica (Oxford, England) England), 2022-12, Vol.100 (S275), p.n/a
Main Authors: Mar Schilt‐Catafal, Maria, Pérez‐Torregrosa, Vicente T., Duch‐Samper, Antonio M.
Format: Article
Language:English
Subjects:
Angiography
Cornea
Eye
Glaucoma
Hypertension
Longitudinal studies
Microvasculature
Perfusion
Statistical analysis
Statistics
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Summary:Purpose: To investigate prospectively macular and peripapillary microvascular changes in patients with glaucoma and ocular hypertension. Methods: A 12‐month prospective longitudinal study was performed with 124 open‐angle‐glaucoma‐eyes (GE), 111 ocular‐hypertension‐eyes (OHE) and 98 gender and age matched control‐eyes (CE). Glaucomatous progression was defined as a decrease of ≥5 μm in average or ≥7 μm in a sector of RNFL thickness. OMAG OCT microangiography (Angioplex, HD OCT, Cirrus 5000, Zeiss) was used to analyse optic disc and macular regions. The statistical analysis was performed using Mann–Whitney‐Test with the SPSS version 23.0 statistical package (SPSS Inc., IL). Results: Among OHE and GE groups, 21.7% of eyes showed progression, being the decrease of Peripapillary Flux Index (PFI), Macular Vessel Density (MVD) and Macular Capillary Perfusion Density (MPD) greater (−0.0067; −0.696 mm/mm2 and −1.56%) compared to non‐progressive eyes (+0.0038; 0.527 mm/mm2 and 1.55%) being the nasal and inferior sectors for PFI, and the superior and temporal sectors for both MVD and MPD, the ones that showed greater differences [p = 0.015 and p 
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2022.0361