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Prognostic markers including immune and inflammatory factors predict outcomes in patients receiving postoperative radiation therapy for cholangiocarcinoma
Purpose This study aimed to analyze treatment outcomes and prognostic markers, including immune and inflammatory factors, of postoperative radiation therapy (RT) administered to patients with cholangiocarcinoma (CCA). Methods We retrospectively included 59 patients with CCA who underwent surgery and...
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| Published in: | Asia-Pacific journal of clinical oncology 2023-02, Vol.19 (1), p.226-233 |
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| container_title | Asia-Pacific journal of clinical oncology |
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| creator | Mukai, Yuki Matsuyama, Ryusei Sugiura, Madoka Yabushita, Yasuhiro Taniuchi, Risa Homma, Yuki Hashimoto, Kotaro Miyake, Kentaro Tabuchi, Yuya Endo, Itaru Hata, Masaharu |
| description | Purpose
This study aimed to analyze treatment outcomes and prognostic markers, including immune and inflammatory factors, of postoperative radiation therapy (RT) administered to patients with cholangiocarcinoma (CCA).
Methods
We retrospectively included 59 patients with CCA who underwent surgery and postoperative RT with curative intent from 2004 to 2019. Patients received external irradiation (50 Gy in 25 fractions) using three‐dimensional RT. We analyzed prognostic factors of inflammation, such as pre‐RT platelet count, hemoglobin, lymphocyte count ratio (LCR) of the leukocyte count, platelet‐to‐lymphocyte ratio (PLR), and neutrophil‐to‐lymphocyte ratio (NLR).
Results
Tumor stages were distributed as follows: I (n = 8), II (n = 25), III (n = 15), and IVA (n = 11). The median follow‐up was 24 months. Two‐year overall survival (OS), cause‐specific survival (CSS), progression‐free survival (PFS), and locoregional control (LRC) rates were 59.5%, 62.0%, 40.1%, and 66.7%, respectively. Univariate analysis revealed that lower LCR was significantly associated with shorter PFS (p = 0.0446). There was no significant difference between the median baseline values of PLR and NLR; and age ≥75, positive regional lymph node metastases (N+), and chemotherapy after RT were significantly associated with poor OS. Multivariate analysis revealed a significant association of N+ with worse OS, PFS, and CSS and that lower LCR was significantly associated with better PFS (p = 0.0234). Among late toxicity events, two patients (3.38%) were suspected with therapy‐related liver toxicity.
Conclusions
Lower LCR before RT was a better prognostic factor for postoperative RT of patients with CCA.
Image‐guided percutaneous pericardial effusion drainage for cancer patients is safe and contributes to the alleviation of symptoms. Additionally, catheter removal is possible in most patients, thereby allowing a catheter‐free period for them. |
| doi_str_mv | 10.1111/ajco.13809 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2773703223</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2773703223</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3579-5a22d8eeb06f5cb628752335e80aa06eadf2b42edbb2aaf674d7a01615ca13f23</originalsourceid><addsrcrecordid>eNp9kc9OGzEQh62qqEDaSx8AWeqtUsB_4vXuEUW0FCHBgZ5Xs_Zs4nTXXuzdVHkVnhanSTniy4zGnz9L8yPkK2eXPJ8r2JhwyWXJqg_kjOuFnGtVyI9vvVKn5DylDWOyEhX_RE6lKiWvqvKMvDzGsPIhjc7QHuIfjIk6b7rJOr-iru8njxS8zcO2g76HMcQdbcHkmugQ0Toz0jCNJvS4f0oHGB36MdGIBt12rxmyPwwY880WaQTrchc8Hdd5NmRdiNSsQwd-5YKBaJwPPXwmJy10Cb8c64z8_nHztLyd3z_8_LW8vp8bqXQ1VyCELREbVrTKNIUotRJSKiwZACsQbCuahUDbNAKgLfTCamC84MoAl62QM_Lt4B1ieJ4wjfUmTNHnL2uhtdRMiuybke8HysSQUsS2HqLLG9vVnNX7GOp9DPW_GDJ8cVROTY_2Df2_9wzwA_DXdbh7R1Vf3y0fDtJXy2eYMw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2773703223</pqid></control><display><type>article</type><title>Prognostic markers including immune and inflammatory factors predict outcomes in patients receiving postoperative radiation therapy for cholangiocarcinoma</title><source>Wiley-Blackwell Journals</source><creator>Mukai, Yuki ; Matsuyama, Ryusei ; Sugiura, Madoka ; Yabushita, Yasuhiro ; Taniuchi, Risa ; Homma, Yuki ; Hashimoto, Kotaro ; Miyake, Kentaro ; Tabuchi, Yuya ; Endo, Itaru ; Hata, Masaharu</creator><creatorcontrib>Mukai, Yuki ; Matsuyama, Ryusei ; Sugiura, Madoka ; Yabushita, Yasuhiro ; Taniuchi, Risa ; Homma, Yuki ; Hashimoto, Kotaro ; Miyake, Kentaro ; Tabuchi, Yuya ; Endo, Itaru ; Hata, Masaharu</creatorcontrib><description>Purpose
This study aimed to analyze treatment outcomes and prognostic markers, including immune and inflammatory factors, of postoperative radiation therapy (RT) administered to patients with cholangiocarcinoma (CCA).
Methods
We retrospectively included 59 patients with CCA who underwent surgery and postoperative RT with curative intent from 2004 to 2019. Patients received external irradiation (50 Gy in 25 fractions) using three‐dimensional RT. We analyzed prognostic factors of inflammation, such as pre‐RT platelet count, hemoglobin, lymphocyte count ratio (LCR) of the leukocyte count, platelet‐to‐lymphocyte ratio (PLR), and neutrophil‐to‐lymphocyte ratio (NLR).
Results
Tumor stages were distributed as follows: I (n = 8), II (n = 25), III (n = 15), and IVA (n = 11). The median follow‐up was 24 months. Two‐year overall survival (OS), cause‐specific survival (CSS), progression‐free survival (PFS), and locoregional control (LRC) rates were 59.5%, 62.0%, 40.1%, and 66.7%, respectively. Univariate analysis revealed that lower LCR was significantly associated with shorter PFS (p = 0.0446). There was no significant difference between the median baseline values of PLR and NLR; and age ≥75, positive regional lymph node metastases (N+), and chemotherapy after RT were significantly associated with poor OS. Multivariate analysis revealed a significant association of N+ with worse OS, PFS, and CSS and that lower LCR was significantly associated with better PFS (p = 0.0234). Among late toxicity events, two patients (3.38%) were suspected with therapy‐related liver toxicity.
Conclusions
Lower LCR before RT was a better prognostic factor for postoperative RT of patients with CCA.
Image‐guided percutaneous pericardial effusion drainage for cancer patients is safe and contributes to the alleviation of symptoms. Additionally, catheter removal is possible in most patients, thereby allowing a catheter‐free period for them.</description><identifier>ISSN: 1743-7555</identifier><identifier>EISSN: 1743-7563</identifier><identifier>DOI: 10.1111/ajco.13809</identifier><identifier>PMID: 35831998</identifier><language>eng</language><publisher>Australia: Wiley Subscription Services, Inc</publisher><subject>Bile Duct Neoplasms - radiotherapy ; Bile Duct Neoplasms - surgery ; Bile Ducts, Intrahepatic ; Blood Platelets - pathology ; Cell number ; Chemotherapy ; Cholangiocarcinoma ; Cholangiocarcinoma - radiotherapy ; Cholangiocarcinoma - surgery ; external beam radiation therapy ; Hemoglobin ; Humans ; Inflammation ; Leukocytes (neutrophilic) ; Lymph nodes ; lymphocyte count ratio ; Lymphocytes ; Lymphocytes - pathology ; Medical prognosis ; Metastases ; Multivariate analysis ; Neutrophils - pathology ; Patients ; Platelets ; postoperative radiation therapy ; Prognosis ; Radiation therapy ; Retrospective Studies ; three‐dimensional radiation therapy ; Toxicity</subject><ispartof>Asia-Pacific journal of clinical oncology, 2023-02, Vol.19 (1), p.226-233</ispartof><rights>2022 John Wiley & Sons Australia, Ltd.</rights><rights>2023 John Wiley & Sons Australia, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3579-5a22d8eeb06f5cb628752335e80aa06eadf2b42edbb2aaf674d7a01615ca13f23</citedby><cites>FETCH-LOGICAL-c3579-5a22d8eeb06f5cb628752335e80aa06eadf2b42edbb2aaf674d7a01615ca13f23</cites><orcidid>0000-0002-0000-1199</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fajco.13809$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fajco.13809$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35831998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mukai, Yuki</creatorcontrib><creatorcontrib>Matsuyama, Ryusei</creatorcontrib><creatorcontrib>Sugiura, Madoka</creatorcontrib><creatorcontrib>Yabushita, Yasuhiro</creatorcontrib><creatorcontrib>Taniuchi, Risa</creatorcontrib><creatorcontrib>Homma, Yuki</creatorcontrib><creatorcontrib>Hashimoto, Kotaro</creatorcontrib><creatorcontrib>Miyake, Kentaro</creatorcontrib><creatorcontrib>Tabuchi, Yuya</creatorcontrib><creatorcontrib>Endo, Itaru</creatorcontrib><creatorcontrib>Hata, Masaharu</creatorcontrib><title>Prognostic markers including immune and inflammatory factors predict outcomes in patients receiving postoperative radiation therapy for cholangiocarcinoma</title><title>Asia-Pacific journal of clinical oncology</title><addtitle>Asia Pac J Clin Oncol</addtitle><description>Purpose
This study aimed to analyze treatment outcomes and prognostic markers, including immune and inflammatory factors, of postoperative radiation therapy (RT) administered to patients with cholangiocarcinoma (CCA).
Methods
We retrospectively included 59 patients with CCA who underwent surgery and postoperative RT with curative intent from 2004 to 2019. Patients received external irradiation (50 Gy in 25 fractions) using three‐dimensional RT. We analyzed prognostic factors of inflammation, such as pre‐RT platelet count, hemoglobin, lymphocyte count ratio (LCR) of the leukocyte count, platelet‐to‐lymphocyte ratio (PLR), and neutrophil‐to‐lymphocyte ratio (NLR).
Results
Tumor stages were distributed as follows: I (n = 8), II (n = 25), III (n = 15), and IVA (n = 11). The median follow‐up was 24 months. Two‐year overall survival (OS), cause‐specific survival (CSS), progression‐free survival (PFS), and locoregional control (LRC) rates were 59.5%, 62.0%, 40.1%, and 66.7%, respectively. Univariate analysis revealed that lower LCR was significantly associated with shorter PFS (p = 0.0446). There was no significant difference between the median baseline values of PLR and NLR; and age ≥75, positive regional lymph node metastases (N+), and chemotherapy after RT were significantly associated with poor OS. Multivariate analysis revealed a significant association of N+ with worse OS, PFS, and CSS and that lower LCR was significantly associated with better PFS (p = 0.0234). Among late toxicity events, two patients (3.38%) were suspected with therapy‐related liver toxicity.
Conclusions
Lower LCR before RT was a better prognostic factor for postoperative RT of patients with CCA.
Image‐guided percutaneous pericardial effusion drainage for cancer patients is safe and contributes to the alleviation of symptoms. Additionally, catheter removal is possible in most patients, thereby allowing a catheter‐free period for them.</description><subject>Bile Duct Neoplasms - radiotherapy</subject><subject>Bile Duct Neoplasms - surgery</subject><subject>Bile Ducts, Intrahepatic</subject><subject>Blood Platelets - pathology</subject><subject>Cell number</subject><subject>Chemotherapy</subject><subject>Cholangiocarcinoma</subject><subject>Cholangiocarcinoma - radiotherapy</subject><subject>Cholangiocarcinoma - surgery</subject><subject>external beam radiation therapy</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Leukocytes (neutrophilic)</subject><subject>Lymph nodes</subject><subject>lymphocyte count ratio</subject><subject>Lymphocytes</subject><subject>Lymphocytes - pathology</subject><subject>Medical prognosis</subject><subject>Metastases</subject><subject>Multivariate analysis</subject><subject>Neutrophils - pathology</subject><subject>Patients</subject><subject>Platelets</subject><subject>postoperative radiation therapy</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Retrospective Studies</subject><subject>three‐dimensional radiation therapy</subject><subject>Toxicity</subject><issn>1743-7555</issn><issn>1743-7563</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kc9OGzEQh62qqEDaSx8AWeqtUsB_4vXuEUW0FCHBgZ5Xs_Zs4nTXXuzdVHkVnhanSTniy4zGnz9L8yPkK2eXPJ8r2JhwyWXJqg_kjOuFnGtVyI9vvVKn5DylDWOyEhX_RE6lKiWvqvKMvDzGsPIhjc7QHuIfjIk6b7rJOr-iru8njxS8zcO2g76HMcQdbcHkmugQ0Toz0jCNJvS4f0oHGB36MdGIBt12rxmyPwwY880WaQTrchc8Hdd5NmRdiNSsQwd-5YKBaJwPPXwmJy10Cb8c64z8_nHztLyd3z_8_LW8vp8bqXQ1VyCELREbVrTKNIUotRJSKiwZACsQbCuahUDbNAKgLfTCamC84MoAl62QM_Lt4B1ieJ4wjfUmTNHnL2uhtdRMiuybke8HysSQUsS2HqLLG9vVnNX7GOp9DPW_GDJ8cVROTY_2Df2_9wzwA_DXdbh7R1Vf3y0fDtJXy2eYMw</recordid><startdate>202302</startdate><enddate>202302</enddate><creator>Mukai, Yuki</creator><creator>Matsuyama, Ryusei</creator><creator>Sugiura, Madoka</creator><creator>Yabushita, Yasuhiro</creator><creator>Taniuchi, Risa</creator><creator>Homma, Yuki</creator><creator>Hashimoto, Kotaro</creator><creator>Miyake, Kentaro</creator><creator>Tabuchi, Yuya</creator><creator>Endo, Itaru</creator><creator>Hata, Masaharu</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><orcidid>https://orcid.org/0000-0002-0000-1199</orcidid></search><sort><creationdate>202302</creationdate><title>Prognostic markers including immune and inflammatory factors predict outcomes in patients receiving postoperative radiation therapy for cholangiocarcinoma</title><author>Mukai, Yuki ; Matsuyama, Ryusei ; Sugiura, Madoka ; Yabushita, Yasuhiro ; Taniuchi, Risa ; Homma, Yuki ; Hashimoto, Kotaro ; Miyake, Kentaro ; Tabuchi, Yuya ; Endo, Itaru ; Hata, Masaharu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3579-5a22d8eeb06f5cb628752335e80aa06eadf2b42edbb2aaf674d7a01615ca13f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Bile Duct Neoplasms - radiotherapy</topic><topic>Bile Duct Neoplasms - surgery</topic><topic>Bile Ducts, Intrahepatic</topic><topic>Blood Platelets - pathology</topic><topic>Cell number</topic><topic>Chemotherapy</topic><topic>Cholangiocarcinoma</topic><topic>Cholangiocarcinoma - radiotherapy</topic><topic>Cholangiocarcinoma - surgery</topic><topic>external beam radiation therapy</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Leukocytes (neutrophilic)</topic><topic>Lymph nodes</topic><topic>lymphocyte count ratio</topic><topic>Lymphocytes</topic><topic>Lymphocytes - pathology</topic><topic>Medical prognosis</topic><topic>Metastases</topic><topic>Multivariate analysis</topic><topic>Neutrophils - pathology</topic><topic>Patients</topic><topic>Platelets</topic><topic>postoperative radiation therapy</topic><topic>Prognosis</topic><topic>Radiation therapy</topic><topic>Retrospective Studies</topic><topic>three‐dimensional radiation therapy</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mukai, Yuki</creatorcontrib><creatorcontrib>Matsuyama, Ryusei</creatorcontrib><creatorcontrib>Sugiura, Madoka</creatorcontrib><creatorcontrib>Yabushita, Yasuhiro</creatorcontrib><creatorcontrib>Taniuchi, Risa</creatorcontrib><creatorcontrib>Homma, Yuki</creatorcontrib><creatorcontrib>Hashimoto, Kotaro</creatorcontrib><creatorcontrib>Miyake, Kentaro</creatorcontrib><creatorcontrib>Tabuchi, Yuya</creatorcontrib><creatorcontrib>Endo, Itaru</creatorcontrib><creatorcontrib>Hata, Masaharu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Asia-Pacific journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mukai, Yuki</au><au>Matsuyama, Ryusei</au><au>Sugiura, Madoka</au><au>Yabushita, Yasuhiro</au><au>Taniuchi, Risa</au><au>Homma, Yuki</au><au>Hashimoto, Kotaro</au><au>Miyake, Kentaro</au><au>Tabuchi, Yuya</au><au>Endo, Itaru</au><au>Hata, Masaharu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic markers including immune and inflammatory factors predict outcomes in patients receiving postoperative radiation therapy for cholangiocarcinoma</atitle><jtitle>Asia-Pacific journal of clinical oncology</jtitle><addtitle>Asia Pac J Clin Oncol</addtitle><date>2023-02</date><risdate>2023</risdate><volume>19</volume><issue>1</issue><spage>226</spage><epage>233</epage><pages>226-233</pages><issn>1743-7555</issn><eissn>1743-7563</eissn><abstract>Purpose
This study aimed to analyze treatment outcomes and prognostic markers, including immune and inflammatory factors, of postoperative radiation therapy (RT) administered to patients with cholangiocarcinoma (CCA).
Methods
We retrospectively included 59 patients with CCA who underwent surgery and postoperative RT with curative intent from 2004 to 2019. Patients received external irradiation (50 Gy in 25 fractions) using three‐dimensional RT. We analyzed prognostic factors of inflammation, such as pre‐RT platelet count, hemoglobin, lymphocyte count ratio (LCR) of the leukocyte count, platelet‐to‐lymphocyte ratio (PLR), and neutrophil‐to‐lymphocyte ratio (NLR).
Results
Tumor stages were distributed as follows: I (n = 8), II (n = 25), III (n = 15), and IVA (n = 11). The median follow‐up was 24 months. Two‐year overall survival (OS), cause‐specific survival (CSS), progression‐free survival (PFS), and locoregional control (LRC) rates were 59.5%, 62.0%, 40.1%, and 66.7%, respectively. Univariate analysis revealed that lower LCR was significantly associated with shorter PFS (p = 0.0446). There was no significant difference between the median baseline values of PLR and NLR; and age ≥75, positive regional lymph node metastases (N+), and chemotherapy after RT were significantly associated with poor OS. Multivariate analysis revealed a significant association of N+ with worse OS, PFS, and CSS and that lower LCR was significantly associated with better PFS (p = 0.0234). Among late toxicity events, two patients (3.38%) were suspected with therapy‐related liver toxicity.
Conclusions
Lower LCR before RT was a better prognostic factor for postoperative RT of patients with CCA.
Image‐guided percutaneous pericardial effusion drainage for cancer patients is safe and contributes to the alleviation of symptoms. Additionally, catheter removal is possible in most patients, thereby allowing a catheter‐free period for them.</abstract><cop>Australia</cop><pub>Wiley Subscription Services, Inc</pub><pmid>35831998</pmid><doi>10.1111/ajco.13809</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0000-1199</orcidid></addata></record> |
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| subjects | Bile Duct Neoplasms - radiotherapy Bile Duct Neoplasms - surgery Bile Ducts, Intrahepatic Blood Platelets - pathology Cell number Chemotherapy Cholangiocarcinoma Cholangiocarcinoma - radiotherapy Cholangiocarcinoma - surgery external beam radiation therapy Hemoglobin Humans Inflammation Leukocytes (neutrophilic) Lymph nodes lymphocyte count ratio Lymphocytes Lymphocytes - pathology Medical prognosis Metastases Multivariate analysis Neutrophils - pathology Patients Platelets postoperative radiation therapy Prognosis Radiation therapy Retrospective Studies three‐dimensional radiation therapy Toxicity |
| title | Prognostic markers including immune and inflammatory factors predict outcomes in patients receiving postoperative radiation therapy for cholangiocarcinoma |
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