Loading…
Synthetic α-Tocopherol, Compared with Natural α-Tocopherol, Downregulates Myelin Genes in Cerebella of Adolescent Ttpa-null Mice
Vitamin E (α-tocopherol; αα-T) deficiency causes spinocerebellar ataxia. α-T supplementation improves neurological symptoms, but little is known about the differential bioactivities of natural versus synthetic α-T during early life. We assessed the effects of dietary α-T dose and source on tissue α-...
Saved in:
| Published in: | The Journal of nutrition 2020-05, Vol.150 (5), p.1031-1040 |
|---|---|
| Main Authors: | , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c421t-749b9054bafd0299fb6d2d373d7e2ab828d84a9eb8f39f572e83ef8dd52cddc63 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c421t-749b9054bafd0299fb6d2d373d7e2ab828d84a9eb8f39f572e83ef8dd52cddc63 |
| container_end_page | 1040 |
| container_issue | 5 |
| container_start_page | 1031 |
| container_title | The Journal of nutrition |
| container_volume | 150 |
| creator | Ranard, Katherine M Kuchan, Matthew J Bruno, Richard S Juraska, Janice M Erdman, John W |
| description | Vitamin E (α-tocopherol; αα-T) deficiency causes spinocerebellar ataxia. α-T supplementation improves neurological symptoms, but little is known about the differential bioactivities of natural versus synthetic α-T during early life.
We assessed the effects of dietary α-T dose and source on tissue α-T accumulation and gene expression in adolescent α-Tocopherol transfer protein-null (Ttpa–/–) mice.
Three-week-old male Ttpa–/– mice (n = 7/group) were fed 1 of 4 AIN-93Gbased diets for 4 wk: vitamin Edeficient (VED; below α-T limit of detection); natural α-T, 600 mg/kg diet (NAT); synthetic α-T, 816 mg/kg diet (SYN); orhigh synthetic α-T, 1200 mg/kg diet (HSYN). Male Ttpa+/+ littermates fed AIN-93G [75 mg synthetic α-T (CON)] servedas controls (n = 7). At 7 wk of age, tissue α-T concentrations and stereoisomer profiles were measured for all groups.
Ttpa–/– mice fed VED had undetectable brain α-T concentrations. Cerebral cortex α-T concentrations weregreater in Ttpa–/– mice fed NAT (9.1 ± 0.7 nmol/g), SYN (10.8 ± 1.0 nmol/g), and HSYN (13.9 ± 1.6 nmol/g) compared withthe VED group but were significantly lower than in Ttpa+/+ mice fed CON (24.6 ± 1.2 nmol/g) (P < 0.001). RRR-α-T wasthe predominant stereoisomer in brains of Ttpa+/+ mice (~40%) and Ttpa–/– mice fed NAT (~94%). α-T stereoisomercomposition was similar in brains of Ttpa–/– mice fed SYN and HSYN (2R: ~53%; 2S: ~47%). Very few of the 16,774genes measured were differentially expressed. However, compared with the NAT diet, HSYN significantly downregulated20 myelin genes, including 2 transcription factors: SRY-box transcription factor 10 (Sox10) and myelin regulatory factor(Myrf), and several downstream target genes (false discovery rate |
| doi_str_mv | 10.1093/jn/nxz330 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2401841977</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><oup_id>10.1093/jn/nxz330</oup_id><els_id>S0022316622021721</els_id><sourcerecordid>2401841977</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-749b9054bafd0299fb6d2d373d7e2ab828d84a9eb8f39f572e83ef8dd52cddc63</originalsourceid><addsrcrecordid>eNp90M1u1DAUBWALgdqh7YIXQJZgg0SofzKJvawGKEgtXTCsLce-YTzy2MF2KMOSN-qL9JkalMKiQqx8LX0-Vz4IPaPkDSWSn27Dafjxk3PyCC3osqZVQwl5jBaEMFZx2jSH6GnOW0IIraU4QIecCsEJbRbo1-d9KBsozuDbm2odTRw2kKJ_jVdxN-gEFl-7ssGfdBmT9g_R23gdEnwdvS6Q8eUevAv4HMJ0mYYVJOjAe41jj89s9JANhILXZdBVGL3Hl87AMXrSa5_h5P48Ql_ev1uvPlQXV-cfV2cXlakZLVVby06SZd3p3hImZd81llnectsC051gwopaS-hEz2W_bBkIDr2wdsmMtabhR-jFnDuk-G2EXNQ2jilMKxWrCRU1lW07qVezMinmnKBXQ3I7nfaKEvW7bbUNam57ss_vE8duB_av_FPvBF7OII7Df3P4zGD6_ncHSWXjIBiwLoEpykb3j1d3ttec8Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2401841977</pqid></control><display><type>article</type><title>Synthetic α-Tocopherol, Compared with Natural α-Tocopherol, Downregulates Myelin Genes in Cerebella of Adolescent Ttpa-null Mice</title><source>ScienceDirect</source><source>Alma/SFX Local Collection</source><creator>Ranard, Katherine M ; Kuchan, Matthew J ; Bruno, Richard S ; Juraska, Janice M ; Erdman, John W</creator><creatorcontrib>Ranard, Katherine M ; Kuchan, Matthew J ; Bruno, Richard S ; Juraska, Janice M ; Erdman, John W</creatorcontrib><description>Vitamin E (α-tocopherol; αα-T) deficiency causes spinocerebellar ataxia. α-T supplementation improves neurological symptoms, but little is known about the differential bioactivities of natural versus synthetic α-T during early life.
We assessed the effects of dietary α-T dose and source on tissue α-T accumulation and gene expression in adolescent α-Tocopherol transfer protein-null (Ttpa–/–) mice.
Three-week-old male Ttpa–/– mice (n = 7/group) were fed 1 of 4 AIN-93Gbased diets for 4 wk: vitamin Edeficient (VED; below α-T limit of detection); natural α-T, 600 mg/kg diet (NAT); synthetic α-T, 816 mg/kg diet (SYN); orhigh synthetic α-T, 1200 mg/kg diet (HSYN). Male Ttpa+/+ littermates fed AIN-93G [75 mg synthetic α-T (CON)] servedas controls (n = 7). At 7 wk of age, tissue α-T concentrations and stereoisomer profiles were measured for all groups.
Ttpa–/– mice fed VED had undetectable brain α-T concentrations. Cerebral cortex α-T concentrations weregreater in Ttpa–/– mice fed NAT (9.1 ± 0.7 nmol/g), SYN (10.8 ± 1.0 nmol/g), and HSYN (13.9 ± 1.6 nmol/g) compared withthe VED group but were significantly lower than in Ttpa+/+ mice fed CON (24.6 ± 1.2 nmol/g) (P < 0.001). RRR-α-T wasthe predominant stereoisomer in brains of Ttpa+/+ mice (~40%) and Ttpa–/– mice fed NAT (~94%). α-T stereoisomercomposition was similar in brains of Ttpa–/– mice fed SYN and HSYN (2R: ~53%; 2S: ~47%). Very few of the 16,774genes measured were differentially expressed. However, compared with the NAT diet, HSYN significantly downregulated20 myelin genes, including 2 transcription factors: SRY-box transcription factor 10 (Sox10) and myelin regulatory factor(Myrf), and several downstream target genes (false discovery rate <0.05).
High-dose synthetic α-T compared with natural α-T alters myelin gene expression in the adolescent mouse cerebellum, which could lead to morphological and functional abnormalities later in life.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/nxz330</identifier><identifier>PMID: 31883016</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Abnormalities ; adolescent ; Adolescents ; all-rac α-tocopherol ; alpha-Tocopherol - chemical synthesis ; alpha-Tocopherol - pharmacology ; Animal Feed - analysis ; Animals ; Ataxia ; Bioaccumulation ; Body Weight ; brain ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; Cerebellum ; Cerebellum - drug effects ; Cerebellum - metabolism ; Cerebral cortex ; Diet ; Dietary supplements ; Dosage ; Eating ; Effects ; Gene expression ; Gene Expression Regulation - drug effects ; Gene sequencing ; Genes ; Male ; Mice ; Mice, Knockout ; Myelin ; Myelin Sheath - metabolism ; Nutrient deficiency ; Ribonucleic acid ; RNA ; RNA-sequencing ; RRR α-tocopherol ; Sox10 protein ; Stereoisomers ; Teenagers ; Tocopherol ; Transcription factors ; Ttpa-null mouse ; Vitamin E</subject><ispartof>The Journal of nutrition, 2020-05, Vol.150 (5), p.1031-1040</ispartof><rights>2020 American Society for Nutrition.</rights><rights>Copyright © The Author(s) 2019. 2019</rights><rights>Copyright © The Author(s) 2019.</rights><rights>Copyright American Institute of Nutrition May 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-749b9054bafd0299fb6d2d373d7e2ab828d84a9eb8f39f572e83ef8dd52cddc63</citedby><cites>FETCH-LOGICAL-c421t-749b9054bafd0299fb6d2d373d7e2ab828d84a9eb8f39f572e83ef8dd52cddc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0022316622021721$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,783,787,3556,27936,27937,45792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31883016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ranard, Katherine M</creatorcontrib><creatorcontrib>Kuchan, Matthew J</creatorcontrib><creatorcontrib>Bruno, Richard S</creatorcontrib><creatorcontrib>Juraska, Janice M</creatorcontrib><creatorcontrib>Erdman, John W</creatorcontrib><title>Synthetic α-Tocopherol, Compared with Natural α-Tocopherol, Downregulates Myelin Genes in Cerebella of Adolescent Ttpa-null Mice</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>Vitamin E (α-tocopherol; αα-T) deficiency causes spinocerebellar ataxia. α-T supplementation improves neurological symptoms, but little is known about the differential bioactivities of natural versus synthetic α-T during early life.
We assessed the effects of dietary α-T dose and source on tissue α-T accumulation and gene expression in adolescent α-Tocopherol transfer protein-null (Ttpa–/–) mice.
Three-week-old male Ttpa–/– mice (n = 7/group) were fed 1 of 4 AIN-93Gbased diets for 4 wk: vitamin Edeficient (VED; below α-T limit of detection); natural α-T, 600 mg/kg diet (NAT); synthetic α-T, 816 mg/kg diet (SYN); orhigh synthetic α-T, 1200 mg/kg diet (HSYN). Male Ttpa+/+ littermates fed AIN-93G [75 mg synthetic α-T (CON)] servedas controls (n = 7). At 7 wk of age, tissue α-T concentrations and stereoisomer profiles were measured for all groups.
Ttpa–/– mice fed VED had undetectable brain α-T concentrations. Cerebral cortex α-T concentrations weregreater in Ttpa–/– mice fed NAT (9.1 ± 0.7 nmol/g), SYN (10.8 ± 1.0 nmol/g), and HSYN (13.9 ± 1.6 nmol/g) compared withthe VED group but were significantly lower than in Ttpa+/+ mice fed CON (24.6 ± 1.2 nmol/g) (P < 0.001). RRR-α-T wasthe predominant stereoisomer in brains of Ttpa+/+ mice (~40%) and Ttpa–/– mice fed NAT (~94%). α-T stereoisomercomposition was similar in brains of Ttpa–/– mice fed SYN and HSYN (2R: ~53%; 2S: ~47%). Very few of the 16,774genes measured were differentially expressed. However, compared with the NAT diet, HSYN significantly downregulated20 myelin genes, including 2 transcription factors: SRY-box transcription factor 10 (Sox10) and myelin regulatory factor(Myrf), and several downstream target genes (false discovery rate <0.05).
High-dose synthetic α-T compared with natural α-T alters myelin gene expression in the adolescent mouse cerebellum, which could lead to morphological and functional abnormalities later in life.</description><subject>Abnormalities</subject><subject>adolescent</subject><subject>Adolescents</subject><subject>all-rac α-tocopherol</subject><subject>alpha-Tocopherol - chemical synthesis</subject><subject>alpha-Tocopherol - pharmacology</subject><subject>Animal Feed - analysis</subject><subject>Animals</subject><subject>Ataxia</subject><subject>Bioaccumulation</subject><subject>Body Weight</subject><subject>brain</subject><subject>Carrier Proteins - genetics</subject><subject>Carrier Proteins - metabolism</subject><subject>Cerebellum</subject><subject>Cerebellum - drug effects</subject><subject>Cerebellum - metabolism</subject><subject>Cerebral cortex</subject><subject>Diet</subject><subject>Dietary supplements</subject><subject>Dosage</subject><subject>Eating</subject><subject>Effects</subject><subject>Gene expression</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Gene sequencing</subject><subject>Genes</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Knockout</subject><subject>Myelin</subject><subject>Myelin Sheath - metabolism</subject><subject>Nutrient deficiency</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><subject>RNA-sequencing</subject><subject>RRR α-tocopherol</subject><subject>Sox10 protein</subject><subject>Stereoisomers</subject><subject>Teenagers</subject><subject>Tocopherol</subject><subject>Transcription factors</subject><subject>Ttpa-null mouse</subject><subject>Vitamin E</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp90M1u1DAUBWALgdqh7YIXQJZgg0SofzKJvawGKEgtXTCsLce-YTzy2MF2KMOSN-qL9JkalMKiQqx8LX0-Vz4IPaPkDSWSn27Dafjxk3PyCC3osqZVQwl5jBaEMFZx2jSH6GnOW0IIraU4QIecCsEJbRbo1-d9KBsozuDbm2odTRw2kKJ_jVdxN-gEFl-7ssGfdBmT9g_R23gdEnwdvS6Q8eUevAv4HMJ0mYYVJOjAe41jj89s9JANhILXZdBVGL3Hl87AMXrSa5_h5P48Ql_ev1uvPlQXV-cfV2cXlakZLVVby06SZd3p3hImZd81llnectsC051gwopaS-hEz2W_bBkIDr2wdsmMtabhR-jFnDuk-G2EXNQ2jilMKxWrCRU1lW07qVezMinmnKBXQ3I7nfaKEvW7bbUNam57ss_vE8duB_av_FPvBF7OII7Df3P4zGD6_ncHSWXjIBiwLoEpykb3j1d3ttec8Q</recordid><startdate>202005</startdate><enddate>202005</enddate><creator>Ranard, Katherine M</creator><creator>Kuchan, Matthew J</creator><creator>Bruno, Richard S</creator><creator>Juraska, Janice M</creator><creator>Erdman, John W</creator><general>Elsevier Inc</general><general>Oxford University Press</general><general>American Institute of Nutrition</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>202005</creationdate><title>Synthetic α-Tocopherol, Compared with Natural α-Tocopherol, Downregulates Myelin Genes in Cerebella of Adolescent Ttpa-null Mice</title><author>Ranard, Katherine M ; Kuchan, Matthew J ; Bruno, Richard S ; Juraska, Janice M ; Erdman, John W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-749b9054bafd0299fb6d2d373d7e2ab828d84a9eb8f39f572e83ef8dd52cddc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Abnormalities</topic><topic>adolescent</topic><topic>Adolescents</topic><topic>all-rac α-tocopherol</topic><topic>alpha-Tocopherol - chemical synthesis</topic><topic>alpha-Tocopherol - pharmacology</topic><topic>Animal Feed - analysis</topic><topic>Animals</topic><topic>Ataxia</topic><topic>Bioaccumulation</topic><topic>Body Weight</topic><topic>brain</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - metabolism</topic><topic>Cerebellum</topic><topic>Cerebellum - drug effects</topic><topic>Cerebellum - metabolism</topic><topic>Cerebral cortex</topic><topic>Diet</topic><topic>Dietary supplements</topic><topic>Dosage</topic><topic>Eating</topic><topic>Effects</topic><topic>Gene expression</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Gene sequencing</topic><topic>Genes</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Knockout</topic><topic>Myelin</topic><topic>Myelin Sheath - metabolism</topic><topic>Nutrient deficiency</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><topic>RNA-sequencing</topic><topic>RRR α-tocopherol</topic><topic>Sox10 protein</topic><topic>Stereoisomers</topic><topic>Teenagers</topic><topic>Tocopherol</topic><topic>Transcription factors</topic><topic>Ttpa-null mouse</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ranard, Katherine M</creatorcontrib><creatorcontrib>Kuchan, Matthew J</creatorcontrib><creatorcontrib>Bruno, Richard S</creatorcontrib><creatorcontrib>Juraska, Janice M</creatorcontrib><creatorcontrib>Erdman, John W</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ranard, Katherine M</au><au>Kuchan, Matthew J</au><au>Bruno, Richard S</au><au>Juraska, Janice M</au><au>Erdman, John W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthetic α-Tocopherol, Compared with Natural α-Tocopherol, Downregulates Myelin Genes in Cerebella of Adolescent Ttpa-null Mice</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>2020-05</date><risdate>2020</risdate><volume>150</volume><issue>5</issue><spage>1031</spage><epage>1040</epage><pages>1031-1040</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><abstract>Vitamin E (α-tocopherol; αα-T) deficiency causes spinocerebellar ataxia. α-T supplementation improves neurological symptoms, but little is known about the differential bioactivities of natural versus synthetic α-T during early life.
We assessed the effects of dietary α-T dose and source on tissue α-T accumulation and gene expression in adolescent α-Tocopherol transfer protein-null (Ttpa–/–) mice.
Three-week-old male Ttpa–/– mice (n = 7/group) were fed 1 of 4 AIN-93Gbased diets for 4 wk: vitamin Edeficient (VED; below α-T limit of detection); natural α-T, 600 mg/kg diet (NAT); synthetic α-T, 816 mg/kg diet (SYN); orhigh synthetic α-T, 1200 mg/kg diet (HSYN). Male Ttpa+/+ littermates fed AIN-93G [75 mg synthetic α-T (CON)] servedas controls (n = 7). At 7 wk of age, tissue α-T concentrations and stereoisomer profiles were measured for all groups.
Ttpa–/– mice fed VED had undetectable brain α-T concentrations. Cerebral cortex α-T concentrations weregreater in Ttpa–/– mice fed NAT (9.1 ± 0.7 nmol/g), SYN (10.8 ± 1.0 nmol/g), and HSYN (13.9 ± 1.6 nmol/g) compared withthe VED group but were significantly lower than in Ttpa+/+ mice fed CON (24.6 ± 1.2 nmol/g) (P < 0.001). RRR-α-T wasthe predominant stereoisomer in brains of Ttpa+/+ mice (~40%) and Ttpa–/– mice fed NAT (~94%). α-T stereoisomercomposition was similar in brains of Ttpa–/– mice fed SYN and HSYN (2R: ~53%; 2S: ~47%). Very few of the 16,774genes measured were differentially expressed. However, compared with the NAT diet, HSYN significantly downregulated20 myelin genes, including 2 transcription factors: SRY-box transcription factor 10 (Sox10) and myelin regulatory factor(Myrf), and several downstream target genes (false discovery rate <0.05).
High-dose synthetic α-T compared with natural α-T alters myelin gene expression in the adolescent mouse cerebellum, which could lead to morphological and functional abnormalities later in life.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31883016</pmid><doi>10.1093/jn/nxz330</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3166 |
| ispartof | The Journal of nutrition, 2020-05, Vol.150 (5), p.1031-1040 |
| issn | 0022-3166 1541-6100 |
| language | eng |
| recordid | cdi_proquest_journals_2401841977 |
| source | ScienceDirect; Alma/SFX Local Collection |
| subjects | Abnormalities adolescent Adolescents all-rac α-tocopherol alpha-Tocopherol - chemical synthesis alpha-Tocopherol - pharmacology Animal Feed - analysis Animals Ataxia Bioaccumulation Body Weight brain Carrier Proteins - genetics Carrier Proteins - metabolism Cerebellum Cerebellum - drug effects Cerebellum - metabolism Cerebral cortex Diet Dietary supplements Dosage Eating Effects Gene expression Gene Expression Regulation - drug effects Gene sequencing Genes Male Mice Mice, Knockout Myelin Myelin Sheath - metabolism Nutrient deficiency Ribonucleic acid RNA RNA-sequencing RRR α-tocopherol Sox10 protein Stereoisomers Teenagers Tocopherol Transcription factors Ttpa-null mouse Vitamin E |
| title | Synthetic α-Tocopherol, Compared with Natural α-Tocopherol, Downregulates Myelin Genes in Cerebella of Adolescent Ttpa-null Mice |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-11-15T10%3A39%3A37IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthetic%20%CE%B1-Tocopherol,%20Compared%20with%20Natural%20%CE%B1-Tocopherol,%20Downregulates%20Myelin%20Genes%20in%20Cerebella%20of%20Adolescent%20Ttpa-null%20Mice&rft.jtitle=The%20Journal%20of%20nutrition&rft.au=Ranard,%20Katherine%20M&rft.date=2020-05&rft.volume=150&rft.issue=5&rft.spage=1031&rft.epage=1040&rft.pages=1031-1040&rft.issn=0022-3166&rft.eissn=1541-6100&rft_id=info:doi/10.1093/jn/nxz330&rft_dat=%3Cproquest_cross%3E2401841977%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c421t-749b9054bafd0299fb6d2d373d7e2ab828d84a9eb8f39f572e83ef8dd52cddc63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2401841977&rft_id=info:pmid/31883016&rft_oup_id=10.1093/jn/nxz330&rfr_iscdi=true |