Genotoxic activity of Eucalyptus globulus essential oil in Aspergillus nidulans diploid cells

Eucalyptus globulus essential oil was evaluated for its genotoxic potential using a somatic segregation assay and a diploid strain of the fungus Aspergillus nidulans , heterozygous for nutritional and conidia color markers. The main compounds of the current essential oil sample were eucalyptol (49.0...

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Bibliographic Details
Published in:Folia microbiologica 2009-11, Vol.54 (6), p.493-498
Main Authors: Miyamoto, C. T., Rocha De Sant’anna, J., Da Silva Franco, C. C., Cunico, M. M., Miguel, O. G., Côcco, L. C., Yamamoto, C. I., Corrêa, C., De Castro-Prado, M. A. A.
Format: Article
Language:English
Subjects:
Antifungal Agents - chemistry
Antifungal Agents - pharmacology
Applied Microbiology
Aspergillus nidulans - cytology
Aspergillus nidulans - drug effects
Biomedical and Life Sciences
Cells
Chromosomes
Chromosomes - drug effects
Diploidy
DNA, Fungal - genetics
Environmental Engineering/Biotechnology
Eucalyptus - chemistry
Immunology
Life Sciences
Microbiology
Mitosis - drug effects
Mutagens - chemistry
Mutagens - pharmacology
Oils & fats
Oils, Volatile - chemistry
Oils, Volatile - isolation & purification
Oils, Volatile - pharmacology
Toxicity
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Summary:Eucalyptus globulus essential oil was evaluated for its genotoxic potential using a somatic segregation assay and a diploid strain of the fungus Aspergillus nidulans , heterozygous for nutritional and conidia color markers. The main compounds of the current essential oil sample were eucalyptol (49.0 %), α-pinene (8.9), β-pinene (1.5), globulol (6.9), α-eudesmol (1.12), spathulenol (1.42), γ-cadinene (1.45), trans -β-elemenone (1.23) and aromandendrene (2.3), totaling 74 % of oil. Oil at 0.12 and 0.25 μL/mL was found to increase the mitotic instability of the original diploid strain and the number of diploid mitotic recombinants of A. nidulans . The genotoxicity of the oil was associated with the induction of mitotic crossing-over or with oil-broken chromosomes.
ISSN:0015-5632
1874-9356
DOI:10.1007/s12223-009-0070-1