Molecular interactions between Pluronic F127 and saponin in aqueous solution

Nanotechnology is important for the development of new materials capable to improve the development of novel drug delivery systems. Such systems may result in more efficient therapeutic effects with reduced toxicity and extended time in the organism and increase in bioavailability, biocompatibility,...

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Bibliographic Details
Published in:Colloid and polymer science 2020-02, Vol.298 (2), p.113-122
Main Authors: de Oliveira, Rosemaire S. S., Marín Huachaca, Nélida S., Lemos, Monique, Santos, Natália F., Feitosa, Eloi, Salay, Luiz C.
Format: Article
Language:English
Subjects:
Aqueous solutions
Bioavailability
Biocompatibility
Block copolymers
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Differential scanning calorimetry
Drug delivery systems
Food Science
Micelles
Molecular interactions
Nanotechnology
Nanotechnology and Microengineering
Original Contribution
Photon correlation spectroscopy
Physical Chemistry
Poloxamers
Polymer Sciences
Saponins
Scattering
Soft and Granular Matter
Toxicity
Zeta potential
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Summary:Nanotechnology is important for the development of new materials capable to improve the development of novel drug delivery systems. Such systems may result in more efficient therapeutic effects with reduced toxicity and extended time in the organism and increase in bioavailability, biocompatibility, and solubility of drugs. Here it was investigated the interaction between the triblock copolymer Pluronic F127 (F127) and a natural bioactive amphiphilic saponin (SAP), extracted from Glycyrrhiza glabra roots, aiming to form micelle-like F127-SAP complexes in a pH 7.4 HEPES buffered aqueous solution, with potential nanobiotechnological applications. Differential scanning calorimetry (DSC), dynamic light scattering (DLS), and dynamic electrophoretic light scattering (DESL) were the techniques used in this investigation, at varied SAP concentrations below and above CMC at fixed 500 μM F127. The SAP-F127 molecular interactions were verified by changes in the critical micellar temperature (CMT) of F127 obtained from the DSC thermograms, while DLS and DELS data showed, respectively, the formation larger structures of the complexes relative to the single Pluronic micelles and zeta potential (ζ) values ranging from ca − 6.5 to − 9 mV, on varying the SAP concentration. Combined, these results indicate the formation of micelle-like complexes, with structure dependent on the SAP concentration, as highly promising agents in nanobiotechnology applications.
ISSN:0303-402X
1435-1536
DOI:10.1007/s00396-019-04552-z