Amino acid–intercalated layered double hydroxide core @ ordered porous silica shell as drug carriers: Design and applications

A nanoparticle-based drug delivery system is first established by mesoporous silica encapsulating amino acid–intercalated layered double hydroxide (LDH) to construct nanocomposites AA-LDH@MS. The amino acids including phenylalanine (Phe) and histidine (His) with aromatic groups are intercalated into...

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Published in:Journal of materials research 2019-11, Vol.34 (22), p.3747-3756
Main Authors: Wang, Jianqiang, Zhang, Wenpei, Hao, Lifeng, Sun, Jun, Zhang, Wenqi, Guo, Cheng, Mu, Yuhan, Ji, Weiting, Yu, Caiyuan, Yuan, Fangming
Format: Article
Language:English
Subjects:
Amino acids
Applied and Technical Physics
Biocompatibility
Biomaterials
Biomedical Materials
Drug carriers
Drug delivery systems
Fourier transforms
Histidine
Hydroxides
Inorganic Chemistry
Interlayers
Materials Engineering
Materials research
Materials Science
Nanocomposites
Nanoparticles
Nanotechnology
Phenylalanine
Regenerative Medicine and Drug Delivery
Silicon dioxide
Surfactants
Sustained release
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cited_by cdi_FETCH-LOGICAL-c338t-a23a063133c0784723bb9336adf41ec810071ce8124519eee2e25cd549f039f3
cites cdi_FETCH-LOGICAL-c338t-a23a063133c0784723bb9336adf41ec810071ce8124519eee2e25cd549f039f3
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container_issue 22
container_start_page 3747
container_title Journal of materials research
container_volume 34
creator Wang, Jianqiang
Zhang, Wenpei
Hao, Lifeng
Sun, Jun
Zhang, Wenqi
Guo, Cheng
Mu, Yuhan
Ji, Weiting
Yu, Caiyuan
Yuan, Fangming
description A nanoparticle-based drug delivery system is first established by mesoporous silica encapsulating amino acid–intercalated layered double hydroxide (LDH) to construct nanocomposites AA-LDH@MS. The amino acids including phenylalanine (Phe) and histidine (His) with aromatic groups are intercalated into LDH as the cores Phe-LDH and His-LDH. These nanocomposites AA-LDH@MS display multispaces of the interlayer spaces of LDH and porous channels of mesoporous silica to load drugs. Moreover, amino acid molecules provide the interaction sites to improve effectively loading amounts of drugs. 5-Fluorouracil (5-FU) is used as the cargo molecules to observe the delivery in vitro. The results indicate that the maximum loading amounts of drugs are up to 392 mg/g at 60 °C for 12 h in the nanocomposite Phe-LDH@MS. All the nanocomposites exhibit the sustained release of 5-FU at pH 4 and pH 7.4. The Korsmeyer–Peppas model is used to fit the kinetic plot of the drug release in vitro, which concludes that 5-FU release from AA-LDH@MS belongs to Fickian diffusion.
doi_str_mv 10.1557/jmr.2019.324
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The amino acids including phenylalanine (Phe) and histidine (His) with aromatic groups are intercalated into LDH as the cores Phe-LDH and His-LDH. These nanocomposites AA-LDH@MS display multispaces of the interlayer spaces of LDH and porous channels of mesoporous silica to load drugs. Moreover, amino acid molecules provide the interaction sites to improve effectively loading amounts of drugs. 5-Fluorouracil (5-FU) is used as the cargo molecules to observe the delivery in vitro. The results indicate that the maximum loading amounts of drugs are up to 392 mg/g at 60 °C for 12 h in the nanocomposite Phe-LDH@MS. All the nanocomposites exhibit the sustained release of 5-FU at pH 4 and pH 7.4. 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The amino acids including phenylalanine (Phe) and histidine (His) with aromatic groups are intercalated into LDH as the cores Phe-LDH and His-LDH. These nanocomposites AA-LDH@MS display multispaces of the interlayer spaces of LDH and porous channels of mesoporous silica to load drugs. Moreover, amino acid molecules provide the interaction sites to improve effectively loading amounts of drugs. 5-Fluorouracil (5-FU) is used as the cargo molecules to observe the delivery in vitro. The results indicate that the maximum loading amounts of drugs are up to 392 mg/g at 60 °C for 12 h in the nanocomposite Phe-LDH@MS. All the nanocomposites exhibit the sustained release of 5-FU at pH 4 and pH 7.4. 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subjects Amino acids
Applied and Technical Physics
Biocompatibility
Biomaterials
Biomedical Materials
Drug carriers
Drug delivery systems
Fourier transforms
Histidine
Hydroxides
Inorganic Chemistry
Interlayers
Materials Engineering
Materials research
Materials Science
Nanocomposites
Nanoparticles
Nanotechnology
Phenylalanine
Regenerative Medicine and Drug Delivery
Silicon dioxide
Surfactants
Sustained release
title Amino acid–intercalated layered double hydroxide core @ ordered porous silica shell as drug carriers: Design and applications
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