Solid standards for positron emitters

Positron Emission Tomography is a well establish technique to obtain physiological information of a patient or a process. In order to guarantee all the benefits of this technique it is important to establish quality control routines on the equipment utilized to perform radioactive measurements, the...

Full description

Saved in:
Bibliographic Details
Published in:Radiation physics and chemistry (Oxford, England : 1993) England : 1993), 2020-02, Vol.167, p.108327, Article 108327
Main Authors: de Oliveira, Mércia L., Reis, Luciane C.O., Leão, Renata L.C., Fragoso, Maria C.F., Lima, Fernando R.A.
Format: Article
Language:English
Subjects:
Biocompatibility
Compressive strength
Control equipment
Curing agents
Dosimeters
Emitters
Epoxy resin
Epoxy resins
Fluorescent dye
Fluorescent dyes
Ionizing radiation
Organic chemistry
Penicillin
Performance tests
Positron emission
Positrons
Quality control
Radioactive materials
Sodium 22
Standardization
Toxicity
Traceability
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Positron Emission Tomography is a well establish technique to obtain physiological information of a patient or a process. In order to guarantee all the benefits of this technique it is important to establish quality control routines on the equipment utilized to perform radioactive measurements, the activimeter. In this way, this paper describes the procedure to obtain solid radioactive standard sources, based on sodium-22, which could be used on performance tests as well as to calibration purposes. The solid standards were prepared using the epoxy resin, as it presents advantages such as chemical stability, compressive strength and low toxicity. Initially, the compatibility between epoxy resins and curing agents with the radioactive materials was evaluated. It was verified that the combination between resin SQ2220 (Redelease) and curing agent SQ3154 (Redelease) was the most adequate in a 2:1 ratio. In addition, an anti-bubble solution (0.5%) was added. Fluorescent dyes were used in order to verify the deposition of the radioactive material throughout the extension of the source. The geometry chosen to prepare the radioactive standards was the penicillin-type glass bottle (10 ml). An analytical balance was used for the accurate determination of the mass of the radioactive material and a vortex mixer for homogenization. Liquid radioactive sources (master solutions) were provided by the National Laboratory of Ionizing Radiation Metrology (LNMRI), Institute of Radioprotection and Dosimetry (IRD/CNEN/Brazil). Through the procedure established on the present work was possible to prepare solid standard sources for positrons emitters adequate to measurements on activimeters. The activity values determined experimentally were compared to the certificated value. •Radiation detectors should be tested with adequate sources in terms of energy emission characteristics and geometry.•Epoxy resin are extensively utilized to obtain radioactive standards.•Solid standards are safer and adequate to execute key-comparison and performance tests.•A simple methodology for standardize positron emitters was developed.•Sodium 22 solid sources were obtained in geometries are utilized in nuclear medicine.
ISSN:0969-806X
1879-0895
DOI:10.1016/j.radphyschem.2019.05.017