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A Cluster of Children With Seizures Caused by Camphor Poisoning
Isolated cases of camphor-induced seizures have been reported in young children after gastrointestinal, dermal, and inhalation exposure. In 1982, after a series of unintentional ingestions of camphor products, the US Food and Drug Administration restricted the camphor content to
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| Published in: | Pediatrics (Evanston) 2009-05, Vol.123 (5), p.1269-1272 |
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| container_end_page | 1272 |
| container_issue | 5 |
| container_start_page | 1269 |
| container_title | Pediatrics (Evanston) |
| container_volume | 123 |
| creator | Khine, Hnin Weiss, Don Graber, Nathan Hoffman, Robert S Esteban-Cruciani, Nora Avner, Jeffrey R |
| description | Isolated cases of camphor-induced seizures have been reported in young children after gastrointestinal, dermal, and inhalation exposure. In 1982, after a series of unintentional ingestions of camphor products, the US Food and Drug Administration restricted the camphor content to |
| doi_str_mv | 10.1542/peds.2008-2097 |
| format | article |
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To describe a cluster of cases of camphor-associated seizure activity resulting from the availability of imported camphor products in certain ethnic populations that use it as a natural remedy.
We present 3 cases of seizures associated with imported, illegally sold camphor in young children who presented to a large, urban children's hospital in Bronx, New York, during a 2-week period.
The children's ages ranged from 15 to 36 months. Two children ingested camphor, and 1 child was exposed through repetitive rubbing of camphor on her skin. All 3 patients required pharmacologic intervention to terminate the seizures. One patient required bag-valve-mask ventilation for transient respiratory depression. All 3 patients had leukocytosis, and 2 patients had hyperglycemia. Exposure occurred as a result of using camphor for spiritual purposes, cold remedy, or pest control. After identification of these cases, the New York City Department of Health released a public health warning to keep camphor products away from children. Similar warnings were issued later by other state health departments.
These cases highlight the toxicity associated with camphor usage in the community and that inappropriate use of illegally sold camphor products is an important public health issue. Camphor may be a common, yet unrecognized, source of seizures in children in certain ethnic populations that use it as a natural remedy. Efforts are needed to educate the communities about the hazards of using camphor products and to limit the illegal availability of these products.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2008-2097</identifier><identifier>PMID: 19403490</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: Am Acad Pediatrics</publisher><subject>Adolescent ; Adult ; Anti-Infective Agents, Local - poisoning ; Biological and medical sciences ; Camphor ; Camphor - poisoning ; Chemical compounds ; Child ; Children ; Children & youth ; Cluster Analysis ; Complications and side effects ; Convulsions & seizures ; Diseases ; Epilepsy, Tonic-Clonic - chemically induced ; Female ; General aspects ; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy ; Humans ; Male ; Medical sciences ; Nervous system (semeiology, syndromes) ; Neurology ; New York City - epidemiology ; Pediatric diseases ; Pediatrics ; Poisoning ; Poisoning - epidemiology ; Psychological aspects ; Recurrence ; Risk factors ; Seizures (Medicine) ; Seizures - chemically induced ; Seizures - therapy ; Toxicity ; Urban Population ; Young Adult</subject><ispartof>Pediatrics (Evanston), 2009-05, Vol.123 (5), p.1269-1272</ispartof><rights>2009 INIST-CNRS</rights><rights>Copyright American Academy of Pediatrics May 2009</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c428t-5643fb71dbec26e12260795e40f9e5624bfe57cf9fd6245763cfb9e8b7abef663</citedby><cites>FETCH-LOGICAL-c428t-5643fb71dbec26e12260795e40f9e5624bfe57cf9fd6245763cfb9e8b7abef663</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21458781$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19403490$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khine, Hnin</creatorcontrib><creatorcontrib>Weiss, Don</creatorcontrib><creatorcontrib>Graber, Nathan</creatorcontrib><creatorcontrib>Hoffman, Robert S</creatorcontrib><creatorcontrib>Esteban-Cruciani, Nora</creatorcontrib><creatorcontrib>Avner, Jeffrey R</creatorcontrib><title>A Cluster of Children With Seizures Caused by Camphor Poisoning</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>Isolated cases of camphor-induced seizures have been reported in young children after gastrointestinal, dermal, and inhalation exposure. In 1982, after a series of unintentional ingestions of camphor products, the US Food and Drug Administration restricted the camphor content to <11% in some products intended for medicinal use. Camphor products intended for use as pesticides must be registered with the US Environmental Protection Agency. Still, many imported camphor-containing products fail to meet Food and Drug Administration and Environmental Protection Agency requirements for labeling and content.
To describe a cluster of cases of camphor-associated seizure activity resulting from the availability of imported camphor products in certain ethnic populations that use it as a natural remedy.
We present 3 cases of seizures associated with imported, illegally sold camphor in young children who presented to a large, urban children's hospital in Bronx, New York, during a 2-week period.
The children's ages ranged from 15 to 36 months. Two children ingested camphor, and 1 child was exposed through repetitive rubbing of camphor on her skin. All 3 patients required pharmacologic intervention to terminate the seizures. One patient required bag-valve-mask ventilation for transient respiratory depression. All 3 patients had leukocytosis, and 2 patients had hyperglycemia. Exposure occurred as a result of using camphor for spiritual purposes, cold remedy, or pest control. After identification of these cases, the New York City Department of Health released a public health warning to keep camphor products away from children. Similar warnings were issued later by other state health departments.
These cases highlight the toxicity associated with camphor usage in the community and that inappropriate use of illegally sold camphor products is an important public health issue. Camphor may be a common, yet unrecognized, source of seizures in children in certain ethnic populations that use it as a natural remedy. Efforts are needed to educate the communities about the hazards of using camphor products and to limit the illegal availability of these products.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Anti-Infective Agents, Local - poisoning</subject><subject>Biological and medical sciences</subject><subject>Camphor</subject><subject>Camphor - poisoning</subject><subject>Chemical compounds</subject><subject>Child</subject><subject>Children</subject><subject>Children & youth</subject><subject>Cluster Analysis</subject><subject>Complications and side effects</subject><subject>Convulsions & seizures</subject><subject>Diseases</subject><subject>Epilepsy, Tonic-Clonic - chemically induced</subject><subject>Female</subject><subject>General aspects</subject><subject>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>New York City - epidemiology</subject><subject>Pediatric diseases</subject><subject>Pediatrics</subject><subject>Poisoning</subject><subject>Poisoning - epidemiology</subject><subject>Psychological aspects</subject><subject>Recurrence</subject><subject>Risk factors</subject><subject>Seizures (Medicine)</subject><subject>Seizures - chemically induced</subject><subject>Seizures - therapy</subject><subject>Toxicity</subject><subject>Urban Population</subject><subject>Young Adult</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNpNkEFr3DAQRkVpaLZprz0WU8jRG0mWLOkUFpM2gUACbelRyPJoreC1NpJNmvz6yuzS5DQz8Gbm4yH0heA14Yxe7KFLa4qxLClW4h1aEaxkyajg79EK44qUDGN-ij6m9IAxZlzQD-iUKIYrpvAKXW6KZpjTBLEIrmh6P3QRxuKPn_riJ_iXOUIqGjMn6Ir2OXe7fR9icR98CqMft5_QiTNDgs_HeoZ-f7_61VyXt3c_bprNbWkZlVPJa1a5VpCuBUtrIJTWWCgODDsFvKasdcCFdcp1eeCirqxrFchWmBZcXVdn6Nvh7j6GxxnSpB_CHMf8UlMqKymkpBkqD9DWDKD9aMM4wd_JhmGALegcqLnTG6KUzMaUzPz6wNsYUorg9D76nYnPmmC96NWLXr3o1YvevPD1mGJud9C94kefGTg_AiZZM7hoRuvTf44SxnNUkrmLA9f7bf_kIyyfvJmit-lNS2iluSa0VtU_9EORnQ</recordid><startdate>20090501</startdate><enddate>20090501</enddate><creator>Khine, Hnin</creator><creator>Weiss, Don</creator><creator>Graber, Nathan</creator><creator>Hoffman, Robert S</creator><creator>Esteban-Cruciani, Nora</creator><creator>Avner, Jeffrey R</creator><general>Am Acad Pediatrics</general><general>American Academy of Pediatrics</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope></search><sort><creationdate>20090501</creationdate><title>A Cluster of Children With Seizures Caused by Camphor Poisoning</title><author>Khine, Hnin ; Weiss, Don ; Graber, Nathan ; Hoffman, Robert S ; Esteban-Cruciani, Nora ; Avner, Jeffrey R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c428t-5643fb71dbec26e12260795e40f9e5624bfe57cf9fd6245763cfb9e8b7abef663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Anti-Infective Agents, Local - poisoning</topic><topic>Biological and medical sciences</topic><topic>Camphor</topic><topic>Camphor - poisoning</topic><topic>Chemical compounds</topic><topic>Child</topic><topic>Children</topic><topic>Children & youth</topic><topic>Cluster Analysis</topic><topic>Complications and side effects</topic><topic>Convulsions & seizures</topic><topic>Diseases</topic><topic>Epilepsy, Tonic-Clonic - chemically induced</topic><topic>Female</topic><topic>General aspects</topic><topic>Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>New York City - epidemiology</topic><topic>Pediatric diseases</topic><topic>Pediatrics</topic><topic>Poisoning</topic><topic>Poisoning - epidemiology</topic><topic>Psychological aspects</topic><topic>Recurrence</topic><topic>Risk factors</topic><topic>Seizures (Medicine)</topic><topic>Seizures - chemically induced</topic><topic>Seizures - therapy</topic><topic>Toxicity</topic><topic>Urban Population</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khine, Hnin</creatorcontrib><creatorcontrib>Weiss, Don</creatorcontrib><creatorcontrib>Graber, Nathan</creatorcontrib><creatorcontrib>Hoffman, Robert S</creatorcontrib><creatorcontrib>Esteban-Cruciani, Nora</creatorcontrib><creatorcontrib>Avner, Jeffrey R</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khine, Hnin</au><au>Weiss, Don</au><au>Graber, Nathan</au><au>Hoffman, Robert S</au><au>Esteban-Cruciani, Nora</au><au>Avner, Jeffrey R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Cluster of Children With Seizures Caused by Camphor Poisoning</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2009-05-01</date><risdate>2009</risdate><volume>123</volume><issue>5</issue><spage>1269</spage><epage>1272</epage><pages>1269-1272</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>Isolated cases of camphor-induced seizures have been reported in young children after gastrointestinal, dermal, and inhalation exposure. In 1982, after a series of unintentional ingestions of camphor products, the US Food and Drug Administration restricted the camphor content to <11% in some products intended for medicinal use. Camphor products intended for use as pesticides must be registered with the US Environmental Protection Agency. Still, many imported camphor-containing products fail to meet Food and Drug Administration and Environmental Protection Agency requirements for labeling and content.
To describe a cluster of cases of camphor-associated seizure activity resulting from the availability of imported camphor products in certain ethnic populations that use it as a natural remedy.
We present 3 cases of seizures associated with imported, illegally sold camphor in young children who presented to a large, urban children's hospital in Bronx, New York, during a 2-week period.
The children's ages ranged from 15 to 36 months. Two children ingested camphor, and 1 child was exposed through repetitive rubbing of camphor on her skin. All 3 patients required pharmacologic intervention to terminate the seizures. One patient required bag-valve-mask ventilation for transient respiratory depression. All 3 patients had leukocytosis, and 2 patients had hyperglycemia. Exposure occurred as a result of using camphor for spiritual purposes, cold remedy, or pest control. After identification of these cases, the New York City Department of Health released a public health warning to keep camphor products away from children. Similar warnings were issued later by other state health departments.
These cases highlight the toxicity associated with camphor usage in the community and that inappropriate use of illegally sold camphor products is an important public health issue. Camphor may be a common, yet unrecognized, source of seizures in children in certain ethnic populations that use it as a natural remedy. Efforts are needed to educate the communities about the hazards of using camphor products and to limit the illegal availability of these products.</abstract><cop>Elk Grove Village, IL</cop><pub>Am Acad Pediatrics</pub><pmid>19403490</pmid><doi>10.1542/peds.2008-2097</doi><tpages>4</tpages></addata></record> |
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| identifier | ISSN: 0031-4005 |
| ispartof | Pediatrics (Evanston), 2009-05, Vol.123 (5), p.1269-1272 |
| issn | 0031-4005 1098-4275 |
| language | eng |
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| subjects | Adolescent Adult Anti-Infective Agents, Local - poisoning Biological and medical sciences Camphor Camphor - poisoning Chemical compounds Child Children Children & youth Cluster Analysis Complications and side effects Convulsions & seizures Diseases Epilepsy, Tonic-Clonic - chemically induced Female General aspects Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Medical sciences Nervous system (semeiology, syndromes) Neurology New York City - epidemiology Pediatric diseases Pediatrics Poisoning Poisoning - epidemiology Psychological aspects Recurrence Risk factors Seizures (Medicine) Seizures - chemically induced Seizures - therapy Toxicity Urban Population Young Adult |
| title | A Cluster of Children With Seizures Caused by Camphor Poisoning |
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