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UV Spectrophotometric Method for Estimation of Sacubitril in Synthetic Mixture
Literature survey reveal few analytical methods are reported for estimation of sacubitril with valsartan in combined dosage form includes spectrophotometric2-4 and RP-HPLC5-12 methods but no UV spectrophotometric method reported yet for estimation of sacubitril alone in pharmaceutical dosage form, s...
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Published in: | Asian Journal of Research in Chemistry 2019, Vol.12 (1), p.7-10 |
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container_title | Asian Journal of Research in Chemistry |
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creator | Madhuri, P Leela Kumar, T Hemant Rao, Y Srinivasa Rao, K Vara Prasada |
description | Literature survey reveal few analytical methods are reported for estimation of sacubitril with valsartan in combined dosage form includes spectrophotometric2-4 and RP-HPLC5-12 methods but no UV spectrophotometric method reported yet for estimation of sacubitril alone in pharmaceutical dosage form, synthetic mixture or biological fluids. [...]an attempt was made to develop a rapid, accurate, sensitive and economical UV spectrophotometric method for estimation of Sacubitril from synthetic mixture. [...]the analytical method would be concluded as robust. The results and the statistical parameters demonstrate that the proposed UV spectrophotometric method is simple, specific, accurate and precise. [...]this method can be used for the determination of sacubitril either in bulk or in synthetic mixture without interference with commonly used excipients. |
doi_str_mv | 10.5958/0974-4150.2019.00002.6 |
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subjects | Accuracy Analytical methods Calibration Dosage Drug dosages Methods Pharmaceutical sciences Pharmacy Solvents Spectrophotometry |
title | UV Spectrophotometric Method for Estimation of Sacubitril in Synthetic Mixture |
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