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Prospective evaluation of 3T MRI findings for primary adnexal lesions and comparison with the final histological diagnosis
Purpose We prospectively investigated the diagnostic accuracy of magnetic resonance imaging (MRI) at 3.0 Tesla (3T) for the detection of suspected primary adnexal masses in a large cohort of patients. Methods This prospective clinical study included 223 patients with suspected gynaecological disease...
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| Published in: | Archives of gynecology and obstetrics 2014-02, Vol.289 (2), p.357-364 |
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| container_end_page | 364 |
| container_issue | 2 |
| container_start_page | 357 |
| container_title | Archives of gynecology and obstetrics |
| container_volume | 289 |
| creator | Zhang, He Zhang, Guo-Fu He, Zhi-Yan Li, Zheng-Yu Zhang, Gui-Xiang |
| description | Purpose
We prospectively investigated the diagnostic accuracy of magnetic resonance imaging (MRI) at 3.0 Tesla (3T) for the detection of suspected primary adnexal masses in a large cohort of patients.
Methods
This prospective clinical study included 223 patients with suspected gynaecological disease who were referred for 3T MRI assessments before laparoscopy or laparotomy. Fifty-nine patients were excluded. All detected adnexal pathologies on MRI were categorized into the four groups (endometric cysts, teratomas, benign tumours and malignant tumours). Histological findings were used as the comparative reference standard. As measures to detect or rule out primary adnexal masses, accuracy, sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) were determined by lesion-based evaluations.
Results
The reference standard method detected 141 primary adnexal lesions in 125 patients. The areas under the receiver operating characteristic curve of the lesion-based evaluations for endometric cysts, teratomas, benign lesions and malignant lesions were 92.8, 93.6, 95.1 and 94.4 %. Lesion-based evaluation yielded an accuracy of 90.3 %, sensitivity of 92.7 %, specificity of 89.3 %, PPV of 77.6 % and NPV of 96.8 % in differentiating malignancies from non-malignant lesions. The diagnostic value of 3T MRI for detecting malignancies was superior to that for benign tumours.
Conclusions
3T MRI well categorize the characteristics of primary adnexal lesions and may be a reliable modality for distinguishing malignancies from benign tumours. |
| doi_str_mv | 10.1007/s00404-013-2990-x |
| format | article |
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We prospectively investigated the diagnostic accuracy of magnetic resonance imaging (MRI) at 3.0 Tesla (3T) for the detection of suspected primary adnexal masses in a large cohort of patients.
Methods
This prospective clinical study included 223 patients with suspected gynaecological disease who were referred for 3T MRI assessments before laparoscopy or laparotomy. Fifty-nine patients were excluded. All detected adnexal pathologies on MRI were categorized into the four groups (endometric cysts, teratomas, benign tumours and malignant tumours). Histological findings were used as the comparative reference standard. As measures to detect or rule out primary adnexal masses, accuracy, sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) were determined by lesion-based evaluations.
Results
The reference standard method detected 141 primary adnexal lesions in 125 patients. The areas under the receiver operating characteristic curve of the lesion-based evaluations for endometric cysts, teratomas, benign lesions and malignant lesions were 92.8, 93.6, 95.1 and 94.4 %. Lesion-based evaluation yielded an accuracy of 90.3 %, sensitivity of 92.7 %, specificity of 89.3 %, PPV of 77.6 % and NPV of 96.8 % in differentiating malignancies from non-malignant lesions. The diagnostic value of 3T MRI for detecting malignancies was superior to that for benign tumours.
Conclusions
3T MRI well categorize the characteristics of primary adnexal lesions and may be a reliable modality for distinguishing malignancies from benign tumours.</description><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-013-2990-x</identifier><identifier>PMID: 23934242</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Accuracy ; Adnexal Diseases - diagnosis ; Adnexal Diseases - pathology ; Adult ; Contrast Media ; Cysts ; Cysts - diagnosis ; Cysts - pathology ; Diagnosis, Differential ; Diffusion Magnetic Resonance Imaging ; Endocrinology ; Female ; Gadolinium DTPA ; Gynecologic Oncology ; Gynecology ; Human Genetics ; Humans ; Magnetic Resonance Imaging - methods ; Medicine ; Medicine & Public Health ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Obstetrics/Perinatology/Midwifery ; Ovarian Neoplasms - diagnosis ; Ovarian Neoplasms - pathology ; Predictive Value of Tests ; Prospective Studies ; Sensitivity and Specificity ; Teratoma - diagnosis ; Teratoma - pathology ; Tumors</subject><ispartof>Archives of gynecology and obstetrics, 2014-02, Vol.289 (2), p.357-364</ispartof><rights>Springer-Verlag Berlin Heidelberg 2013</rights><rights>Archives of Gynecology and Obstetrics is a copyright of Springer, (2013). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-1b79eff661463751d0bb00ff0074bb03b1d14a442fc5078edd2e6dee54eb87613</citedby><cites>FETCH-LOGICAL-c372t-1b79eff661463751d0bb00ff0074bb03b1d14a442fc5078edd2e6dee54eb87613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23934242$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, He</creatorcontrib><creatorcontrib>Zhang, Guo-Fu</creatorcontrib><creatorcontrib>He, Zhi-Yan</creatorcontrib><creatorcontrib>Li, Zheng-Yu</creatorcontrib><creatorcontrib>Zhang, Gui-Xiang</creatorcontrib><title>Prospective evaluation of 3T MRI findings for primary adnexal lesions and comparison with the final histological diagnosis</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Purpose
We prospectively investigated the diagnostic accuracy of magnetic resonance imaging (MRI) at 3.0 Tesla (3T) for the detection of suspected primary adnexal masses in a large cohort of patients.
Methods
This prospective clinical study included 223 patients with suspected gynaecological disease who were referred for 3T MRI assessments before laparoscopy or laparotomy. Fifty-nine patients were excluded. All detected adnexal pathologies on MRI were categorized into the four groups (endometric cysts, teratomas, benign tumours and malignant tumours). Histological findings were used as the comparative reference standard. As measures to detect or rule out primary adnexal masses, accuracy, sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) were determined by lesion-based evaluations.
Results
The reference standard method detected 141 primary adnexal lesions in 125 patients. The areas under the receiver operating characteristic curve of the lesion-based evaluations for endometric cysts, teratomas, benign lesions and malignant lesions were 92.8, 93.6, 95.1 and 94.4 %. Lesion-based evaluation yielded an accuracy of 90.3 %, sensitivity of 92.7 %, specificity of 89.3 %, PPV of 77.6 % and NPV of 96.8 % in differentiating malignancies from non-malignant lesions. The diagnostic value of 3T MRI for detecting malignancies was superior to that for benign tumours.
Conclusions
3T MRI well categorize the characteristics of primary adnexal lesions and may be a reliable modality for distinguishing malignancies from benign tumours.</description><subject>Accuracy</subject><subject>Adnexal Diseases - diagnosis</subject><subject>Adnexal Diseases - pathology</subject><subject>Adult</subject><subject>Contrast Media</subject><subject>Cysts</subject><subject>Cysts - diagnosis</subject><subject>Cysts - pathology</subject><subject>Diagnosis, Differential</subject><subject>Diffusion Magnetic Resonance Imaging</subject><subject>Endocrinology</subject><subject>Female</subject><subject>Gadolinium DTPA</subject><subject>Gynecologic Oncology</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Ovarian Neoplasms - diagnosis</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Sensitivity and Specificity</subject><subject>Teratoma - diagnosis</subject><subject>Teratoma - pathology</subject><subject>Tumors</subject><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNp1kM1uGyEURlHVqnbdPkA2EVLX015-PMwsI6tJI7lKFTlrxAwXG2s8ODBOnDx9cO2kq6y4iPN9wCHkjMEPBqB-JgAJsgAmCl7XUOw_kDGTghegGPtIxlAfZijViHxJaQ3AeFWVn8mIi1pILvmYPP-NIW2xHfwDUnww3c4MPvQ0OCoW9M_tNXW-t75fJupCpNvoNyY-UWN73JuOdpgynajpLW3DZmuiTzn96IcVHVZ4CGdq5dMQurD0bd5Yb5Z9SD59JZ-c6RJ-O60Tcnf5azH7Xcxvrq5nF_OiFYoPBWtUjc6VJZOlUFNmoWkAnMsCZJ5EwyyTRkru2imoCq3lWFrEqcSmUiUTE_L92LuN4X6HadDrsIv5XUlzXrJKKfGPYkeqzUJSRKdPf9UM9MG2PtrW2bY-2Nb7nDk_Ne-aDdq3xKveDPAjkPJRv8T4_-r3W18AS_iMhA</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Zhang, He</creator><creator>Zhang, Guo-Fu</creator><creator>He, Zhi-Yan</creator><creator>Li, Zheng-Yu</creator><creator>Zhang, Gui-Xiang</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20140201</creationdate><title>Prospective evaluation of 3T MRI findings for primary adnexal lesions and comparison with the final histological diagnosis</title><author>Zhang, He ; Zhang, Guo-Fu ; He, Zhi-Yan ; Li, Zheng-Yu ; Zhang, Gui-Xiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-1b79eff661463751d0bb00ff0074bb03b1d14a442fc5078edd2e6dee54eb87613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Accuracy</topic><topic>Adnexal Diseases - diagnosis</topic><topic>Adnexal Diseases - pathology</topic><topic>Adult</topic><topic>Contrast Media</topic><topic>Cysts</topic><topic>Cysts - diagnosis</topic><topic>Cysts - pathology</topic><topic>Diagnosis, Differential</topic><topic>Diffusion Magnetic Resonance Imaging</topic><topic>Endocrinology</topic><topic>Female</topic><topic>Gadolinium DTPA</topic><topic>Gynecologic Oncology</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Ovarian Neoplasms - diagnosis</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Sensitivity and Specificity</topic><topic>Teratoma - diagnosis</topic><topic>Teratoma - pathology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, He</creatorcontrib><creatorcontrib>Zhang, Guo-Fu</creatorcontrib><creatorcontrib>He, Zhi-Yan</creatorcontrib><creatorcontrib>Li, Zheng-Yu</creatorcontrib><creatorcontrib>Zhang, Gui-Xiang</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, He</au><au>Zhang, Guo-Fu</au><au>He, Zhi-Yan</au><au>Li, Zheng-Yu</au><au>Zhang, Gui-Xiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prospective evaluation of 3T MRI findings for primary adnexal lesions and comparison with the final histological diagnosis</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2014-02-01</date><risdate>2014</risdate><volume>289</volume><issue>2</issue><spage>357</spage><epage>364</epage><pages>357-364</pages><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Purpose
We prospectively investigated the diagnostic accuracy of magnetic resonance imaging (MRI) at 3.0 Tesla (3T) for the detection of suspected primary adnexal masses in a large cohort of patients.
Methods
This prospective clinical study included 223 patients with suspected gynaecological disease who were referred for 3T MRI assessments before laparoscopy or laparotomy. Fifty-nine patients were excluded. All detected adnexal pathologies on MRI were categorized into the four groups (endometric cysts, teratomas, benign tumours and malignant tumours). Histological findings were used as the comparative reference standard. As measures to detect or rule out primary adnexal masses, accuracy, sensitivity, specificity, positive predictive values (PPV) and negative predictive values (NPV) were determined by lesion-based evaluations.
Results
The reference standard method detected 141 primary adnexal lesions in 125 patients. The areas under the receiver operating characteristic curve of the lesion-based evaluations for endometric cysts, teratomas, benign lesions and malignant lesions were 92.8, 93.6, 95.1 and 94.4 %. Lesion-based evaluation yielded an accuracy of 90.3 %, sensitivity of 92.7 %, specificity of 89.3 %, PPV of 77.6 % and NPV of 96.8 % in differentiating malignancies from non-malignant lesions. The diagnostic value of 3T MRI for detecting malignancies was superior to that for benign tumours.
Conclusions
3T MRI well categorize the characteristics of primary adnexal lesions and may be a reliable modality for distinguishing malignancies from benign tumours.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>23934242</pmid><doi>10.1007/s00404-013-2990-x</doi><tpages>8</tpages></addata></record> |
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| ispartof | Archives of gynecology and obstetrics, 2014-02, Vol.289 (2), p.357-364 |
| issn | 0932-0067 1432-0711 |
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| source | Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List |
| subjects | Accuracy Adnexal Diseases - diagnosis Adnexal Diseases - pathology Adult Contrast Media Cysts Cysts - diagnosis Cysts - pathology Diagnosis, Differential Diffusion Magnetic Resonance Imaging Endocrinology Female Gadolinium DTPA Gynecologic Oncology Gynecology Human Genetics Humans Magnetic Resonance Imaging - methods Medicine Medicine & Public Health Middle Aged NMR Nuclear magnetic resonance Obstetrics/Perinatology/Midwifery Ovarian Neoplasms - diagnosis Ovarian Neoplasms - pathology Predictive Value of Tests Prospective Studies Sensitivity and Specificity Teratoma - diagnosis Teratoma - pathology Tumors |
| title | Prospective evaluation of 3T MRI findings for primary adnexal lesions and comparison with the final histological diagnosis |
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