Effects of Chronic Topiramate, Lacosamide, and Levetiracetam Pre-treatment on a Status Epilepticus Model in Rat Pups

We examined possible neuroprotective and prophylactic effects of chronic pre-treatment with levetiracetam (Lev), topiramate (Tpm), and lacosamide (Lcm) on the pentylenetetrazol (PTZ)-induced status epilepticus (SE) in rat pups. Forty-six rats were divided into four groups; all of them were on postna...

Full description

Saved in:
Bibliographic Details
Published in:Neurophysiology (New York) 2019-01, Vol.51 (1), p.35-42
Main Authors: Gencpinar, P., Basaranlar, G., Sati, L., Duman, O., Derin, N.
Format: Article
Language:English
Subjects:
Animal behavior
Anticonvulsants
Apoptosis
Biomedical and Life Sciences
Biomedicine
Brain
Epilepsy
Etiracetam
Hippocampus
Lacosamide
Levetiracetam
Locomotor activity
Neurons
Neuroprotection
Neurosciences
Open-field behavior
Oxidative stress
Pyramidal cells
Rodents
Status epilepticus
Topiramate
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c420t-138fbd44612ccb59352ccc7ff342dc821e238448e8f5790af55884c89026b8be3
cites cdi_FETCH-LOGICAL-c420t-138fbd44612ccb59352ccc7ff342dc821e238448e8f5790af55884c89026b8be3
container_end_page 42
container_issue 1
container_start_page 35
container_title Neurophysiology (New York)
container_volume 51
creator Gencpinar, P.
Basaranlar, G.
Sati, L.
Duman, O.
Derin, N.
description We examined possible neuroprotective and prophylactic effects of chronic pre-treatment with levetiracetam (Lev), topiramate (Tpm), and lacosamide (Lcm) on the pentylenetetrazol (PTZ)-induced status epilepticus (SE) in rat pups. Forty-six rats were divided into four groups; all of them were on postnatal day (PD) 21 i.p. injected with 60 mg/kg PTZ. Rat pups of three experimental groups were pre-treated during 14 days (PD7–PD21) with Tpm, Lcm, or Lev via gavage in doses of 60, 50, and 150 mg/kg per day, respectively; animals of the PTZ group were treated with 0.2 ml saline per day. Animals of the latter group demonstrated intense behavioral changes of a stage 3 of the Racine scale or higher, while no significant behavioral alterations were observed in all pre-treated groups. Protein carbonyl and TBARS levels were markedly elevated in the PTZ group, while these indices were significantly smaller in the Tpm and Lev groups. Immunohistochemical analysis demonstrated an increased apoptosis level in hippocampal pyramidal neurons in the Lev group with respect to the PTZ group. In the open field test, the total distance moved and duration of stay in the outer squares were significantly greater in the PTZ group than in the Lcm and Lev groups. Thus, Tpm, Lcm, and Lev treatment provided clear prophylactic effects on the PTZ-induced SE development; such treatment decreased the intensity of oxidative stress and protected from changes in locomotor activity and anxietyrelated behavior in immature organisms. However, some pro-apoptotic action of Lev on the developing hippocampus needs to be noted and investigated in more detail.
doi_str_mv 10.1007/s11062-019-09788-7
format article
fullrecord <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_journals_2225947467</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A597716189</galeid><sourcerecordid>A597716189</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-138fbd44612ccb59352ccc7ff342dc821e238448e8f5790af55884c89026b8be3</originalsourceid><addsrcrecordid>eNqFkVFvFCEUhYnRxLX6B3wi8clEKjAwwGOzWbXJGpu2PhOWuaw0O8MITKP_XuqYmL5oeLg3ud-ByzkIvWb0nFGq3hfGaM8JZYZQo7Qm6gnaMKk6Ytr4KdpQaijhRqnn6EUpd5TSXhu5QXUXAvhacAp4-y2nKXp8m-aY3egqvMN751NxYxxa76YB7-Eeapt6qG7EVxlIzeDqCFPFacIO31RXl4J3czzBXKNv_ec0wAnHCV-7iq-WubxEz4I7FXj1p56hrx92t9tPZP_l4-X2Yk-84LQS1ulwGIToGff-IE0nW_UqhE7wwWvOgHdaCA06SGWoC1JqLbw2lPcHfYDuDL1Z751z-r5AqfYuLXlqT1rOuTRCiV79h2KyGdXLRp2v1NGdwMYppNpcaGeAMfo0QWgftheyWcx6pk0TvH0kaEyFH_XollLs5c31Y5avrM-plAzBzjmOLv-0jNqHgO0asG0B298B24e9u1VUGjwdIf_d-x-qX4ZSpnY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2221568965</pqid></control><display><type>article</type><title>Effects of Chronic Topiramate, Lacosamide, and Levetiracetam Pre-treatment on a Status Epilepticus Model in Rat Pups</title><source>Springer Link</source><creator>Gencpinar, P. ; Basaranlar, G. ; Sati, L. ; Duman, O. ; Derin, N.</creator><creatorcontrib>Gencpinar, P. ; Basaranlar, G. ; Sati, L. ; Duman, O. ; Derin, N.</creatorcontrib><description>We examined possible neuroprotective and prophylactic effects of chronic pre-treatment with levetiracetam (Lev), topiramate (Tpm), and lacosamide (Lcm) on the pentylenetetrazol (PTZ)-induced status epilepticus (SE) in rat pups. Forty-six rats were divided into four groups; all of them were on postnatal day (PD) 21 i.p. injected with 60 mg/kg PTZ. Rat pups of three experimental groups were pre-treated during 14 days (PD7–PD21) with Tpm, Lcm, or Lev via gavage in doses of 60, 50, and 150 mg/kg per day, respectively; animals of the PTZ group were treated with 0.2 ml saline per day. Animals of the latter group demonstrated intense behavioral changes of a stage 3 of the Racine scale or higher, while no significant behavioral alterations were observed in all pre-treated groups. Protein carbonyl and TBARS levels were markedly elevated in the PTZ group, while these indices were significantly smaller in the Tpm and Lev groups. Immunohistochemical analysis demonstrated an increased apoptosis level in hippocampal pyramidal neurons in the Lev group with respect to the PTZ group. In the open field test, the total distance moved and duration of stay in the outer squares were significantly greater in the PTZ group than in the Lcm and Lev groups. Thus, Tpm, Lcm, and Lev treatment provided clear prophylactic effects on the PTZ-induced SE development; such treatment decreased the intensity of oxidative stress and protected from changes in locomotor activity and anxietyrelated behavior in immature organisms. However, some pro-apoptotic action of Lev on the developing hippocampus needs to be noted and investigated in more detail.</description><identifier>ISSN: 0090-2977</identifier><identifier>EISSN: 1573-9007</identifier><identifier>DOI: 10.1007/s11062-019-09788-7</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animal behavior ; Anticonvulsants ; Apoptosis ; Biomedical and Life Sciences ; Biomedicine ; Brain ; Epilepsy ; Etiracetam ; Hippocampus ; Lacosamide ; Levetiracetam ; Locomotor activity ; Neurons ; Neuroprotection ; Neurosciences ; Open-field behavior ; Oxidative stress ; Pyramidal cells ; Rodents ; Status epilepticus ; Topiramate</subject><ispartof>Neurophysiology (New York), 2019-01, Vol.51 (1), p.35-42</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2019</rights><rights>COPYRIGHT 2019 Springer</rights><rights>Neurophysiology is a copyright of Springer, (2019). All Rights Reserved.</rights><rights>Copyright Springer Nature B.V. 2019</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-138fbd44612ccb59352ccc7ff342dc821e238448e8f5790af55884c89026b8be3</citedby><cites>FETCH-LOGICAL-c420t-138fbd44612ccb59352ccc7ff342dc821e238448e8f5790af55884c89026b8be3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Gencpinar, P.</creatorcontrib><creatorcontrib>Basaranlar, G.</creatorcontrib><creatorcontrib>Sati, L.</creatorcontrib><creatorcontrib>Duman, O.</creatorcontrib><creatorcontrib>Derin, N.</creatorcontrib><title>Effects of Chronic Topiramate, Lacosamide, and Levetiracetam Pre-treatment on a Status Epilepticus Model in Rat Pups</title><title>Neurophysiology (New York)</title><addtitle>Neurophysiology</addtitle><description>We examined possible neuroprotective and prophylactic effects of chronic pre-treatment with levetiracetam (Lev), topiramate (Tpm), and lacosamide (Lcm) on the pentylenetetrazol (PTZ)-induced status epilepticus (SE) in rat pups. Forty-six rats were divided into four groups; all of them were on postnatal day (PD) 21 i.p. injected with 60 mg/kg PTZ. Rat pups of three experimental groups were pre-treated during 14 days (PD7–PD21) with Tpm, Lcm, or Lev via gavage in doses of 60, 50, and 150 mg/kg per day, respectively; animals of the PTZ group were treated with 0.2 ml saline per day. Animals of the latter group demonstrated intense behavioral changes of a stage 3 of the Racine scale or higher, while no significant behavioral alterations were observed in all pre-treated groups. Protein carbonyl and TBARS levels were markedly elevated in the PTZ group, while these indices were significantly smaller in the Tpm and Lev groups. Immunohistochemical analysis demonstrated an increased apoptosis level in hippocampal pyramidal neurons in the Lev group with respect to the PTZ group. In the open field test, the total distance moved and duration of stay in the outer squares were significantly greater in the PTZ group than in the Lcm and Lev groups. Thus, Tpm, Lcm, and Lev treatment provided clear prophylactic effects on the PTZ-induced SE development; such treatment decreased the intensity of oxidative stress and protected from changes in locomotor activity and anxietyrelated behavior in immature organisms. However, some pro-apoptotic action of Lev on the developing hippocampus needs to be noted and investigated in more detail.</description><subject>Animal behavior</subject><subject>Anticonvulsants</subject><subject>Apoptosis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Brain</subject><subject>Epilepsy</subject><subject>Etiracetam</subject><subject>Hippocampus</subject><subject>Lacosamide</subject><subject>Levetiracetam</subject><subject>Locomotor activity</subject><subject>Neurons</subject><subject>Neuroprotection</subject><subject>Neurosciences</subject><subject>Open-field behavior</subject><subject>Oxidative stress</subject><subject>Pyramidal cells</subject><subject>Rodents</subject><subject>Status epilepticus</subject><subject>Topiramate</subject><issn>0090-2977</issn><issn>1573-9007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqFkVFvFCEUhYnRxLX6B3wi8clEKjAwwGOzWbXJGpu2PhOWuaw0O8MITKP_XuqYmL5oeLg3ud-ByzkIvWb0nFGq3hfGaM8JZYZQo7Qm6gnaMKk6Ytr4KdpQaijhRqnn6EUpd5TSXhu5QXUXAvhacAp4-y2nKXp8m-aY3egqvMN751NxYxxa76YB7-Eeapt6qG7EVxlIzeDqCFPFacIO31RXl4J3czzBXKNv_ec0wAnHCV-7iq-WubxEz4I7FXj1p56hrx92t9tPZP_l4-X2Yk-84LQS1ulwGIToGff-IE0nW_UqhE7wwWvOgHdaCA06SGWoC1JqLbw2lPcHfYDuDL1Z751z-r5AqfYuLXlqT1rOuTRCiV79h2KyGdXLRp2v1NGdwMYppNpcaGeAMfo0QWgftheyWcx6pk0TvH0kaEyFH_XollLs5c31Y5avrM-plAzBzjmOLv-0jNqHgO0asG0B298B24e9u1VUGjwdIf_d-x-qX4ZSpnY</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Gencpinar, P.</creator><creator>Basaranlar, G.</creator><creator>Sati, L.</creator><creator>Duman, O.</creator><creator>Derin, N.</creator><general>Springer US</general><general>Springer</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>ISR</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20190101</creationdate><title>Effects of Chronic Topiramate, Lacosamide, and Levetiracetam Pre-treatment on a Status Epilepticus Model in Rat Pups</title><author>Gencpinar, P. ; Basaranlar, G. ; Sati, L. ; Duman, O. ; Derin, N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-138fbd44612ccb59352ccc7ff342dc821e238448e8f5790af55884c89026b8be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animal behavior</topic><topic>Anticonvulsants</topic><topic>Apoptosis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Brain</topic><topic>Epilepsy</topic><topic>Etiracetam</topic><topic>Hippocampus</topic><topic>Lacosamide</topic><topic>Levetiracetam</topic><topic>Locomotor activity</topic><topic>Neurons</topic><topic>Neuroprotection</topic><topic>Neurosciences</topic><topic>Open-field behavior</topic><topic>Oxidative stress</topic><topic>Pyramidal cells</topic><topic>Rodents</topic><topic>Status epilepticus</topic><topic>Topiramate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gencpinar, P.</creatorcontrib><creatorcontrib>Basaranlar, G.</creatorcontrib><creatorcontrib>Sati, L.</creatorcontrib><creatorcontrib>Duman, O.</creatorcontrib><creatorcontrib>Derin, N.</creatorcontrib><collection>CrossRef</collection><collection>Gale In Context: Science</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Premium</collection><jtitle>Neurophysiology (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gencpinar, P.</au><au>Basaranlar, G.</au><au>Sati, L.</au><au>Duman, O.</au><au>Derin, N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Chronic Topiramate, Lacosamide, and Levetiracetam Pre-treatment on a Status Epilepticus Model in Rat Pups</atitle><jtitle>Neurophysiology (New York)</jtitle><stitle>Neurophysiology</stitle><date>2019-01-01</date><risdate>2019</risdate><volume>51</volume><issue>1</issue><spage>35</spage><epage>42</epage><pages>35-42</pages><issn>0090-2977</issn><eissn>1573-9007</eissn><abstract>We examined possible neuroprotective and prophylactic effects of chronic pre-treatment with levetiracetam (Lev), topiramate (Tpm), and lacosamide (Lcm) on the pentylenetetrazol (PTZ)-induced status epilepticus (SE) in rat pups. Forty-six rats were divided into four groups; all of them were on postnatal day (PD) 21 i.p. injected with 60 mg/kg PTZ. Rat pups of three experimental groups were pre-treated during 14 days (PD7–PD21) with Tpm, Lcm, or Lev via gavage in doses of 60, 50, and 150 mg/kg per day, respectively; animals of the PTZ group were treated with 0.2 ml saline per day. Animals of the latter group demonstrated intense behavioral changes of a stage 3 of the Racine scale or higher, while no significant behavioral alterations were observed in all pre-treated groups. Protein carbonyl and TBARS levels were markedly elevated in the PTZ group, while these indices were significantly smaller in the Tpm and Lev groups. Immunohistochemical analysis demonstrated an increased apoptosis level in hippocampal pyramidal neurons in the Lev group with respect to the PTZ group. In the open field test, the total distance moved and duration of stay in the outer squares were significantly greater in the PTZ group than in the Lcm and Lev groups. Thus, Tpm, Lcm, and Lev treatment provided clear prophylactic effects on the PTZ-induced SE development; such treatment decreased the intensity of oxidative stress and protected from changes in locomotor activity and anxietyrelated behavior in immature organisms. However, some pro-apoptotic action of Lev on the developing hippocampus needs to be noted and investigated in more detail.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s11062-019-09788-7</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0090-2977
ispartof Neurophysiology (New York), 2019-01, Vol.51 (1), p.35-42
issn 0090-2977
1573-9007
language eng
recordid cdi_proquest_journals_2225947467
source Springer Link
subjects Animal behavior
Anticonvulsants
Apoptosis
Biomedical and Life Sciences
Biomedicine
Brain
Epilepsy
Etiracetam
Hippocampus
Lacosamide
Levetiracetam
Locomotor activity
Neurons
Neuroprotection
Neurosciences
Open-field behavior
Oxidative stress
Pyramidal cells
Rodents
Status epilepticus
Topiramate
title Effects of Chronic Topiramate, Lacosamide, and Levetiracetam Pre-treatment on a Status Epilepticus Model in Rat Pups
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T03%3A32%3A07IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20Chronic%20Topiramate,%20Lacosamide,%20and%20Levetiracetam%20Pre-treatment%20on%20a%20Status%20Epilepticus%20Model%20in%20Rat%20Pups&rft.jtitle=Neurophysiology%20(New%20York)&rft.au=Gencpinar,%20P.&rft.date=2019-01-01&rft.volume=51&rft.issue=1&rft.spage=35&rft.epage=42&rft.pages=35-42&rft.issn=0090-2977&rft.eissn=1573-9007&rft_id=info:doi/10.1007/s11062-019-09788-7&rft_dat=%3Cgale_proqu%3EA597716189%3C/gale_proqu%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c420t-138fbd44612ccb59352ccc7ff342dc821e238448e8f5790af55884c89026b8be3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2221568965&rft_id=info:pmid/&rft_galeid=A597716189&rfr_iscdi=true