Protective effect of Abutilon indicum against lead‐induced reproductive toxicity in male Wistar rats

Despite ample literature on the toxic impact of lead on the environment and health, the exact mechanism of pathogenesis/toxicity is not clearly known. Because it is well established that lead induces oxidative stress, it is assumed that exposure to antioxidants may reduce the toxic impact of lead. I...

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Published in:Journal of cellular biochemistry 2019-07, Vol.120 (7), p.11196-11205
Main Authors: R, Santhoshkumar, S, Asha Devi
Format: Article
Language:English
Subjects:
Abutilon indicum
Animals
antioxidant
Antioxidants
Catalase
Drinking water
Exposure
Glutathione
Glutathione peroxidase
histology
Histopathology
Lead
Lead acetates
Oxidative stress
Parameters
Pathogenesis
Peroxidase
Plant extracts
Plant roots
Reproductive system
Rodents
sperm count
Sperm count decline
stigmasterol
Superoxide dismutase
Testes
testis
Testosterone
Toxicity
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creator R, Santhoshkumar
S, Asha Devi
description Despite ample literature on the toxic impact of lead on the environment and health, the exact mechanism of pathogenesis/toxicity is not clearly known. Because it is well established that lead induces oxidative stress, it is assumed that exposure to antioxidants may reduce the toxic impact of lead. In this study, we evaluated the impact of coadministration of the methanolic root extract of a plant Abutilon indicum (50, 100, 200 mg kg −1b.wt.) in mitigating the toxic impact of lead on the reproductive system of rats. In brief, Wistar rats were exposed to lead acetate in drinking water with or without coadministration of plant root extract and compared with that of control animals. After 45 days of exposure as outlined above, the animals were killed and the reproductive toxicity was assessed by sperm parameters, hormone and antioxidant enzyme assays, and testis histopathology. Significant reduction in testis weight, sperm count, testosterone levels, and antioxidant enzymes levels such as Superoxide Dismutase, Catalase, and Glutathione peroxidase was seen in lead‐treated animals, confirming the toxic impact. The coadministration of A. Indicum (100 and 200 mg kg −1b.wt.) was found to bring the studied parameters close to the levels seen in untreated (control) animals. Our findings are indicative of the protective nature of A. Indicum against lead‐induced reproductive toxicity in a dose‐dependent manner. However, further characterization of the root extract is required to elucidate the probable mechanism of protection.
doi_str_mv 10.1002/jcb.28395
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Because it is well established that lead induces oxidative stress, it is assumed that exposure to antioxidants may reduce the toxic impact of lead. In this study, we evaluated the impact of coadministration of the methanolic root extract of a plant Abutilon indicum (50, 100, 200 mg kg −1b.wt.) in mitigating the toxic impact of lead on the reproductive system of rats. In brief, Wistar rats were exposed to lead acetate in drinking water with or without coadministration of plant root extract and compared with that of control animals. After 45 days of exposure as outlined above, the animals were killed and the reproductive toxicity was assessed by sperm parameters, hormone and antioxidant enzyme assays, and testis histopathology. Significant reduction in testis weight, sperm count, testosterone levels, and antioxidant enzymes levels such as Superoxide Dismutase, Catalase, and Glutathione peroxidase was seen in lead‐treated animals, confirming the toxic impact. The coadministration of A. 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source Wiley-Blackwell Journals
subjects Abutilon indicum
Animals
antioxidant
Antioxidants
Catalase
Drinking water
Exposure
Glutathione
Glutathione peroxidase
histology
Histopathology
Lead
Lead acetates
Oxidative stress
Parameters
Pathogenesis
Peroxidase
Plant extracts
Plant roots
Reproductive system
Rodents
sperm count
Sperm count decline
stigmasterol
Superoxide dismutase
Testes
testis
Testosterone
Toxicity
title Protective effect of Abutilon indicum against lead‐induced reproductive toxicity in male Wistar rats
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