Cocrystallization of C-Propyl Pyrogallol[4]arene and the Pharmaceutical Gabapentin

The single crystal X-ray diffraction structure for a new cocrystal of C-propyl pyrogallol[4]arene and the pharmaceutical gabapentin is discussed. Slight changes in solvent environment can lead to large changes in structure of the cocrystal. Variation of the parameters of cocrystallization of pyrogal...

Full description

Saved in:
Bibliographic Details
Published in:Journal of chemical crystallography 2019-06, Vol.49 (2), p.119-124
Main Authors: Spiel, Paul D., Sikligar, Kanishka, Baker, Gary A., Kelley, Steven P., Atwood, Jerry L.
Format: Article
Language:English
Subjects:
Brief Communication
Chemistry
Chemistry and Materials Science
Cocrystallization
Crystal structure
Crystallography and Scattering Methods
Crystals
Inorganic Chemistry
Organometallic Chemistry
Parameters
Pharmaceuticals
Physical Chemistry
Single crystals
Solvents
X-ray diffraction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The single crystal X-ray diffraction structure for a new cocrystal of C-propyl pyrogallol[4]arene and the pharmaceutical gabapentin is discussed. Slight changes in solvent environment can lead to large changes in structure of the cocrystal. Variation of the parameters of cocrystallization of pyrogallolarenes with gabapentin leads to the novel structure presented herein [space group P-1, a = 11.7633(9) Å, b = 15.6968(12) Å, c = 17.8554(14) Å, V = 2977.06 Å 3 . α = 71.987(2)°, β = 82.735(3)°,γ = 71.812(3)°]. Graphical Abstract In this manuscript we present the solvent parameters that led to a new cocrystallization structure of C-propyl pyrogallol[4]arene and the pharmaceutical gabapentin.
ISSN:1074-1542
1572-8854
DOI:10.1007/s10870-018-0742-2