Pubertal alterations in growth and body composition. VI. Pubertal insulin resistance: relation to adiposity, body fat distribution and hormone release

Objective: To investigate the independent influence of alterations in fat mass, body fat distribution and hormone release on pubertal increases in fasting serum insulin concentrations and on insulin resistance assessed by the homeostasis model (HOMA). Design and Subjects: Cross-sectional investigati...

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Bibliographic Details
Published in:International Journal of Obesity 2002-05, Vol.26 (5), p.701-709
Main Authors: Roemmich, J.N, Clark, P.A, Lusk, M, Friel, A, Weltman, A, Epstein, L.H, Rogol, A.D
Format: Article
Language:English
Subjects:
Abdomen
abdominal fat
adiposity
Analysis. Health state
Biological and medical sciences
blood glucose
blood serum
Body composition
Body fat
body size
body weight
boys
Children & youth
Endocrinology
Epidemiology
fasting
gender differences
General aspects
Girls
Glucose
Growth hormones
Health sciences
homeostasis
insulin
Insulin resistance
insulin-like growth factor I
Insulin-like growth factors
leptin
magnetic resonance imaging
Medical sciences
Medicine
Metabolic diseases
Metabolism
Obesity
Pediatrics
Puberty
Public health. Hygiene
Public health. Hygiene-occupational medicine
regression analysis
somatotropin
steroids
subcutaneous fat
visceral fat
youth
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Summary:Objective: To investigate the independent influence of alterations in fat mass, body fat distribution and hormone release on pubertal increases in fasting serum insulin concentrations and on insulin resistance assessed by the homeostasis model (HOMA). Design and Subjects: Cross-sectional investigation of pre- (n=11, n=8), mid- (n=10, n=11), and late-pubertal (n=10, n=11) boys and girls with normal body weight and growth velocity. Measurements: Body composition (by a four-compartment model), abdominal fat distribution and mid-thigh interfascicular plus intermuscle (extramyocellular) fat (by magnetic resonance imaging), total body subcutaneous fat (by skinfolds), mean nocturnal growth hormone (GH) release and 06:00 h samples of serum insulin, sex steroids, leptin and insulin-like growth factor-I (IGF-I). Results: Pubertal insulin resistance was suggested by greater (P
ISSN:0307-0565
1476-5497
DOI:10.1038/sj.ijo.0801975