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Metabolic profiling of wheat rachis node infection by Fusarium graminearum – decoding deoxynivalenol-dependent susceptibility
Fusarium graminearum is a filamentous ascomycete and the causal agent of Fusarium head blight on wheat that threatens food and feed production worldwide as infection reduces crop yield both quantitatively by interfering with kernel development and qualitatively by poisoning any remaining kernels wit...
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| Published in: | The New phytologist 2019-01, Vol.221 (1), p.459-469 |
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| creator | Bönnighausen, Jakob Schauer, Nicolas Schäfer, Wilhelm Bormann, Jörg |
| description | Fusarium graminearum is a filamentous ascomycete and the causal agent of Fusarium head blight on wheat that threatens food and feed production worldwide as infection reduces crop yield both quantitatively by interfering with kernel development and qualitatively by poisoning any remaining kernels with mycotoxins. In wheat, F. graminearum infects spikelets and colonizes the entire head by growing through the rachis node at the bottom of each spikelet. Without the mycotoxin deoxynivalenol (DON), the pathogen cannot penetrate the rachis node and wheat is able to resist colonization.
Using a global metabolite profiling approach we compared the metabolic profile of rachis nodes inoculated with either water, the Fusarium graminearum wild-type or the DON-deficient Δtri5 mutant.
Extensive metabolic rearrangements mainly affect metabolites for general stress perception and signaling, reactive oxygen species (ROS) metabolism, cell wall composition, the tricarbonic acid (TCA) cycle and c-aminobutyric acid (GABA) shunt as well as sugar alcohols, amino acids, and storage carbohydrates.
The results revealed specific, DON-related susceptibility factors. Wild-type infection resulted in an oxidative burst and the induction of plant programmed cell death, while spread of the DON-deficient mutant was blocked in a jasmonate (JA)-related defense reaction in concert with other factors. Hence, the Δtri5 mutant is prone to defense reactions that are, in the case of a wild-type infection, not initiated. |
| doi_str_mv | 10.1111/nph.15377 |
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Using a global metabolite profiling approach we compared the metabolic profile of rachis nodes inoculated with either water, the Fusarium graminearum wild-type or the DON-deficient Δtri5 mutant.
Extensive metabolic rearrangements mainly affect metabolites for general stress perception and signaling, reactive oxygen species (ROS) metabolism, cell wall composition, the tricarbonic acid (TCA) cycle and c-aminobutyric acid (GABA) shunt as well as sugar alcohols, amino acids, and storage carbohydrates.
The results revealed specific, DON-related susceptibility factors. Wild-type infection resulted in an oxidative burst and the induction of plant programmed cell death, while spread of the DON-deficient mutant was blocked in a jasmonate (JA)-related defense reaction in concert with other factors. Hence, the Δtri5 mutant is prone to defense reactions that are, in the case of a wild-type infection, not initiated.</description><identifier>ISSN: 0028-646X</identifier><identifier>EISSN: 1469-8137</identifier><identifier>DOI: 10.1111/nph.15377</identifier><identifier>PMID: 30084118</identifier><language>eng</language><publisher>England: New Phytologist Trust</publisher><subject>Agricultural production ; Alcohols ; Amino acids ; Amino Acids - metabolism ; Apoptosis ; Blight ; Carbohydrates ; Carbonic acid ; Cell death ; Cell Wall - metabolism ; Cell walls ; Colonization ; Crop yield ; Decoding ; Deficient mutant ; Deoxynivalenol ; Food production ; Fusarium ; Fusarium - genetics ; Fusarium - metabolism ; Fusarium - pathogenicity ; Fusarium graminearum ; Fusarium head blight ; gamma-Aminobutyric Acid - metabolism ; Host-Pathogen Interactions - physiology ; Infections ; Jasmonic acid ; Metabolism ; Metabolites ; Metabolome ; Mutation ; mycotoxin ; Mycotoxins ; Mycotoxins - metabolism ; Nodes ; pathogenicity ; plant defense ; Plant Diseases - microbiology ; rachis node ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Sugar ; Sugar Alcohols - metabolism ; Trichothecenes - metabolism ; Triticum - metabolism ; Triticum - microbiology ; virulence ; Wheat ; γ-Aminobutyric acid</subject><ispartof>The New phytologist, 2019-01, Vol.221 (1), p.459-469</ispartof><rights>2018 New Phytologist Trust</rights><rights>2018 The Authors. New Phytologist © 2018 New Phytologist Trust</rights><rights>2018 The Authors. New Phytologist © 2018 New Phytologist Trust.</rights><rights>Copyright © 2018 New Phytologist Trust</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4107-c8b1392306a63b3c0c838c9e5f340be7a0b466e7bfa9f8f40851c2ae3500e06c3</citedby><cites>FETCH-LOGICAL-c4107-c8b1392306a63b3c0c838c9e5f340be7a0b466e7bfa9f8f40851c2ae3500e06c3</cites><orcidid>0000-0002-3493-2450</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fnph.15377$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fnph.15377$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032,58593,58826</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30084118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bönnighausen, Jakob</creatorcontrib><creatorcontrib>Schauer, Nicolas</creatorcontrib><creatorcontrib>Schäfer, Wilhelm</creatorcontrib><creatorcontrib>Bormann, Jörg</creatorcontrib><title>Metabolic profiling of wheat rachis node infection by Fusarium graminearum – decoding deoxynivalenol-dependent susceptibility</title><title>The New phytologist</title><addtitle>New Phytol</addtitle><description>Fusarium graminearum is a filamentous ascomycete and the causal agent of Fusarium head blight on wheat that threatens food and feed production worldwide as infection reduces crop yield both quantitatively by interfering with kernel development and qualitatively by poisoning any remaining kernels with mycotoxins. In wheat, F. graminearum infects spikelets and colonizes the entire head by growing through the rachis node at the bottom of each spikelet. Without the mycotoxin deoxynivalenol (DON), the pathogen cannot penetrate the rachis node and wheat is able to resist colonization.
Using a global metabolite profiling approach we compared the metabolic profile of rachis nodes inoculated with either water, the Fusarium graminearum wild-type or the DON-deficient Δtri5 mutant.
Extensive metabolic rearrangements mainly affect metabolites for general stress perception and signaling, reactive oxygen species (ROS) metabolism, cell wall composition, the tricarbonic acid (TCA) cycle and c-aminobutyric acid (GABA) shunt as well as sugar alcohols, amino acids, and storage carbohydrates.
The results revealed specific, DON-related susceptibility factors. Wild-type infection resulted in an oxidative burst and the induction of plant programmed cell death, while spread of the DON-deficient mutant was blocked in a jasmonate (JA)-related defense reaction in concert with other factors. Hence, the Δtri5 mutant is prone to defense reactions that are, in the case of a wild-type infection, not initiated.</description><subject>Agricultural production</subject><subject>Alcohols</subject><subject>Amino acids</subject><subject>Amino Acids - metabolism</subject><subject>Apoptosis</subject><subject>Blight</subject><subject>Carbohydrates</subject><subject>Carbonic acid</subject><subject>Cell death</subject><subject>Cell Wall - metabolism</subject><subject>Cell walls</subject><subject>Colonization</subject><subject>Crop yield</subject><subject>Decoding</subject><subject>Deficient mutant</subject><subject>Deoxynivalenol</subject><subject>Food production</subject><subject>Fusarium</subject><subject>Fusarium - genetics</subject><subject>Fusarium - metabolism</subject><subject>Fusarium - pathogenicity</subject><subject>Fusarium graminearum</subject><subject>Fusarium head blight</subject><subject>gamma-Aminobutyric Acid - metabolism</subject><subject>Host-Pathogen Interactions - physiology</subject><subject>Infections</subject><subject>Jasmonic acid</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Metabolome</subject><subject>Mutation</subject><subject>mycotoxin</subject><subject>Mycotoxins</subject><subject>Mycotoxins - metabolism</subject><subject>Nodes</subject><subject>pathogenicity</subject><subject>plant defense</subject><subject>Plant Diseases - microbiology</subject><subject>rachis node</subject><subject>Reactive oxygen species</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Sugar</subject><subject>Sugar Alcohols - metabolism</subject><subject>Trichothecenes - metabolism</subject><subject>Triticum - metabolism</subject><subject>Triticum - microbiology</subject><subject>virulence</subject><subject>Wheat</subject><subject>γ-Aminobutyric acid</subject><issn>0028-646X</issn><issn>1469-8137</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kMFu1DAQhi1ERZfCgQcAWeLUQ9pxnDjOEVW0RWoLB5C4RbYz7nqVtYOdtOQE78Ab8iS43bY35uI5fPPN-CfkDYMjluvYj-sjVvOmeUZWrBJtIRlvnpMVQCkLUYnv--RlShsAaGtRviD7HEBWjMkV-XWJk9JhcIaOMVg3OH9Ng6W3a1QTjcqsXaI-9Eidt2gmFzzVCz2dk4pu3tLrqLbOo4q5__v7D-3RhP7O0WP4uXh3owb0YSh6HNH36Cea5mRwnJzOu6blFdmzakj4-uE9IN9OP349OS8uPp99OvlwUZiKQVMYqRlvSw5CCa65ASO5NC3WllegsVGgKyGw0Va1VtoKZM1MqZDXAAjC8APyfufNv_wxY5q6TZijzyu7MpsBGmjaTB3uKBNDShFtN0a3VXHpGHR3UXc56u4-6sy-ezDOeov9E_mYbQaOd8CtG3D5v6m7-nL-qHy7m9ikKcSniXxdKSSU_B-L5ZVD</recordid><startdate>20190101</startdate><enddate>20190101</enddate><creator>Bönnighausen, Jakob</creator><creator>Schauer, Nicolas</creator><creator>Schäfer, Wilhelm</creator><creator>Bormann, Jörg</creator><general>New Phytologist Trust</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7SN</scope><scope>8FD</scope><scope>C1K</scope><scope>F1W</scope><scope>FR3</scope><scope>H95</scope><scope>L.G</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><orcidid>https://orcid.org/0000-0002-3493-2450</orcidid></search><sort><creationdate>20190101</creationdate><title>Metabolic profiling of wheat rachis node infection by Fusarium graminearum – decoding deoxynivalenol-dependent susceptibility</title><author>Bönnighausen, Jakob ; Schauer, Nicolas ; Schäfer, Wilhelm ; Bormann, Jörg</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4107-c8b1392306a63b3c0c838c9e5f340be7a0b466e7bfa9f8f40851c2ae3500e06c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Agricultural production</topic><topic>Alcohols</topic><topic>Amino acids</topic><topic>Amino Acids - metabolism</topic><topic>Apoptosis</topic><topic>Blight</topic><topic>Carbohydrates</topic><topic>Carbonic acid</topic><topic>Cell death</topic><topic>Cell Wall - metabolism</topic><topic>Cell walls</topic><topic>Colonization</topic><topic>Crop yield</topic><topic>Decoding</topic><topic>Deficient mutant</topic><topic>Deoxynivalenol</topic><topic>Food production</topic><topic>Fusarium</topic><topic>Fusarium - genetics</topic><topic>Fusarium - metabolism</topic><topic>Fusarium - pathogenicity</topic><topic>Fusarium graminearum</topic><topic>Fusarium head blight</topic><topic>gamma-Aminobutyric Acid - metabolism</topic><topic>Host-Pathogen Interactions - physiology</topic><topic>Infections</topic><topic>Jasmonic acid</topic><topic>Metabolism</topic><topic>Metabolites</topic><topic>Metabolome</topic><topic>Mutation</topic><topic>mycotoxin</topic><topic>Mycotoxins</topic><topic>Mycotoxins - metabolism</topic><topic>Nodes</topic><topic>pathogenicity</topic><topic>plant defense</topic><topic>Plant Diseases - microbiology</topic><topic>rachis node</topic><topic>Reactive oxygen species</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Sugar</topic><topic>Sugar Alcohols - metabolism</topic><topic>Trichothecenes - metabolism</topic><topic>Triticum - metabolism</topic><topic>Triticum - microbiology</topic><topic>virulence</topic><topic>Wheat</topic><topic>γ-Aminobutyric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bönnighausen, Jakob</creatorcontrib><creatorcontrib>Schauer, Nicolas</creatorcontrib><creatorcontrib>Schäfer, Wilhelm</creatorcontrib><creatorcontrib>Bormann, Jörg</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Ecology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>The New phytologist</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bönnighausen, Jakob</au><au>Schauer, Nicolas</au><au>Schäfer, Wilhelm</au><au>Bormann, Jörg</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic profiling of wheat rachis node infection by Fusarium graminearum – decoding deoxynivalenol-dependent susceptibility</atitle><jtitle>The New phytologist</jtitle><addtitle>New Phytol</addtitle><date>2019-01-01</date><risdate>2019</risdate><volume>221</volume><issue>1</issue><spage>459</spage><epage>469</epage><pages>459-469</pages><issn>0028-646X</issn><eissn>1469-8137</eissn><abstract>Fusarium graminearum is a filamentous ascomycete and the causal agent of Fusarium head blight on wheat that threatens food and feed production worldwide as infection reduces crop yield both quantitatively by interfering with kernel development and qualitatively by poisoning any remaining kernels with mycotoxins. In wheat, F. graminearum infects spikelets and colonizes the entire head by growing through the rachis node at the bottom of each spikelet. Without the mycotoxin deoxynivalenol (DON), the pathogen cannot penetrate the rachis node and wheat is able to resist colonization.
Using a global metabolite profiling approach we compared the metabolic profile of rachis nodes inoculated with either water, the Fusarium graminearum wild-type or the DON-deficient Δtri5 mutant.
Extensive metabolic rearrangements mainly affect metabolites for general stress perception and signaling, reactive oxygen species (ROS) metabolism, cell wall composition, the tricarbonic acid (TCA) cycle and c-aminobutyric acid (GABA) shunt as well as sugar alcohols, amino acids, and storage carbohydrates.
The results revealed specific, DON-related susceptibility factors. Wild-type infection resulted in an oxidative burst and the induction of plant programmed cell death, while spread of the DON-deficient mutant was blocked in a jasmonate (JA)-related defense reaction in concert with other factors. Hence, the Δtri5 mutant is prone to defense reactions that are, in the case of a wild-type infection, not initiated.</abstract><cop>England</cop><pub>New Phytologist Trust</pub><pmid>30084118</pmid><doi>10.1111/nph.15377</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-3493-2450</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | The New phytologist, 2019-01, Vol.221 (1), p.459-469 |
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| source | Wiley-Blackwell Journals; JSTOR Archival Journals and Primary Sources Collection |
| subjects | Agricultural production Alcohols Amino acids Amino Acids - metabolism Apoptosis Blight Carbohydrates Carbonic acid Cell death Cell Wall - metabolism Cell walls Colonization Crop yield Decoding Deficient mutant Deoxynivalenol Food production Fusarium Fusarium - genetics Fusarium - metabolism Fusarium - pathogenicity Fusarium graminearum Fusarium head blight gamma-Aminobutyric Acid - metabolism Host-Pathogen Interactions - physiology Infections Jasmonic acid Metabolism Metabolites Metabolome Mutation mycotoxin Mycotoxins Mycotoxins - metabolism Nodes pathogenicity plant defense Plant Diseases - microbiology rachis node Reactive oxygen species Reactive Oxygen Species - metabolism Sugar Sugar Alcohols - metabolism Trichothecenes - metabolism Triticum - metabolism Triticum - microbiology virulence Wheat γ-Aminobutyric acid |
| title | Metabolic profiling of wheat rachis node infection by Fusarium graminearum – decoding deoxynivalenol-dependent susceptibility |
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