Protective Effect of Sodium Tetraborate on Chromium-induced Brain Damage in Rats

Hexavalent chromium presents a particular threat due to its high toxicity. In this study showed the neuroprotective effect of sodium tetraborate in chromic intoxication. The experiment was performed on Wistar rats divided into 4 groups: 1 group - control; 2 group - single intraperitoneal injection o...

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Bibliographic Details
Published in:Biomedical & pharmacology journal 2018-03, Vol.11 (1), p.227-236
Main Authors: Iztleuov, Yerbolat, Abilov, Talgar, Zhanabayeva, Ganiya, Ismailova, Irina, Iztleuov, Marat
Format: Article
Language:English
Subjects:
Aluminum
Animal experimentation
Antioxidants
Antioxidants (Nutrients)
Body weight
Borates
Boron
Brain damage
Brain injury
Catalase
Chromium
Drinking water
Experiments
Injection
Intoxication
Laboratories
Lipid peroxidation
Lipids
Nervous system
Neuroprotection
Neurotoxicity
Oxidation
Oxidative stress
Pharmacology
Potassium
Proteins
Rodents
Sodium
Sodium tetraborate
Superoxide dismutase
Superoxides
Thiols
Toxicity
Toxicology
Water
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Summary:Hexavalent chromium presents a particular threat due to its high toxicity. In this study showed the neuroprotective effect of sodium tetraborate in chromic intoxication. The experiment was performed on Wistar rats divided into 4 groups: 1 group - control; 2 group - single intraperitoneal injection of K2Сr2O7 in a dose of 0,5LD50, in the 3 and 4 groups with drinking water received Na2B4O7. Animals of the 3 group - 4 mg/kg of body weight, in 4 group - 72 mg/kg of body weight daily for 10 days, the last administration of Na2B4O7 was combined with a single intraperitoneal injection of K2Сr2O7 at a dose of 14 mg/kg (0,5LD50). Na2B4O7 in a dose of 4 mg/kg leads to a decrease in the level of MDA by 33%, an increase in the activity of catalase by 69%, superoxide dismutase by 21%, GR by 49%. Na2B4O7 at a dose of 72 mg/kg increases the MDA content by 31% in comparison with the data of rats of chromic intoxication. K2Сr2O7 reduces the GSH level by 42%, the non-protein thiol by 36%. Na2B4O7 at a dose of 4 mg/kg increased the GSH level by 53%, the non-protein thiol by 35%, and at a dose of 72 mg/kg reduced the GSH content by 23% (ρ
ISSN:0974-6242
2456-2610
DOI:10.13005/bpj/1367