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Lead and Mercury Levels in Preterm Infants Before and After Blood Transfusions
Very low birth weight (VLBW) infants usually receive packed red blood cell unit (pRBC) transfusions. Heavy metal transfer via pRBCs is not widely discussed before. This study aimed to determine pre-/post-transfusion erythrocyte lead and mercury levels in infants and to correlate these levels to heav...
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| Published in: | Biological trace element research 2019-04, Vol.188 (2), p.344-352 |
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| cites | cdi_FETCH-LOGICAL-c372t-d4ef39deed3ed1266433a172ac9e735f4df988844ef65c1a1856c493bd2e34e13 |
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| container_title | Biological trace element research |
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| creator | Takci, Sahin Asci, Ali Erkekoglu, Pinar Yiğit, Sule Kocer-Gumusel, Belma Yurdakök, Murat |
| description | Very low birth weight (VLBW) infants usually receive packed red blood cell unit (pRBC) transfusions. Heavy metal transfer via pRBCs is not widely discussed before. This study aimed to determine pre-/post-transfusion erythrocyte lead and mercury levels in infants and to correlate these levels to heavy metal concentrations in pRBCs. VLBW infants (
n
= 80), needing pRBC transfusion for the first time, were enrolled. Erythrocyte heavy metal levels were determined in pre-/post-transfusion blood samples and also in pRBC units. Mean lead and mercury levels in the pRBCs were found to be 16.3 ± 10.8 and 3.75 ± 3.23 μg/L, respectively. Of the infants, 69.7% received lead above reference dose. Erythrocyte lead levels increased significantly after transfusions (10.6 ± 10.3 vs. 13 ± 8.5,
p
0.05). There was a significant correlation between mean difference of mercury levels after transfusion and amount of mercury delivered by pRBCs (
r
= 0.28). Infants can be subject to high levels of lead and mercury through pRBC transfusions. |
| doi_str_mv | 10.1007/s12011-018-1436-5 |
| format | article |
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n
= 80), needing pRBC transfusion for the first time, were enrolled. Erythrocyte heavy metal levels were determined in pre-/post-transfusion blood samples and also in pRBC units. Mean lead and mercury levels in the pRBCs were found to be 16.3 ± 10.8 and 3.75 ± 3.23 μg/L, respectively. Of the infants, 69.7% received lead above reference dose. Erythrocyte lead levels increased significantly after transfusions (10.6 ± 10.3 vs. 13 ± 8.5,
p
< 0.05) with significant correlated to amount of lead within pRBCs (
r
= 0.28). Mean pre-/post-transfusion erythrocyte mercury levels were 3.28 ± 3.08 and 3.5 ± 2.83 μg/L, respectively (
p
> 0.05). There was a significant correlation between mean difference of mercury levels after transfusion and amount of mercury delivered by pRBCs (
r
= 0.28). Infants can be subject to high levels of lead and mercury through pRBC transfusions.</description><identifier>ISSN: 0163-4984</identifier><identifier>EISSN: 1559-0720</identifier><identifier>DOI: 10.1007/s12011-018-1436-5</identifier><identifier>PMID: 30066064</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biochemistry ; Biomedical and Life Sciences ; Biotechnology ; Blood cells ; Blood transfusion ; Correlation ; Erythrocytes ; Heavy metals ; Infants ; Lead content ; Life Sciences ; Low birth weight ; Mercury ; Mercury (metal) ; Metal concentrations ; Nutrition ; Oncology ; Premature babies ; Seafood ; Transfusion</subject><ispartof>Biological trace element research, 2019-04, Vol.188 (2), p.344-352</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2018</rights><rights>Biological Trace Element Research is a copyright of Springer, (2018). All Rights Reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-d4ef39deed3ed1266433a172ac9e735f4df988844ef65c1a1856c493bd2e34e13</citedby><cites>FETCH-LOGICAL-c372t-d4ef39deed3ed1266433a172ac9e735f4df988844ef65c1a1856c493bd2e34e13</cites><orcidid>0000-0003-4311-2291</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,783,787,27936,27937</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30066064$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takci, Sahin</creatorcontrib><creatorcontrib>Asci, Ali</creatorcontrib><creatorcontrib>Erkekoglu, Pinar</creatorcontrib><creatorcontrib>Yiğit, Sule</creatorcontrib><creatorcontrib>Kocer-Gumusel, Belma</creatorcontrib><creatorcontrib>Yurdakök, Murat</creatorcontrib><title>Lead and Mercury Levels in Preterm Infants Before and After Blood Transfusions</title><title>Biological trace element research</title><addtitle>Biol Trace Elem Res</addtitle><addtitle>Biol Trace Elem Res</addtitle><description>Very low birth weight (VLBW) infants usually receive packed red blood cell unit (pRBC) transfusions. Heavy metal transfer via pRBCs is not widely discussed before. This study aimed to determine pre-/post-transfusion erythrocyte lead and mercury levels in infants and to correlate these levels to heavy metal concentrations in pRBCs. VLBW infants (
n
= 80), needing pRBC transfusion for the first time, were enrolled. Erythrocyte heavy metal levels were determined in pre-/post-transfusion blood samples and also in pRBC units. Mean lead and mercury levels in the pRBCs were found to be 16.3 ± 10.8 and 3.75 ± 3.23 μg/L, respectively. Of the infants, 69.7% received lead above reference dose. Erythrocyte lead levels increased significantly after transfusions (10.6 ± 10.3 vs. 13 ± 8.5,
p
< 0.05) with significant correlated to amount of lead within pRBCs (
r
= 0.28). Mean pre-/post-transfusion erythrocyte mercury levels were 3.28 ± 3.08 and 3.5 ± 2.83 μg/L, respectively (
p
> 0.05). There was a significant correlation between mean difference of mercury levels after transfusion and amount of mercury delivered by pRBCs (
r
= 0.28). Infants can be subject to high levels of lead and mercury through pRBC transfusions.</description><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Blood cells</subject><subject>Blood transfusion</subject><subject>Correlation</subject><subject>Erythrocytes</subject><subject>Heavy metals</subject><subject>Infants</subject><subject>Lead content</subject><subject>Life Sciences</subject><subject>Low birth weight</subject><subject>Mercury</subject><subject>Mercury (metal)</subject><subject>Metal concentrations</subject><subject>Nutrition</subject><subject>Oncology</subject><subject>Premature babies</subject><subject>Seafood</subject><subject>Transfusion</subject><issn>0163-4984</issn><issn>1559-0720</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kMtOwzAQRS0EoqXwAWyQJdYBT-w4zrKteFQKj0VZW248Rq3apNgJUv8elxRYsZrFnHtndAi5BHYDjOW3AVIGkDBQCQguk-yIDCHLioTlKTsmQwaSJ6JQYkDOQlgxBnla8FMy4IxJyaQYkucSjaWmtvQJfdX5HS3xE9eBLmv66rFFv6Gz2pm6DXSCrvH4DY9d3NDJumksnXtTB9eFZVOHc3LizDrgxWGOyNv93Xz6mJQvD7PpuEwqnqdtYgU6XlhEy9FCKqXg3MTnTFVgzjMnrCuUUiJiMqvAgMpkJQq-sClygcBH5Lrv3frmo8PQ6lXT-Tqe1ClTTEAuVREp6KnKNyF4dHrrlxvjdxqY3hvUvUEdDeq9QZ3FzNWhuVts0P4mfpRFIO2BEFf1O_q_0_-3fgHFtHpQ</recordid><startdate>20190401</startdate><enddate>20190401</enddate><creator>Takci, Sahin</creator><creator>Asci, Ali</creator><creator>Erkekoglu, Pinar</creator><creator>Yiğit, Sule</creator><creator>Kocer-Gumusel, Belma</creator><creator>Yurdakök, Murat</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QH</scope><scope>7QP</scope><scope>7TN</scope><scope>7U7</scope><scope>7UA</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BKSAR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H97</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>L.G</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PCBAR</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0003-4311-2291</orcidid></search><sort><creationdate>20190401</creationdate><title>Lead and Mercury Levels in Preterm Infants Before and After Blood Transfusions</title><author>Takci, Sahin ; Asci, Ali ; Erkekoglu, Pinar ; Yiğit, Sule ; Kocer-Gumusel, Belma ; Yurdakök, Murat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-d4ef39deed3ed1266433a172ac9e735f4df988844ef65c1a1856c493bd2e34e13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Blood cells</topic><topic>Blood transfusion</topic><topic>Correlation</topic><topic>Erythrocytes</topic><topic>Heavy metals</topic><topic>Infants</topic><topic>Lead content</topic><topic>Life Sciences</topic><topic>Low birth weight</topic><topic>Mercury</topic><topic>Mercury (metal)</topic><topic>Metal concentrations</topic><topic>Nutrition</topic><topic>Oncology</topic><topic>Premature babies</topic><topic>Seafood</topic><topic>Transfusion</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takci, Sahin</creatorcontrib><creatorcontrib>Asci, Ali</creatorcontrib><creatorcontrib>Erkekoglu, Pinar</creatorcontrib><creatorcontrib>Yiğit, Sule</creatorcontrib><creatorcontrib>Kocer-Gumusel, Belma</creatorcontrib><creatorcontrib>Yurdakök, Murat</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Aqualine</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Water Resources Abstracts</collection><collection>ProQuest_Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Earth, Atmospheric & Aquatic Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Earth, Atmospheric & Aquatic Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Biological trace element research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takci, Sahin</au><au>Asci, Ali</au><au>Erkekoglu, Pinar</au><au>Yiğit, Sule</au><au>Kocer-Gumusel, Belma</au><au>Yurdakök, Murat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lead and Mercury Levels in Preterm Infants Before and After Blood Transfusions</atitle><jtitle>Biological trace element research</jtitle><stitle>Biol Trace Elem Res</stitle><addtitle>Biol Trace Elem Res</addtitle><date>2019-04-01</date><risdate>2019</risdate><volume>188</volume><issue>2</issue><spage>344</spage><epage>352</epage><pages>344-352</pages><issn>0163-4984</issn><eissn>1559-0720</eissn><abstract>Very low birth weight (VLBW) infants usually receive packed red blood cell unit (pRBC) transfusions. Heavy metal transfer via pRBCs is not widely discussed before. This study aimed to determine pre-/post-transfusion erythrocyte lead and mercury levels in infants and to correlate these levels to heavy metal concentrations in pRBCs. VLBW infants (
n
= 80), needing pRBC transfusion for the first time, were enrolled. Erythrocyte heavy metal levels were determined in pre-/post-transfusion blood samples and also in pRBC units. Mean lead and mercury levels in the pRBCs were found to be 16.3 ± 10.8 and 3.75 ± 3.23 μg/L, respectively. Of the infants, 69.7% received lead above reference dose. Erythrocyte lead levels increased significantly after transfusions (10.6 ± 10.3 vs. 13 ± 8.5,
p
< 0.05) with significant correlated to amount of lead within pRBCs (
r
= 0.28). Mean pre-/post-transfusion erythrocyte mercury levels were 3.28 ± 3.08 and 3.5 ± 2.83 μg/L, respectively (
p
> 0.05). There was a significant correlation between mean difference of mercury levels after transfusion and amount of mercury delivered by pRBCs (
r
= 0.28). Infants can be subject to high levels of lead and mercury through pRBC transfusions.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>30066064</pmid><doi>10.1007/s12011-018-1436-5</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4311-2291</orcidid></addata></record> |
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| ispartof | Biological trace element research, 2019-04, Vol.188 (2), p.344-352 |
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| language | eng |
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| source | Springer Nature |
| subjects | Biochemistry Biomedical and Life Sciences Biotechnology Blood cells Blood transfusion Correlation Erythrocytes Heavy metals Infants Lead content Life Sciences Low birth weight Mercury Mercury (metal) Metal concentrations Nutrition Oncology Premature babies Seafood Transfusion |
| title | Lead and Mercury Levels in Preterm Infants Before and After Blood Transfusions |
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