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Nanostructured apatite-mullite glass-ceramics for enhanced primary human osteoblast cell response
[Display omitted] •Etched and un-etched nanocrystalline glass-ceramics were prepared.•Nanocrystalline fluorapatite was formed and identified using XRD.•Comparison between cell response on bioactive and nano-structured surfaces.•Cell viability after 24 h and 48 h was significantly greater on the nano...
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| Published in: | Materials letters 2018-03, Vol.214, p.268-271 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c380t-6a1e4b74638915c8f6bc5c343ed75d63e1551eabb60b25b009eb554a927befa23 |
| container_end_page | 271 |
| container_issue | |
| container_start_page | 268 |
| container_title | Materials letters |
| container_volume | 214 |
| creator | Dunne, C.F. Cooke, G. Keane, S. de Faoite, D. Donnelly, S.C. Stanton, K.T. |
| description | [Display omitted]
•Etched and un-etched nanocrystalline glass-ceramics were prepared.•Nanocrystalline fluorapatite was formed and identified using XRD.•Comparison between cell response on bioactive and nano-structured surfaces.•Cell viability after 24 h and 48 h was significantly greater on the nanostructured surface.
This work investigates the difference in viability of primary human foetal osteoblast cells on a glass-ceramic surface with nanoscale topography relative to viability on a smooth glass-ceramic surface containing a bioactive phase. Apatite-mullite glass-ceramics containing bioactive fluorapatite (Ca10(PO4)6F2) and bioinert mullite (Si2Al6O13) were synthesised and subsequent heat-treatment was optimised to form nano-sized fluorapatite crystals. Etching was used to selectively remove the bioactive phase, producing a surface with disordered nanoscale topography. Cells were seeded onto a smooth polished glass-ceramic substrate with the bioactive phase intact, an etched nanostructured glass-ceramic with the bioactive phase removed, and a borosilicate glass control. Cell viability after 24 h and 48 h was significantly greater on the nanostructured surface compared to the smooth bioactive surface, while cell viability at both time points was significantly greater on both nanostructured and smooth bioactive surfaces compared to the control. |
| doi_str_mv | 10.1016/j.matlet.2017.12.051 |
| format | article |
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•Etched and un-etched nanocrystalline glass-ceramics were prepared.•Nanocrystalline fluorapatite was formed and identified using XRD.•Comparison between cell response on bioactive and nano-structured surfaces.•Cell viability after 24 h and 48 h was significantly greater on the nanostructured surface.
This work investigates the difference in viability of primary human foetal osteoblast cells on a glass-ceramic surface with nanoscale topography relative to viability on a smooth glass-ceramic surface containing a bioactive phase. Apatite-mullite glass-ceramics containing bioactive fluorapatite (Ca10(PO4)6F2) and bioinert mullite (Si2Al6O13) were synthesised and subsequent heat-treatment was optimised to form nano-sized fluorapatite crystals. Etching was used to selectively remove the bioactive phase, producing a surface with disordered nanoscale topography. Cells were seeded onto a smooth polished glass-ceramic substrate with the bioactive phase intact, an etched nanostructured glass-ceramic with the bioactive phase removed, and a borosilicate glass control. Cell viability after 24 h and 48 h was significantly greater on the nanostructured surface compared to the smooth bioactive surface, while cell viability at both time points was significantly greater on both nanostructured and smooth bioactive surfaces compared to the control.</description><identifier>ISSN: 0167-577X</identifier><identifier>EISSN: 1873-4979</identifier><identifier>DOI: 10.1016/j.matlet.2017.12.051</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>Apatite ; Bioceramics ; Biocompatibility ; Biological activity ; Borosilicate glass ; Cell response ; Crystals ; Etching ; Fluorapatite ; Glass ceramics ; Glass substrates ; Glass-ceramic ; Heat treating ; Heat treatment ; Human behavior ; Materials science ; Mullite ; Nanocrystalline materials ; Nanostructure ; Topography</subject><ispartof>Materials letters, 2018-03, Vol.214, p.268-271</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright Elsevier BV Mar 1, 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-6a1e4b74638915c8f6bc5c343ed75d63e1551eabb60b25b009eb554a927befa23</citedby><cites>FETCH-LOGICAL-c380t-6a1e4b74638915c8f6bc5c343ed75d63e1551eabb60b25b009eb554a927befa23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Dunne, C.F.</creatorcontrib><creatorcontrib>Cooke, G.</creatorcontrib><creatorcontrib>Keane, S.</creatorcontrib><creatorcontrib>de Faoite, D.</creatorcontrib><creatorcontrib>Donnelly, S.C.</creatorcontrib><creatorcontrib>Stanton, K.T.</creatorcontrib><title>Nanostructured apatite-mullite glass-ceramics for enhanced primary human osteoblast cell response</title><title>Materials letters</title><description>[Display omitted]
•Etched and un-etched nanocrystalline glass-ceramics were prepared.•Nanocrystalline fluorapatite was formed and identified using XRD.•Comparison between cell response on bioactive and nano-structured surfaces.•Cell viability after 24 h and 48 h was significantly greater on the nanostructured surface.
This work investigates the difference in viability of primary human foetal osteoblast cells on a glass-ceramic surface with nanoscale topography relative to viability on a smooth glass-ceramic surface containing a bioactive phase. Apatite-mullite glass-ceramics containing bioactive fluorapatite (Ca10(PO4)6F2) and bioinert mullite (Si2Al6O13) were synthesised and subsequent heat-treatment was optimised to form nano-sized fluorapatite crystals. Etching was used to selectively remove the bioactive phase, producing a surface with disordered nanoscale topography. Cells were seeded onto a smooth polished glass-ceramic substrate with the bioactive phase intact, an etched nanostructured glass-ceramic with the bioactive phase removed, and a borosilicate glass control. Cell viability after 24 h and 48 h was significantly greater on the nanostructured surface compared to the smooth bioactive surface, while cell viability at both time points was significantly greater on both nanostructured and smooth bioactive surfaces compared to the control.</description><subject>Apatite</subject><subject>Bioceramics</subject><subject>Biocompatibility</subject><subject>Biological activity</subject><subject>Borosilicate glass</subject><subject>Cell response</subject><subject>Crystals</subject><subject>Etching</subject><subject>Fluorapatite</subject><subject>Glass ceramics</subject><subject>Glass substrates</subject><subject>Glass-ceramic</subject><subject>Heat treating</subject><subject>Heat treatment</subject><subject>Human behavior</subject><subject>Materials science</subject><subject>Mullite</subject><subject>Nanocrystalline materials</subject><subject>Nanostructure</subject><subject>Topography</subject><issn>0167-577X</issn><issn>1873-4979</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAURYMoOI7-AxcB161JmjTtRpDBLxh0o-AuJOmr09I2NUkF_70ZZtau7ua8-7gHoWtKckpoedvno44DxJwRKnPKciLoCVrRShYZr2V9ilYJk5mQ8vMcXYTQE0J4TfgK6Vc9uRD9YuPiocF61rGLkI3LMKTEX4MOIbPg9djZgFvnMUw7PdnEzr4btf_Fu2XUE04t4EzCI7YwDNhDmN0U4BKdtXoIcHXMNfp4fHjfPGfbt6eXzf02s0VFYlZqCtxIXhZVTYWt2tJYYQteQCNFUxZAhaCgjSmJYcIQUoMRguuaSQOtZsUa3Rx6Z---FwhR9W7xU3qpGGE1pzJNThQ_UNa7EDy06rhCUaL2MlWvDjLVXqaiTCWZ6ezucAZpwU8HXgXbwd5C58FG1bju_4I_wJyBsg</recordid><startdate>20180301</startdate><enddate>20180301</enddate><creator>Dunne, C.F.</creator><creator>Cooke, G.</creator><creator>Keane, S.</creator><creator>de Faoite, D.</creator><creator>Donnelly, S.C.</creator><creator>Stanton, K.T.</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope></search><sort><creationdate>20180301</creationdate><title>Nanostructured apatite-mullite glass-ceramics for enhanced primary human osteoblast cell response</title><author>Dunne, C.F. ; Cooke, G. ; Keane, S. ; de Faoite, D. ; Donnelly, S.C. ; Stanton, K.T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-6a1e4b74638915c8f6bc5c343ed75d63e1551eabb60b25b009eb554a927befa23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Apatite</topic><topic>Bioceramics</topic><topic>Biocompatibility</topic><topic>Biological activity</topic><topic>Borosilicate glass</topic><topic>Cell response</topic><topic>Crystals</topic><topic>Etching</topic><topic>Fluorapatite</topic><topic>Glass ceramics</topic><topic>Glass substrates</topic><topic>Glass-ceramic</topic><topic>Heat treating</topic><topic>Heat treatment</topic><topic>Human behavior</topic><topic>Materials science</topic><topic>Mullite</topic><topic>Nanocrystalline materials</topic><topic>Nanostructure</topic><topic>Topography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dunne, C.F.</creatorcontrib><creatorcontrib>Cooke, G.</creatorcontrib><creatorcontrib>Keane, S.</creatorcontrib><creatorcontrib>de Faoite, D.</creatorcontrib><creatorcontrib>Donnelly, S.C.</creatorcontrib><creatorcontrib>Stanton, K.T.</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Materials letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dunne, C.F.</au><au>Cooke, G.</au><au>Keane, S.</au><au>de Faoite, D.</au><au>Donnelly, S.C.</au><au>Stanton, K.T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nanostructured apatite-mullite glass-ceramics for enhanced primary human osteoblast cell response</atitle><jtitle>Materials letters</jtitle><date>2018-03-01</date><risdate>2018</risdate><volume>214</volume><spage>268</spage><epage>271</epage><pages>268-271</pages><issn>0167-577X</issn><eissn>1873-4979</eissn><abstract>[Display omitted]
•Etched and un-etched nanocrystalline glass-ceramics were prepared.•Nanocrystalline fluorapatite was formed and identified using XRD.•Comparison between cell response on bioactive and nano-structured surfaces.•Cell viability after 24 h and 48 h was significantly greater on the nanostructured surface.
This work investigates the difference in viability of primary human foetal osteoblast cells on a glass-ceramic surface with nanoscale topography relative to viability on a smooth glass-ceramic surface containing a bioactive phase. Apatite-mullite glass-ceramics containing bioactive fluorapatite (Ca10(PO4)6F2) and bioinert mullite (Si2Al6O13) were synthesised and subsequent heat-treatment was optimised to form nano-sized fluorapatite crystals. Etching was used to selectively remove the bioactive phase, producing a surface with disordered nanoscale topography. Cells were seeded onto a smooth polished glass-ceramic substrate with the bioactive phase intact, an etched nanostructured glass-ceramic with the bioactive phase removed, and a borosilicate glass control. Cell viability after 24 h and 48 h was significantly greater on the nanostructured surface compared to the smooth bioactive surface, while cell viability at both time points was significantly greater on both nanostructured and smooth bioactive surfaces compared to the control.</abstract><cop>Amsterdam</cop><pub>Elsevier B.V</pub><doi>10.1016/j.matlet.2017.12.051</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0167-577X |
| ispartof | Materials letters, 2018-03, Vol.214, p.268-271 |
| issn | 0167-577X 1873-4979 |
| language | eng |
| recordid | cdi_proquest_journals_2029417049 |
| source | Elsevier |
| subjects | Apatite Bioceramics Biocompatibility Biological activity Borosilicate glass Cell response Crystals Etching Fluorapatite Glass ceramics Glass substrates Glass-ceramic Heat treating Heat treatment Human behavior Materials science Mullite Nanocrystalline materials Nanostructure Topography |
| title | Nanostructured apatite-mullite glass-ceramics for enhanced primary human osteoblast cell response |
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