sup 68^Ga-DOTATATE PET/CT in recurrent medullary thyroid carcinoma: a lesion-by-lesion comparison with ^sup 111^In-octreotide SPECT/CT and conventional imaging

Purpose The aim of this study was to prospectively compare the detection rate of 68Ga-DOTATATE PET-CT with 111In-octreotide SPECT-CT and conventional imaging (CI) in medullary thyroid carcinoma (MTC) patients with increased calcitonin (Ctn) levels but negative CI after thyroidectomy. Methods Fifteen...

Full description

Saved in:
Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2017-09, Vol.44 (10), p.1695
Main Authors: Yamaga, Lilian Yuri, Itaya, Cunha, Marcelo L, Campos Neto, Guilherme C, Garcia, Marcio R, T, Yang, Ji H, Camacho, Cleber P, Wagner, Jairo, Funari, Marcelo B, G
Format: Article
Language:English
Subjects:
Bone lesions
Calcitonin
Comparative studies
Computed tomography
Histopathology
Imaging
Lesions
Medical imaging
Metastases
Metastasis
Neck
Octreotide
Patients
Positron emission
Sensitivity
Single photon emission computed tomography
Thyroid cancer
Thyroid carcinoma
Thyroidectomy
Tomography
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 10
container_start_page 1695
container_title European journal of nuclear medicine and molecular imaging
container_volume 44
creator Yamaga, Lilian Yuri
Itaya
Cunha, Marcelo L
Campos Neto, Guilherme C
Garcia, Marcio R
T
Yang, Ji H
Camacho, Cleber P
Wagner, Jairo
Funari, Marcelo B
G
description Purpose The aim of this study was to prospectively compare the detection rate of 68Ga-DOTATATE PET-CT with 111In-octreotide SPECT-CT and conventional imaging (CI) in medullary thyroid carcinoma (MTC) patients with increased calcitonin (Ctn) levels but negative CI after thyroidectomy. Methods Fifteen patients with raised Ctn levels and/or CI evidence of recurrence underwent 68Ga-DOTATATE PET-CT, 111In-octreotide SPECT-CT and CI. Histopathology, CI and biochemical/clinical/imaging follow-up were used as the reference standard. PET/CT, SPECT/CT and CI were compared in a lesion-based and organ-based analysis. Results PET/CT evidenced recurrence in 14 of 15 patients. There were 13 true positive (TP), 1 true negative (TN), 1 false positive (FP) and no false negative (FN) cases, resulting in a sensitivity and accuracy of 100% and 93%. SPECT/CT was positive in 6 of 15 cases. There were 6 TP, 2 TN, 7 FN and no FP cases, resulting in a sensitivity of 46% and accuracy of 53%. CI procedures detected tumor lesions in 14 of 15 patients. There were 13 TP, 1TN, 1 FP and no FN cases with a sensitivity of 100% and accuracy of 93%. A significantly higher number of lesions was detected by PET/CT (112 lesions, p = 0.005) and CI (109 lesions, p = 0.005) in comparison to SPECT/CT (16 lesions). There was no significant difference between PET/CT and CI for the total number of detected lesions (p = 0.734). PET/CT detected more lesions than SPECT/CT regardless of the organ. PET/CT detected more bone lesions but missed some neck nodal metastases evidenced by CI. The number of lesions per region demonstrated by PET/CT and CI were similar in the other sites. Conclusion 68Ga-DOTATATE PET/CT is superior to 111In-octreotide SPECT/CT for the detection of recurrent MTC demonstrating a significantly higher number of lesions. 68Ga-DOTATATE PET/CT showed a superior detection rate compared to CI in demonstrating bone metastases.
doi_str_mv 10.1007/s00259-017-3701-9
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1924798865</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1924798865</sourcerecordid><originalsourceid>FETCH-proquest_journals_19247988653</originalsourceid><addsrcrecordid>eNqNjctOwzAQRS0EEuXxAexGYm3qSWlss0MhPFZUIutUJjGtq8QOtgPK1_CrmIdYo7uYs5h7DyFnyC6QMT4PjGVLSRlyuuAMqdwjM8xRUs6E3P9jzg7JUQg7xlBkQs7IRxgHyEV9p-jNY3WdUsKqrOZFBcaC183ovbYRet2OXaf8BHE7eWdaaJRvjHW9ugIFnQ7GWfo80R-CxvWD8iYkfDdxC_WXBxHrB0tdE7120bQanlZl8S1TNi06-5Zcqa46ML3aGLs5IQcvqgv69Pcek_Pbsiru6eDd66hDXO_c6FMhrFFml1wKkS8X__v6BCLDYG0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1924798865</pqid></control><display><type>article</type><title>sup 68^Ga-DOTATATE PET/CT in recurrent medullary thyroid carcinoma: a lesion-by-lesion comparison with ^sup 111^In-octreotide SPECT/CT and conventional imaging</title><source>Springer Link</source><creator>Yamaga, Lilian Yuri; Itaya ; Cunha, Marcelo L ; Campos Neto, Guilherme C ; Garcia, Marcio R; T ; Yang, Ji H ; Camacho, Cleber P ; Wagner, Jairo ; Funari, Marcelo B; G</creator><creatorcontrib>Yamaga, Lilian Yuri; Itaya ; Cunha, Marcelo L ; Campos Neto, Guilherme C ; Garcia, Marcio R; T ; Yang, Ji H ; Camacho, Cleber P ; Wagner, Jairo ; Funari, Marcelo B; G</creatorcontrib><description>Purpose The aim of this study was to prospectively compare the detection rate of 68Ga-DOTATATE PET-CT with 111In-octreotide SPECT-CT and conventional imaging (CI) in medullary thyroid carcinoma (MTC) patients with increased calcitonin (Ctn) levels but negative CI after thyroidectomy. Methods Fifteen patients with raised Ctn levels and/or CI evidence of recurrence underwent 68Ga-DOTATATE PET-CT, 111In-octreotide SPECT-CT and CI. Histopathology, CI and biochemical/clinical/imaging follow-up were used as the reference standard. PET/CT, SPECT/CT and CI were compared in a lesion-based and organ-based analysis. Results PET/CT evidenced recurrence in 14 of 15 patients. There were 13 true positive (TP), 1 true negative (TN), 1 false positive (FP) and no false negative (FN) cases, resulting in a sensitivity and accuracy of 100% and 93%. SPECT/CT was positive in 6 of 15 cases. There were 6 TP, 2 TN, 7 FN and no FP cases, resulting in a sensitivity of 46% and accuracy of 53%. CI procedures detected tumor lesions in 14 of 15 patients. There were 13 TP, 1TN, 1 FP and no FN cases with a sensitivity of 100% and accuracy of 93%. A significantly higher number of lesions was detected by PET/CT (112 lesions, p = 0.005) and CI (109 lesions, p = 0.005) in comparison to SPECT/CT (16 lesions). There was no significant difference between PET/CT and CI for the total number of detected lesions (p = 0.734). PET/CT detected more lesions than SPECT/CT regardless of the organ. PET/CT detected more bone lesions but missed some neck nodal metastases evidenced by CI. The number of lesions per region demonstrated by PET/CT and CI were similar in the other sites. Conclusion 68Ga-DOTATATE PET/CT is superior to 111In-octreotide SPECT/CT for the detection of recurrent MTC demonstrating a significantly higher number of lesions. 68Ga-DOTATATE PET/CT showed a superior detection rate compared to CI in demonstrating bone metastases.</description><identifier>ISSN: 1619-7070</identifier><identifier>EISSN: 1619-7089</identifier><identifier>DOI: 10.1007/s00259-017-3701-9</identifier><language>eng</language><publisher>Heidelberg: Springer Nature B.V</publisher><subject>Bone lesions ; Calcitonin ; Comparative studies ; Computed tomography ; Histopathology ; Imaging ; Lesions ; Medical imaging ; Metastases ; Metastasis ; Neck ; Octreotide ; Patients ; Positron emission ; Sensitivity ; Single photon emission computed tomography ; Thyroid cancer ; Thyroid carcinoma ; Thyroidectomy ; Tomography</subject><ispartof>European journal of nuclear medicine and molecular imaging, 2017-09, Vol.44 (10), p.1695</ispartof><rights>European Journal of Nuclear Medicine and Molecular Imaging is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,786,790,27957,27958</link.rule.ids></links><search><creatorcontrib>Yamaga, Lilian Yuri; Itaya</creatorcontrib><creatorcontrib>Cunha, Marcelo L</creatorcontrib><creatorcontrib>Campos Neto, Guilherme C</creatorcontrib><creatorcontrib>Garcia, Marcio R; T</creatorcontrib><creatorcontrib>Yang, Ji H</creatorcontrib><creatorcontrib>Camacho, Cleber P</creatorcontrib><creatorcontrib>Wagner, Jairo</creatorcontrib><creatorcontrib>Funari, Marcelo B; G</creatorcontrib><title>sup 68^Ga-DOTATATE PET/CT in recurrent medullary thyroid carcinoma: a lesion-by-lesion comparison with ^sup 111^In-octreotide SPECT/CT and conventional imaging</title><title>European journal of nuclear medicine and molecular imaging</title><description>Purpose The aim of this study was to prospectively compare the detection rate of 68Ga-DOTATATE PET-CT with 111In-octreotide SPECT-CT and conventional imaging (CI) in medullary thyroid carcinoma (MTC) patients with increased calcitonin (Ctn) levels but negative CI after thyroidectomy. Methods Fifteen patients with raised Ctn levels and/or CI evidence of recurrence underwent 68Ga-DOTATATE PET-CT, 111In-octreotide SPECT-CT and CI. Histopathology, CI and biochemical/clinical/imaging follow-up were used as the reference standard. PET/CT, SPECT/CT and CI were compared in a lesion-based and organ-based analysis. Results PET/CT evidenced recurrence in 14 of 15 patients. There were 13 true positive (TP), 1 true negative (TN), 1 false positive (FP) and no false negative (FN) cases, resulting in a sensitivity and accuracy of 100% and 93%. SPECT/CT was positive in 6 of 15 cases. There were 6 TP, 2 TN, 7 FN and no FP cases, resulting in a sensitivity of 46% and accuracy of 53%. CI procedures detected tumor lesions in 14 of 15 patients. There were 13 TP, 1TN, 1 FP and no FN cases with a sensitivity of 100% and accuracy of 93%. A significantly higher number of lesions was detected by PET/CT (112 lesions, p = 0.005) and CI (109 lesions, p = 0.005) in comparison to SPECT/CT (16 lesions). There was no significant difference between PET/CT and CI for the total number of detected lesions (p = 0.734). PET/CT detected more lesions than SPECT/CT regardless of the organ. PET/CT detected more bone lesions but missed some neck nodal metastases evidenced by CI. The number of lesions per region demonstrated by PET/CT and CI were similar in the other sites. Conclusion 68Ga-DOTATATE PET/CT is superior to 111In-octreotide SPECT/CT for the detection of recurrent MTC demonstrating a significantly higher number of lesions. 68Ga-DOTATATE PET/CT showed a superior detection rate compared to CI in demonstrating bone metastases.</description><subject>Bone lesions</subject><subject>Calcitonin</subject><subject>Comparative studies</subject><subject>Computed tomography</subject><subject>Histopathology</subject><subject>Imaging</subject><subject>Lesions</subject><subject>Medical imaging</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Neck</subject><subject>Octreotide</subject><subject>Patients</subject><subject>Positron emission</subject><subject>Sensitivity</subject><subject>Single photon emission computed tomography</subject><subject>Thyroid cancer</subject><subject>Thyroid carcinoma</subject><subject>Thyroidectomy</subject><subject>Tomography</subject><issn>1619-7070</issn><issn>1619-7089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNjctOwzAQRS0EEuXxAexGYm3qSWlss0MhPFZUIutUJjGtq8QOtgPK1_CrmIdYo7uYs5h7DyFnyC6QMT4PjGVLSRlyuuAMqdwjM8xRUs6E3P9jzg7JUQg7xlBkQs7IRxgHyEV9p-jNY3WdUsKqrOZFBcaC183ovbYRet2OXaf8BHE7eWdaaJRvjHW9ugIFnQ7GWfo80R-CxvWD8iYkfDdxC_WXBxHrB0tdE7120bQanlZl8S1TNi06-5Zcqa46ML3aGLs5IQcvqgv69Pcek_Pbsiru6eDd66hDXO_c6FMhrFFml1wKkS8X__v6BCLDYG0</recordid><startdate>20170901</startdate><enddate>20170901</enddate><creator>Yamaga, Lilian Yuri; Itaya</creator><creator>Cunha, Marcelo L</creator><creator>Campos Neto, Guilherme C</creator><creator>Garcia, Marcio R; T</creator><creator>Yang, Ji H</creator><creator>Camacho, Cleber P</creator><creator>Wagner, Jairo</creator><creator>Funari, Marcelo B; G</creator><general>Springer Nature B.V</general><scope>3V.</scope><scope>7RV</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope></search><sort><creationdate>20170901</creationdate><title>sup 68^Ga-DOTATATE PET/CT in recurrent medullary thyroid carcinoma: a lesion-by-lesion comparison with ^sup 111^In-octreotide SPECT/CT and conventional imaging</title><author>Yamaga, Lilian Yuri; Itaya ; Cunha, Marcelo L ; Campos Neto, Guilherme C ; Garcia, Marcio R; T ; Yang, Ji H ; Camacho, Cleber P ; Wagner, Jairo ; Funari, Marcelo B; G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_19247988653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Bone lesions</topic><topic>Calcitonin</topic><topic>Comparative studies</topic><topic>Computed tomography</topic><topic>Histopathology</topic><topic>Imaging</topic><topic>Lesions</topic><topic>Medical imaging</topic><topic>Metastases</topic><topic>Metastasis</topic><topic>Neck</topic><topic>Octreotide</topic><topic>Patients</topic><topic>Positron emission</topic><topic>Sensitivity</topic><topic>Single photon emission computed tomography</topic><topic>Thyroid cancer</topic><topic>Thyroid carcinoma</topic><topic>Thyroidectomy</topic><topic>Tomography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yamaga, Lilian Yuri; Itaya</creatorcontrib><creatorcontrib>Cunha, Marcelo L</creatorcontrib><creatorcontrib>Campos Neto, Guilherme C</creatorcontrib><creatorcontrib>Garcia, Marcio R; T</creatorcontrib><creatorcontrib>Yang, Ji H</creatorcontrib><creatorcontrib>Camacho, Cleber P</creatorcontrib><creatorcontrib>Wagner, Jairo</creatorcontrib><creatorcontrib>Funari, Marcelo B; G</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Neurosciences Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><jtitle>European journal of nuclear medicine and molecular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yamaga, Lilian Yuri; Itaya</au><au>Cunha, Marcelo L</au><au>Campos Neto, Guilherme C</au><au>Garcia, Marcio R; T</au><au>Yang, Ji H</au><au>Camacho, Cleber P</au><au>Wagner, Jairo</au><au>Funari, Marcelo B; G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>sup 68^Ga-DOTATATE PET/CT in recurrent medullary thyroid carcinoma: a lesion-by-lesion comparison with ^sup 111^In-octreotide SPECT/CT and conventional imaging</atitle><jtitle>European journal of nuclear medicine and molecular imaging</jtitle><date>2017-09-01</date><risdate>2017</risdate><volume>44</volume><issue>10</issue><spage>1695</spage><pages>1695-</pages><issn>1619-7070</issn><eissn>1619-7089</eissn><abstract>Purpose The aim of this study was to prospectively compare the detection rate of 68Ga-DOTATATE PET-CT with 111In-octreotide SPECT-CT and conventional imaging (CI) in medullary thyroid carcinoma (MTC) patients with increased calcitonin (Ctn) levels but negative CI after thyroidectomy. Methods Fifteen patients with raised Ctn levels and/or CI evidence of recurrence underwent 68Ga-DOTATATE PET-CT, 111In-octreotide SPECT-CT and CI. Histopathology, CI and biochemical/clinical/imaging follow-up were used as the reference standard. PET/CT, SPECT/CT and CI were compared in a lesion-based and organ-based analysis. Results PET/CT evidenced recurrence in 14 of 15 patients. There were 13 true positive (TP), 1 true negative (TN), 1 false positive (FP) and no false negative (FN) cases, resulting in a sensitivity and accuracy of 100% and 93%. SPECT/CT was positive in 6 of 15 cases. There were 6 TP, 2 TN, 7 FN and no FP cases, resulting in a sensitivity of 46% and accuracy of 53%. CI procedures detected tumor lesions in 14 of 15 patients. There were 13 TP, 1TN, 1 FP and no FN cases with a sensitivity of 100% and accuracy of 93%. A significantly higher number of lesions was detected by PET/CT (112 lesions, p = 0.005) and CI (109 lesions, p = 0.005) in comparison to SPECT/CT (16 lesions). There was no significant difference between PET/CT and CI for the total number of detected lesions (p = 0.734). PET/CT detected more lesions than SPECT/CT regardless of the organ. PET/CT detected more bone lesions but missed some neck nodal metastases evidenced by CI. The number of lesions per region demonstrated by PET/CT and CI were similar in the other sites. Conclusion 68Ga-DOTATATE PET/CT is superior to 111In-octreotide SPECT/CT for the detection of recurrent MTC demonstrating a significantly higher number of lesions. 68Ga-DOTATATE PET/CT showed a superior detection rate compared to CI in demonstrating bone metastases.</abstract><cop>Heidelberg</cop><pub>Springer Nature B.V</pub><doi>10.1007/s00259-017-3701-9</doi></addata></record>
fulltext fulltext
identifier ISSN: 1619-7070
ispartof European journal of nuclear medicine and molecular imaging, 2017-09, Vol.44 (10), p.1695
issn 1619-7070
1619-7089
language eng
recordid cdi_proquest_journals_1924798865
source Springer Link
subjects Bone lesions
Calcitonin
Comparative studies
Computed tomography
Histopathology
Imaging
Lesions
Medical imaging
Metastases
Metastasis
Neck
Octreotide
Patients
Positron emission
Sensitivity
Single photon emission computed tomography
Thyroid cancer
Thyroid carcinoma
Thyroidectomy
Tomography
title sup 68^Ga-DOTATATE PET/CT in recurrent medullary thyroid carcinoma: a lesion-by-lesion comparison with ^sup 111^In-octreotide SPECT/CT and conventional imaging
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T21%3A33%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=sup%2068%5EGa-DOTATATE%20PET/CT%20in%20recurrent%20medullary%20thyroid%20carcinoma:%20a%20lesion-by-lesion%20comparison%20with%20%5Esup%20111%5EIn-octreotide%20SPECT/CT%20and%20conventional%20imaging&rft.jtitle=European%20journal%20of%20nuclear%20medicine%20and%20molecular%20imaging&rft.au=Yamaga,%20Lilian%20Yuri;%20Itaya&rft.date=2017-09-01&rft.volume=44&rft.issue=10&rft.spage=1695&rft.pages=1695-&rft.issn=1619-7070&rft.eissn=1619-7089&rft_id=info:doi/10.1007/s00259-017-3701-9&rft_dat=%3Cproquest%3E1924798865%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_journals_19247988653%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1924798865&rft_id=info:pmid/&rfr_iscdi=true