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The effects of graphene oxide on the properties and drug delivery of konjac glucomannan hydrogel
ABSTRACT Konjac glucomannan (KGM) hydrogel has good potential application in food and medical science, although to achieve this, the physical and mechanical properties need further improvement. In this study, graphene oxide (GO) was used to improve the functionality of KGM hydrogel. KGM/GO hydrogels...
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| Published in: | Journal of applied polymer science 2017-10, Vol.134 (38), p.n/a |
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| container_issue | 38 |
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| container_title | Journal of applied polymer science |
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| creator | Yuan, Yi Yan, Zhiming Mu, Ruo‐Jun Wang, Lin Gong, Jingni Hong, Xin Haruna, Maryam Hajia Pang, Jie |
| description | ABSTRACT
Konjac glucomannan (KGM) hydrogel has good potential application in food and medical science, although to achieve this, the physical and mechanical properties need further improvement. In this study, graphene oxide (GO) was used to improve the functionality of KGM hydrogel. KGM/GO hydrogels were prepared by freezing the alkaline KGM/GO sols. Rotational rheometer was used to study the rheological properties of different alkaline KGM/GO sols. Fourier transform infrared, Raman, differential scanning calorimetry, thermogravimetric analyses, and scanning electron microscopy were used to evaluate the structure and properties of the hydrogels. In addition, different pH solutions and an in vitro assay were used to study the swelling property and the release behavior of KGM/GO hydrogels, respectively. The result revealed strong hydrogen‐bond interaction between KGM and GO. The incorporation of GO highly improved the gel properties of KGM/GO sol, higher thermal stability, and more compact structure of KGM/GO hydrogels. KGM/GO hydrogels showed better swelling properties in deionized‐distilled water and pH 7.2 PBS. The release of 5‐aminosalicylic acid (5‐ASA) from KGM/GO (KG4) hydrogel was different in various pH media, but the initial burst release effect was very severe. Therefore, incorporation of GO have a good potential in enhancing the properties of KGM hydrogel, but KGM/GO hydrogel is not an ideal carrier for 5‐ASA release. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45327. |
| doi_str_mv | 10.1002/app.45327 |
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Konjac glucomannan (KGM) hydrogel has good potential application in food and medical science, although to achieve this, the physical and mechanical properties need further improvement. In this study, graphene oxide (GO) was used to improve the functionality of KGM hydrogel. KGM/GO hydrogels were prepared by freezing the alkaline KGM/GO sols. Rotational rheometer was used to study the rheological properties of different alkaline KGM/GO sols. Fourier transform infrared, Raman, differential scanning calorimetry, thermogravimetric analyses, and scanning electron microscopy were used to evaluate the structure and properties of the hydrogels. In addition, different pH solutions and an in vitro assay were used to study the swelling property and the release behavior of KGM/GO hydrogels, respectively. The result revealed strong hydrogen‐bond interaction between KGM and GO. The incorporation of GO highly improved the gel properties of KGM/GO sol, higher thermal stability, and more compact structure of KGM/GO hydrogels. KGM/GO hydrogels showed better swelling properties in deionized‐distilled water and pH 7.2 PBS. The release of 5‐aminosalicylic acid (5‐ASA) from KGM/GO (KG4) hydrogel was different in various pH media, but the initial burst release effect was very severe. Therefore, incorporation of GO have a good potential in enhancing the properties of KGM hydrogel, but KGM/GO hydrogel is not an ideal carrier for 5‐ASA release. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45327.</description><identifier>ISSN: 0021-8995</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.45327</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Assaying ; Bursting ; Deionization ; Differential scanning calorimetry ; Distilled water ; drug delivery ; Drug delivery systems ; Fourier analysis ; Fourier transforms ; Freezing ; Graphene ; graphene oxide ; Heat measurement ; hydrogel ; Hydrogels ; Hydrogen ; In vitro methods and tests ; Infrared analysis ; konjac glucomannan ; Materials science ; Mechanical properties ; Medical science ; microstructure ; Polymers ; Scanning electron microscopy ; Swelling ; Thermal analysis ; Thermal stability ; Thermogravimetric analysis</subject><ispartof>Journal of applied polymer science, 2017-10, Vol.134 (38), p.n/a</ispartof><rights>2017 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2977-3ad61f18324fe7dc27bad95d638e7ebc22f16c3afed2452e08a2bd97e0e8be663</citedby><cites>FETCH-LOGICAL-c2977-3ad61f18324fe7dc27bad95d638e7ebc22f16c3afed2452e08a2bd97e0e8be663</cites><orcidid>0000-0003-0610-4575</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.45327$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.45327$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,786,790,27957,27958,50923,51032</link.rule.ids></links><search><creatorcontrib>Yuan, Yi</creatorcontrib><creatorcontrib>Yan, Zhiming</creatorcontrib><creatorcontrib>Mu, Ruo‐Jun</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><creatorcontrib>Gong, Jingni</creatorcontrib><creatorcontrib>Hong, Xin</creatorcontrib><creatorcontrib>Haruna, Maryam Hajia</creatorcontrib><creatorcontrib>Pang, Jie</creatorcontrib><title>The effects of graphene oxide on the properties and drug delivery of konjac glucomannan hydrogel</title><title>Journal of applied polymer science</title><description>ABSTRACT
Konjac glucomannan (KGM) hydrogel has good potential application in food and medical science, although to achieve this, the physical and mechanical properties need further improvement. In this study, graphene oxide (GO) was used to improve the functionality of KGM hydrogel. KGM/GO hydrogels were prepared by freezing the alkaline KGM/GO sols. Rotational rheometer was used to study the rheological properties of different alkaline KGM/GO sols. Fourier transform infrared, Raman, differential scanning calorimetry, thermogravimetric analyses, and scanning electron microscopy were used to evaluate the structure and properties of the hydrogels. In addition, different pH solutions and an in vitro assay were used to study the swelling property and the release behavior of KGM/GO hydrogels, respectively. The result revealed strong hydrogen‐bond interaction between KGM and GO. The incorporation of GO highly improved the gel properties of KGM/GO sol, higher thermal stability, and more compact structure of KGM/GO hydrogels. KGM/GO hydrogels showed better swelling properties in deionized‐distilled water and pH 7.2 PBS. The release of 5‐aminosalicylic acid (5‐ASA) from KGM/GO (KG4) hydrogel was different in various pH media, but the initial burst release effect was very severe. Therefore, incorporation of GO have a good potential in enhancing the properties of KGM hydrogel, but KGM/GO hydrogel is not an ideal carrier for 5‐ASA release. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45327.</description><subject>Assaying</subject><subject>Bursting</subject><subject>Deionization</subject><subject>Differential scanning calorimetry</subject><subject>Distilled water</subject><subject>drug delivery</subject><subject>Drug delivery systems</subject><subject>Fourier analysis</subject><subject>Fourier transforms</subject><subject>Freezing</subject><subject>Graphene</subject><subject>graphene oxide</subject><subject>Heat measurement</subject><subject>hydrogel</subject><subject>Hydrogels</subject><subject>Hydrogen</subject><subject>In vitro methods and tests</subject><subject>Infrared analysis</subject><subject>konjac glucomannan</subject><subject>Materials science</subject><subject>Mechanical properties</subject><subject>Medical science</subject><subject>microstructure</subject><subject>Polymers</subject><subject>Scanning electron microscopy</subject><subject>Swelling</subject><subject>Thermal analysis</subject><subject>Thermal stability</subject><subject>Thermogravimetric analysis</subject><issn>0021-8995</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp1kD1PwzAQhi0EEqUw8A8sMTGktZ0Px2NV8SVVokOZjWOf05TUCXYC5N8TCCvL3XDPe3d6ELqmZEEJYUvVtoskjRk_QTNKBI-SjOWnaDbOaJQLkZ6jixAOhFCakmyGXnd7wGAt6C7gxuLSq3YPDnDzVZmxOtyNQOubFnxXQcDKGWx8X2IDdfUBfvhJvTXuoDQu6143R-Wccng_GN-UUF-iM6vqAFd_fY5e7u9268do8_zwtF5tIs0E51GsTEYtzWOWWOBGM14oI1KTxTlwKDRjlmY6VhYMS1IGJFesMIIDgbyALIvn6GbaO_763kPo5KHpvRtPSipoyuKcEzFStxOlfROCBytbXx2VHyQl8kegHAXKX4Eju5zYz6qG4X9QrrbbKfENGh9zWw</recordid><startdate>20171010</startdate><enddate>20171010</enddate><creator>Yuan, Yi</creator><creator>Yan, Zhiming</creator><creator>Mu, Ruo‐Jun</creator><creator>Wang, Lin</creator><creator>Gong, Jingni</creator><creator>Hong, Xin</creator><creator>Haruna, Maryam Hajia</creator><creator>Pang, Jie</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><orcidid>https://orcid.org/0000-0003-0610-4575</orcidid></search><sort><creationdate>20171010</creationdate><title>The effects of graphene oxide on the properties and drug delivery of konjac glucomannan hydrogel</title><author>Yuan, Yi ; Yan, Zhiming ; Mu, Ruo‐Jun ; Wang, Lin ; Gong, Jingni ; Hong, Xin ; Haruna, Maryam Hajia ; Pang, Jie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2977-3ad61f18324fe7dc27bad95d638e7ebc22f16c3afed2452e08a2bd97e0e8be663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Assaying</topic><topic>Bursting</topic><topic>Deionization</topic><topic>Differential scanning calorimetry</topic><topic>Distilled water</topic><topic>drug delivery</topic><topic>Drug delivery systems</topic><topic>Fourier analysis</topic><topic>Fourier transforms</topic><topic>Freezing</topic><topic>Graphene</topic><topic>graphene oxide</topic><topic>Heat measurement</topic><topic>hydrogel</topic><topic>Hydrogels</topic><topic>Hydrogen</topic><topic>In vitro methods and tests</topic><topic>Infrared analysis</topic><topic>konjac glucomannan</topic><topic>Materials science</topic><topic>Mechanical properties</topic><topic>Medical science</topic><topic>microstructure</topic><topic>Polymers</topic><topic>Scanning electron microscopy</topic><topic>Swelling</topic><topic>Thermal analysis</topic><topic>Thermal stability</topic><topic>Thermogravimetric analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuan, Yi</creatorcontrib><creatorcontrib>Yan, Zhiming</creatorcontrib><creatorcontrib>Mu, Ruo‐Jun</creatorcontrib><creatorcontrib>Wang, Lin</creatorcontrib><creatorcontrib>Gong, Jingni</creatorcontrib><creatorcontrib>Hong, Xin</creatorcontrib><creatorcontrib>Haruna, Maryam Hajia</creatorcontrib><creatorcontrib>Pang, Jie</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, Yi</au><au>Yan, Zhiming</au><au>Mu, Ruo‐Jun</au><au>Wang, Lin</au><au>Gong, Jingni</au><au>Hong, Xin</au><au>Haruna, Maryam Hajia</au><au>Pang, Jie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effects of graphene oxide on the properties and drug delivery of konjac glucomannan hydrogel</atitle><jtitle>Journal of applied polymer science</jtitle><date>2017-10-10</date><risdate>2017</risdate><volume>134</volume><issue>38</issue><epage>n/a</epage><issn>0021-8995</issn><eissn>1097-4628</eissn><abstract>ABSTRACT
Konjac glucomannan (KGM) hydrogel has good potential application in food and medical science, although to achieve this, the physical and mechanical properties need further improvement. In this study, graphene oxide (GO) was used to improve the functionality of KGM hydrogel. KGM/GO hydrogels were prepared by freezing the alkaline KGM/GO sols. Rotational rheometer was used to study the rheological properties of different alkaline KGM/GO sols. Fourier transform infrared, Raman, differential scanning calorimetry, thermogravimetric analyses, and scanning electron microscopy were used to evaluate the structure and properties of the hydrogels. In addition, different pH solutions and an in vitro assay were used to study the swelling property and the release behavior of KGM/GO hydrogels, respectively. The result revealed strong hydrogen‐bond interaction between KGM and GO. The incorporation of GO highly improved the gel properties of KGM/GO sol, higher thermal stability, and more compact structure of KGM/GO hydrogels. KGM/GO hydrogels showed better swelling properties in deionized‐distilled water and pH 7.2 PBS. The release of 5‐aminosalicylic acid (5‐ASA) from KGM/GO (KG4) hydrogel was different in various pH media, but the initial burst release effect was very severe. Therefore, incorporation of GO have a good potential in enhancing the properties of KGM hydrogel, but KGM/GO hydrogel is not an ideal carrier for 5‐ASA release. © 2017 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017, 134, 45327.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/app.45327</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-0610-4575</orcidid></addata></record> |
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| subjects | Assaying Bursting Deionization Differential scanning calorimetry Distilled water drug delivery Drug delivery systems Fourier analysis Fourier transforms Freezing Graphene graphene oxide Heat measurement hydrogel Hydrogels Hydrogen In vitro methods and tests Infrared analysis konjac glucomannan Materials science Mechanical properties Medical science microstructure Polymers Scanning electron microscopy Swelling Thermal analysis Thermal stability Thermogravimetric analysis |
| title | The effects of graphene oxide on the properties and drug delivery of konjac glucomannan hydrogel |
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