0118 Lifetime Occupational Exposure to Diesel Exhaust and Bladder Cancer among Men in New England

Objectives We examined the association between lifetime occupational diesel engine exhaust (DEE) exposure and risk of bladder cancer in 1171 cases and 1418 controls in a population-based case-control study. Method Lifetime occupational histories combined with additional exposure-oriented questionnai...

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Published in:Occupational and environmental medicine (London, England) England), 2014-06, Vol.71 (Suppl 1), p.A75-A75
Main Authors: Koutros, Stella, Karagas, Margaret, Friesen, Melissa, Pronk, Anjoeka, Stewart, Patricia, Baris, Dalsu, Schwenn, Molly, Waddell, Richard, Johnson, Alison, Clerkin, Castine, Armenti, Karla, Colt, Joanne, Silverman, Debra
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Language:English
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Bladder cancer
Diesel engines
Exhaust emissions
Exposure
Health risks
Lung cancer
Risk factors
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container_end_page A75
container_issue Suppl 1
container_start_page A75
container_title Occupational and environmental medicine (London, England)
container_volume 71
creator Koutros, Stella
Karagas, Margaret
Friesen, Melissa
Pronk, Anjoeka
Stewart, Patricia
Baris, Dalsu
Schwenn, Molly
Waddell, Richard
Johnson, Alison
Clerkin, Castine
Armenti, Karla
Colt, Joanne
Silverman, Debra
description Objectives We examined the association between lifetime occupational diesel engine exhaust (DEE) exposure and risk of bladder cancer in 1171 cases and 1418 controls in a population-based case-control study. Method Lifetime occupational histories combined with additional exposure-oriented questionnaires were administered to obtain detailed information on DEE. We estimated the probability, frequency and intensity of exposure to respirable elemental carbon (REC) (μg/m3), a primary surrogate for DEE. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for smoking and other risk factors. Results DEE was associated with an increased risk of bladder cancer, with the highest level of cumulative REC (>252.8 μg/m3 per year) having a 35% elevated risk (95% CI = 0.86–2.13) compared to those with no exposure. Among nonsmokers, we observed a significant trend in risk with increasing cumulative REC (p-trend = 0.03), with heavily exposed subjects having an OR=2.80 (95% CI =1.08–7.22). Time-period analyses by decade of first DEE-exposed job showed a statistically significant increased risk among men first exposed in the 1950s (heavily exposed: OR=2.73, 95% CI =1.29–5.79, p-trend = 0.009). Conclusions The overall risk observed is modest, but similar in magnitude to those observed at comparable levels of exposure in previous studies of bladder and lung cancer. Greater risk for those first exposed in the 1950s may reflect secular trends in risk or a long latency for bladder cancer. Our results provide additional evidence that DEE is related to an increased bladder cancer risk.
doi_str_mv 10.1136/oemed-2014-102362.234
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Method Lifetime occupational histories combined with additional exposure-oriented questionnaires were administered to obtain detailed information on DEE. We estimated the probability, frequency and intensity of exposure to respirable elemental carbon (REC) (μg/m3), a primary surrogate for DEE. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for smoking and other risk factors. Results DEE was associated with an increased risk of bladder cancer, with the highest level of cumulative REC (&gt;252.8 μg/m3 per year) having a 35% elevated risk (95% CI = 0.86–2.13) compared to those with no exposure. Among nonsmokers, we observed a significant trend in risk with increasing cumulative REC (p-trend = 0.03), with heavily exposed subjects having an OR=2.80 (95% CI =1.08–7.22). Time-period analyses by decade of first DEE-exposed job showed a statistically significant increased risk among men first exposed in the 1950s (heavily exposed: OR=2.73, 95% CI =1.29–5.79, p-trend = 0.009). Conclusions The overall risk observed is modest, but similar in magnitude to those observed at comparable levels of exposure in previous studies of bladder and lung cancer. Greater risk for those first exposed in the 1950s may reflect secular trends in risk or a long latency for bladder cancer. 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Time-period analyses by decade of first DEE-exposed job showed a statistically significant increased risk among men first exposed in the 1950s (heavily exposed: OR=2.73, 95% CI =1.29–5.79, p-trend = 0.009). Conclusions The overall risk observed is modest, but similar in magnitude to those observed at comparable levels of exposure in previous studies of bladder and lung cancer. Greater risk for those first exposed in the 1950s may reflect secular trends in risk or a long latency for bladder cancer. 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source JSTOR Archival Journals and Primary Sources Collection【Remote access available】; BMJ Journals - NESLi2
subjects Bladder cancer
Diesel engines
Exhaust emissions
Exposure
Health risks
Lung cancer
Risk factors
title 0118 Lifetime Occupational Exposure to Diesel Exhaust and Bladder Cancer among Men in New England
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