Clinical observations of cattle and buffalos with experimentally induced chronic copper poisoning

The susceptibility of cattle and buffalos to chronic copper poisoning (CCP) was compared by using cattle ( n = 10) and buffalo ( n = 10) steers distributed into two copper supplemented ( n = 6) and two control ( n = 4) groups. Supplemented animals received 2 mg copper (Cu)/kg body weight daily for o...

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Bibliographic Details
Published in:Research in veterinary science 2009-12, Vol.87 (3), p.473-478
Main Authors: Minervino, Antonio H.H., Barrêto Júnior, Raimundo A., Ferreira, Rodrigo N.F., Rodrigues, Frederico A.M.L., Headley, Selwyn A., Mori, Clara S., Ortolani, Enrico L.
Format: Article
Language:English
Subjects:
animal diseases
Animals
Aqueous solutions
bioaccumulation
biomarkers
blood chemistry
blood serum
Buffalo
Buffaloes
Cattle
Cattle Diseases - chemically induced
Cattle Diseases - mortality
Chronic Disease
chronic diseases
copper
Copper - poisoning
Copper toxicosis
Disease
disease models
disease resistance
Experiments
histopathology
liver
Liver - metabolism
liver function
Male
morbidity
Mortality
pathogenesis
Poisoning
Poisoning - veterinary
Sheep
signs and symptoms (animals and humans)
species differences
Species Specificity
toxicity
Veterinary medicine
Zinc
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Summary:The susceptibility of cattle and buffalos to chronic copper poisoning (CCP) was compared by using cattle ( n = 10) and buffalo ( n = 10) steers distributed into two copper supplemented ( n = 6) and two control ( n = 4) groups. Supplemented animals received 2 mg copper (Cu)/kg body weight daily for one week, with an additional 2 mg weekly until the end of the experiment (day 105). Three liver biopsies (day 0, 45, and 105) were obtained for mineral analyses; clinical examinations and blood samples were obtained every 15 days. Three supplemented cattle and two buffalos with typical manifestations of CCP died. There were no differences in the frequency of mortality between cattle and buffalos; hepatic copper concentration was higher in cattle than buffalos. These findings suggest that buffalos and cattle might be equally susceptible to CCP. However, buffalos accumulate less liver copper than cattle and have a lower threshold of hepatic Cu accumulation, which leads to clinical manifestation of CCP.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2009.05.002