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Effects of chronic exposure to arsenic on the fecal carriage of antibiotic-resistant Escherichia coli among people in rural Bangladesh
Antibiotic resistance is a leading cause of hospitalization and death worldwide. Heavy metals such as arsenic have been shown to drive co-selection of antibiotic resistance, suggesting arsenic-contaminated drinking water is a risk factor for antibiotic resistance carriage. This study aimed to determ...
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| Published in: | PLoS pathogens 2022-12, Vol.18 (12), p.e1010952 |
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| creator | Amin, Mohammed Badrul Talukdar, Prabhat Kumar Asaduzzaman, Muhammad Roy, Subarna Flatgard, Brandon M Islam, Md Rayhanul Saha, Sumita Rani Mahmud, Zahid Hayat Navab-Daneshmand, Tala Kile, Molly L Levy, Karen Julian, Timothy R Islam, Mohammad Aminul |
| description | Antibiotic resistance is a leading cause of hospitalization and death worldwide. Heavy metals such as arsenic have been shown to drive co-selection of antibiotic resistance, suggesting arsenic-contaminated drinking water is a risk factor for antibiotic resistance carriage. This study aimed to determine the prevalence and abundance of antibiotic-resistant Escherichia coli (AR-Ec) among people and drinking water in high (Hajiganj, >100 μg/L) and low arsenic-contaminated (Matlab, |
| doi_str_mv | 10.1371/journal.ppat.1010952 |
| format | article |
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Heavy metals such as arsenic have been shown to drive co-selection of antibiotic resistance, suggesting arsenic-contaminated drinking water is a risk factor for antibiotic resistance carriage. This study aimed to determine the prevalence and abundance of antibiotic-resistant Escherichia coli (AR-Ec) among people and drinking water in high (Hajiganj, >100 μg/L) and low arsenic-contaminated (Matlab, <20 μg/L) areas in Bangladesh. Drinking water and stool from mothers and their children (<1 year) were collected from 50 households per area. AR-Ec was detected via selective culture plating and isolates were tested for antibiotic resistance, arsenic resistance, and diarrheagenic genes by PCR. Whole-genome sequencing (WGS) analysis was done for 30 E. coli isolates from 10 households. Prevalence of AR-Ec was significantly higher in water in Hajiganj (48%) compared to water in Matlab (22%, p <0.05) and among children in Hajiganj (94%) compared to children in Matlab (76%, p <0.05), but not among mothers. A significantly higher proportion of E. coli isolates from Hajiganj were multidrug-resistant (83%) compared to isolates from Matlab (71%, p <0.05). Co-resistance to arsenic and multiple antibiotics (MAR index >0.2) was observed in a higher proportion of water (78%) and child stool (100%) isolates in Hajiganj than in water (57%) and children (89%) in Matlab (p <0.05). The odds of arsenic-resistant bacteria being resistant to third-generation cephalosporin antibiotics were higher compared to arsenic-sensitive bacteria (odds ratios, OR 1.2-7.0, p <0.01). WGS-based phylogenetic analysis of E. coli isolates did not reveal any clustering based on arsenic exposure and no significant difference in resistome was found among the isolates between the two areas. The positive association detected between arsenic exposure and antibiotic resistance carriage among children in arsenic-affected areas in Bangladesh is an important public health concern that warrants redoubling efforts to reduce arsenic exposure.]]></description><identifier>ISSN: 1553-7374</identifier><identifier>ISSN: 1553-7366</identifier><identifier>EISSN: 1553-7374</identifier><identifier>DOI: 10.1371/journal.ppat.1010952</identifier><identifier>PMID: 36480516</identifier><language>eng ; nor</language><publisher>United States: Public Library of Science</publisher><subject>Anti-Bacterial Agents - pharmacology ; Antibiotic resistance ; Antibiotics ; Antimicrobial agents ; Arsenic ; Arsenic - pharmacology ; Bacteria ; Bangladesh ; Biology and Life Sciences ; Cephalosporins ; Chi-square test ; Child ; Children ; Chronic exposure ; Clustering ; Drinking Water ; Drug resistance ; Drug resistance in microorganisms ; E coli ; Ecology and Environmental Sciences ; Escherichia coli ; Escherichia coli - genetics ; Escherichia coli infections ; Exposure ; Feces ; Gene sequencing ; Genomes ; Groundwater ; Health aspects ; Heavy metals ; Households ; Humans ; Matlab ; Medicine and Health Sciences ; Mothers ; Multidrug resistance ; Phylogeny ; Physical Sciences ; Public health ; Research and Analysis Methods ; Resistance factors ; Risk analysis ; Risk factors ; Rural population ; Statistics ; Water pollution ; Whole genome sequencing</subject><ispartof>PLoS pathogens, 2022-12, Vol.18 (12), p.e1010952</ispartof><rights>Copyright: © 2022 Amin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</rights><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Amin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>info:eu-repo/semantics/openAccess</rights><rights>2022 Amin et al 2022 Amin et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c686t-a25d18705d078a91ee66152eebe7ecc1a906aab2fe712c38d9cf6f4e9c9e5dc23</citedby><cites>FETCH-LOGICAL-c686t-a25d18705d078a91ee66152eebe7ecc1a906aab2fe712c38d9cf6f4e9c9e5dc23</cites><orcidid>0000-0001-5107-5289</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2762701003/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2762701003?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,25783,26600,27957,27958,37047,37048,44625,53827,53829,75483</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36480516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Oswald, Eric</contributor><creatorcontrib>Amin, Mohammed Badrul</creatorcontrib><creatorcontrib>Talukdar, Prabhat Kumar</creatorcontrib><creatorcontrib>Asaduzzaman, Muhammad</creatorcontrib><creatorcontrib>Roy, Subarna</creatorcontrib><creatorcontrib>Flatgard, Brandon M</creatorcontrib><creatorcontrib>Islam, Md Rayhanul</creatorcontrib><creatorcontrib>Saha, Sumita Rani</creatorcontrib><creatorcontrib>Mahmud, Zahid Hayat</creatorcontrib><creatorcontrib>Navab-Daneshmand, Tala</creatorcontrib><creatorcontrib>Kile, Molly L</creatorcontrib><creatorcontrib>Levy, Karen</creatorcontrib><creatorcontrib>Julian, Timothy R</creatorcontrib><creatorcontrib>Islam, Mohammad Aminul</creatorcontrib><title>Effects of chronic exposure to arsenic on the fecal carriage of antibiotic-resistant Escherichia coli among people in rural Bangladesh</title><title>PLoS pathogens</title><addtitle>PLoS Pathog</addtitle><description><![CDATA[Antibiotic resistance is a leading cause of hospitalization and death worldwide. Heavy metals such as arsenic have been shown to drive co-selection of antibiotic resistance, suggesting arsenic-contaminated drinking water is a risk factor for antibiotic resistance carriage. This study aimed to determine the prevalence and abundance of antibiotic-resistant Escherichia coli (AR-Ec) among people and drinking water in high (Hajiganj, >100 μg/L) and low arsenic-contaminated (Matlab, <20 μg/L) areas in Bangladesh. Drinking water and stool from mothers and their children (<1 year) were collected from 50 households per area. AR-Ec was detected via selective culture plating and isolates were tested for antibiotic resistance, arsenic resistance, and diarrheagenic genes by PCR. Whole-genome sequencing (WGS) analysis was done for 30 E. coli isolates from 10 households. Prevalence of AR-Ec was significantly higher in water in Hajiganj (48%) compared to water in Matlab (22%, p <0.05) and among children in Hajiganj (94%) compared to children in Matlab (76%, p <0.05), but not among mothers. A significantly higher proportion of E. coli isolates from Hajiganj were multidrug-resistant (83%) compared to isolates from Matlab (71%, p <0.05). Co-resistance to arsenic and multiple antibiotics (MAR index >0.2) was observed in a higher proportion of water (78%) and child stool (100%) isolates in Hajiganj than in water (57%) and children (89%) in Matlab (p <0.05). The odds of arsenic-resistant bacteria being resistant to third-generation cephalosporin antibiotics were higher compared to arsenic-sensitive bacteria (odds ratios, OR 1.2-7.0, p <0.01). WGS-based phylogenetic analysis of E. coli isolates did not reveal any clustering based on arsenic exposure and no significant difference in resistome was found among the isolates between the two areas. The positive association detected between arsenic exposure and antibiotic resistance carriage among children in arsenic-affected areas in Bangladesh is an important public health concern that warrants redoubling efforts to reduce arsenic exposure.]]></description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibiotic resistance</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Arsenic</subject><subject>Arsenic - pharmacology</subject><subject>Bacteria</subject><subject>Bangladesh</subject><subject>Biology and Life Sciences</subject><subject>Cephalosporins</subject><subject>Chi-square test</subject><subject>Child</subject><subject>Children</subject><subject>Chronic exposure</subject><subject>Clustering</subject><subject>Drinking Water</subject><subject>Drug resistance</subject><subject>Drug resistance in microorganisms</subject><subject>E coli</subject><subject>Ecology and Environmental Sciences</subject><subject>Escherichia coli</subject><subject>Escherichia coli - genetics</subject><subject>Escherichia coli infections</subject><subject>Exposure</subject><subject>Feces</subject><subject>Gene sequencing</subject><subject>Genomes</subject><subject>Groundwater</subject><subject>Health aspects</subject><subject>Heavy metals</subject><subject>Households</subject><subject>Humans</subject><subject>Matlab</subject><subject>Medicine and Health Sciences</subject><subject>Mothers</subject><subject>Multidrug resistance</subject><subject>Phylogeny</subject><subject>Physical Sciences</subject><subject>Public health</subject><subject>Research and Analysis Methods</subject><subject>Resistance factors</subject><subject>Risk analysis</subject><subject>Risk factors</subject><subject>Rural population</subject><subject>Statistics</subject><subject>Water pollution</subject><subject>Whole genome sequencing</subject><issn>1553-7374</issn><issn>1553-7366</issn><issn>1553-7374</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>3HK</sourceid><sourceid>DOA</sourceid><recordid>eNqVk11v0zAUhiMEYmPwDxBY4gYuWvwR28kN0pgKVJpA4uPaOnVOUk-pndkJGn-A341L22lFu0GREuv4eV_nvNYpiueMzpnQ7O1VmKKHfj4MMM4ZZbSW_EFxyqQUMy10-fDO-qR4ktIVpSUTTD0uToQqKyqZOi1-L9oW7ZhIaIldx-CdJXgzhDRFJGMgEBNua8GTcY0ks9ATCzE66HArAj-6lQujs7OIyaUxF8gi2TVGZ9cOiA29I7AJviMDhqFH4jyJU8w-78F3PTSY1k-LRy30CZ_tv2fFjw-L7xefZpdfPi4vzi9nVlVqnAGXDas0lQ3VFdQMUSkmOeIKNVrLoKYKYMVb1IxbUTW1bVVbYm1rlI3l4qx4ufMd-pDMPsJkuFZc5wipyMRyRzQBrswQ3QbiLxPAmb-FEDsDMXfbo5GWgsRGMiqgXNXVSislGDaVrm1TN5i93u1Pm1YbbCz6Mbd9ZHq8493adOGnqbVgpSyzAdkZ2JiTdd74EMEwWkme35SVdUZe78-I4XrCNJqNSxb7HjyGaduaFLxmnNOMvvoHvT-APdVB7tH5NuRfs1tTc64FL2klSpWp-T1UfhrcOBs8ti7XjwRvjgSZGfFm7GBKySy_ff0P9vMxWx4iCilFbG_jZdRsB-XQpNkOitkPSpa9uHs1t6LDZIg_8bUPKQ</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Amin, Mohammed Badrul</creator><creator>Talukdar, Prabhat Kumar</creator><creator>Asaduzzaman, Muhammad</creator><creator>Roy, Subarna</creator><creator>Flatgard, Brandon M</creator><creator>Islam, Md Rayhanul</creator><creator>Saha, Sumita Rani</creator><creator>Mahmud, Zahid Hayat</creator><creator>Navab-Daneshmand, Tala</creator><creator>Kile, Molly L</creator><creator>Levy, Karen</creator><creator>Julian, Timothy R</creator><creator>Islam, Mohammad Aminul</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ISN</scope><scope>ISR</scope><scope>3V.</scope><scope>7QL</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>3HK</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0001-5107-5289</orcidid></search><sort><creationdate>20221201</creationdate><title>Effects of chronic exposure to arsenic on the fecal carriage of antibiotic-resistant Escherichia coli among people in rural Bangladesh</title><author>Amin, Mohammed Badrul ; Talukdar, Prabhat Kumar ; Asaduzzaman, Muhammad ; Roy, Subarna ; Flatgard, Brandon M ; Islam, Md Rayhanul ; Saha, Sumita Rani ; Mahmud, Zahid Hayat ; Navab-Daneshmand, Tala ; Kile, Molly L ; Levy, Karen ; Julian, Timothy R ; Islam, Mohammad Aminul</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c686t-a25d18705d078a91ee66152eebe7ecc1a906aab2fe712c38d9cf6f4e9c9e5dc23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; nor</language><creationdate>2022</creationdate><topic>Anti-Bacterial Agents - 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Heavy metals such as arsenic have been shown to drive co-selection of antibiotic resistance, suggesting arsenic-contaminated drinking water is a risk factor for antibiotic resistance carriage. This study aimed to determine the prevalence and abundance of antibiotic-resistant Escherichia coli (AR-Ec) among people and drinking water in high (Hajiganj, >100 μg/L) and low arsenic-contaminated (Matlab, <20 μg/L) areas in Bangladesh. Drinking water and stool from mothers and their children (<1 year) were collected from 50 households per area. AR-Ec was detected via selective culture plating and isolates were tested for antibiotic resistance, arsenic resistance, and diarrheagenic genes by PCR. Whole-genome sequencing (WGS) analysis was done for 30 E. coli isolates from 10 households. Prevalence of AR-Ec was significantly higher in water in Hajiganj (48%) compared to water in Matlab (22%, p <0.05) and among children in Hajiganj (94%) compared to children in Matlab (76%, p <0.05), but not among mothers. A significantly higher proportion of E. coli isolates from Hajiganj were multidrug-resistant (83%) compared to isolates from Matlab (71%, p <0.05). Co-resistance to arsenic and multiple antibiotics (MAR index >0.2) was observed in a higher proportion of water (78%) and child stool (100%) isolates in Hajiganj than in water (57%) and children (89%) in Matlab (p <0.05). The odds of arsenic-resistant bacteria being resistant to third-generation cephalosporin antibiotics were higher compared to arsenic-sensitive bacteria (odds ratios, OR 1.2-7.0, p <0.01). WGS-based phylogenetic analysis of E. coli isolates did not reveal any clustering based on arsenic exposure and no significant difference in resistome was found among the isolates between the two areas. The positive association detected between arsenic exposure and antibiotic resistance carriage among children in arsenic-affected areas in Bangladesh is an important public health concern that warrants redoubling efforts to reduce arsenic exposure.]]></abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>36480516</pmid><doi>10.1371/journal.ppat.1010952</doi><tpages>e1010952</tpages><orcidid>https://orcid.org/0000-0001-5107-5289</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | PLoS pathogens, 2022-12, Vol.18 (12), p.e1010952 |
| issn | 1553-7374 1553-7366 1553-7374 |
| language | eng ; nor |
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| source | PubMed Central (Open access); NORA - Norwegian Open Research Archives; ProQuest - Publicly Available Content Database |
| subjects | Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Antimicrobial agents Arsenic Arsenic - pharmacology Bacteria Bangladesh Biology and Life Sciences Cephalosporins Chi-square test Child Children Chronic exposure Clustering Drinking Water Drug resistance Drug resistance in microorganisms E coli Ecology and Environmental Sciences Escherichia coli Escherichia coli - genetics Escherichia coli infections Exposure Feces Gene sequencing Genomes Groundwater Health aspects Heavy metals Households Humans Matlab Medicine and Health Sciences Mothers Multidrug resistance Phylogeny Physical Sciences Public health Research and Analysis Methods Resistance factors Risk analysis Risk factors Rural population Statistics Water pollution Whole genome sequencing |
| title | Effects of chronic exposure to arsenic on the fecal carriage of antibiotic-resistant Escherichia coli among people in rural Bangladesh |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-23T07%3A28%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effects%20of%20chronic%20exposure%20to%20arsenic%20on%20the%20fecal%20carriage%20of%20antibiotic-resistant%20Escherichia%20coli%20among%20people%20in%20rural%20Bangladesh&rft.jtitle=PLoS%20pathogens&rft.au=Amin,%20Mohammed%20Badrul&rft.date=2022-12-01&rft.volume=18&rft.issue=12&rft.spage=e1010952&rft.pages=e1010952-&rft.issn=1553-7374&rft.eissn=1553-7374&rft_id=info:doi/10.1371/journal.ppat.1010952&rft_dat=%3Cgale_plos_%3EA732408346%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c686t-a25d18705d078a91ee66152eebe7ecc1a906aab2fe712c38d9cf6f4e9c9e5dc23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2762701003&rft_id=info:pmid/36480516&rft_galeid=A732408346&rfr_iscdi=true |