Risk of cardiovascular disease in patients with alcohol use disorder: A population-based retrospective cohort study

The complex effects of alcohol consumption on the cardiovascular system vary with mean daily consumption and duration of intake. This population-based retrospective cohort study aimed to explore the risk of cardiovascular disease (CVD) in patients with alcohol use disorder (AUD). Data was collected...

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Published in:PloS one 2022-10, Vol.17 (10), p.e0276690-e0276690
Main Authors: Sung, Chieh, Chung, Chi-Hsiang, Lin, Fu-Huang, Chien, Wu-Chien, Sun, Chien-An, Tsao, Chang-Huei, Weng, Chih-Erh
Format: Article
Language:English
Subjects:
Age
Alcohol use
Alcoholic beverages
Alcoholism
Anxiety
Biology and Life Sciences
Cardiovascular disease
Cardiovascular diseases
Cardiovascular system
Care and treatment
Chronic obstructive pulmonary disease
Codes
Cohort analysis
Comorbidity
Complications and side effects
Confidence intervals
Coronary artery disease
Diabetes mellitus
Diagnosis
Drug use
Earth Sciences
Health facilities
Health hazards
Health risks
Heart diseases
Hospitals
Hyperlipidemia
Hypertension
Ischemia
Kidney diseases
Liver cirrhosis
Low income groups
Lung diseases
Medicine and Health Sciences
National health insurance
Obstructive lung disease
Patients
Population
Population studies
Population-based studies
Prevention
Regression analysis
Risk
Risk assessment
Risk factors
Services
Sex
Social Sciences
Statistical analysis
Stroke
Subgroups
Survival analysis
Urbanization
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creator Sung, Chieh
Chung, Chi-Hsiang
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Tsao, Chang-Huei
Weng, Chih-Erh
description The complex effects of alcohol consumption on the cardiovascular system vary with mean daily consumption and duration of intake. This population-based retrospective cohort study aimed to explore the risk of cardiovascular disease (CVD) in patients with alcohol use disorder (AUD). Data was collected from the Taiwan National Health Insurance Research Database from 2000 to 2013. A total of 7,420 patients with AUD were included in our study group, and 29,680 age- and sex-matched controls without AUD in the control group. Cox proportional hazard regression analysis was used to investigate the effects of AUD on the risk of CVD. Most patients were men aged 25–44 years. At the end of the follow-up period, the AUD group had a significantly higher incidence of CVD (27.39% vs. 19.97%, P
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This population-based retrospective cohort study aimed to explore the risk of cardiovascular disease (CVD) in patients with alcohol use disorder (AUD). Data was collected from the Taiwan National Health Insurance Research Database from 2000 to 2013. A total of 7,420 patients with AUD were included in our study group, and 29,680 age- and sex-matched controls without AUD in the control group. Cox proportional hazard regression analysis was used to investigate the effects of AUD on the risk of CVD. Most patients were men aged 25–44 years. At the end of the follow-up period, the AUD group had a significantly higher incidence of CVD (27.39% vs. 19.97%, P&lt;0.001) and more comorbidities than the control group. The AUD group also exhibited a significantly higher incidence of CVD than the control group based on the Cox regression analysis and Fine and Gray’s competing risk model (adjusted hazard ratio [AHR] = 1.447, 95% confidence interval [CI] = 1.372–1.52 5, P&lt;0.001). Furthermore, male sex, diabetes mellitus, hypertension, hyperlipidemia, chronic kidney disease, chronic obstructive pulmonary disease, anxiety, depression, and a high Charlson Comorbidity Index were also associated with an increased risk of CVD. Patients with AUD in different CVD subgroups, such as those with CVD, ischemic heart disease (IHD), and stroke, were at a significantly higher risk of disease than those without AUD; CVD (AHR = 1.447, 95% CI = 1.372–1.525, P&lt;0.001), IHD (AHR = 1.304, 95% CI = 1.214–1.401, P&lt;0.001), and stroke (AHR = 1.640, 95% CI = 1.519–1.770, P&lt;0.001). The risk also significantly differed among patients in the different CVD subgroups. We observed an association between AUD and development of CVD even after adjusting for several comorbidities and medications in our nationwide population cohort.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0276690</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Age ; Alcohol use ; Alcoholic beverages ; Alcoholism ; Anxiety ; Biology and Life Sciences ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular system ; Care and treatment ; Chronic obstructive pulmonary disease ; Codes ; Cohort analysis ; Comorbidity ; Complications and side effects ; Confidence intervals ; Coronary artery disease ; Diabetes mellitus ; Diagnosis ; Drug use ; Earth Sciences ; Health facilities ; Health hazards ; Health risks ; Heart diseases ; Hospitals ; Hyperlipidemia ; Hypertension ; Ischemia ; Kidney diseases ; Liver cirrhosis ; Low income groups ; Lung diseases ; Medicine and Health Sciences ; National health insurance ; Obstructive lung disease ; Patients ; Population ; Population studies ; Population-based studies ; Prevention ; Regression analysis ; Risk ; Risk assessment ; Risk factors ; Services ; Sex ; Social Sciences ; Statistical analysis ; Stroke ; Subgroups ; Survival analysis ; Urbanization</subject><ispartof>PloS one, 2022-10, Vol.17 (10), p.e0276690-e0276690</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Sung et al. 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of cardiovascular disease in patients with alcohol use disorder: A population-based retrospective cohort study</title><author>Sung, Chieh ; Chung, Chi-Hsiang ; Lin, Fu-Huang ; Chien, Wu-Chien ; Sun, Chien-An ; Tsao, Chang-Huei ; Weng, Chih-Erh</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-9261b515bef4dabcca1494b45f2a9e40c99c5325329226e71899c9e7f9a3d8283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Alcohol use</topic><topic>Alcoholic beverages</topic><topic>Alcoholism</topic><topic>Anxiety</topic><topic>Biology and Life Sciences</topic><topic>Cardiovascular disease</topic><topic>Cardiovascular diseases</topic><topic>Cardiovascular system</topic><topic>Care and treatment</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Codes</topic><topic>Cohort analysis</topic><topic>Comorbidity</topic><topic>Complications and side 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of alcohol consumption on the cardiovascular system vary with mean daily consumption and duration of intake. This population-based retrospective cohort study aimed to explore the risk of cardiovascular disease (CVD) in patients with alcohol use disorder (AUD). Data was collected from the Taiwan National Health Insurance Research Database from 2000 to 2013. A total of 7,420 patients with AUD were included in our study group, and 29,680 age- and sex-matched controls without AUD in the control group. Cox proportional hazard regression analysis was used to investigate the effects of AUD on the risk of CVD. Most patients were men aged 25–44 years. At the end of the follow-up period, the AUD group had a significantly higher incidence of CVD (27.39% vs. 19.97%, P&lt;0.001) and more comorbidities than the control group. The AUD group also exhibited a significantly higher incidence of CVD than the control group based on the Cox regression analysis and Fine and Gray’s competing risk model (adjusted hazard ratio [AHR] = 1.447, 95% confidence interval [CI] = 1.372–1.52 5, P&lt;0.001). Furthermore, male sex, diabetes mellitus, hypertension, hyperlipidemia, chronic kidney disease, chronic obstructive pulmonary disease, anxiety, depression, and a high Charlson Comorbidity Index were also associated with an increased risk of CVD. Patients with AUD in different CVD subgroups, such as those with CVD, ischemic heart disease (IHD), and stroke, were at a significantly higher risk of disease than those without AUD; CVD (AHR = 1.447, 95% CI = 1.372–1.525, P&lt;0.001), IHD (AHR = 1.304, 95% CI = 1.214–1.401, P&lt;0.001), and stroke (AHR = 1.640, 95% CI = 1.519–1.770, P&lt;0.001). The risk also significantly differed among patients in the different CVD subgroups. We observed an association between AUD and development of CVD even after adjusting for several comorbidities and medications in our nationwide population cohort.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><doi>10.1371/journal.pone.0276690</doi><tpages>e0276690</tpages><orcidid>https://orcid.org/0000-0002-5759-137X</orcidid><orcidid>https://orcid.org/0000-0002-4576-9900</orcidid><orcidid>https://orcid.org/0000-0002-3286-0780</orcidid><oa>free_for_read</oa></addata></record>
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language eng
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source Publicly Available Content Database; PubMed Central
subjects Age
Alcohol use
Alcoholic beverages
Alcoholism
Anxiety
Biology and Life Sciences
Cardiovascular disease
Cardiovascular diseases
Cardiovascular system
Care and treatment
Chronic obstructive pulmonary disease
Codes
Cohort analysis
Comorbidity
Complications and side effects
Confidence intervals
Coronary artery disease
Diabetes mellitus
Diagnosis
Drug use
Earth Sciences
Health facilities
Health hazards
Health risks
Heart diseases
Hospitals
Hyperlipidemia
Hypertension
Ischemia
Kidney diseases
Liver cirrhosis
Low income groups
Lung diseases
Medicine and Health Sciences
National health insurance
Obstructive lung disease
Patients
Population
Population studies
Population-based studies
Prevention
Regression analysis
Risk
Risk assessment
Risk factors
Services
Sex
Social Sciences
Statistical analysis
Stroke
Subgroups
Survival analysis
Urbanization
title Risk of cardiovascular disease in patients with alcohol use disorder: A population-based retrospective cohort study
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