Association of GSTP1 Ile105Val polymorphism with the risk of coronary heart disease: An updated meta-analysis

Background Numerous case-control studies have investigated the association between GSTP1 Ile105Val polymorphism and CHD risk, but the results from published studies were inconclusive. The present meta-analysis was performed to derive a more precise estimation. Methods PubMed, EMBASE, and Web of Scie...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2021-07, Vol.16 (7), p.e0254738-e0254738
Main Authors: Song, Yadong, Liu, Xiaoli, Luo, Cheng, Chen, Liangkai, Gong, Lin, Yu, Hanbin, Wang, Bin, Liu, Ernan, Xu, Huiqiong, Liang, Jiansheng
Format: Article
Language:English
Subjects:
Alcohol use
Analysis
Atherosclerosis
Biology and Life Sciences
Cardiovascular disease
Cardiovascular diseases
Coronary artery disease
Coronary heart disease
Disease prevention
DNA damage
Ethnicity
Food
Genetic aspects
Genetic polymorphisms
Genotype & phenotype
Glutathione transferase
Health risk assessment
Health risks
Heart
Heart diseases
Heterogeneity
Infections
Laboratories
Medical schools
Medicine and Health Sciences
Meta-analysis
Nutrition
Oxidative stress
People and Places
Pest control
Physical Sciences
Polymorphism
Public health
Quality control
Research and Analysis Methods
Risk
Risk factors
Sensitivity analysis
Statistical analysis
Subgroups
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Numerous case-control studies have investigated the association between GSTP1 Ile105Val polymorphism and CHD risk, but the results from published studies were inconclusive. The present meta-analysis was performed to derive a more precise estimation. Methods PubMed, EMBASE, and Web of Science database searches were conducted to retrieve relevant articles. Results Ultimately, 5,451 CHD cases and 5,561 controls from 15 studies were included. Pooled analysis did not yield any statistically significant association between GSTP1 Ile105Val polymorphism and CHD risk for the overall population (Val vs. Ile: OR, 1.05; 95% CI, 0.93 to 1.18; Val/Val vs. Ile/Ile: OR, 1.09; 95% CI, 0.83 to 1.42; Val/Ile vs. Ile/Ile: OR, 1.09; 95% CI, 0.93 to 1.28; Val/Val vs. Val/Ile+Ile/Ile: OR, 1.04; 95% CI, 0.83 to 1.30; Val/Val+Val/Ile vs. Ile/Ile: OR, 1.14; 95% CI, 0.97 to 1.33). Subgroup analyses and sensitivity analyses indicated that GSTP1 Ile105Val polymorphism was still not associated with an increased risk of CHD. After excluding studies detected by Galbraith plots as major sources of heterogeneity, these relationships were still not significant. Conclusions The overall results did not reveal a major role of the GSTP1 Ile105Val polymorphism in modulating CHD risk. Well-designed studies with large sample sizes are needed to validate our findings and explore the possible gene-gene or gene-environment interactions.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0254738