A quantitative CT parameter for the assessment of pulmonary oedema in patients with acute respiratory distress syndrome

The aim of this study was to establish quantitative CT (qCT) parameters for pathophysiological understanding and clinical use in patients with acute respiratory distress syndrome (ARDS). The most promising parameter is introduced. 28 intubated patients with ARDS obtained a conventional CT scan in en...

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Bibliographic Details
Published in:PloS one 2020-11, Vol.15 (11), p.e0241590-e0241590
Main Authors: Leiser, Patrick, Kirschning, Thomas, Weiß, Christel, Hagmann, Michael, Schoettler, Jochen, Centner, Franz-Simon, Haubenreisser, Holger, Riffel, Philipp, Janssen, Sonja, Henzler, Claudia, Henzler, Thomas, Schoenberg, Stefan, Overhoff, Daniel
Format: Article
Language:English
Subjects:
Adult
Adult respiratory distress syndrome
Aged
Anesthesiology
Biology and Life Sciences
Cardiac output
Computed tomography
Correlation
Diagnosis
Edema
Feasibility Studies
Female
Gases
Hospital Mortality
Humans
Intensive care
Intensive Care Units - statistics & numerical data
Lung - diagnostic imaging
Lung - physiopathology
Lung Volume Measurements - methods
Lungs
Male
Mechanical ventilation
Medical imaging
Medical prognosis
Medical statistics
Medicine and Health Sciences
Middle Aged
Mortality
Nuclear medicine
Oxygenation
Parameters
Patients
Physical Sciences
Physiology
Pulmonary edema
Pulmonary Edema - diagnosis
Pulmonary Edema - etiology
Pulmonary Edema - mortality
Pulmonary Edema - physiopathology
Radiology
Research and Analysis Methods
Respiratory distress syndrome
Respiratory Distress Syndrome - complications
Respiratory Distress Syndrome - diagnosis
Respiratory Distress Syndrome - mortality
Respiratory Distress Syndrome - physiopathology
Respiratory Function Tests
Segmentation
Severity of Illness Index
Statistical analysis
Tomography, X-Ray Computed
Ventilation
Weight
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Summary:The aim of this study was to establish quantitative CT (qCT) parameters for pathophysiological understanding and clinical use in patients with acute respiratory distress syndrome (ARDS). The most promising parameter is introduced. 28 intubated patients with ARDS obtained a conventional CT scan in end-expiratory breathhold within the first 48 hours after admission to intensive care unit (ICU). Following manual segmentation, 137 volume- and lung weight-associated qCT parameters were correlated with 71 clinical parameters such as blood gases, applied ventilation pressures, pulse contour cardiac output measurements and established status and prognosis scores (SOFA, SAPS II). Of all examined qCT parameters, excess lung weight (ELW), i.e. the difference between a patient's current lung weight and the virtual lung weight of a healthy person at the same height, displayed the most significant results. ELW correlated significantly with the amount of inflated lung tissue [%] (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0241590