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Sero-prevalence of arthropod-borne viral infections among Lukanga swamp residents in Zambia
The re-emergence of vector borne diseases affecting millions of people in recent years has drawn attention to arboviruses globally. Here, we report on the sero-prevalence of chikungunya virus (CHIKV), dengue virus (DENV), mayaro virus (MAYV) and zika virus (ZIKV) in a swamp community in Zambia. We c...
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| Published in: | PloS one 2020-07, Vol.15 (7), p.e0235322-e0235322 |
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| creator | Chisenga, Caroline C Bosomprah, Samuel Musukuma, Kalo Mubanga, Cynthia Chilyabanyama, Obvious N Velu, Rachel M Kim, Young Chan Reyes-Sandoval, Arturo Chilengi, Roma |
| description | The re-emergence of vector borne diseases affecting millions of people in recent years has drawn attention to arboviruses globally. Here, we report on the sero-prevalence of chikungunya virus (CHIKV), dengue virus (DENV), mayaro virus (MAYV) and zika virus (ZIKV) in a swamp community in Zambia.
We collected blood and saliva samples from residents of Lukanga swamps in 2016 during a mass-cholera vaccination campaign. Over 10,000 residents were vaccinated with two doses of Shanchol™ during this period. The biological samples were collected prior to vaccination (baseline) and at specified time points after vaccination. We tested a total of 214 baseline stored serum samples for IgG antibodies against NS1 of DENV and ZIKV and E2 of CHIKV and MAYV on ELISA. We defined sero-prevalence as the proportion of participants with optical density (OD) values above a defined cut-off value, determined using a finite mixture model.
Of the 214 participants, 79 (36.9%; 95% CI 30.5-43.8) were sero-positive for Chikungunya; 23 (10.8%; 95% CI 6.9-15.7) for Zika, 36 (16.8%; 95% CI 12.1-22.5) for Dengue and 42 (19.6%; 95% CI 14.5-25.6) for Mayaro. Older participants were more likely to have Zika virus whilst those involved with fishing activities were at greater risk of contracting Chikungunya virus. Among all the antigens tested, we also found that Chikungunya saliva antibody titres correlated with baseline serum titres (Spearman's correlation coefficient = 0.222; p = 0.03).
Arbovirus transmission is occurring in Zambia. This requires proper screening tools as well as surveillance data to accurately report on disease burden in Zambia. |
| doi_str_mv | 10.1371/journal.pone.0235322 |
| format | article |
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We collected blood and saliva samples from residents of Lukanga swamps in 2016 during a mass-cholera vaccination campaign. Over 10,000 residents were vaccinated with two doses of Shanchol™ during this period. The biological samples were collected prior to vaccination (baseline) and at specified time points after vaccination. We tested a total of 214 baseline stored serum samples for IgG antibodies against NS1 of DENV and ZIKV and E2 of CHIKV and MAYV on ELISA. We defined sero-prevalence as the proportion of participants with optical density (OD) values above a defined cut-off value, determined using a finite mixture model.
Of the 214 participants, 79 (36.9%; 95% CI 30.5-43.8) were sero-positive for Chikungunya; 23 (10.8%; 95% CI 6.9-15.7) for Zika, 36 (16.8%; 95% CI 12.1-22.5) for Dengue and 42 (19.6%; 95% CI 14.5-25.6) for Mayaro. Older participants were more likely to have Zika virus whilst those involved with fishing activities were at greater risk of contracting Chikungunya virus. Among all the antigens tested, we also found that Chikungunya saliva antibody titres correlated with baseline serum titres (Spearman's correlation coefficient = 0.222; p = 0.03).
Arbovirus transmission is occurring in Zambia. This requires proper screening tools as well as surveillance data to accurately report on disease burden in Zambia.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0235322</identifier><identifier>PMID: 32609784</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Antibodies ; Antigens ; Arbovirus Infections - epidemiology ; Arbovirus Infections - virology ; Arboviruses - classification ; Arboviruses - isolation & purification ; Arthropods ; Biological properties ; Biological samples ; Biology and life sciences ; Chikungunya virus ; Cholera ; Coinfection - epidemiology ; Congenital diseases ; Consent ; Correlation coefficient ; Correlation coefficients ; Dengue ; Dengue fever ; Distribution ; Earth Sciences ; Ecology and Environmental Sciences ; Environmental aspects ; Epidemics ; Female ; Fever ; Fishing ; Health aspects ; Humans ; Immunization ; Immunoglobulin G ; Infections ; Infectious diseases ; Malaria ; Male ; Medicine and Health Sciences ; Methods ; Middle Aged ; Mosquitoes ; Optical density ; People and Places ; Physiology ; Population ; Prevalence ; Public health ; Saliva ; Sentinel surveillance ; Serogroup ; Swamps ; Tropical diseases ; Vaccination ; Vector-borne diseases ; Viral infections ; Viruses ; Waterborne diseases ; Wetlands ; Young Adult ; Zambia - epidemiology</subject><ispartof>PloS one, 2020-07, Vol.15 (7), p.e0235322-e0235322</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Chisenga et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Chisenga et al 2020 Chisenga et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-baf4c7ca453423726f9404154ef3d57a69437c7ae8b744b76fcae23c9b5fdff83</citedby><cites>FETCH-LOGICAL-c758t-baf4c7ca453423726f9404154ef3d57a69437c7ae8b744b76fcae23c9b5fdff83</cites><orcidid>0000-0002-7850-7915 ; 0000-0002-2826-3887 ; 0000-0003-2847-9407</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2419348238/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2419348238?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,25783,27957,27958,37047,37048,44625,53827,53829,75483</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32609784$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Samy, Abdallah M.</contributor><creatorcontrib>Chisenga, Caroline C</creatorcontrib><creatorcontrib>Bosomprah, Samuel</creatorcontrib><creatorcontrib>Musukuma, Kalo</creatorcontrib><creatorcontrib>Mubanga, Cynthia</creatorcontrib><creatorcontrib>Chilyabanyama, Obvious N</creatorcontrib><creatorcontrib>Velu, Rachel M</creatorcontrib><creatorcontrib>Kim, Young Chan</creatorcontrib><creatorcontrib>Reyes-Sandoval, Arturo</creatorcontrib><creatorcontrib>Chilengi, Roma</creatorcontrib><title>Sero-prevalence of arthropod-borne viral infections among Lukanga swamp residents in Zambia</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The re-emergence of vector borne diseases affecting millions of people in recent years has drawn attention to arboviruses globally. Here, we report on the sero-prevalence of chikungunya virus (CHIKV), dengue virus (DENV), mayaro virus (MAYV) and zika virus (ZIKV) in a swamp community in Zambia.
We collected blood and saliva samples from residents of Lukanga swamps in 2016 during a mass-cholera vaccination campaign. Over 10,000 residents were vaccinated with two doses of Shanchol™ during this period. The biological samples were collected prior to vaccination (baseline) and at specified time points after vaccination. We tested a total of 214 baseline stored serum samples for IgG antibodies against NS1 of DENV and ZIKV and E2 of CHIKV and MAYV on ELISA. We defined sero-prevalence as the proportion of participants with optical density (OD) values above a defined cut-off value, determined using a finite mixture model.
Of the 214 participants, 79 (36.9%; 95% CI 30.5-43.8) were sero-positive for Chikungunya; 23 (10.8%; 95% CI 6.9-15.7) for Zika, 36 (16.8%; 95% CI 12.1-22.5) for Dengue and 42 (19.6%; 95% CI 14.5-25.6) for Mayaro. Older participants were more likely to have Zika virus whilst those involved with fishing activities were at greater risk of contracting Chikungunya virus. Among all the antigens tested, we also found that Chikungunya saliva antibody titres correlated with baseline serum titres (Spearman's correlation coefficient = 0.222; p = 0.03).
Arbovirus transmission is occurring in Zambia. This requires proper screening tools as well as surveillance data to accurately report on disease burden in Zambia.</description><subject>Adult</subject><subject>Antibodies</subject><subject>Antigens</subject><subject>Arbovirus Infections - epidemiology</subject><subject>Arbovirus Infections - virology</subject><subject>Arboviruses - classification</subject><subject>Arboviruses - isolation & purification</subject><subject>Arthropods</subject><subject>Biological properties</subject><subject>Biological samples</subject><subject>Biology and life sciences</subject><subject>Chikungunya virus</subject><subject>Cholera</subject><subject>Coinfection - epidemiology</subject><subject>Congenital diseases</subject><subject>Consent</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Dengue</subject><subject>Dengue fever</subject><subject>Distribution</subject><subject>Earth Sciences</subject><subject>Ecology and Environmental Sciences</subject><subject>Environmental aspects</subject><subject>Epidemics</subject><subject>Female</subject><subject>Fever</subject><subject>Fishing</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunization</subject><subject>Immunoglobulin G</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Methods</subject><subject>Middle Aged</subject><subject>Mosquitoes</subject><subject>Optical density</subject><subject>People and Places</subject><subject>Physiology</subject><subject>Population</subject><subject>Prevalence</subject><subject>Public health</subject><subject>Saliva</subject><subject>Sentinel surveillance</subject><subject>Serogroup</subject><subject>Swamps</subject><subject>Tropical diseases</subject><subject>Vaccination</subject><subject>Vector-borne diseases</subject><subject>Viral infections</subject><subject>Viruses</subject><subject>Waterborne diseases</subject><subject>Wetlands</subject><subject>Young Adult</subject><subject>Zambia - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chisenga, Caroline C</au><au>Bosomprah, Samuel</au><au>Musukuma, Kalo</au><au>Mubanga, Cynthia</au><au>Chilyabanyama, Obvious N</au><au>Velu, Rachel M</au><au>Kim, Young Chan</au><au>Reyes-Sandoval, Arturo</au><au>Chilengi, Roma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sero-prevalence of arthropod-borne viral infections among Lukanga swamp residents in Zambia</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2020-07-01</date><risdate>2020</risdate><volume>15</volume><issue>7</issue><spage>e0235322</spage><epage>e0235322</epage><pages>e0235322-e0235322</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Competing Interests: The authors have declared that no competing interests exist.</notes><abstract>The re-emergence of vector borne diseases affecting millions of people in recent years has drawn attention to arboviruses globally. Here, we report on the sero-prevalence of chikungunya virus (CHIKV), dengue virus (DENV), mayaro virus (MAYV) and zika virus (ZIKV) in a swamp community in Zambia.
We collected blood and saliva samples from residents of Lukanga swamps in 2016 during a mass-cholera vaccination campaign. Over 10,000 residents were vaccinated with two doses of Shanchol™ during this period. The biological samples were collected prior to vaccination (baseline) and at specified time points after vaccination. We tested a total of 214 baseline stored serum samples for IgG antibodies against NS1 of DENV and ZIKV and E2 of CHIKV and MAYV on ELISA. We defined sero-prevalence as the proportion of participants with optical density (OD) values above a defined cut-off value, determined using a finite mixture model.
Of the 214 participants, 79 (36.9%; 95% CI 30.5-43.8) were sero-positive for Chikungunya; 23 (10.8%; 95% CI 6.9-15.7) for Zika, 36 (16.8%; 95% CI 12.1-22.5) for Dengue and 42 (19.6%; 95% CI 14.5-25.6) for Mayaro. Older participants were more likely to have Zika virus whilst those involved with fishing activities were at greater risk of contracting Chikungunya virus. Among all the antigens tested, we also found that Chikungunya saliva antibody titres correlated with baseline serum titres (Spearman's correlation coefficient = 0.222; p = 0.03).
Arbovirus transmission is occurring in Zambia. This requires proper screening tools as well as surveillance data to accurately report on disease burden in Zambia.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>32609784</pmid><doi>10.1371/journal.pone.0235322</doi><tpages>e0235322</tpages><orcidid>https://orcid.org/0000-0002-7850-7915</orcidid><orcidid>https://orcid.org/0000-0002-2826-3887</orcidid><orcidid>https://orcid.org/0000-0003-2847-9407</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2020-07, Vol.15 (7), p.e0235322-e0235322 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2419348238 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Adult Antibodies Antigens Arbovirus Infections - epidemiology Arbovirus Infections - virology Arboviruses - classification Arboviruses - isolation & purification Arthropods Biological properties Biological samples Biology and life sciences Chikungunya virus Cholera Coinfection - epidemiology Congenital diseases Consent Correlation coefficient Correlation coefficients Dengue Dengue fever Distribution Earth Sciences Ecology and Environmental Sciences Environmental aspects Epidemics Female Fever Fishing Health aspects Humans Immunization Immunoglobulin G Infections Infectious diseases Malaria Male Medicine and Health Sciences Methods Middle Aged Mosquitoes Optical density People and Places Physiology Population Prevalence Public health Saliva Sentinel surveillance Serogroup Swamps Tropical diseases Vaccination Vector-borne diseases Viral infections Viruses Waterborne diseases Wetlands Young Adult Zambia - epidemiology |
| title | Sero-prevalence of arthropod-borne viral infections among Lukanga swamp residents in Zambia |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T19%3A40%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Sero-prevalence%20of%20arthropod-borne%20viral%20infections%20among%20Lukanga%20swamp%20residents%20in%20Zambia&rft.jtitle=PloS%20one&rft.au=Chisenga,%20Caroline%20C&rft.date=2020-07-01&rft.volume=15&rft.issue=7&rft.spage=e0235322&rft.epage=e0235322&rft.pages=e0235322-e0235322&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0235322&rft_dat=%3Cgale_plos_%3EA628243381%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c758t-baf4c7ca453423726f9404154ef3d57a69437c7ae8b744b76fcae23c9b5fdff83%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2419348238&rft_id=info:pmid/32609784&rft_galeid=A628243381&rfr_iscdi=true |