Loading…
Risk Factors for Developing Metabolic Acidosis after Radical Cystectomy and Ileal Neobladder
To investigate the serial changes of metabolic acidosis and identify associated risk factors in patients who underwent radical cystectomy and ileal neobladder. From January 2010 to August 2014, 123 patients who underwent radical cystectomy and ileal neobladder reconstruction for bladder cancer were...
Saved in:
Published in: | PloS one 2016-07, Vol.11 (7), p.e0158220-e0158220 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c725t-76798fd7e842cb60ac71ae30c7d83ba773e9bb594c5c8a8f57174a3e6c45dc623 |
---|---|
cites | cdi_FETCH-LOGICAL-c725t-76798fd7e842cb60ac71ae30c7d83ba773e9bb594c5c8a8f57174a3e6c45dc623 |
container_end_page | e0158220 |
container_issue | 7 |
container_start_page | e0158220 |
container_title | PloS one |
container_volume | 11 |
creator | Kim, Kwang Hyun Yoon, Hyun Suk Yoon, Hana Chung, Woo Sik Sim, Bong Suk Ryu, Dong-Ryeol Lee, Dong Hyeon |
description | To investigate the serial changes of metabolic acidosis and identify associated risk factors in patients who underwent radical cystectomy and ileal neobladder.
From January 2010 to August 2014, 123 patients who underwent radical cystectomy and ileal neobladder reconstruction for bladder cancer were included in this study. Metabolic acidosis was defined as a serum bicarbonate level less than 22 mEq/L and impaired renal function was defined as a GFR |
doi_str_mv | 10.1371/journal.pone.0158220 |
format | article |
fullrecord | <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_1802192799</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A457195764</galeid><doaj_id>oai_doaj_org_article_79e7f2b2eeda4d5f89489efa8ed55378</doaj_id><sourcerecordid>A457195764</sourcerecordid><originalsourceid>FETCH-LOGICAL-c725t-76798fd7e842cb60ac71ae30c7d83ba773e9bb594c5c8a8f57174a3e6c45dc623</originalsourceid><addsrcrecordid>eNqNk12PEyEUhidG466r_8DoJCZGL1qHYRjgxqSprjZZ3aR-XJkQBs60VDpUYDb230u3s5vW7MWGC8jhed8DB06WPUfFGGGK3q1c7ztpxxvXwbhAhJVl8SA7RRyXo7os8MOD9Un2JIRVURDM6vpxdlJSzKqa1afZr7kJv_NzqaLzIW-dzz_AFVi3Md0i_wJRNs4alU-U0S6YkMs2gs_nUhslbT7dhghJut7mstP5zEIKfgXXWKk1-KfZo1baAM-G-Sz7cf7x-_Tz6OLy02w6uRgpWpI4ojXlrNUUWFWqpi6kokgCLhTVDDeSUgy8aQivFFFMspZQRCuJoVYV0aou8Vn2cu-7sS6IoTBBIFaUiJeU80TM9oR2ciU23qyl3wonjbgOOL8Q0kejLAjKgbZlUwJoWWnSMl4xDq1koAnBlCWv90O2vlmDVtBFL-2R6fFOZ5Zi4a5ExXFF653Bm8HAuz89hCjWJiiwVnbg-utzs5pwjKr7oJhyxBBJ6Kv_0LsLMVALme5qutalI6qdqZhUqbCc0HqXdnwHlYaGtVHpw7UmxY8Eb48EiYnwNy5kH4KYfZvfn738ecy-PmCX6XvFZXC2j8Z14Ris9qDyLgQP7e17oELs-uWmGmLXL2LolyR7cfiWt6KbBsH_AJJDD8A</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1802192799</pqid></control><display><type>article</type><title>Risk Factors for Developing Metabolic Acidosis after Radical Cystectomy and Ileal Neobladder</title><source>ProQuest - Publicly Available Content Database</source><source>PubMed Central</source><creator>Kim, Kwang Hyun ; Yoon, Hyun Suk ; Yoon, Hana ; Chung, Woo Sik ; Sim, Bong Suk ; Ryu, Dong-Ryeol ; Lee, Dong Hyeon</creator><contributor>Schwentner, Christian</contributor><creatorcontrib>Kim, Kwang Hyun ; Yoon, Hyun Suk ; Yoon, Hana ; Chung, Woo Sik ; Sim, Bong Suk ; Ryu, Dong-Ryeol ; Lee, Dong Hyeon ; Schwentner, Christian</creatorcontrib><description>To investigate the serial changes of metabolic acidosis and identify associated risk factors in patients who underwent radical cystectomy and ileal neobladder.
From January 2010 to August 2014, 123 patients who underwent radical cystectomy and ileal neobladder reconstruction for bladder cancer were included in this study. Metabolic acidosis was defined as a serum bicarbonate level less than 22 mEq/L and impaired renal function was defined as a GFR <50ml/min. The presence of metabolic acidosis was evaluated at 1 month, 1 year, and 2 years after surgery. Multivariate logistic regression analysis was conducted to identify risk factors associated with development of metabolic acidosis.
Metabolic acidosis was observed in 52%, 19.5%, and 7.3% of patients at 1 month, 1 year, and 2 years after surgery, respectively. At 1 month after surgery, impaired renal function was the only independent risk factor associated with metabolic acidosis (OR 3.87, P = 0.046). At 1 year after surgery, diabetes was the only independent risk factor associated with metabolic acidosis (OR 5.68, P = 0.002). At 2 years post-surgery, both age and diabetes were significant risk factors associated with metabolic acidosis.
Approximately, half of patients experienced metabolic acidosis one month after ileal neobladder reconstruction. Preoperative impaired renal function was the most significant risk factor for developing metabolic acidosis in the early postoperative period. However, the incidence of metabolic acidosis decreased to less than 20% 1 year after surgery, and diabetes was an independent risk factor during this period.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0158220</identifier><identifier>PMID: 27384686</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acidosis ; Acidosis - etiology ; Adenosine triphosphatase ; Aged ; Bicarbonate ; Bicarbonates ; Bicarbonates - blood ; Biology and Life Sciences ; Bladder ; Bladder cancer ; Cancer ; Carbonates ; Catheters ; Cohort Studies ; Cystectomy ; Cystectomy - adverse effects ; Development and progression ; Diabetes ; Diabetes mellitus ; Electrolytes ; Female ; Gene expression ; Glomerular Filtration Rate ; Health risks ; Humans ; Laboratories ; Male ; Medicine ; Medicine and Health Sciences ; Metabolic acidosis ; Metabolism ; Middle Aged ; Multivariate Analysis ; Patient outcomes ; Patients ; Physical Sciences ; Physiological aspects ; Reconstruction ; Regression analysis ; Renal function ; Risk analysis ; Risk Factors ; Rodents ; Surgery ; Time Factors ; Treatment Outcome ; Urinary Bladder - surgery ; Urinary Bladder Neoplasms - surgery ; Urinary Diversion - adverse effects ; Urine ; Urologic surgery ; Urology</subject><ispartof>PloS one, 2016-07, Vol.11 (7), p.e0158220-e0158220</ispartof><rights>COPYRIGHT 2016 Public Library of Science</rights><rights>2016 Kim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2016 Kim et al 2016 Kim et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c725t-76798fd7e842cb60ac71ae30c7d83ba773e9bb594c5c8a8f57174a3e6c45dc623</citedby><cites>FETCH-LOGICAL-c725t-76798fd7e842cb60ac71ae30c7d83ba773e9bb594c5c8a8f57174a3e6c45dc623</cites><orcidid>0000-0002-6264-5109</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1802192799/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1802192799?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,25783,27957,27958,37047,37048,44625,53827,53829,75483</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27384686$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Schwentner, Christian</contributor><creatorcontrib>Kim, Kwang Hyun</creatorcontrib><creatorcontrib>Yoon, Hyun Suk</creatorcontrib><creatorcontrib>Yoon, Hana</creatorcontrib><creatorcontrib>Chung, Woo Sik</creatorcontrib><creatorcontrib>Sim, Bong Suk</creatorcontrib><creatorcontrib>Ryu, Dong-Ryeol</creatorcontrib><creatorcontrib>Lee, Dong Hyeon</creatorcontrib><title>Risk Factors for Developing Metabolic Acidosis after Radical Cystectomy and Ileal Neobladder</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>To investigate the serial changes of metabolic acidosis and identify associated risk factors in patients who underwent radical cystectomy and ileal neobladder.
From January 2010 to August 2014, 123 patients who underwent radical cystectomy and ileal neobladder reconstruction for bladder cancer were included in this study. Metabolic acidosis was defined as a serum bicarbonate level less than 22 mEq/L and impaired renal function was defined as a GFR <50ml/min. The presence of metabolic acidosis was evaluated at 1 month, 1 year, and 2 years after surgery. Multivariate logistic regression analysis was conducted to identify risk factors associated with development of metabolic acidosis.
Metabolic acidosis was observed in 52%, 19.5%, and 7.3% of patients at 1 month, 1 year, and 2 years after surgery, respectively. At 1 month after surgery, impaired renal function was the only independent risk factor associated with metabolic acidosis (OR 3.87, P = 0.046). At 1 year after surgery, diabetes was the only independent risk factor associated with metabolic acidosis (OR 5.68, P = 0.002). At 2 years post-surgery, both age and diabetes were significant risk factors associated with metabolic acidosis.
Approximately, half of patients experienced metabolic acidosis one month after ileal neobladder reconstruction. Preoperative impaired renal function was the most significant risk factor for developing metabolic acidosis in the early postoperative period. However, the incidence of metabolic acidosis decreased to less than 20% 1 year after surgery, and diabetes was an independent risk factor during this period.</description><subject>Acidosis</subject><subject>Acidosis - etiology</subject><subject>Adenosine triphosphatase</subject><subject>Aged</subject><subject>Bicarbonate</subject><subject>Bicarbonates</subject><subject>Bicarbonates - blood</subject><subject>Biology and Life Sciences</subject><subject>Bladder</subject><subject>Bladder cancer</subject><subject>Cancer</subject><subject>Carbonates</subject><subject>Catheters</subject><subject>Cohort Studies</subject><subject>Cystectomy</subject><subject>Cystectomy - adverse effects</subject><subject>Development and progression</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Electrolytes</subject><subject>Female</subject><subject>Gene expression</subject><subject>Glomerular Filtration Rate</subject><subject>Health risks</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metabolic acidosis</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Physical Sciences</subject><subject>Physiological aspects</subject><subject>Reconstruction</subject><subject>Regression analysis</subject><subject>Renal function</subject><subject>Risk analysis</subject><subject>Risk Factors</subject><subject>Rodents</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Urinary Bladder - surgery</subject><subject>Urinary Bladder Neoplasms - surgery</subject><subject>Urinary Diversion - adverse effects</subject><subject>Urine</subject><subject>Urologic surgery</subject><subject>Urology</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12PEyEUhidG466r_8DoJCZGL1qHYRjgxqSprjZZ3aR-XJkQBs60VDpUYDb230u3s5vW7MWGC8jhed8DB06WPUfFGGGK3q1c7ztpxxvXwbhAhJVl8SA7RRyXo7os8MOD9Un2JIRVURDM6vpxdlJSzKqa1afZr7kJv_NzqaLzIW-dzz_AFVi3Md0i_wJRNs4alU-U0S6YkMs2gs_nUhslbT7dhghJut7mstP5zEIKfgXXWKk1-KfZo1baAM-G-Sz7cf7x-_Tz6OLy02w6uRgpWpI4ojXlrNUUWFWqpi6kokgCLhTVDDeSUgy8aQivFFFMspZQRCuJoVYV0aou8Vn2cu-7sS6IoTBBIFaUiJeU80TM9oR2ciU23qyl3wonjbgOOL8Q0kejLAjKgbZlUwJoWWnSMl4xDq1koAnBlCWv90O2vlmDVtBFL-2R6fFOZ5Zi4a5ExXFF653Bm8HAuz89hCjWJiiwVnbg-utzs5pwjKr7oJhyxBBJ6Kv_0LsLMVALme5qutalI6qdqZhUqbCc0HqXdnwHlYaGtVHpw7UmxY8Eb48EiYnwNy5kH4KYfZvfn738ecy-PmCX6XvFZXC2j8Z14Ris9qDyLgQP7e17oELs-uWmGmLXL2LolyR7cfiWt6KbBsH_AJJDD8A</recordid><startdate>20160706</startdate><enddate>20160706</enddate><creator>Kim, Kwang Hyun</creator><creator>Yoon, Hyun Suk</creator><creator>Yoon, Hana</creator><creator>Chung, Woo Sik</creator><creator>Sim, Bong Suk</creator><creator>Ryu, Dong-Ryeol</creator><creator>Lee, Dong Hyeon</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-6264-5109</orcidid></search><sort><creationdate>20160706</creationdate><title>Risk Factors for Developing Metabolic Acidosis after Radical Cystectomy and Ileal Neobladder</title><author>Kim, Kwang Hyun ; Yoon, Hyun Suk ; Yoon, Hana ; Chung, Woo Sik ; Sim, Bong Suk ; Ryu, Dong-Ryeol ; Lee, Dong Hyeon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c725t-76798fd7e842cb60ac71ae30c7d83ba773e9bb594c5c8a8f57174a3e6c45dc623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Acidosis</topic><topic>Acidosis - etiology</topic><topic>Adenosine triphosphatase</topic><topic>Aged</topic><topic>Bicarbonate</topic><topic>Bicarbonates</topic><topic>Bicarbonates - blood</topic><topic>Biology and Life Sciences</topic><topic>Bladder</topic><topic>Bladder cancer</topic><topic>Cancer</topic><topic>Carbonates</topic><topic>Catheters</topic><topic>Cohort Studies</topic><topic>Cystectomy</topic><topic>Cystectomy - adverse effects</topic><topic>Development and progression</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Electrolytes</topic><topic>Female</topic><topic>Gene expression</topic><topic>Glomerular Filtration Rate</topic><topic>Health risks</topic><topic>Humans</topic><topic>Laboratories</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine and Health Sciences</topic><topic>Metabolic acidosis</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Physical Sciences</topic><topic>Physiological aspects</topic><topic>Reconstruction</topic><topic>Regression analysis</topic><topic>Renal function</topic><topic>Risk analysis</topic><topic>Risk Factors</topic><topic>Rodents</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Urinary Bladder - surgery</topic><topic>Urinary Bladder Neoplasms - surgery</topic><topic>Urinary Diversion - adverse effects</topic><topic>Urine</topic><topic>Urologic surgery</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Kwang Hyun</creatorcontrib><creatorcontrib>Yoon, Hyun Suk</creatorcontrib><creatorcontrib>Yoon, Hana</creatorcontrib><creatorcontrib>Chung, Woo Sik</creatorcontrib><creatorcontrib>Sim, Bong Suk</creatorcontrib><creatorcontrib>Ryu, Dong-Ryeol</creatorcontrib><creatorcontrib>Lee, Dong Hyeon</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: Opposing Viewpoints</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological & Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>ProQuest Agricultural & Environmental Science</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Materials Science Database</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Meteorological & Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>Biological Sciences</collection><collection>Agriculture Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>ProQuest Engineering Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ: Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Kwang Hyun</au><au>Yoon, Hyun Suk</au><au>Yoon, Hana</au><au>Chung, Woo Sik</au><au>Sim, Bong Suk</au><au>Ryu, Dong-Ryeol</au><au>Lee, Dong Hyeon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk Factors for Developing Metabolic Acidosis after Radical Cystectomy and Ileal Neobladder</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2016-07-06</date><risdate>2016</risdate><volume>11</volume><issue>7</issue><spage>e0158220</spage><epage>e0158220</epage><pages>e0158220-e0158220</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Conceived and designed the experiments: KHK DR DHL. Performed the experiments: KHK HSY. Analyzed the data: KHK HSY. Contributed reagents/materials/analysis tools: HSY HY. Wrote the paper: KHK WSC BSS DR.</notes><notes>Competing Interests: The authors have declared that no competing interests exist.</notes><abstract>To investigate the serial changes of metabolic acidosis and identify associated risk factors in patients who underwent radical cystectomy and ileal neobladder.
From January 2010 to August 2014, 123 patients who underwent radical cystectomy and ileal neobladder reconstruction for bladder cancer were included in this study. Metabolic acidosis was defined as a serum bicarbonate level less than 22 mEq/L and impaired renal function was defined as a GFR <50ml/min. The presence of metabolic acidosis was evaluated at 1 month, 1 year, and 2 years after surgery. Multivariate logistic regression analysis was conducted to identify risk factors associated with development of metabolic acidosis.
Metabolic acidosis was observed in 52%, 19.5%, and 7.3% of patients at 1 month, 1 year, and 2 years after surgery, respectively. At 1 month after surgery, impaired renal function was the only independent risk factor associated with metabolic acidosis (OR 3.87, P = 0.046). At 1 year after surgery, diabetes was the only independent risk factor associated with metabolic acidosis (OR 5.68, P = 0.002). At 2 years post-surgery, both age and diabetes were significant risk factors associated with metabolic acidosis.
Approximately, half of patients experienced metabolic acidosis one month after ileal neobladder reconstruction. Preoperative impaired renal function was the most significant risk factor for developing metabolic acidosis in the early postoperative period. However, the incidence of metabolic acidosis decreased to less than 20% 1 year after surgery, and diabetes was an independent risk factor during this period.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>27384686</pmid><doi>10.1371/journal.pone.0158220</doi><orcidid>https://orcid.org/0000-0002-6264-5109</orcidid><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 1932-6203 |
ispartof | PloS one, 2016-07, Vol.11 (7), p.e0158220-e0158220 |
issn | 1932-6203 1932-6203 |
language | eng |
recordid | cdi_plos_journals_1802192799 |
source | ProQuest - Publicly Available Content Database; PubMed Central |
subjects | Acidosis Acidosis - etiology Adenosine triphosphatase Aged Bicarbonate Bicarbonates Bicarbonates - blood Biology and Life Sciences Bladder Bladder cancer Cancer Carbonates Catheters Cohort Studies Cystectomy Cystectomy - adverse effects Development and progression Diabetes Diabetes mellitus Electrolytes Female Gene expression Glomerular Filtration Rate Health risks Humans Laboratories Male Medicine Medicine and Health Sciences Metabolic acidosis Metabolism Middle Aged Multivariate Analysis Patient outcomes Patients Physical Sciences Physiological aspects Reconstruction Regression analysis Renal function Risk analysis Risk Factors Rodents Surgery Time Factors Treatment Outcome Urinary Bladder - surgery Urinary Bladder Neoplasms - surgery Urinary Diversion - adverse effects Urine Urologic surgery Urology |
title | Risk Factors for Developing Metabolic Acidosis after Radical Cystectomy and Ileal Neobladder |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T05%3A30%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Risk%20Factors%20for%20Developing%20Metabolic%20Acidosis%20after%20Radical%20Cystectomy%20and%20Ileal%20Neobladder&rft.jtitle=PloS%20one&rft.au=Kim,%20Kwang%20Hyun&rft.date=2016-07-06&rft.volume=11&rft.issue=7&rft.spage=e0158220&rft.epage=e0158220&rft.pages=e0158220-e0158220&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0158220&rft_dat=%3Cgale_plos_%3EA457195764%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c725t-76798fd7e842cb60ac71ae30c7d83ba773e9bb594c5c8a8f57174a3e6c45dc623%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1802192799&rft_id=info:pmid/27384686&rft_galeid=A457195764&rfr_iscdi=true |