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Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas
Isocitrate dehydrogenase 1 gene mutations are found in most World Health Organization grade II and III gliomas and secondary glioblastomas. Isocitrate dehydrogenase 1 mutations are known to have prognostic value in high-grade gliomas. However, their prognostic significance in low-grade gliomas remai...
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| Published in: | PloS one 2015-06, Vol.10 (6), p.e0130872-e0130872 |
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| description | Isocitrate dehydrogenase 1 gene mutations are found in most World Health Organization grade II and III gliomas and secondary glioblastomas. Isocitrate dehydrogenase 1 mutations are known to have prognostic value in high-grade gliomas. However, their prognostic significance in low-grade gliomas remains controversial. We determined the predictive and prognostic value of isocitrate dehydrogenase 1 status in low-grade gliomas. The association of isocitrate dehydrogenase 1 status with clinicopathological and genetic factors was also evaluated. Clinical information and genetic data including isocitrate dehydrogenase 1 mutation, O 6-methylguanine DNA methyltransferase promoter methylation, 1p/19q chromosome loss, and TP53 mutation of 417 low-grade gliomas were collected from the Chinese Glioma Genome Atlas database. Kaplan-Meier and Cox proportional hazards regression analyses were performed to evaluate the prognostic effect of clinical characteristics and molecular biomarkers. Isocitrate dehydrogenase 1 mutation was identified as an independent prognostic factor for overall, but not progression-free, survival. Notably, isocitrate dehydrogenase 1 mutation was found to be a significant prognostic factor in patients with oligodendrogliomas, but not in patients with astrocytomas. Furthermore, O 6-methylguanine DNA methyltransferase promoter methylation (p = 0.017) and TP53 mutation (p < 0.001), but not 1p/19q loss (p = 0.834), occurred at a higher frequency in isocitrate dehydrogenase 1-mutated tumors than in isocitrate dehydrogenase 1 wild-type tumors. Younger patient age (p = 0.041) and frontal lobe location (p = 0.010) were significantly correlated with isocitrate dehydrogenase 1 mutation. Chemotherapy did not provide a survival benefit in patients with isocitrate dehydrogenase 1-mutated tumors. Isocitrate dehydrogenase 1 mutation was an independent prognostic factor in low-grade gliomas, whereas it showed no predictive value for chemotherapy response. Isocitrate dehydrogenase 1 mutation was highly associated with O 6-methylguanine DNA methyltransferase promoter methylation and TP53 mutation. |
| doi_str_mv | 10.1371/journal.pone.0130872 |
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Isocitrate dehydrogenase 1 mutations are known to have prognostic value in high-grade gliomas. However, their prognostic significance in low-grade gliomas remains controversial. We determined the predictive and prognostic value of isocitrate dehydrogenase 1 status in low-grade gliomas. The association of isocitrate dehydrogenase 1 status with clinicopathological and genetic factors was also evaluated. Clinical information and genetic data including isocitrate dehydrogenase 1 mutation, O 6-methylguanine DNA methyltransferase promoter methylation, 1p/19q chromosome loss, and TP53 mutation of 417 low-grade gliomas were collected from the Chinese Glioma Genome Atlas database. Kaplan-Meier and Cox proportional hazards regression analyses were performed to evaluate the prognostic effect of clinical characteristics and molecular biomarkers. Isocitrate dehydrogenase 1 mutation was identified as an independent prognostic factor for overall, but not progression-free, survival. Notably, isocitrate dehydrogenase 1 mutation was found to be a significant prognostic factor in patients with oligodendrogliomas, but not in patients with astrocytomas. Furthermore, O 6-methylguanine DNA methyltransferase promoter methylation (p = 0.017) and TP53 mutation (p < 0.001), but not 1p/19q loss (p = 0.834), occurred at a higher frequency in isocitrate dehydrogenase 1-mutated tumors than in isocitrate dehydrogenase 1 wild-type tumors. Younger patient age (p = 0.041) and frontal lobe location (p = 0.010) were significantly correlated with isocitrate dehydrogenase 1 mutation. Chemotherapy did not provide a survival benefit in patients with isocitrate dehydrogenase 1-mutated tumors. Isocitrate dehydrogenase 1 mutation was an independent prognostic factor in low-grade gliomas, whereas it showed no predictive value for chemotherapy response. Isocitrate dehydrogenase 1 mutation was highly associated with O 6-methylguanine DNA methyltransferase promoter methylation and TP53 mutation.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0130872</identifier><identifier>PMID: 26115094</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Adult ; Aged ; Astrocytoma ; Biomarkers ; Brain cancer ; Brain research ; Brain tumors ; Cancer genetics ; Chemotherapy ; Chi-square test ; Dehydrogenase ; Dehydrogenases ; Deoxyribonucleic acid ; DNA ; DNA methylation ; DNA methyltransferase ; DNA Modification Methylases - genetics ; DNA Repair Enzymes - genetics ; Female ; Frontal lobe ; Gene mutation ; Genes ; Genetic aspects ; Genetic factors ; Genomes ; Genomics ; Glioma ; Glioma - enzymology ; Glioma - genetics ; Glioma - pathology ; Gliomas ; Hazards ; Hospitals ; Humans ; Isocitrate dehydrogenase ; Isocitrate Dehydrogenase - genetics ; Kaplan-Meier Estimate ; Li, Yang ; Male ; Medical prognosis ; Methylation ; Methylguanine ; Middle Aged ; Molecular chains ; Mutation ; Neurosurgery ; p53 Protein ; Patients ; Point mutation ; Polymerase chain reaction ; Prognosis ; Promoter Regions, Genetic - genetics ; Radiation therapy ; Regression analysis ; Studies ; Survival ; Tumor proteins ; Tumor Suppressor Proteins - genetics ; Tumors ; Young Adult</subject><ispartof>PloS one, 2015-06, Vol.10 (6), p.e0130872-e0130872</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Li et al 2015 Li et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-a7e3c8d2e0bdd8cc95a53018f963dcabaa1f10b4149d4753ab7dc96da1cda9713</citedby><cites>FETCH-LOGICAL-c692t-a7e3c8d2e0bdd8cc95a53018f963dcabaa1f10b4149d4753ab7dc96da1cda9713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1691408802/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1691408802?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,25783,27957,27958,37047,37048,44625,53827,53829,75483</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26115094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Coleman, William B.</contributor><creatorcontrib>Li, Ming-Yang</creatorcontrib><creatorcontrib>Wang, Yin-Yan</creatorcontrib><creatorcontrib>Cai, Jin-Quan</creatorcontrib><creatorcontrib>Zhang, Chuan-Bao</creatorcontrib><creatorcontrib>Wang, Kuan-Yu</creatorcontrib><creatorcontrib>Cheng, Wen</creatorcontrib><creatorcontrib>Liu, Yan-Wei</creatorcontrib><creatorcontrib>Zhang, Wei</creatorcontrib><creatorcontrib>Jiang, Tao</creatorcontrib><title>Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Isocitrate dehydrogenase 1 gene mutations are found in most World Health Organization grade II and III gliomas and secondary glioblastomas. Isocitrate dehydrogenase 1 mutations are known to have prognostic value in high-grade gliomas. However, their prognostic significance in low-grade gliomas remains controversial. We determined the predictive and prognostic value of isocitrate dehydrogenase 1 status in low-grade gliomas. The association of isocitrate dehydrogenase 1 status with clinicopathological and genetic factors was also evaluated. Clinical information and genetic data including isocitrate dehydrogenase 1 mutation, O 6-methylguanine DNA methyltransferase promoter methylation, 1p/19q chromosome loss, and TP53 mutation of 417 low-grade gliomas were collected from the Chinese Glioma Genome Atlas database. Kaplan-Meier and Cox proportional hazards regression analyses were performed to evaluate the prognostic effect of clinical characteristics and molecular biomarkers. Isocitrate dehydrogenase 1 mutation was identified as an independent prognostic factor for overall, but not progression-free, survival. Notably, isocitrate dehydrogenase 1 mutation was found to be a significant prognostic factor in patients with oligodendrogliomas, but not in patients with astrocytomas. Furthermore, O 6-methylguanine DNA methyltransferase promoter methylation (p = 0.017) and TP53 mutation (p < 0.001), but not 1p/19q loss (p = 0.834), occurred at a higher frequency in isocitrate dehydrogenase 1-mutated tumors than in isocitrate dehydrogenase 1 wild-type tumors. Younger patient age (p = 0.041) and frontal lobe location (p = 0.010) were significantly correlated with isocitrate dehydrogenase 1 mutation. Chemotherapy did not provide a survival benefit in patients with isocitrate dehydrogenase 1-mutated tumors. Isocitrate dehydrogenase 1 mutation was an independent prognostic factor in low-grade gliomas, whereas it showed no predictive value for chemotherapy response. Isocitrate dehydrogenase 1 mutation was highly associated with O 6-methylguanine DNA methyltransferase promoter methylation and TP53 mutation.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Astrocytoma</subject><subject>Biomarkers</subject><subject>Brain cancer</subject><subject>Brain research</subject><subject>Brain tumors</subject><subject>Cancer genetics</subject><subject>Chemotherapy</subject><subject>Chi-square test</subject><subject>Dehydrogenase</subject><subject>Dehydrogenases</subject><subject>Deoxyribonucleic acid</subject><subject>DNA</subject><subject>DNA methylation</subject><subject>DNA methyltransferase</subject><subject>DNA Modification Methylases - genetics</subject><subject>DNA Repair Enzymes - genetics</subject><subject>Female</subject><subject>Frontal lobe</subject><subject>Gene mutation</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic factors</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Glioma</subject><subject>Glioma - enzymology</subject><subject>Glioma - genetics</subject><subject>Glioma - pathology</subject><subject>Gliomas</subject><subject>Hazards</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Isocitrate dehydrogenase</subject><subject>Isocitrate Dehydrogenase - genetics</subject><subject>Kaplan-Meier Estimate</subject><subject>Li, Yang</subject><subject>Male</subject><subject>Medical prognosis</subject><subject>Methylation</subject><subject>Methylguanine</subject><subject>Middle Aged</subject><subject>Molecular chains</subject><subject>Mutation</subject><subject>Neurosurgery</subject><subject>p53 Protein</subject><subject>Patients</subject><subject>Point mutation</subject><subject>Polymerase chain reaction</subject><subject>Prognosis</subject><subject>Promoter Regions, Genetic - genetics</subject><subject>Radiation therapy</subject><subject>Regression analysis</subject><subject>Studies</subject><subject>Survival</subject><subject>Tumor proteins</subject><subject>Tumor Suppressor Proteins - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Ming-Yang</au><au>Wang, Yin-Yan</au><au>Cai, Jin-Quan</au><au>Zhang, Chuan-Bao</au><au>Wang, Kuan-Yu</au><au>Cheng, Wen</au><au>Liu, Yan-Wei</au><au>Zhang, Wei</au><au>Jiang, Tao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-06-26</date><risdate>2015</risdate><volume>10</volume><issue>6</issue><spage>e0130872</spage><epage>e0130872</epage><pages>e0130872-e0130872</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Conceived and designed the experiments: TJ WZ. Performed the experiments: MYL YYW WC WZ. Analyzed the data: JQC CBZ. Contributed reagents/materials/analysis tools: YWL KYW. Wrote the paper: MYL YYW.</notes><notes>Competing Interests: The authors have declared that no competing interests exist.</notes><abstract>Isocitrate dehydrogenase 1 gene mutations are found in most World Health Organization grade II and III gliomas and secondary glioblastomas. Isocitrate dehydrogenase 1 mutations are known to have prognostic value in high-grade gliomas. However, their prognostic significance in low-grade gliomas remains controversial. We determined the predictive and prognostic value of isocitrate dehydrogenase 1 status in low-grade gliomas. The association of isocitrate dehydrogenase 1 status with clinicopathological and genetic factors was also evaluated. Clinical information and genetic data including isocitrate dehydrogenase 1 mutation, O 6-methylguanine DNA methyltransferase promoter methylation, 1p/19q chromosome loss, and TP53 mutation of 417 low-grade gliomas were collected from the Chinese Glioma Genome Atlas database. Kaplan-Meier and Cox proportional hazards regression analyses were performed to evaluate the prognostic effect of clinical characteristics and molecular biomarkers. Isocitrate dehydrogenase 1 mutation was identified as an independent prognostic factor for overall, but not progression-free, survival. Notably, isocitrate dehydrogenase 1 mutation was found to be a significant prognostic factor in patients with oligodendrogliomas, but not in patients with astrocytomas. Furthermore, O 6-methylguanine DNA methyltransferase promoter methylation (p = 0.017) and TP53 mutation (p < 0.001), but not 1p/19q loss (p = 0.834), occurred at a higher frequency in isocitrate dehydrogenase 1-mutated tumors than in isocitrate dehydrogenase 1 wild-type tumors. Younger patient age (p = 0.041) and frontal lobe location (p = 0.010) were significantly correlated with isocitrate dehydrogenase 1 mutation. Chemotherapy did not provide a survival benefit in patients with isocitrate dehydrogenase 1-mutated tumors. Isocitrate dehydrogenase 1 mutation was an independent prognostic factor in low-grade gliomas, whereas it showed no predictive value for chemotherapy response. Isocitrate dehydrogenase 1 mutation was highly associated with O 6-methylguanine DNA methyltransferase promoter methylation and TP53 mutation.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>26115094</pmid><doi>10.1371/journal.pone.0130872</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2015-06, Vol.10 (6), p.e0130872-e0130872 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1691408802 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | Adolescent Adult Aged Astrocytoma Biomarkers Brain cancer Brain research Brain tumors Cancer genetics Chemotherapy Chi-square test Dehydrogenase Dehydrogenases Deoxyribonucleic acid DNA DNA methylation DNA methyltransferase DNA Modification Methylases - genetics DNA Repair Enzymes - genetics Female Frontal lobe Gene mutation Genes Genetic aspects Genetic factors Genomes Genomics Glioma Glioma - enzymology Glioma - genetics Glioma - pathology Gliomas Hazards Hospitals Humans Isocitrate dehydrogenase Isocitrate Dehydrogenase - genetics Kaplan-Meier Estimate Li, Yang Male Medical prognosis Methylation Methylguanine Middle Aged Molecular chains Mutation Neurosurgery p53 Protein Patients Point mutation Polymerase chain reaction Prognosis Promoter Regions, Genetic - genetics Radiation therapy Regression analysis Studies Survival Tumor proteins Tumor Suppressor Proteins - genetics Tumors Young Adult |
| title | Isocitrate dehydrogenase 1 Gene Mutation Is Associated with Prognosis in Clinical Low-Grade Gliomas |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T07%3A32%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Isocitrate%20dehydrogenase%201%20Gene%20Mutation%20Is%20Associated%20with%20Prognosis%20in%20Clinical%20Low-Grade%20Gliomas&rft.jtitle=PloS%20one&rft.au=Li,%20Ming-Yang&rft.date=2015-06-26&rft.volume=10&rft.issue=6&rft.spage=e0130872&rft.epage=e0130872&rft.pages=e0130872-e0130872&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0130872&rft_dat=%3Cgale_plos_%3EA419506142%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c692t-a7e3c8d2e0bdd8cc95a53018f963dcabaa1f10b4149d4753ab7dc96da1cda9713%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1691408802&rft_id=info:pmid/26115094&rft_galeid=A419506142&rfr_iscdi=true |