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Prognostic value of tissue inhibitor of metalloproteinase-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis
Tissue inhibitor of metalloproteinase-2 (TIMP-2) is a small secretory glycoprotein with anti-matrix metalloproteinase activity. Data on the value of TIMP-2 as a prognostic factor in non-small cell lung cancer (NSCLC) are discordant and remain controversial. A systematic review and meta-analysis was...
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Published in: | PloS one 2015-04, Vol.10 (4), p.e0124230-e0124230 |
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description | Tissue inhibitor of metalloproteinase-2 (TIMP-2) is a small secretory glycoprotein with anti-matrix metalloproteinase activity. Data on the value of TIMP-2 as a prognostic factor in non-small cell lung cancer (NSCLC) are discordant and remain controversial. A systematic review and meta-analysis was performed to explore this issue.
We identified the relevant literature by searching the PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, SinoMed, and Wanfang Data databases (search terms: "non-small cell lung cancer" or "NSCLC" or "Lung Carcinoma, Non-Small-Cell", "Tissue Inhibitor of Metalloproteinase-2" or "TIMP-2", and "prognosis" or "prognostic" or "survive") for updates prior to March 1, 2014. The pooled hazard ratio (HR) of overall survival with a 95% confidence interval (95% CI) was used to evaluate the strength of the association between positive TIMP-2 expression and survival in patients with NSCLC.
We included 12 studies in our systematic review; five studies involving 399 patients with NSCLC were meta-analyzed. The pooled HR of all included patients was 0.57 (95% CI: 0.43-0.77), and the HRs of subgroup analysis according to stage (I-IV), testing method (immunohistochemistry) and high TIMP-2 expression percentage ( |
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We identified the relevant literature by searching the PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, SinoMed, and Wanfang Data databases (search terms: "non-small cell lung cancer" or "NSCLC" or "Lung Carcinoma, Non-Small-Cell", "Tissue Inhibitor of Metalloproteinase-2" or "TIMP-2", and "prognosis" or "prognostic" or "survive") for updates prior to March 1, 2014. The pooled hazard ratio (HR) of overall survival with a 95% confidence interval (95% CI) was used to evaluate the strength of the association between positive TIMP-2 expression and survival in patients with NSCLC.
We included 12 studies in our systematic review; five studies involving 399 patients with NSCLC were meta-analyzed. The pooled HR of all included patients was 0.57 (95% CI: 0.43-0.77), and the HRs of subgroup analysis according to stage (I-IV), testing method (immunohistochemistry) and high TIMP-2 expression percentage (<50%) were 0.63 (95% CI: 0.43-0.92), 0.55 (95% CI: 0.41-0.74), and 0.50 (95% CI: 0.28-0.88), respectively. These data suggested that high TIMP-2 expression is associated with favorable prognosis in NSCLC. The meta-analysis did not reveal heterogeneity or publication bias.
TIMP-2 expression indicates favorable prognosis in patients with NSCLC; as a protective factor, it could help predict outcome and may guide clinical therapy in the future.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0124230</identifier><identifier>PMID: 25905787</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Analysis ; Biomarkers, Tumor - metabolism ; Cancer ; Cancer therapies ; Carcinoma, Non-Small-Cell Lung - enzymology ; Care and treatment ; Confidence intervals ; Female ; Glycoproteins ; Heterogeneity ; Hospitals ; Humans ; Immunohistochemistry ; Inhibitors ; Lung cancer ; Lung carcinoma ; Lung diseases ; Lung Neoplasms - enzymology ; Male ; Matrix metalloproteinase ; Medical ethics ; Medical imaging ; Medical prognosis ; Medical research ; Meta-analysis ; Metalloproteinase ; Metastasis ; Middle Aged ; Mutation ; Non-small cell lung cancer ; Non-small cell lung carcinoma ; Patients ; Prognosis ; Proteins ; Small cell lung cancer ; Small cell lung carcinoma ; Subgroups ; Survival ; Systematic review ; Test procedures ; Tissue inhibitor of metalloproteinase 2 ; Tissue Inhibitor of Metalloproteinase-2 - metabolism ; Tissues</subject><ispartof>PloS one, 2015-04, Vol.10 (4), p.e0124230-e0124230</ispartof><rights>COPYRIGHT 2015 Public Library of Science</rights><rights>2015 Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2015 Zhu et al 2015 Zhu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-e77c52bf7b54cd87afbd5b44a9da89f0a46c0fbe56c6708b13ba591009a120043</citedby><cites>FETCH-LOGICAL-c692t-e77c52bf7b54cd87afbd5b44a9da89f0a46c0fbe56c6708b13ba591009a120043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1675171904/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1675171904?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,730,783,787,888,25767,27938,27939,37026,37027,44604,53806,53808,75462</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25905787$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Rosell, Rafael</contributor><creatorcontrib>Zhu, Lin</creatorcontrib><creatorcontrib>Yu, Hong</creatorcontrib><creatorcontrib>Liu, Shi-Yuan</creatorcontrib><creatorcontrib>Xiao, Xiang-Sheng</creatorcontrib><creatorcontrib>Dong, Wei-Hua</creatorcontrib><creatorcontrib>Chen, Yi-Nan</creatorcontrib><creatorcontrib>Xu, Wei</creatorcontrib><creatorcontrib>Zhu, Tong</creatorcontrib><title>Prognostic value of tissue inhibitor of metalloproteinase-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Tissue inhibitor of metalloproteinase-2 (TIMP-2) is a small secretory glycoprotein with anti-matrix metalloproteinase activity. Data on the value of TIMP-2 as a prognostic factor in non-small cell lung cancer (NSCLC) are discordant and remain controversial. A systematic review and meta-analysis was performed to explore this issue.
We identified the relevant literature by searching the PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, SinoMed, and Wanfang Data databases (search terms: "non-small cell lung cancer" or "NSCLC" or "Lung Carcinoma, Non-Small-Cell", "Tissue Inhibitor of Metalloproteinase-2" or "TIMP-2", and "prognosis" or "prognostic" or "survive") for updates prior to March 1, 2014. The pooled hazard ratio (HR) of overall survival with a 95% confidence interval (95% CI) was used to evaluate the strength of the association between positive TIMP-2 expression and survival in patients with NSCLC.
We included 12 studies in our systematic review; five studies involving 399 patients with NSCLC were meta-analyzed. The pooled HR of all included patients was 0.57 (95% CI: 0.43-0.77), and the HRs of subgroup analysis according to stage (I-IV), testing method (immunohistochemistry) and high TIMP-2 expression percentage (<50%) were 0.63 (95% CI: 0.43-0.92), 0.55 (95% CI: 0.41-0.74), and 0.50 (95% CI: 0.28-0.88), respectively. These data suggested that high TIMP-2 expression is associated with favorable prognosis in NSCLC. The meta-analysis did not reveal heterogeneity or publication bias.
TIMP-2 expression indicates favorable prognosis in patients with NSCLC; as a protective factor, it could help predict outcome and may guide clinical therapy in the future.</description><subject>Analysis</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carcinoma, Non-Small-Cell Lung - enzymology</subject><subject>Care and treatment</subject><subject>Confidence intervals</subject><subject>Female</subject><subject>Glycoproteins</subject><subject>Heterogeneity</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Inhibitors</subject><subject>Lung cancer</subject><subject>Lung carcinoma</subject><subject>Lung diseases</subject><subject>Lung Neoplasms - enzymology</subject><subject>Male</subject><subject>Matrix metalloproteinase</subject><subject>Medical ethics</subject><subject>Medical imaging</subject><subject>Medical prognosis</subject><subject>Medical research</subject><subject>Meta-analysis</subject><subject>Metalloproteinase</subject><subject>Metastasis</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Non-small cell lung cancer</subject><subject>Non-small cell lung carcinoma</subject><subject>Patients</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Small cell lung cancer</subject><subject>Small cell lung carcinoma</subject><subject>Subgroups</subject><subject>Survival</subject><subject>Systematic review</subject><subject>Test procedures</subject><subject>Tissue inhibitor of metalloproteinase 2</subject><subject>Tissue Inhibitor of Metalloproteinase-2 - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Lin</au><au>Yu, Hong</au><au>Liu, Shi-Yuan</au><au>Xiao, Xiang-Sheng</au><au>Dong, Wei-Hua</au><au>Chen, Yi-Nan</au><au>Xu, Wei</au><au>Zhu, Tong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic value of tissue inhibitor of metalloproteinase-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2015-04-23</date><risdate>2015</risdate><volume>10</volume><issue>4</issue><spage>e0124230</spage><epage>e0124230</epage><pages>e0124230-e0124230</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><notes>ObjectType-Article-2</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-1</notes><notes>ObjectType-Review-4</notes><notes>content type line 23</notes><notes>ObjectType-Undefined-3</notes><notes>Conceived and designed the experiments: HY LZ SYL XSX. Performed the experiments: HY LZ TZ YNC. Analyzed the data: LZ SYL WHD WX. Contributed reagents/materials/analysis tools: TZ YNC WHD WX XSX. Wrote the paper: LZ HY YNC TZ.</notes><notes>Competing Interests: The authors have the following interests: co-author Tong Zhu is employed by Shanghai United Imaging Healthcare Co., Ltd. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.</notes><abstract>Tissue inhibitor of metalloproteinase-2 (TIMP-2) is a small secretory glycoprotein with anti-matrix metalloproteinase activity. Data on the value of TIMP-2 as a prognostic factor in non-small cell lung cancer (NSCLC) are discordant and remain controversial. A systematic review and meta-analysis was performed to explore this issue.
We identified the relevant literature by searching the PubMed, EMBASE, Web of Science, China National Knowledge Infrastructure, SinoMed, and Wanfang Data databases (search terms: "non-small cell lung cancer" or "NSCLC" or "Lung Carcinoma, Non-Small-Cell", "Tissue Inhibitor of Metalloproteinase-2" or "TIMP-2", and "prognosis" or "prognostic" or "survive") for updates prior to March 1, 2014. The pooled hazard ratio (HR) of overall survival with a 95% confidence interval (95% CI) was used to evaluate the strength of the association between positive TIMP-2 expression and survival in patients with NSCLC.
We included 12 studies in our systematic review; five studies involving 399 patients with NSCLC were meta-analyzed. The pooled HR of all included patients was 0.57 (95% CI: 0.43-0.77), and the HRs of subgroup analysis according to stage (I-IV), testing method (immunohistochemistry) and high TIMP-2 expression percentage (<50%) were 0.63 (95% CI: 0.43-0.92), 0.55 (95% CI: 0.41-0.74), and 0.50 (95% CI: 0.28-0.88), respectively. These data suggested that high TIMP-2 expression is associated with favorable prognosis in NSCLC. The meta-analysis did not reveal heterogeneity or publication bias.
TIMP-2 expression indicates favorable prognosis in patients with NSCLC; as a protective factor, it could help predict outcome and may guide clinical therapy in the future.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25905787</pmid><doi>10.1371/journal.pone.0124230</doi><oa>free_for_read</oa></addata></record> |
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recordid | cdi_plos_journals_1675171904 |
source | Publicly Available Content Database; PubMed Central |
subjects | Analysis Biomarkers, Tumor - metabolism Cancer Cancer therapies Carcinoma, Non-Small-Cell Lung - enzymology Care and treatment Confidence intervals Female Glycoproteins Heterogeneity Hospitals Humans Immunohistochemistry Inhibitors Lung cancer Lung carcinoma Lung diseases Lung Neoplasms - enzymology Male Matrix metalloproteinase Medical ethics Medical imaging Medical prognosis Medical research Meta-analysis Metalloproteinase Metastasis Middle Aged Mutation Non-small cell lung cancer Non-small cell lung carcinoma Patients Prognosis Proteins Small cell lung cancer Small cell lung carcinoma Subgroups Survival Systematic review Test procedures Tissue inhibitor of metalloproteinase 2 Tissue Inhibitor of Metalloproteinase-2 - metabolism Tissues |
title | Prognostic value of tissue inhibitor of metalloproteinase-2 expression in patients with non-small cell lung cancer: a systematic review and meta-analysis |
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