Humoral response against small heat shock proteins in Parkinson's disease

In the light of evidence for the increased heat shock proteins (HSP) expression in neurodegenerative disorders, the presence of the adaptive humoral response of the immune system can be expected. The aim of the study was to check whether Parkinson's disease (PD) has the ability to elicit immune...

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Published in:PloS one 2015-01, Vol.10 (1), p.e0115480-e0115480
Main Authors: Papuć, Ewa, Kurys-Denis, Ewa, Krupski, Witold, Rejdak, Konrad
Format: Article
Language:English
Subjects:
Adaptive systems
Aged
alpha-Crystallin B Chain - immunology
Antibodies
Antigens
Apoptosis
Atherosclerosis
Autoantibodies
Autoantibodies - blood
Autoantibodies - immunology
Autoimmunity
Basal ganglia
Biomarkers
Case-Control Studies
Central nervous system diseases
Crystal structure
Crystallin
Crystallinity
Dementia
Female
Heat shock proteins
Heat-Shock Proteins, Small - immunology
Homeostasis
Humans
Immune response
Immune response (humoral)
Immune system
Immunity, Humoral
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunoglobulin M
Immunoglobulin M - blood
Immunoglobulin M - immunology
Immunoglobulins
Male
Middle Aged
Movement disorders
Neurodegenerative diseases
Neurology
Parkinson Disease - blood
Parkinson Disease - immunology
Parkinson's disease
Pathogenesis
Patients
Proteins
Small heat shock proteins
Statistical analysis
Statistical methods
Toxicity
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cited_by cdi_FETCH-LOGICAL-c692t-ee9bba2f6500d90cb0b1bdf76ea535ed9f5d9e9c7b5d2a62f8f14c1ebc0eb9963
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Kurys-Denis, Ewa
Krupski, Witold
Rejdak, Konrad
description In the light of evidence for the increased heat shock proteins (HSP) expression in neurodegenerative disorders, the presence of the adaptive humoral response of the immune system can be expected. The aim of the study was to check whether Parkinson's disease (PD) has the ability to elicit immune response against small heat shock proteins. IgG and IgM autoantibodies against alpha B-crystallin were assessed in 26 PD patients 26 healthy subjects. For the assessment of anti-HSP IgG autoantibodies serum samples from 31 parkinsonian patients and 31 healthy control subjects were collected. Serum samples from PD patients and healthy control subjects were collected twice, at baseline and after mean of 13 months follow up. Both IgM and IgG autoantibodies against alpha ß-crystallin in PD patients were significantly higher compared to healthy controls (p
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The aim of the study was to check whether Parkinson's disease (PD) has the ability to elicit immune response against small heat shock proteins. IgG and IgM autoantibodies against alpha B-crystallin were assessed in 26 PD patients 26 healthy subjects. For the assessment of anti-HSP IgG autoantibodies serum samples from 31 parkinsonian patients and 31 healthy control subjects were collected. Serum samples from PD patients and healthy control subjects were collected twice, at baseline and after mean of 13 months follow up. Both IgM and IgG autoantibodies against alpha ß-crystallin in PD patients were significantly higher compared to healthy controls (p&lt;0.05). We also found statistically significant increase in antibodies titers against alpha ß-crystallin over the time of 13 months, both for IgG (p = 0.021) and for IgM (p&lt;0.0001). Additionally, PD patients presented higher levels of anti-HSP IgG autoantibodies than healthy controls (p = 0.02). Increase of IgG and IgM autoantibodies against alpha B-crystallin in PD patients over time may suggest their involvement in the disease pathogenesis and progression. 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Performed the experiments: EP EKD. Analyzed the data: EP EKD. Contributed reagents/materials/analysis tools: EP EKD. Wrote the paper: EP. Critique of the manuscript: KR WK.</notes><abstract>In the light of evidence for the increased heat shock proteins (HSP) expression in neurodegenerative disorders, the presence of the adaptive humoral response of the immune system can be expected. The aim of the study was to check whether Parkinson's disease (PD) has the ability to elicit immune response against small heat shock proteins. IgG and IgM autoantibodies against alpha B-crystallin were assessed in 26 PD patients 26 healthy subjects. For the assessment of anti-HSP IgG autoantibodies serum samples from 31 parkinsonian patients and 31 healthy control subjects were collected. Serum samples from PD patients and healthy control subjects were collected twice, at baseline and after mean of 13 months follow up. Both IgM and IgG autoantibodies against alpha ß-crystallin in PD patients were significantly higher compared to healthy controls (p&lt;0.05). We also found statistically significant increase in antibodies titers against alpha ß-crystallin over the time of 13 months, both for IgG (p = 0.021) and for IgM (p&lt;0.0001). Additionally, PD patients presented higher levels of anti-HSP IgG autoantibodies than healthy controls (p = 0.02). Increase of IgG and IgM autoantibodies against alpha B-crystallin in PD patients over time may suggest their involvement in the disease pathogenesis and progression. Further studies are required to confirm the role of this antibody as a biomarker of the disease progression.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>25629316</pmid><doi>10.1371/journal.pone.0115480</doi><oa>free_for_read</oa></addata></record>
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subjects Adaptive systems
Aged
alpha-Crystallin B Chain - immunology
Antibodies
Antigens
Apoptosis
Atherosclerosis
Autoantibodies
Autoantibodies - blood
Autoantibodies - immunology
Autoimmunity
Basal ganglia
Biomarkers
Case-Control Studies
Central nervous system diseases
Crystal structure
Crystallin
Crystallinity
Dementia
Female
Heat shock proteins
Heat-Shock Proteins, Small - immunology
Homeostasis
Humans
Immune response
Immune response (humoral)
Immune system
Immunity, Humoral
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulin G - immunology
Immunoglobulin M
Immunoglobulin M - blood
Immunoglobulin M - immunology
Immunoglobulins
Male
Middle Aged
Movement disorders
Neurodegenerative diseases
Neurology
Parkinson Disease - blood
Parkinson Disease - immunology
Parkinson's disease
Pathogenesis
Patients
Proteins
Small heat shock proteins
Statistical analysis
Statistical methods
Toxicity
title Humoral response against small heat shock proteins in Parkinson's disease
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