Chronic sleep restriction during pregnancy--repercussion on cardiovascular and renal functioning of male offspring

Changes in the maternal environment can induce fetal adaptations that result in the progression of chronic diseases in the offspring. The objective of the present study was to evaluate the effects of maternal chronic sleep restriction on blood pressure, renal function and cardiac baroreflex response...

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Bibliographic Details
Published in:PloS one 2014-11, Vol.9 (11), p.e113075-e113075
Main Authors: Lima, Ingrid L B, Rodrigues, Aline F A C, Bergamaschi, Cássia T, Campos, Ruy R, Hirata, Aparecida E, Tufik, Sergio, Xylaras, Beatriz D P, Visniauskas, Bruna, Chagas, Jair R, Gomes, Guiomar N
Format: Article
Language:English
Subjects:
Adaptation
Adult
Animals
Baroreceptors
Baroreflex - physiology
Biology and Life Sciences
Blood
Blood pressure
Blood Pressure - physiology
Brain research
Cardiovascular Physiological Phenomena
Development and progression
Diabetes
Female
Females
Fetuses
Glomerular filtration rate
Glomerular Filtration Rate - physiology
Heart
Heart diseases
Heart rate
Homeostasis
Humans
Hypertension
Hypothalamus
Hypothalamus - metabolism
Kidney - physiopathology
Laboratory animals
Male
Offspring
Peptidyl-Dipeptidase A - metabolism
Plethysmography
Pregnancy
Pregnant women
Prenatal Exposure Delayed Effects - physiopathology
Rats
Rats, Wistar
Reflexes
Renal function
Rodents
Sleep
Sleep deprivation
Sleep Deprivation - physiopathology
Smear
Studies
Vagina
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Summary:Changes in the maternal environment can induce fetal adaptations that result in the progression of chronic diseases in the offspring. The objective of the present study was to evaluate the effects of maternal chronic sleep restriction on blood pressure, renal function and cardiac baroreflex response on male offspring at adult age. Female 3-month-old Wistar rats were divided in two experimental groups: control (C) and chronic sleep restricted (CSR). Pregnancy was confirmed by vaginal smear. Chronic sleep restricted females were subjected to sleep restriction by the multiple platform technique for 20 h daily, between the 1st and 20th day of pregnancy. After birth, the litters were reduced to 6 rats per mother, and were designated as offspring from control (OC) and offspring from chronic sleep restricted (OCSR). Indirect blood pressure (BPi - tail cuff) was measured by plethysmography in male offspring at 3 months old. Following, the renal function and cardiac baroreflex response were analyzed. Values of BPi in OCSR were significantly higher compared to OC [OC: 127 ± 2.6 (19); OCSR: 144 ± 2.5 (17) mmHg]. The baroreflex sensitivity to the increase of blood pressure was reduced in OCSR [Slope: OC: -2.6 ± 0.15 (9); OCRS: -1.6 ± 0.13 (9)]. Hypothalamic activity of ACE2 was significantly reduced in OCSR compared to OC [OC: 97.4 ± 15 (18); OSR: 60.2 ± 3.6 (16) UAF/min/protein mg]. Renal function alteration was noticed by the increase in glomerular filtration rate (GFR) observed in OCSR [OC: 6.4 ± 0.2 (10); OCSR: 7.4 ± 0.3 (7)]. Chronic sleep restriction during pregnancy caused in the offspring hypertension, altered cardiac baroreflex response, reduced ACE-2 activity in the hypothalamus and renal alterations. Our data suggest that the reduction of sleeping time along the pregnancy is able to modify maternal homeostasis leading to functional alterations in offspring.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0113075