Estimating the risk of parvovirus B19 infection in blood donors and pregnant women in Japan

Seroepidemiological study of parvovirus B19 has not taken place for some 20 years in Japan. To estimate the risk of parvovirus B19 infection in Japan among blood donors and pregnant women in this century, a seroepidemiological survey and statistical modeling of the force of infection were conducted....

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Bibliographic Details
Published in:PloS one 2014-03, Vol.9 (3), p.e92519-e92519
Main Authors: Nabae, Koji, Satoh, Hiroshi, Nishiura, Hiroshi, Tanaka-Taya, Keiko, Okabe, Nobuhiko, Oishi, Kazunori, Matsumoto, Kunichika, Hasegawa, Tomonori
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age
Antibodies, Viral - blood
Antigens
Biology and Life Sciences
Blood
Blood & organ donations
Blood donation
Blood donors
Blood Donors - statistics & numerical data
Blood products
Child, Preschool
Edema
Epidemiology
Female
Fetal Death
Fetuses
Health aspects
Health risks
Humans
Hydrops fetalis
Hydrops Fetalis - epidemiology
Immunization
Infant
Infant, Newborn
Infection
Infections
Infectious diseases
Influenza
Japan - epidemiology
Mathematical models
Measles
Medical research
Medicine
Medicine and Health Sciences
Middle Aged
Parvoviridae Infections - epidemiology
Parvovirus B19, Human - immunology
Parvoviruses
Physical Sciences
Pregnancy
Pregnancy Complications, Infectious - epidemiology
Pregnancy Complications, Infectious - virology
Pregnant women
Risk
Risk factors
Rubella
Seroepidemiologic Studies
Seroepidemiology
Statistical models
Studies
Surveys
Womens health
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Summary:Seroepidemiological study of parvovirus B19 has not taken place for some 20 years in Japan. To estimate the risk of parvovirus B19 infection in Japan among blood donors and pregnant women in this century, a seroepidemiological survey and statistical modeling of the force of infection were conducted. The time- and age-specific seroprevalence data were suggestive of strong age-dependency in the risk of infection. Employing a piecewise constant model, the highest forces of infection of 0.05 and 0.12 per year were observed among those aged 0-4 and 5-9 years, respectively, while estimates among older individuals were less than 0.01 per year. Analyzing the antigen detection data among blood donors, the age-specific proportion positive was highest among those aged 30-39 years, agreeing with the presence of dip in seroprevalence in this age-group. Among pregnant women, up to 107 fetal deaths and 21 hydrops fetalis were estimated to have occurred annually across Japan. Seroepidemiological profiles of PVB19 infection in Japan was characterized with particular emphasis on the risk of infection in blood donors and the burden of infection among pregnant women. When a vaccine becomes available in the future, a similar seroepidemiological study is expected to play a key role in planning the appropriate immunization policy.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0092519