Evaluation of physical and mechanical properties of porous poly (ethylene glycol)-co-(L-lactic acid) hydrogels during degradation

Porous hydrogels of poly(ethylene glycol) (PEG) have been shown to facilitate vascularized tissue formation. However, PEG hydrogels exhibit limited degradation under physiological conditions which hinders their ultimate applicability for tissue engineering therapies. Introduction of poly(L-lactic ac...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2013-04, Vol.8 (4), p.e60728-e60728
Main Authors: Chiu, Yu-Chieh, Kocagöz, Sevi, Larson, Jeffery C, Brey, Eric M
Format: Article
Language:English
Subjects:
Acids
Animals
Biocompatible Materials
Biology
Biomechanical Phenomena
Biomedical engineering
Biomedical materials
Cell Line
Chemistry
Degradation
Engineering
Fibroblasts - metabolism
Focal Adhesions
Hydrogels
Hydrogels - chemistry
Influence
Leaching
Materials Science
Mechanical properties
Mice
Modulus of elasticity
Particle Size
Particulate size
Particulates
Photopolymerization
Physical chemistry
Polyethylene glycol
Polyethylene Glycols - chemistry
Polylactic acid
Polymerization
Polymers
Pore size
Porosity
Tissue engineering
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c526t-db54ae6aeb6812565e7069b2b0390b16240a00744ebb3e484203c35c01a8f2723
cites cdi_FETCH-LOGICAL-c526t-db54ae6aeb6812565e7069b2b0390b16240a00744ebb3e484203c35c01a8f2723
container_end_page e60728
container_issue 4
container_start_page e60728
container_title PloS one
container_volume 8
creator Chiu, Yu-Chieh
Kocagöz, Sevi
Larson, Jeffery C
Brey, Eric M
description Porous hydrogels of poly(ethylene glycol) (PEG) have been shown to facilitate vascularized tissue formation. However, PEG hydrogels exhibit limited degradation under physiological conditions which hinders their ultimate applicability for tissue engineering therapies. Introduction of poly(L-lactic acid) (PLLA) chains into the PEG backbone results in copolymers that exhibit degradation via hydrolysis that can be controlled, in part, by the copolymer conditions. In this study, porous, PEG-PLLA hydrogels were generated by solvent casting/particulate leaching and photopolymerization. The influence of polymer conditions on hydrogel architecture, degradation and mechanical properties was investigated. Autofluorescence exhibited by the hydrogels allowed for three-dimensional, non-destructive monitoring of hydrogel structure under fully swelled conditions. The initial pore size depended on particulate size but not polymer concentration, while degradation time was dependent on polymer concentration. Compressive modulus was a function of polymer concentration and decreased as the hydrogels degraded. Interestingly, pore size did not vary during degradation contrary to what has been observed in other polymer systems. These results provide a technique for generating porous, degradable PEG-PLLA hydrogels and insight into how the degradation, structure, and mechanical properties depend on synthesis conditions.
doi_str_mv 10.1371/journal.pone.0060728
format article
fullrecord <record><control><sourceid>proquest_plos_</sourceid><recordid>TN_cdi_plos_journals_1330895106</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_b3ea8940f6154dec9ff32fb561da8fc0</doaj_id><sourcerecordid>2949834941</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-db54ae6aeb6812565e7069b2b0390b16240a00744ebb3e484203c35c01a8f2723</originalsourceid><addsrcrecordid>eNptUk1v1DAQjRCIlsI_QBCJy_aQxR-xk1wqoapApZW4wNma2JOPlTcOdlIpR_457m5atYiTP-bNe_NGL0neU7KlvKCf9272A9jt6AbcEiJJwcoXyTmtOMskI_zlk_tZ8iaEPSGCl1K-Ts4YF7FUyfPkz80d2Bmm3g2pa9KxW0KvwaYwmPSAuoPh-By9G9FPPYYjynk3h3jYJd3g1C0WB0xbu2hnLzPtss0us6CnXqege3OZdovxrkUbUjP7fmhTg60Hc5R9m7xqwAZ8t54Xya-vNz-vv2e7H99ur7_sMi2YnDJTixxQAtaypExIgQWRVc1qwitSU8lyAoQUeY51zTEv82hbc6EJhbJhBeMXyccT72hdUOv2gqKck7ISlMiIuD0hjIO9Gn1_AL8oB706fjjfKog70BZVlICyykkjqcgN6qppOGtqIamJcppErqtVba4PaDQOkwf7jPR5Zeg71bo7xSWjZVVFgs1K4N3vGcOkDn3QaC0MGJcf52alyKP3MkI__QP9v7v8hNLeheCxeRyGEnWfqIcudZ8otSYqtn14auSx6SFC_C8o9csu</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1330895106</pqid></control><display><type>article</type><title>Evaluation of physical and mechanical properties of porous poly (ethylene glycol)-co-(L-lactic acid) hydrogels during degradation</title><source>Open Access: PubMed Central</source><source>Publicly Available Content Database</source><creator>Chiu, Yu-Chieh ; Kocagöz, Sevi ; Larson, Jeffery C ; Brey, Eric M</creator><contributor>Barbosa, Mário A.</contributor><creatorcontrib>Chiu, Yu-Chieh ; Kocagöz, Sevi ; Larson, Jeffery C ; Brey, Eric M ; Barbosa, Mário A.</creatorcontrib><description>Porous hydrogels of poly(ethylene glycol) (PEG) have been shown to facilitate vascularized tissue formation. However, PEG hydrogels exhibit limited degradation under physiological conditions which hinders their ultimate applicability for tissue engineering therapies. Introduction of poly(L-lactic acid) (PLLA) chains into the PEG backbone results in copolymers that exhibit degradation via hydrolysis that can be controlled, in part, by the copolymer conditions. In this study, porous, PEG-PLLA hydrogels were generated by solvent casting/particulate leaching and photopolymerization. The influence of polymer conditions on hydrogel architecture, degradation and mechanical properties was investigated. Autofluorescence exhibited by the hydrogels allowed for three-dimensional, non-destructive monitoring of hydrogel structure under fully swelled conditions. The initial pore size depended on particulate size but not polymer concentration, while degradation time was dependent on polymer concentration. Compressive modulus was a function of polymer concentration and decreased as the hydrogels degraded. Interestingly, pore size did not vary during degradation contrary to what has been observed in other polymer systems. These results provide a technique for generating porous, degradable PEG-PLLA hydrogels and insight into how the degradation, structure, and mechanical properties depend on synthesis conditions.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0060728</identifier><identifier>PMID: 23593296</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Acids ; Animals ; Biocompatible Materials ; Biology ; Biomechanical Phenomena ; Biomedical engineering ; Biomedical materials ; Cell Line ; Chemistry ; Degradation ; Engineering ; Fibroblasts - metabolism ; Focal Adhesions ; Hydrogels ; Hydrogels - chemistry ; Influence ; Leaching ; Materials Science ; Mechanical properties ; Mice ; Modulus of elasticity ; Particle Size ; Particulate size ; Particulates ; Photopolymerization ; Physical chemistry ; Polyethylene glycol ; Polyethylene Glycols - chemistry ; Polylactic acid ; Polymerization ; Polymers ; Pore size ; Porosity ; Tissue engineering</subject><ispartof>PloS one, 2013-04, Vol.8 (4), p.e60728-e60728</ispartof><rights>2013 Chiu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2013 Chiu et al 2013 Chiu et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-db54ae6aeb6812565e7069b2b0390b16240a00744ebb3e484203c35c01a8f2723</citedby><cites>FETCH-LOGICAL-c526t-db54ae6aeb6812565e7069b2b0390b16240a00744ebb3e484203c35c01a8f2723</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1330895106/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1330895106?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,25783,27957,27958,37047,37048,44625,53827,53829,75483</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23593296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Barbosa, Mário A.</contributor><creatorcontrib>Chiu, Yu-Chieh</creatorcontrib><creatorcontrib>Kocagöz, Sevi</creatorcontrib><creatorcontrib>Larson, Jeffery C</creatorcontrib><creatorcontrib>Brey, Eric M</creatorcontrib><title>Evaluation of physical and mechanical properties of porous poly (ethylene glycol)-co-(L-lactic acid) hydrogels during degradation</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Porous hydrogels of poly(ethylene glycol) (PEG) have been shown to facilitate vascularized tissue formation. However, PEG hydrogels exhibit limited degradation under physiological conditions which hinders their ultimate applicability for tissue engineering therapies. Introduction of poly(L-lactic acid) (PLLA) chains into the PEG backbone results in copolymers that exhibit degradation via hydrolysis that can be controlled, in part, by the copolymer conditions. In this study, porous, PEG-PLLA hydrogels were generated by solvent casting/particulate leaching and photopolymerization. The influence of polymer conditions on hydrogel architecture, degradation and mechanical properties was investigated. Autofluorescence exhibited by the hydrogels allowed for three-dimensional, non-destructive monitoring of hydrogel structure under fully swelled conditions. The initial pore size depended on particulate size but not polymer concentration, while degradation time was dependent on polymer concentration. Compressive modulus was a function of polymer concentration and decreased as the hydrogels degraded. Interestingly, pore size did not vary during degradation contrary to what has been observed in other polymer systems. These results provide a technique for generating porous, degradable PEG-PLLA hydrogels and insight into how the degradation, structure, and mechanical properties depend on synthesis conditions.</description><subject>Acids</subject><subject>Animals</subject><subject>Biocompatible Materials</subject><subject>Biology</subject><subject>Biomechanical Phenomena</subject><subject>Biomedical engineering</subject><subject>Biomedical materials</subject><subject>Cell Line</subject><subject>Chemistry</subject><subject>Degradation</subject><subject>Engineering</subject><subject>Fibroblasts - metabolism</subject><subject>Focal Adhesions</subject><subject>Hydrogels</subject><subject>Hydrogels - chemistry</subject><subject>Influence</subject><subject>Leaching</subject><subject>Materials Science</subject><subject>Mechanical properties</subject><subject>Mice</subject><subject>Modulus of elasticity</subject><subject>Particle Size</subject><subject>Particulate size</subject><subject>Particulates</subject><subject>Photopolymerization</subject><subject>Physical chemistry</subject><subject>Polyethylene glycol</subject><subject>Polyethylene Glycols - chemistry</subject><subject>Polylactic acid</subject><subject>Polymerization</subject><subject>Polymers</subject><subject>Pore size</subject><subject>Porosity</subject><subject>Tissue engineering</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptUk1v1DAQjRCIlsI_QBCJy_aQxR-xk1wqoapApZW4wNma2JOPlTcOdlIpR_457m5atYiTP-bNe_NGL0neU7KlvKCf9272A9jt6AbcEiJJwcoXyTmtOMskI_zlk_tZ8iaEPSGCl1K-Ts4YF7FUyfPkz80d2Bmm3g2pa9KxW0KvwaYwmPSAuoPh-By9G9FPPYYjynk3h3jYJd3g1C0WB0xbu2hnLzPtss0us6CnXqege3OZdovxrkUbUjP7fmhTg60Hc5R9m7xqwAZ8t54Xya-vNz-vv2e7H99ur7_sMi2YnDJTixxQAtaypExIgQWRVc1qwitSU8lyAoQUeY51zTEv82hbc6EJhbJhBeMXyccT72hdUOv2gqKck7ISlMiIuD0hjIO9Gn1_AL8oB706fjjfKog70BZVlICyykkjqcgN6qppOGtqIamJcppErqtVba4PaDQOkwf7jPR5Zeg71bo7xSWjZVVFgs1K4N3vGcOkDn3QaC0MGJcf52alyKP3MkI__QP9v7v8hNLeheCxeRyGEnWfqIcudZ8otSYqtn14auSx6SFC_C8o9csu</recordid><startdate>20130409</startdate><enddate>20130409</enddate><creator>Chiu, Yu-Chieh</creator><creator>Kocagöz, Sevi</creator><creator>Larson, Jeffery C</creator><creator>Brey, Eric M</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20130409</creationdate><title>Evaluation of physical and mechanical properties of porous poly (ethylene glycol)-co-(L-lactic acid) hydrogels during degradation</title><author>Chiu, Yu-Chieh ; Kocagöz, Sevi ; Larson, Jeffery C ; Brey, Eric M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-db54ae6aeb6812565e7069b2b0390b16240a00744ebb3e484203c35c01a8f2723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acids</topic><topic>Animals</topic><topic>Biocompatible Materials</topic><topic>Biology</topic><topic>Biomechanical Phenomena</topic><topic>Biomedical engineering</topic><topic>Biomedical materials</topic><topic>Cell Line</topic><topic>Chemistry</topic><topic>Degradation</topic><topic>Engineering</topic><topic>Fibroblasts - metabolism</topic><topic>Focal Adhesions</topic><topic>Hydrogels</topic><topic>Hydrogels - chemistry</topic><topic>Influence</topic><topic>Leaching</topic><topic>Materials Science</topic><topic>Mechanical properties</topic><topic>Mice</topic><topic>Modulus of elasticity</topic><topic>Particle Size</topic><topic>Particulate size</topic><topic>Particulates</topic><topic>Photopolymerization</topic><topic>Physical chemistry</topic><topic>Polyethylene glycol</topic><topic>Polyethylene Glycols - chemistry</topic><topic>Polylactic acid</topic><topic>Polymerization</topic><topic>Polymers</topic><topic>Pore size</topic><topic>Porosity</topic><topic>Tissue engineering</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chiu, Yu-Chieh</creatorcontrib><creatorcontrib>Kocagöz, Sevi</creatorcontrib><creatorcontrib>Larson, Jeffery C</creatorcontrib><creatorcontrib>Brey, Eric M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chiu, Yu-Chieh</au><au>Kocagöz, Sevi</au><au>Larson, Jeffery C</au><au>Brey, Eric M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of physical and mechanical properties of porous poly (ethylene glycol)-co-(L-lactic acid) hydrogels during degradation</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2013-04-09</date><risdate>2013</risdate><volume>8</volume><issue>4</issue><spage>e60728</spage><epage>e60728</epage><pages>e60728-e60728</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Competing Interests: The authors have declared that no competing interests exist.</notes><notes>Conceived and designed the experiments: YCC SK EMB. Performed the experiments: YCC SK JCL. Analyzed the data: YCC SK JCL EMB. Wrote the paper: YCC SK JCL EMB.</notes><abstract>Porous hydrogels of poly(ethylene glycol) (PEG) have been shown to facilitate vascularized tissue formation. However, PEG hydrogels exhibit limited degradation under physiological conditions which hinders their ultimate applicability for tissue engineering therapies. Introduction of poly(L-lactic acid) (PLLA) chains into the PEG backbone results in copolymers that exhibit degradation via hydrolysis that can be controlled, in part, by the copolymer conditions. In this study, porous, PEG-PLLA hydrogels were generated by solvent casting/particulate leaching and photopolymerization. The influence of polymer conditions on hydrogel architecture, degradation and mechanical properties was investigated. Autofluorescence exhibited by the hydrogels allowed for three-dimensional, non-destructive monitoring of hydrogel structure under fully swelled conditions. The initial pore size depended on particulate size but not polymer concentration, while degradation time was dependent on polymer concentration. Compressive modulus was a function of polymer concentration and decreased as the hydrogels degraded. Interestingly, pore size did not vary during degradation contrary to what has been observed in other polymer systems. These results provide a technique for generating porous, degradable PEG-PLLA hydrogels and insight into how the degradation, structure, and mechanical properties depend on synthesis conditions.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23593296</pmid><doi>10.1371/journal.pone.0060728</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2013-04, Vol.8 (4), p.e60728-e60728
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_1330895106
source Open Access: PubMed Central; Publicly Available Content Database
subjects Acids
Animals
Biocompatible Materials
Biology
Biomechanical Phenomena
Biomedical engineering
Biomedical materials
Cell Line
Chemistry
Degradation
Engineering
Fibroblasts - metabolism
Focal Adhesions
Hydrogels
Hydrogels - chemistry
Influence
Leaching
Materials Science
Mechanical properties
Mice
Modulus of elasticity
Particle Size
Particulate size
Particulates
Photopolymerization
Physical chemistry
Polyethylene glycol
Polyethylene Glycols - chemistry
Polylactic acid
Polymerization
Polymers
Pore size
Porosity
Tissue engineering
title Evaluation of physical and mechanical properties of porous poly (ethylene glycol)-co-(L-lactic acid) hydrogels during degradation
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T09%3A39%3A48IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evaluation%20of%20physical%20and%20mechanical%20properties%20of%20porous%20poly%20(ethylene%20glycol)-co-(L-lactic%20acid)%20hydrogels%20during%20degradation&rft.jtitle=PloS%20one&rft.au=Chiu,%20Yu-Chieh&rft.date=2013-04-09&rft.volume=8&rft.issue=4&rft.spage=e60728&rft.epage=e60728&rft.pages=e60728-e60728&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0060728&rft_dat=%3Cproquest_plos_%3E2949834941%3C/proquest_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c526t-db54ae6aeb6812565e7069b2b0390b16240a00744ebb3e484203c35c01a8f2723%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1330895106&rft_id=info:pmid/23593296&rfr_iscdi=true