A genome-wide analysis of populations from European Russia reveals a new pole of genetic diversity in northern Europe

Several studies examined the fine-scale structure of human genetic variation in Europe. However, the European sets analyzed represent mainly northern, western, central, and southern Europe. Here, we report an analysis of approximately 166,000 single nucleotide polymorphisms in populations from easte...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2013-03, Vol.8 (3), p.e58552-e58552
Main Authors: Khrunin, Andrey V, Khokhrin, Denis V, Filippova, Irina N, Esko, Tõnu, Nelis, Mari, Bebyakova, Natalia A, Bolotova, Natalia L, Klovins, Janis, Nikitina-Zake, Liene, Rehnström, Karola, Ripatti, Samuli, Schreiber, Stefan, Franke, Andre, Macek, Milan, Krulišová, Veronika, Lubinski, Jan, Metspalu, Andres, Limborska, Svetlana A
Format: Article
Language:English
Subjects:
Biodiversity
Biology
Biomedical research
Chromosomes
Cluster Analysis
Comparative analysis
Ethnicity - genetics
Europe
Genetic aspects
Genetic diversity
Genetic Variation
Genetics, Population
Genome-Wide Association Study
Genomes
Genomics
Genotype
Geography
Humans
Medicine
Minority & ethnic groups
Mitochondrial DNA
Poles
Polymorphism, Single Nucleotide
Population genetics
Population studies
Populations
Principal Component Analysis
Russia
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Studies
White People - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Several studies examined the fine-scale structure of human genetic variation in Europe. However, the European sets analyzed represent mainly northern, western, central, and southern Europe. Here, we report an analysis of approximately 166,000 single nucleotide polymorphisms in populations from eastern (northeastern) Europe: four Russian populations from European Russia, and three populations from the northernmost Finno-Ugric ethnicities (Veps and two contrast groups of Komi people). These were compared with several reference European samples, including Finns, Estonians, Latvians, Poles, Czechs, Germans, and Italians. The results obtained demonstrated genetic heterogeneity of populations living in the region studied. Russians from the central part of European Russia (Tver, Murom, and Kursk) exhibited similarities with populations from central-eastern Europe, and were distant from Russian sample from the northern Russia (Mezen district, Archangelsk region). Komi samples, especially Izhemski Komi, were significantly different from all other populations studied. These can be considered as a second pole of genetic diversity in northern Europe (in addition to the pole, occupied by Finns), as they had a distinct ancestry component. Russians from Mezen and the Finnic-speaking Veps were positioned between the two poles, but differed from each other in the proportions of Komi and Finnic ancestries. In general, our data provides a more complete genetic map of Europe accounting for the diversity in its most eastern (northeastern) populations.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0058552