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Retrospective study of the incidence of HFMD and seroepidemiology of antibodies against EV71 and CoxA16 in prenatal women and their infants
Hand, foot, and mouth disease (HFMD) has been emerging as an important public problem over the past few decades, especially in Asian and Pacific regions. A national program on EV71 vaccine development against HFMD was initiated in China, in 2008, which called for a need for seroepidemiological study...
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| Published in: | PloS one 2012-05, Vol.7 (5), p.e37206 |
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| creator | Zhu, Feng-Cai Liang, Zheng-Lun Meng, Fan-Yue Zeng, Ying Mao, Qun-Ying Chu, Kai Song, Xue-Fang Yao, Xin Li, Jing-Xin Ji, Hong Zhang, Yi-Ju Li, Liang Pan, Hong-Xing Xu, Ke Dai, Wei-Ming Zhang, Wei-Wei Deng, Fei Wang, Hua Wang, Jun-Zhi |
| description | Hand, foot, and mouth disease (HFMD) has been emerging as an important public problem over the past few decades, especially in Asian and Pacific regions. A national program on EV71 vaccine development against HFMD was initiated in China, in 2008, which called for a need for seroepidemiological study for the target population.
This was a retrospective study conducted in Jiangsu Province, in October, 2010. We measured the neutralizing antibodies against EV71 and CoxA16 in a cohort of infants aged of 2, 7, 12, and 27-38 months and their mothers just before delivery. Series sera samples from 975 infants and 555 mothers were collected and analyzed. Questionnaires on the history of HFMD were completed in the survey. A total of 143 HFMD cases were collected, but only 11.2% were reported to the National Infectious Disease Information Management System. The level of maternal antibody titers decreased dramatically during the first 7 month and remained at a relatively low level thereafter. But it increased significantly from month 12 to months 27-38. The accumulate incidence density of HFMD demonstrated a significant increase after 14 months of age, resulting in a accumulate incidence density of 50.8/1000 person-years in survey period. Seropositivity of EV71 antibody in infants at the age of 2 months seems to demonstrate a protective effect against HFMD.
High seropositive rate of EV71 and CoxA16 antibody was found in prenatal women in mainland China, and there is a need to enhance the HFMD case management and the current surveillance system. We suggest that infants aged between 6 to 14 months should have the first priority to receive EV71 vaccine. |
| doi_str_mv | 10.1371/journal.pone.0037206 |
| format | article |
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This was a retrospective study conducted in Jiangsu Province, in October, 2010. We measured the neutralizing antibodies against EV71 and CoxA16 in a cohort of infants aged of 2, 7, 12, and 27-38 months and their mothers just before delivery. Series sera samples from 975 infants and 555 mothers were collected and analyzed. Questionnaires on the history of HFMD were completed in the survey. A total of 143 HFMD cases were collected, but only 11.2% were reported to the National Infectious Disease Information Management System. The level of maternal antibody titers decreased dramatically during the first 7 month and remained at a relatively low level thereafter. But it increased significantly from month 12 to months 27-38. The accumulate incidence density of HFMD demonstrated a significant increase after 14 months of age, resulting in a accumulate incidence density of 50.8/1000 person-years in survey period. Seropositivity of EV71 antibody in infants at the age of 2 months seems to demonstrate a protective effect against HFMD.
High seropositive rate of EV71 and CoxA16 antibody was found in prenatal women in mainland China, and there is a need to enhance the HFMD case management and the current surveillance system. We suggest that infants aged between 6 to 14 months should have the first priority to receive EV71 vaccine.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0037206</identifier><identifier>PMID: 22662137</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adult ; Analysis ; Antibodies ; Antibodies, Neutralizing - blood ; Antibodies, Viral - blood ; Antigens ; Child, Preschool ; China - epidemiology ; Communicable diseases ; Coxsackievirus infections ; Data base management systems ; Disease control ; Disease prevention ; Enterovirus ; Enterovirus A, Human - immunology ; Epidemics ; Epidemiology ; Female ; Food ; Guardians ; Hand, Foot and Mouth Disease - epidemiology ; Hand, Foot and Mouth Disease - immunology ; Hand-foot-and-mouth disease ; Health care ; Humans ; Immunoglobulins ; Incidence ; Infant ; Infants ; Infections ; Infectious diseases ; Information management ; Information systems ; Laboratories ; Low level ; Male ; Maternal Exposure ; Medicine ; Newborn babies ; Pathogenesis ; Poliomyelitis ; Population studies ; Pregnancy ; Pregnant women ; Retrospective Studies ; Seroepidemiologic Studies ; Seroepidemiology ; Vaccine development ; Vaccines ; Womens health ; Working groups ; Young Adult</subject><ispartof>PloS one, 2012-05, Vol.7 (5), p.e37206</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>2012 Zhu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Zhu et al. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-88506d6f6a97d62a723478927e4a30ca95694a8710968a23cf7d761014ad21393</citedby><cites>FETCH-LOGICAL-c692t-88506d6f6a97d62a723478927e4a30ca95694a8710968a23cf7d761014ad21393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1325012823/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1325012823?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,25783,27957,27958,37047,44625,53827,53829,75483</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22662137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Yu, Xiao-Fang</contributor><creatorcontrib>Zhu, Feng-Cai</creatorcontrib><creatorcontrib>Liang, Zheng-Lun</creatorcontrib><creatorcontrib>Meng, Fan-Yue</creatorcontrib><creatorcontrib>Zeng, Ying</creatorcontrib><creatorcontrib>Mao, Qun-Ying</creatorcontrib><creatorcontrib>Chu, Kai</creatorcontrib><creatorcontrib>Song, Xue-Fang</creatorcontrib><creatorcontrib>Yao, Xin</creatorcontrib><creatorcontrib>Li, Jing-Xin</creatorcontrib><creatorcontrib>Ji, Hong</creatorcontrib><creatorcontrib>Zhang, Yi-Ju</creatorcontrib><creatorcontrib>Li, Liang</creatorcontrib><creatorcontrib>Pan, Hong-Xing</creatorcontrib><creatorcontrib>Xu, Ke</creatorcontrib><creatorcontrib>Dai, Wei-Ming</creatorcontrib><creatorcontrib>Zhang, Wei-Wei</creatorcontrib><creatorcontrib>Deng, Fei</creatorcontrib><creatorcontrib>Wang, Hua</creatorcontrib><creatorcontrib>Wang, Jun-Zhi</creatorcontrib><title>Retrospective study of the incidence of HFMD and seroepidemiology of antibodies against EV71 and CoxA16 in prenatal women and their infants</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Hand, foot, and mouth disease (HFMD) has been emerging as an important public problem over the past few decades, especially in Asian and Pacific regions. A national program on EV71 vaccine development against HFMD was initiated in China, in 2008, which called for a need for seroepidemiological study for the target population.
This was a retrospective study conducted in Jiangsu Province, in October, 2010. We measured the neutralizing antibodies against EV71 and CoxA16 in a cohort of infants aged of 2, 7, 12, and 27-38 months and their mothers just before delivery. Series sera samples from 975 infants and 555 mothers were collected and analyzed. Questionnaires on the history of HFMD were completed in the survey. A total of 143 HFMD cases were collected, but only 11.2% were reported to the National Infectious Disease Information Management System. The level of maternal antibody titers decreased dramatically during the first 7 month and remained at a relatively low level thereafter. But it increased significantly from month 12 to months 27-38. The accumulate incidence density of HFMD demonstrated a significant increase after 14 months of age, resulting in a accumulate incidence density of 50.8/1000 person-years in survey period. Seropositivity of EV71 antibody in infants at the age of 2 months seems to demonstrate a protective effect against HFMD.
High seropositive rate of EV71 and CoxA16 antibody was found in prenatal women in mainland China, and there is a need to enhance the HFMD case management and the current surveillance system. We suggest that infants aged between 6 to 14 months should have the first priority to receive EV71 vaccine.</description><subject>Adult</subject><subject>Analysis</subject><subject>Antibodies</subject><subject>Antibodies, Neutralizing - blood</subject><subject>Antibodies, Viral - blood</subject><subject>Antigens</subject><subject>Child, Preschool</subject><subject>China - epidemiology</subject><subject>Communicable diseases</subject><subject>Coxsackievirus infections</subject><subject>Data base management systems</subject><subject>Disease control</subject><subject>Disease prevention</subject><subject>Enterovirus</subject><subject>Enterovirus A, Human - immunology</subject><subject>Epidemics</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Food</subject><subject>Guardians</subject><subject>Hand, Foot and Mouth Disease - epidemiology</subject><subject>Hand, Foot and Mouth Disease - immunology</subject><subject>Hand-foot-and-mouth disease</subject><subject>Health care</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Incidence</subject><subject>Infant</subject><subject>Infants</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Information management</subject><subject>Information systems</subject><subject>Laboratories</subject><subject>Low level</subject><subject>Male</subject><subject>Maternal Exposure</subject><subject>Medicine</subject><subject>Newborn babies</subject><subject>Pathogenesis</subject><subject>Poliomyelitis</subject><subject>Population studies</subject><subject>Pregnancy</subject><subject>Pregnant women</subject><subject>Retrospective Studies</subject><subject>Seroepidemiologic Studies</subject><subject>Seroepidemiology</subject><subject>Vaccine development</subject><subject>Vaccines</subject><subject>Womens health</subject><subject>Working groups</subject><subject>Young 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Premium</collection><collection>ProQuest Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials Science Collection</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering Collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhu, Feng-Cai</au><au>Liang, Zheng-Lun</au><au>Meng, Fan-Yue</au><au>Zeng, Ying</au><au>Mao, Qun-Ying</au><au>Chu, Kai</au><au>Song, Xue-Fang</au><au>Yao, Xin</au><au>Li, Jing-Xin</au><au>Ji, Hong</au><au>Zhang, Yi-Ju</au><au>Li, Liang</au><au>Pan, Hong-Xing</au><au>Xu, Ke</au><au>Dai, Wei-Ming</au><au>Zhang, Wei-Wei</au><au>Deng, Fei</au><au>Wang, Hua</au><au>Wang, Jun-Zhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retrospective study of the incidence of HFMD and seroepidemiology of antibodies against EV71 and CoxA16 in prenatal women and their infants</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-05-25</date><risdate>2012</risdate><volume>7</volume><issue>5</issue><spage>e37206</spage><pages>e37206-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><notes>Conceived and designed the experiments: F-CZ Z-LL F-YM J-ZW. Performed the experiments: F-YM Q-YM KC XY HJ Y-JZ LL H-XP KX W-MD W-WZ FD. Analyzed the data: J-XL. Contributed reagents/materials/analysis tools: Z-LL HW J-ZW YZ X-FS. Wrote the paper: F-CZ Z-LL F-YM J-ZW J-XL.</notes><abstract>Hand, foot, and mouth disease (HFMD) has been emerging as an important public problem over the past few decades, especially in Asian and Pacific regions. A national program on EV71 vaccine development against HFMD was initiated in China, in 2008, which called for a need for seroepidemiological study for the target population.
This was a retrospective study conducted in Jiangsu Province, in October, 2010. We measured the neutralizing antibodies against EV71 and CoxA16 in a cohort of infants aged of 2, 7, 12, and 27-38 months and their mothers just before delivery. Series sera samples from 975 infants and 555 mothers were collected and analyzed. Questionnaires on the history of HFMD were completed in the survey. A total of 143 HFMD cases were collected, but only 11.2% were reported to the National Infectious Disease Information Management System. The level of maternal antibody titers decreased dramatically during the first 7 month and remained at a relatively low level thereafter. But it increased significantly from month 12 to months 27-38. The accumulate incidence density of HFMD demonstrated a significant increase after 14 months of age, resulting in a accumulate incidence density of 50.8/1000 person-years in survey period. Seropositivity of EV71 antibody in infants at the age of 2 months seems to demonstrate a protective effect against HFMD.
High seropositive rate of EV71 and CoxA16 antibody was found in prenatal women in mainland China, and there is a need to enhance the HFMD case management and the current surveillance system. We suggest that infants aged between 6 to 14 months should have the first priority to receive EV71 vaccine.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>22662137</pmid><doi>10.1371/journal.pone.0037206</doi><tpages>e37206</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-05, Vol.7 (5), p.e37206 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1325012823 |
| source | PubMed Central (Open access); ProQuest - Publicly Available Content Database |
| subjects | Adult Analysis Antibodies Antibodies, Neutralizing - blood Antibodies, Viral - blood Antigens Child, Preschool China - epidemiology Communicable diseases Coxsackievirus infections Data base management systems Disease control Disease prevention Enterovirus Enterovirus A, Human - immunology Epidemics Epidemiology Female Food Guardians Hand, Foot and Mouth Disease - epidemiology Hand, Foot and Mouth Disease - immunology Hand-foot-and-mouth disease Health care Humans Immunoglobulins Incidence Infant Infants Infections Infectious diseases Information management Information systems Laboratories Low level Male Maternal Exposure Medicine Newborn babies Pathogenesis Poliomyelitis Population studies Pregnancy Pregnant women Retrospective Studies Seroepidemiologic Studies Seroepidemiology Vaccine development Vaccines Womens health Working groups Young Adult |
| title | Retrospective study of the incidence of HFMD and seroepidemiology of antibodies against EV71 and CoxA16 in prenatal women and their infants |
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