Health related quality of life among patients with tuberculosis and HIV in Thailand

Health utilities of tuberculosis (TB) patients may be diminished by side effects from medication, prolonged treatment duration, physical effects of the disease itself, and social stigma attached to the disease. We collected health utility data from Thai patients who were on TB treatment or had been...

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Bibliographic Details
Published in:PloS one 2012-01, Vol.7 (1), p.e29775-e29775
Main Authors: Kittikraisak, Wanitchaya, Kingkaew, Pritaporn, Teerawattananon, Yot, Yothasamut, Jomkwan, Natesuwan, Supalert, Manosuthi, Weerawat, Chongsuvivatwong, Virasakdi, Whitehead, Sara J
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
Analysis
Care and treatment
Correlation analysis
Correlation coefficient
Correlation coefficients
Data collection
Demography
Drug resistance
Economic models
Female
Health
Health services
Health Status Indicators
HIV
HIV Infections - complications
HIV Infections - epidemiology
HIV patients
Human immunodeficiency virus
Humans
Income
Male
Mathematical analysis
Medical diagnosis
Medical treatment
Medicine
Middle Aged
Models, Biological
Multidrug resistance
Multivariate Analysis
Pain Measurement
Patients
Quality of Life
Regression Analysis
Regression models
Side effects
Social and Behavioral Sciences
Studies
Surveys
Surveys and Questionnaires
Thailand - epidemiology
Tuberculosis
Tuberculosis - complications
Tuberculosis - epidemiology
Utilities
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Summary:Health utilities of tuberculosis (TB) patients may be diminished by side effects from medication, prolonged treatment duration, physical effects of the disease itself, and social stigma attached to the disease. We collected health utility data from Thai patients who were on TB treatment or had been successfully treated for TB for the purpose of economic modeling. Structured questionnaire and EuroQol (EQ-5D) and EuroQol visual analog scale (EQ-VAS) instruments were used as data collection tools. We compared utility of patients with two co-morbidities calculated using multiplicative model (U(CAL)) with the direct measures and fitted Tobit regression models to examine factors predictive of health utility and to assess difference in health utilities of patients in various medical conditions. Of 222 patients analyzed, 138 (62%) were male; median age at enrollment was 40 years (interquartile range [IQR], 35-47). Median monthly household income was 6,000 Baht (187 US$; IQR, 4,000-15,000 Baht [125-469 US$]). Concordance correlation coefficient between utilities measured using EQ-5D and EQ-VAS (U(EQ-5D) and U(VAS), respectively) was 0.6. U(CAL) for HIV-infected TB patients was statistically different from the measured U(EQ-5D) (p-value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0029775