Deficient Gastric Lipase Secretion in Pancreatic Insufficiency

Background: Gastrin is an important stimulator of gastric lipase secretion in man. In advanced pancreatic insufficiency gastric lipases might compensate for the lack of pancreatic lipases, hut the role of gastrin in such compensation remains to be evaluated. The aim of this study was to examine the...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 1997, Vol.32 (3), p.268-272
Main Authors: Wøjdemann, M., Olsen, O., Larsen, S., Sternby, B., Rehfeld, J. F.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Case-Control Studies
Cholecystokinin
Cholecystokinin - blood
Exocrine Pancreatic Insufficiency - enzymology
Exocrine Pancreatic Insufficiency - etiology
Female
gastric lipase
Gastric Mucosa - enzymology
gastrin
Gastrins - blood
Gastrins - physiology
Gastroenterology. Liver. Pancreas. Abdomen
Hormones - therapeutic use
Humans
Lipase - biosynthesis
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Male
Medical sciences
Middle Aged
Other diseases. Semiology
pancreatitis
Pancreatitis, Alcoholic - complications
secretin
Secretin - blood
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Summary:Background: Gastrin is an important stimulator of gastric lipase secretion in man. In advanced pancreatic insufficiency gastric lipases might compensate for the lack of pancreatic lipases, hut the role of gastrin in such compensation remains to be evaluated. The aim of this study was to examine the effect of gastrin on the gastric lipase secretion in patients with pancreatic insufficiency. Methods: Eight patients with pancreatic insufficiency secondary to alcohol abuse were studied, and six healthy subjects volunteered as controls for the study. All volunteers received identical doses of intravenous gastrin-17 (10, 30, and 60 pmol/kg/h). The gastric content was measured, using a nasogastric tube for aspiration, and the amount and activity of gastric lipase output were determined. Plasma concentrations of gastrin, secretin, and cholecystokinin were measured by radioimmunoassays. Results: The increased plasma levels of gastrin were accompanied by a dose-dependent increase in the amount and activity of gastric lipase in controls, but in the patients the response was almost abolished. Conclusions: Gastrin in postprandial concentrations does not influence the secretion of gastric lipase in patients with pancreatic insufficiency due to chronic pancreatitis.
ISSN:0036-5521
1502-7708
DOI:10.3109/00365529709000205