Mycoplasma fermentans glycolipid-antigen as a pathogen of rheumatoid arthritis

Mycoplasma fermentans has been suspected as one of the causative pathogenic microorganisms of rheumatoid arthritis (RA) however, the pathogenic mechanism is still unclear. We, previously, reported that glycolipid-antigens (GGPL-I and III) are the major antigens of M. fermentans. Monoclonal antibody...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2008-05, Vol.369 (2), p.561-566
Main Authors: Kawahito, Yutaka, Ichinose, Sizuko, Sano, Hajime, Tsubouchi, Yasunori, Kohno, Masataka, Yoshikawa, Toshikazu, Tokunaga, Daisaku, Hojo, Tatsuya, Harasawa, Ryo, Nakano, Teruaki, Matsuda, Kazuhiro
Format: Article
Language:English
Subjects:
60 APPLIED LIFE SCIENCES
Aged
Antigen presentation
ANTIGENS
Arthritis, Rheumatoid - immunology
Arthritis, Rheumatoid - microbiology
BLOOD
CD1
DISEASES
ENDOPLASMIC RETICULUM
Female
FIBROBLASTS
Glycolipid
Glycolipid-antigen
Glycolipids - immunology
Humans
Lipid antigen
LIPIDS
Male
MICROSCOPY
Middle Aged
MONOCLONAL ANTIBODIES
MYCOPLASMA
Mycoplasma fermentans
Mycoplasma fermentans - metabolism
NKT
PATHOGENESIS
PATHOGENS
PATIENTS
Phosphocholine-containing glycolipid
RHEUMATIC DISEASES
Rheumatoid arthritis
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Summary:Mycoplasma fermentans has been suspected as one of the causative pathogenic microorganisms of rheumatoid arthritis (RA) however, the pathogenic mechanism is still unclear. We, previously, reported that glycolipid-antigens (GGPL-I and III) are the major antigens of M. fermentans. Monoclonal antibody against the GGPL-III could detect the existence of the GGPL-III antigens in synovial tissues from RA patients. GGPL-III antigens were detected in 38.1% (32/84) of RA patient’s tissues, but not in osteoarthritis (OA) and normal synovial tissues. Immunoelectron microscopy revealed that a part of GGPL-III antigens are located at endoplasmic reticulum. GGPL-III significantly induced TNF-α and IL-6 production from peripheral blood mononulear cells, and also proliferation of synovial fibroblasts. Further study is necessary to prove that M. fermentans is a causative microorganism of RA; however, the new mechanisms of disease pathogenesis provides hope for the development of effective and safe immunotherapeutic strategies based on the lipid-antigen, GGPL-III, in the near future.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2008.02.079