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Boron delivery with liposomes for boron neutron capture therapy (BNCT): biodistribution studies in an experimental model of oral cancer demonstrating therapeutic potential
Boron neutron capture therapy (BNCT) combines selective accumulation of 10 B carriers in tumor tissue with subsequent neutron irradiation. We previously demonstrated the therapeutic efficacy of BNCT in the hamster cheek pouch oral cancer model. Optimization of BNCT depends largely on improving boron...
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| Published in: | Radiation and environmental biophysics 2012-05, Vol.51 (2), p.195-204 |
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| Main Authors: | , , , , , , , , , , , |
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| container_end_page | 204 |
| container_issue | 2 |
| container_start_page | 195 |
| container_title | Radiation and environmental biophysics |
| container_volume | 51 |
| creator | Heber, Elisa M. Kueffer, Peter J. Lee, Mark W. Hawthorne, M. Frederick Garabalino, Marcela A. Molinari, Ana J. Nigg, David W. Bauer, William Hughes, Andrea Monti Pozzi, Emiliano C. C. Trivillin, Verónica A. Schwint, Amanda E. |
| description | Boron neutron capture therapy (BNCT) combines selective accumulation of
10
B carriers in tumor tissue with subsequent neutron irradiation. We previously demonstrated the therapeutic efficacy of BNCT in the hamster cheek pouch oral cancer model. Optimization of BNCT depends largely on improving boron targeting to tumor cells. Seeking to maximize the potential of BNCT for the treatment for head and neck cancer, the aim of the present study was to perform boron biodistribution studies in the oral cancer model employing two different liposome formulations that were previously tested for a different pathology, i.e., in experimental mammary carcinoma in BALB/c mice: (1) MAC: liposomes incorporating K[
nido
-7-CH
3
(CH
2
)
15
-7,8-C
2
B
9
H
11
] in the bilayer membrane and encapsulating a hypertonic buffer, administered intravenously at 6 mg B per kg body weight, and (2) MAC-TAC: liposomes incorporating K[
nido
-7-CH
3
(CH
2
)
15
-7,8-C
2
B
9
H
11
] in the bilayer membrane and encapsulating a concentrated aqueous solution of the hydrophilic species Na
3
[
ae
-B
20
H
17
NH
3
], administered intravenously at 18 mg B per kg body weight. Samples of tumor, precancerous and normal pouch tissue, spleen, liver, kidney, and blood were taken at different times post-administration and processed to measure boron content by inductively coupled plasma mass spectrometry. No ostensible clinical toxic effects were observed with the selected formulations. Both MAC and MAC-TAC delivered boron selectively to tumor tissue. Absolute tumor values for MAC-TAC peaked to 66.6 ± 16.1 ppm at 48 h and to 43.9 ± 17.6 ppm at 54 h with very favorable ratios of tumor boron relative to precancerous and normal tissue, making these protocols particularly worthy of radiobiological assessment. Boron concentration values obtained would result in therapeutic BNCT doses in tumor without exceeding radiotolerance in precancerous/normal tissue at the thermal neutron facility at RA-3. |
| doi_str_mv | 10.1007/s00411-011-0399-0 |
| format | article |
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10
B carriers in tumor tissue with subsequent neutron irradiation. We previously demonstrated the therapeutic efficacy of BNCT in the hamster cheek pouch oral cancer model. Optimization of BNCT depends largely on improving boron targeting to tumor cells. Seeking to maximize the potential of BNCT for the treatment for head and neck cancer, the aim of the present study was to perform boron biodistribution studies in the oral cancer model employing two different liposome formulations that were previously tested for a different pathology, i.e., in experimental mammary carcinoma in BALB/c mice: (1) MAC: liposomes incorporating K[
nido
-7-CH
3
(CH
2
)
15
-7,8-C
2
B
9
H
11
] in the bilayer membrane and encapsulating a hypertonic buffer, administered intravenously at 6 mg B per kg body weight, and (2) MAC-TAC: liposomes incorporating K[
nido
-7-CH
3
(CH
2
)
15
-7,8-C
2
B
9
H
11
] in the bilayer membrane and encapsulating a concentrated aqueous solution of the hydrophilic species Na
3
[
ae
-B
20
H
17
NH
3
], administered intravenously at 18 mg B per kg body weight. Samples of tumor, precancerous and normal pouch tissue, spleen, liver, kidney, and blood were taken at different times post-administration and processed to measure boron content by inductively coupled plasma mass spectrometry. No ostensible clinical toxic effects were observed with the selected formulations. Both MAC and MAC-TAC delivered boron selectively to tumor tissue. Absolute tumor values for MAC-TAC peaked to 66.6 ± 16.1 ppm at 48 h and to 43.9 ± 17.6 ppm at 54 h with very favorable ratios of tumor boron relative to precancerous and normal tissue, making these protocols particularly worthy of radiobiological assessment. Boron concentration values obtained would result in therapeutic BNCT doses in tumor without exceeding radiotolerance in precancerous/normal tissue at the thermal neutron facility at RA-3.</description><identifier>ISSN: 0301-634X</identifier><identifier>EISSN: 1432-2099</identifier><identifier>DOI: 10.1007/s00411-011-0399-0</identifier><identifier>PMID: 22271404</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Animals ; AQUEOUS SOLUTIONS ; BASIC BIOLOGICAL SCIENCES ; Biological and Medical Physics ; Biophysics ; BLOOD ; BORON ; Boron - administration & dosage ; Boron - pharmacokinetics ; boron neutron capture therapy ; Boron Neutron Capture Therapy - methods ; CARCINOMAS ; Cricetinae ; Disease Models, Animal ; Drug Carriers - administration & dosage ; Drug Carriers - pharmacokinetics ; Ecosystems ; Effects of Radiation/Radiation Protection ; Environmental Physics ; HAMSTERS ; IRRADIATION ; Isotopes - administration & dosage ; LIPOSOMES ; Liposomes - administration & dosage ; Liposomes - pharmacokinetics ; LIVER ; MASS SPECTROSCOPY ; MEMBRANES ; MICE ; Monitoring/Environmental Analysis ; Mouth Neoplasms - chemically induced ; Mouth Neoplasms - metabolism ; Mouth Neoplasms - pathology ; Mouth Neoplasms - radiotherapy ; NEOPLASMS ; NEUTRON CAPTURE THERAPY ; NEUTRONS ; OPTIMIZATION ; Oral cancer ; Original Paper ; PATHOLOGY ; Physics ; Physics and Astronomy ; RADIOLOGY AND NUCLEAR MEDICINE ; SPLEEN ; THERMAL NEUTRONS ; Tissue Distribution ; TUMOR CELLS</subject><ispartof>Radiation and environmental biophysics, 2012-05, Vol.51 (2), p.195-204</ispartof><rights>Springer-Verlag 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c399t-1828447db0ab5ac56d54b8ff172422e66394985f06fdaf087aa59e554c52dc173</citedby><cites>FETCH-LOGICAL-c399t-1828447db0ab5ac56d54b8ff172422e66394985f06fdaf087aa59e554c52dc173</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22271404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/1044919$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Heber, Elisa M.</creatorcontrib><creatorcontrib>Kueffer, Peter J.</creatorcontrib><creatorcontrib>Lee, Mark W.</creatorcontrib><creatorcontrib>Hawthorne, M. Frederick</creatorcontrib><creatorcontrib>Garabalino, Marcela A.</creatorcontrib><creatorcontrib>Molinari, Ana J.</creatorcontrib><creatorcontrib>Nigg, David W.</creatorcontrib><creatorcontrib>Bauer, William</creatorcontrib><creatorcontrib>Hughes, Andrea Monti</creatorcontrib><creatorcontrib>Pozzi, Emiliano C. C.</creatorcontrib><creatorcontrib>Trivillin, Verónica A.</creatorcontrib><creatorcontrib>Schwint, Amanda E.</creatorcontrib><creatorcontrib>Idaho National Laboratory (INL)</creatorcontrib><title>Boron delivery with liposomes for boron neutron capture therapy (BNCT): biodistribution studies in an experimental model of oral cancer demonstrating therapeutic potential</title><title>Radiation and environmental biophysics</title><addtitle>Radiat Environ Biophys</addtitle><addtitle>Radiat Environ Biophys</addtitle><description>Boron neutron capture therapy (BNCT) combines selective accumulation of
10
B carriers in tumor tissue with subsequent neutron irradiation. We previously demonstrated the therapeutic efficacy of BNCT in the hamster cheek pouch oral cancer model. Optimization of BNCT depends largely on improving boron targeting to tumor cells. Seeking to maximize the potential of BNCT for the treatment for head and neck cancer, the aim of the present study was to perform boron biodistribution studies in the oral cancer model employing two different liposome formulations that were previously tested for a different pathology, i.e., in experimental mammary carcinoma in BALB/c mice: (1) MAC: liposomes incorporating K[
nido
-7-CH
3
(CH
2
)
15
-7,8-C
2
B
9
H
11
] in the bilayer membrane and encapsulating a hypertonic buffer, administered intravenously at 6 mg B per kg body weight, and (2) MAC-TAC: liposomes incorporating K[
nido
-7-CH
3
(CH
2
)
15
-7,8-C
2
B
9
H
11
] in the bilayer membrane and encapsulating a concentrated aqueous solution of the hydrophilic species Na
3
[
ae
-B
20
H
17
NH
3
], administered intravenously at 18 mg B per kg body weight. Samples of tumor, precancerous and normal pouch tissue, spleen, liver, kidney, and blood were taken at different times post-administration and processed to measure boron content by inductively coupled plasma mass spectrometry. No ostensible clinical toxic effects were observed with the selected formulations. Both MAC and MAC-TAC delivered boron selectively to tumor tissue. Absolute tumor values for MAC-TAC peaked to 66.6 ± 16.1 ppm at 48 h and to 43.9 ± 17.6 ppm at 54 h with very favorable ratios of tumor boron relative to precancerous and normal tissue, making these protocols particularly worthy of radiobiological assessment. Boron concentration values obtained would result in therapeutic BNCT doses in tumor without exceeding radiotolerance in precancerous/normal tissue at the thermal neutron facility at RA-3.</description><subject>Animals</subject><subject>AQUEOUS SOLUTIONS</subject><subject>BASIC BIOLOGICAL SCIENCES</subject><subject>Biological and Medical Physics</subject><subject>Biophysics</subject><subject>BLOOD</subject><subject>BORON</subject><subject>Boron - administration & dosage</subject><subject>Boron - pharmacokinetics</subject><subject>boron neutron capture therapy</subject><subject>Boron Neutron Capture Therapy - methods</subject><subject>CARCINOMAS</subject><subject>Cricetinae</subject><subject>Disease Models, Animal</subject><subject>Drug Carriers - administration & dosage</subject><subject>Drug Carriers - pharmacokinetics</subject><subject>Ecosystems</subject><subject>Effects of Radiation/Radiation Protection</subject><subject>Environmental Physics</subject><subject>HAMSTERS</subject><subject>IRRADIATION</subject><subject>Isotopes - administration & dosage</subject><subject>LIPOSOMES</subject><subject>Liposomes - administration & dosage</subject><subject>Liposomes - pharmacokinetics</subject><subject>LIVER</subject><subject>MASS SPECTROSCOPY</subject><subject>MEMBRANES</subject><subject>MICE</subject><subject>Monitoring/Environmental Analysis</subject><subject>Mouth Neoplasms - chemically induced</subject><subject>Mouth Neoplasms - metabolism</subject><subject>Mouth Neoplasms - pathology</subject><subject>Mouth Neoplasms - radiotherapy</subject><subject>NEOPLASMS</subject><subject>NEUTRON CAPTURE THERAPY</subject><subject>NEUTRONS</subject><subject>OPTIMIZATION</subject><subject>Oral cancer</subject><subject>Original Paper</subject><subject>PATHOLOGY</subject><subject>Physics</subject><subject>Physics and Astronomy</subject><subject>RADIOLOGY AND NUCLEAR MEDICINE</subject><subject>SPLEEN</subject><subject>THERMAL NEUTRONS</subject><subject>Tissue Distribution</subject><subject>TUMOR CELLS</subject><issn>0301-634X</issn><issn>1432-2099</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNp1kU1v1DAQhi0EosvCD-CCLLiUQ2DsOB_uja74kiq4FIlb5Dh211ViB9uB7m_iTzJLFsSFw3g08jPvO5oh5CmDVwygeZ0ABGMFHKOUsoB7ZMNEyQsOUt4nGyiBFXUpvp6RRyndArCmruVDcsY5b5gAsSE_L0MMng5mdN9NPNAfLu_p6OaQwmQStSHS_jfhzZKPWas5L9HQvDdRzQd6fvlpd_3ygvYuDC7l6PolO-RSXgaHCs5T5am5m010k_FZjXQKaEeDpSFipZXXJuIEU_DYr7LzNyd1tHSaziFjn1PjY_LAqjGZJ6e8JV_evb3efSiuPr__uHtzVWhcQi5Yy1shmqEH1VdKV_VQib61ljVccG7qupRCtpWF2g7KQtsoVUlTVUJXfNCsKbfk-aobUnZd0i4bvdfBe6Nzx0AIySRCL1ZojuHbYlLubsMSPc6FCLQScMclUmyldAwpRWO7Gdeg4gGhI9d06w07OAaOj8-WPDspL_1khr8df46GAF-BhF_-xsR_rf-n-gszVqoW</recordid><startdate>20120501</startdate><enddate>20120501</enddate><creator>Heber, Elisa M.</creator><creator>Kueffer, Peter J.</creator><creator>Lee, Mark W.</creator><creator>Hawthorne, M. Frederick</creator><creator>Garabalino, Marcela A.</creator><creator>Molinari, Ana J.</creator><creator>Nigg, David W.</creator><creator>Bauer, William</creator><creator>Hughes, Andrea Monti</creator><creator>Pozzi, Emiliano C. C.</creator><creator>Trivillin, Verónica A.</creator><creator>Schwint, Amanda E.</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7ST</scope><scope>7TK</scope><scope>7TM</scope><scope>7U7</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>SOI</scope><scope>OTOTI</scope></search><sort><creationdate>20120501</creationdate><title>Boron delivery with liposomes for boron neutron capture therapy (BNCT): biodistribution studies in an experimental model of oral cancer demonstrating therapeutic potential</title><author>Heber, Elisa M. ; Kueffer, Peter J. ; Lee, Mark W. ; Hawthorne, M. Frederick ; Garabalino, Marcela A. ; Molinari, Ana J. ; Nigg, David W. ; Bauer, William ; Hughes, Andrea Monti ; Pozzi, Emiliano C. C. ; Trivillin, Verónica A. ; Schwint, Amanda E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-1828447db0ab5ac56d54b8ff172422e66394985f06fdaf087aa59e554c52dc173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>AQUEOUS SOLUTIONS</topic><topic>BASIC BIOLOGICAL SCIENCES</topic><topic>Biological and Medical Physics</topic><topic>Biophysics</topic><topic>BLOOD</topic><topic>BORON</topic><topic>Boron - administration & dosage</topic><topic>Boron - pharmacokinetics</topic><topic>boron neutron capture therapy</topic><topic>Boron Neutron Capture Therapy - methods</topic><topic>CARCINOMAS</topic><topic>Cricetinae</topic><topic>Disease Models, Animal</topic><topic>Drug Carriers - administration & dosage</topic><topic>Drug Carriers - pharmacokinetics</topic><topic>Ecosystems</topic><topic>Effects of Radiation/Radiation Protection</topic><topic>Environmental Physics</topic><topic>HAMSTERS</topic><topic>IRRADIATION</topic><topic>Isotopes - administration & dosage</topic><topic>LIPOSOMES</topic><topic>Liposomes - administration & dosage</topic><topic>Liposomes - pharmacokinetics</topic><topic>LIVER</topic><topic>MASS SPECTROSCOPY</topic><topic>MEMBRANES</topic><topic>MICE</topic><topic>Monitoring/Environmental Analysis</topic><topic>Mouth Neoplasms - chemically induced</topic><topic>Mouth Neoplasms - metabolism</topic><topic>Mouth Neoplasms - pathology</topic><topic>Mouth Neoplasms - radiotherapy</topic><topic>NEOPLASMS</topic><topic>NEUTRON CAPTURE THERAPY</topic><topic>NEUTRONS</topic><topic>OPTIMIZATION</topic><topic>Oral cancer</topic><topic>Original Paper</topic><topic>PATHOLOGY</topic><topic>Physics</topic><topic>Physics and Astronomy</topic><topic>RADIOLOGY AND NUCLEAR MEDICINE</topic><topic>SPLEEN</topic><topic>THERMAL NEUTRONS</topic><topic>Tissue Distribution</topic><topic>TUMOR CELLS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heber, Elisa M.</creatorcontrib><creatorcontrib>Kueffer, Peter J.</creatorcontrib><creatorcontrib>Lee, Mark W.</creatorcontrib><creatorcontrib>Hawthorne, M. 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C.</creatorcontrib><creatorcontrib>Trivillin, Verónica A.</creatorcontrib><creatorcontrib>Schwint, Amanda E.</creatorcontrib><creatorcontrib>Idaho National Laboratory (INL)</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Environment Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Agriculture & Environmental Science Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biological Sciences</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Science Database (ProQuest)</collection><collection>Biological Science Database</collection><collection>Environmental Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Environmental Science Collection</collection><collection>ProQuest Central Basic</collection><collection>Environment Abstracts</collection><collection>OSTI.GOV</collection><jtitle>Radiation and environmental biophysics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heber, Elisa M.</au><au>Kueffer, Peter J.</au><au>Lee, Mark W.</au><au>Hawthorne, M. Frederick</au><au>Garabalino, Marcela A.</au><au>Molinari, Ana J.</au><au>Nigg, David W.</au><au>Bauer, William</au><au>Hughes, Andrea Monti</au><au>Pozzi, Emiliano C. C.</au><au>Trivillin, Verónica A.</au><au>Schwint, Amanda E.</au><aucorp>Idaho National Laboratory (INL)</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Boron delivery with liposomes for boron neutron capture therapy (BNCT): biodistribution studies in an experimental model of oral cancer demonstrating therapeutic potential</atitle><jtitle>Radiation and environmental biophysics</jtitle><stitle>Radiat Environ Biophys</stitle><addtitle>Radiat Environ Biophys</addtitle><date>2012-05-01</date><risdate>2012</risdate><volume>51</volume><issue>2</issue><spage>195</spage><epage>204</epage><pages>195-204</pages><issn>0301-634X</issn><eissn>1432-2099</eissn><notes>USDOE</notes><notes>DE-AC07-05ID14517</notes><notes>INL/JOU-12-26486</notes><abstract>Boron neutron capture therapy (BNCT) combines selective accumulation of
10
B carriers in tumor tissue with subsequent neutron irradiation. We previously demonstrated the therapeutic efficacy of BNCT in the hamster cheek pouch oral cancer model. Optimization of BNCT depends largely on improving boron targeting to tumor cells. Seeking to maximize the potential of BNCT for the treatment for head and neck cancer, the aim of the present study was to perform boron biodistribution studies in the oral cancer model employing two different liposome formulations that were previously tested for a different pathology, i.e., in experimental mammary carcinoma in BALB/c mice: (1) MAC: liposomes incorporating K[
nido
-7-CH
3
(CH
2
)
15
-7,8-C
2
B
9
H
11
] in the bilayer membrane and encapsulating a hypertonic buffer, administered intravenously at 6 mg B per kg body weight, and (2) MAC-TAC: liposomes incorporating K[
nido
-7-CH
3
(CH
2
)
15
-7,8-C
2
B
9
H
11
] in the bilayer membrane and encapsulating a concentrated aqueous solution of the hydrophilic species Na
3
[
ae
-B
20
H
17
NH
3
], administered intravenously at 18 mg B per kg body weight. Samples of tumor, precancerous and normal pouch tissue, spleen, liver, kidney, and blood were taken at different times post-administration and processed to measure boron content by inductively coupled plasma mass spectrometry. No ostensible clinical toxic effects were observed with the selected formulations. Both MAC and MAC-TAC delivered boron selectively to tumor tissue. Absolute tumor values for MAC-TAC peaked to 66.6 ± 16.1 ppm at 48 h and to 43.9 ± 17.6 ppm at 54 h with very favorable ratios of tumor boron relative to precancerous and normal tissue, making these protocols particularly worthy of radiobiological assessment. Boron concentration values obtained would result in therapeutic BNCT doses in tumor without exceeding radiotolerance in precancerous/normal tissue at the thermal neutron facility at RA-3.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>22271404</pmid><doi>10.1007/s00411-011-0399-0</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-634X |
| ispartof | Radiation and environmental biophysics, 2012-05, Vol.51 (2), p.195-204 |
| issn | 0301-634X 1432-2099 |
| language | eng |
| recordid | cdi_osti_scitechconnect_1044919 |
| source | Springer Link |
| subjects | Animals AQUEOUS SOLUTIONS BASIC BIOLOGICAL SCIENCES Biological and Medical Physics Biophysics BLOOD BORON Boron - administration & dosage Boron - pharmacokinetics boron neutron capture therapy Boron Neutron Capture Therapy - methods CARCINOMAS Cricetinae Disease Models, Animal Drug Carriers - administration & dosage Drug Carriers - pharmacokinetics Ecosystems Effects of Radiation/Radiation Protection Environmental Physics HAMSTERS IRRADIATION Isotopes - administration & dosage LIPOSOMES Liposomes - administration & dosage Liposomes - pharmacokinetics LIVER MASS SPECTROSCOPY MEMBRANES MICE Monitoring/Environmental Analysis Mouth Neoplasms - chemically induced Mouth Neoplasms - metabolism Mouth Neoplasms - pathology Mouth Neoplasms - radiotherapy NEOPLASMS NEUTRON CAPTURE THERAPY NEUTRONS OPTIMIZATION Oral cancer Original Paper PATHOLOGY Physics Physics and Astronomy RADIOLOGY AND NUCLEAR MEDICINE SPLEEN THERMAL NEUTRONS Tissue Distribution TUMOR CELLS |
| title | Boron delivery with liposomes for boron neutron capture therapy (BNCT): biodistribution studies in an experimental model of oral cancer demonstrating therapeutic potential |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-22T14%3A23%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_osti_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Boron%20delivery%20with%20liposomes%20for%20boron%20neutron%20capture%20therapy%20(BNCT):%20biodistribution%20studies%20in%20an%20experimental%20model%20of%20oral%20cancer%20demonstrating%20therapeutic%20potential&rft.jtitle=Radiation%20and%20environmental%20biophysics&rft.au=Heber,%20Elisa%20M.&rft.aucorp=Idaho%20National%20Laboratory%20(INL)&rft.date=2012-05-01&rft.volume=51&rft.issue=2&rft.spage=195&rft.epage=204&rft.pages=195-204&rft.issn=0301-634X&rft.eissn=1432-2099&rft_id=info:doi/10.1007/s00411-011-0399-0&rft_dat=%3Cproquest_osti_%3E2641342291%3C/proquest_osti_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c399t-1828447db0ab5ac56d54b8ff172422e66394985f06fdaf087aa59e554c52dc173%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1008902223&rft_id=info:pmid/22271404&rfr_iscdi=true |