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Lack of Effects of HER-2/neu on Prognosis in Colorectal Cancer: a Meta-analysis
Background: The prognostic value of human epidermal growth factor receptor-2 (HER-2/neu) for survival of patients with colorectal cancer (CRC) is still ambiguous. We therefore performed a meta-analysis to evaluate its prognostic significance. Materials and Methods: We searched the MEDLINE and EMBASE...
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| Published in: | Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15 (14), p.5551-5556 |
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| Main Authors: | , , , , , |
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| Language: | Korean |
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| container_issue | 14 |
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| container_title | Asian Pacific journal of cancer prevention : APJCP |
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| creator | Han, Jun Meng, Qing-Yang Liu, Xiao Xi, Qiu-Lei Zhuang, Qiu-Lin Wu, Guo-Hao |
| description | Background: The prognostic value of human epidermal growth factor receptor-2 (HER-2/neu) for survival of patients with colorectal cancer (CRC) is still ambiguous. We therefore performed a meta-analysis to evaluate its prognostic significance. Materials and Methods: We searched the MEDLINE and EMBASE databases for published literature investigating associations between HER-2/neu status and overall survival of patients with CRC. A meta-analysis was performed using a DerSimonian-Laird model and publication bias was investigated by Begg's and Egger's tests. Subgroup analysis was also conducted according to the study design type, study quality score, cut-off value for HER-2/neu overexpression, publication region, patient number and publication year. Results: A total of 17 eligible studies involving 2,347 patients were identified for this meta-analysis. The combined hazard ratio (HR) was 1.31 (95% confidence interval (CI): 0.96-1.79), suggesting that HER-2/neu overexpression was not significantly associated with overall survival of patients with CRC. However, subgroup analysis revealed that HER-2/neu overexpression had an unfavorable impact on survival when the analysis was restricted to subgroups of study quality score ${\leq}5 $(HR=1.56, 95%CI: 1.17-2.10), Asian patients (HR=1.74, 95%CI: 1.22-2.49), patient number ${\leq}106$ (HR=1.57, 95%CI: 1.01-2.44), publication year before 2003 (HR=1.59, 95%CI: 1.02-2.49), and prospectively designed study (HR=3.62, 95%CI: 1.42-9.24). The effect disappeared in subgroups of study quality scores > 5 (HR=0.69, 95%CI: 0.33-1.44), non Asian patients (HR=1.14, 95%CI: 0.77-1.70), patients' number > 106 (HR=1.07, 95%CI: 0.67-1.72), publication year after 2003 (HR=1.13, 95%CI: 0.76-1.69), and retrospectively designed study (HR=1.22, 95%CI: 0.89-1.67). Conclusions: Our meta-analysis suggests that HER-2/neu overexpression might not be a significantly prognostic indicator for patients with CRC. Further studies are required to confirm these results. |
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| fullrecord | <record><control><sourceid>kisti</sourceid><recordid>TN_cdi_kisti_ndsl_JAKO201429765167316</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JAKO201429765167316</sourcerecordid><originalsourceid>FETCH-kisti_ndsl_JAKO2014297651673163</originalsourceid><addsrcrecordid>eNqNyrsKwjAYQOEgChbtO_yLY7C5NFE3KZXihYo4uJVYUwkNCTR18O2t4AM4nTN8IxRRLgWWgt7GKCIpYVgysZqiOARzTziXLBGcR6g8qroF30DeNLruw3eL_ILp0ukXeAfnzj-dDyaAcZB567uBKQuZcrXuNqDgpHuFlVP2Pag5mjTKBh3_OkOLXX7NCtya0JvKPYKt9ttDSRPC6VqKlAjJiGD_ug9Zdzz7</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Lack of Effects of HER-2/neu on Prognosis in Colorectal Cancer: a Meta-analysis</title><source>EZB Electronic Journals Library</source><creator>Han, Jun ; Meng, Qing-Yang ; Liu, Xiao ; Xi, Qiu-Lei ; Zhuang, Qiu-Lin ; Wu, Guo-Hao</creator><creatorcontrib>Han, Jun ; Meng, Qing-Yang ; Liu, Xiao ; Xi, Qiu-Lei ; Zhuang, Qiu-Lin ; Wu, Guo-Hao</creatorcontrib><description>Background: The prognostic value of human epidermal growth factor receptor-2 (HER-2/neu) for survival of patients with colorectal cancer (CRC) is still ambiguous. We therefore performed a meta-analysis to evaluate its prognostic significance. Materials and Methods: We searched the MEDLINE and EMBASE databases for published literature investigating associations between HER-2/neu status and overall survival of patients with CRC. A meta-analysis was performed using a DerSimonian-Laird model and publication bias was investigated by Begg's and Egger's tests. Subgroup analysis was also conducted according to the study design type, study quality score, cut-off value for HER-2/neu overexpression, publication region, patient number and publication year. Results: A total of 17 eligible studies involving 2,347 patients were identified for this meta-analysis. The combined hazard ratio (HR) was 1.31 (95% confidence interval (CI): 0.96-1.79), suggesting that HER-2/neu overexpression was not significantly associated with overall survival of patients with CRC. However, subgroup analysis revealed that HER-2/neu overexpression had an unfavorable impact on survival when the analysis was restricted to subgroups of study quality score ${\leq}5 $(HR=1.56, 95%CI: 1.17-2.10), Asian patients (HR=1.74, 95%CI: 1.22-2.49), patient number ${\leq}106$ (HR=1.57, 95%CI: 1.01-2.44), publication year before 2003 (HR=1.59, 95%CI: 1.02-2.49), and prospectively designed study (HR=3.62, 95%CI: 1.42-9.24). The effect disappeared in subgroups of study quality scores > 5 (HR=0.69, 95%CI: 0.33-1.44), non Asian patients (HR=1.14, 95%CI: 0.77-1.70), patients' number > 106 (HR=1.07, 95%CI: 0.67-1.72), publication year after 2003 (HR=1.13, 95%CI: 0.76-1.69), and retrospectively designed study (HR=1.22, 95%CI: 0.89-1.67). Conclusions: Our meta-analysis suggests that HER-2/neu overexpression might not be a significantly prognostic indicator for patients with CRC. Further studies are required to confirm these results.</description><identifier>ISSN: 1513-7368</identifier><identifier>EISSN: 2476-762X</identifier><language>kor</language><ispartof>Asian Pacific journal of cancer prevention : APJCP, 2014, Vol.15 (14), p.5551-5556</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,4043</link.rule.ids></links><search><creatorcontrib>Han, Jun</creatorcontrib><creatorcontrib>Meng, Qing-Yang</creatorcontrib><creatorcontrib>Liu, Xiao</creatorcontrib><creatorcontrib>Xi, Qiu-Lei</creatorcontrib><creatorcontrib>Zhuang, Qiu-Lin</creatorcontrib><creatorcontrib>Wu, Guo-Hao</creatorcontrib><title>Lack of Effects of HER-2/neu on Prognosis in Colorectal Cancer: a Meta-analysis</title><title>Asian Pacific journal of cancer prevention : APJCP</title><addtitle>Asian Pacific journal of cancer prevention : APJCP</addtitle><description>Background: The prognostic value of human epidermal growth factor receptor-2 (HER-2/neu) for survival of patients with colorectal cancer (CRC) is still ambiguous. We therefore performed a meta-analysis to evaluate its prognostic significance. Materials and Methods: We searched the MEDLINE and EMBASE databases for published literature investigating associations between HER-2/neu status and overall survival of patients with CRC. A meta-analysis was performed using a DerSimonian-Laird model and publication bias was investigated by Begg's and Egger's tests. Subgroup analysis was also conducted according to the study design type, study quality score, cut-off value for HER-2/neu overexpression, publication region, patient number and publication year. Results: A total of 17 eligible studies involving 2,347 patients were identified for this meta-analysis. The combined hazard ratio (HR) was 1.31 (95% confidence interval (CI): 0.96-1.79), suggesting that HER-2/neu overexpression was not significantly associated with overall survival of patients with CRC. However, subgroup analysis revealed that HER-2/neu overexpression had an unfavorable impact on survival when the analysis was restricted to subgroups of study quality score ${\leq}5 $(HR=1.56, 95%CI: 1.17-2.10), Asian patients (HR=1.74, 95%CI: 1.22-2.49), patient number ${\leq}106$ (HR=1.57, 95%CI: 1.01-2.44), publication year before 2003 (HR=1.59, 95%CI: 1.02-2.49), and prospectively designed study (HR=3.62, 95%CI: 1.42-9.24). The effect disappeared in subgroups of study quality scores > 5 (HR=0.69, 95%CI: 0.33-1.44), non Asian patients (HR=1.14, 95%CI: 0.77-1.70), patients' number > 106 (HR=1.07, 95%CI: 0.67-1.72), publication year after 2003 (HR=1.13, 95%CI: 0.76-1.69), and retrospectively designed study (HR=1.22, 95%CI: 0.89-1.67). Conclusions: Our meta-analysis suggests that HER-2/neu overexpression might not be a significantly prognostic indicator for patients with CRC. Further studies are required to confirm these results.</description><issn>1513-7368</issn><issn>2476-762X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><recordid>eNqNyrsKwjAYQOEgChbtO_yLY7C5NFE3KZXihYo4uJVYUwkNCTR18O2t4AM4nTN8IxRRLgWWgt7GKCIpYVgysZqiOARzTziXLBGcR6g8qroF30DeNLruw3eL_ILp0ukXeAfnzj-dDyaAcZB567uBKQuZcrXuNqDgpHuFlVP2Pag5mjTKBh3_OkOLXX7NCtya0JvKPYKt9ttDSRPC6VqKlAjJiGD_ug9Zdzz7</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Han, Jun</creator><creator>Meng, Qing-Yang</creator><creator>Liu, Xiao</creator><creator>Xi, Qiu-Lei</creator><creator>Zhuang, Qiu-Lin</creator><creator>Wu, Guo-Hao</creator><scope>JDI</scope></search><sort><creationdate>2014</creationdate><title>Lack of Effects of HER-2/neu on Prognosis in Colorectal Cancer: a Meta-analysis</title><author>Han, Jun ; Meng, Qing-Yang ; Liu, Xiao ; Xi, Qiu-Lei ; Zhuang, Qiu-Lin ; Wu, Guo-Hao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-kisti_ndsl_JAKO2014297651673163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>kor</language><creationdate>2014</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, Jun</creatorcontrib><creatorcontrib>Meng, Qing-Yang</creatorcontrib><creatorcontrib>Liu, Xiao</creatorcontrib><creatorcontrib>Xi, Qiu-Lei</creatorcontrib><creatorcontrib>Zhuang, Qiu-Lin</creatorcontrib><creatorcontrib>Wu, Guo-Hao</creatorcontrib><collection>KoreaScience</collection><jtitle>Asian Pacific journal of cancer prevention : APJCP</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, Jun</au><au>Meng, Qing-Yang</au><au>Liu, Xiao</au><au>Xi, Qiu-Lei</au><au>Zhuang, Qiu-Lin</au><au>Wu, Guo-Hao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lack of Effects of HER-2/neu on Prognosis in Colorectal Cancer: a Meta-analysis</atitle><jtitle>Asian Pacific journal of cancer prevention : APJCP</jtitle><addtitle>Asian Pacific journal of cancer prevention : APJCP</addtitle><date>2014</date><risdate>2014</risdate><volume>15</volume><issue>14</issue><spage>5551</spage><epage>5556</epage><pages>5551-5556</pages><issn>1513-7368</issn><eissn>2476-762X</eissn><notes>KISTI1.1003/JNL.JAKO201429765167316</notes><abstract>Background: The prognostic value of human epidermal growth factor receptor-2 (HER-2/neu) for survival of patients with colorectal cancer (CRC) is still ambiguous. We therefore performed a meta-analysis to evaluate its prognostic significance. Materials and Methods: We searched the MEDLINE and EMBASE databases for published literature investigating associations between HER-2/neu status and overall survival of patients with CRC. A meta-analysis was performed using a DerSimonian-Laird model and publication bias was investigated by Begg's and Egger's tests. Subgroup analysis was also conducted according to the study design type, study quality score, cut-off value for HER-2/neu overexpression, publication region, patient number and publication year. Results: A total of 17 eligible studies involving 2,347 patients were identified for this meta-analysis. The combined hazard ratio (HR) was 1.31 (95% confidence interval (CI): 0.96-1.79), suggesting that HER-2/neu overexpression was not significantly associated with overall survival of patients with CRC. However, subgroup analysis revealed that HER-2/neu overexpression had an unfavorable impact on survival when the analysis was restricted to subgroups of study quality score ${\leq}5 $(HR=1.56, 95%CI: 1.17-2.10), Asian patients (HR=1.74, 95%CI: 1.22-2.49), patient number ${\leq}106$ (HR=1.57, 95%CI: 1.01-2.44), publication year before 2003 (HR=1.59, 95%CI: 1.02-2.49), and prospectively designed study (HR=3.62, 95%CI: 1.42-9.24). The effect disappeared in subgroups of study quality scores > 5 (HR=0.69, 95%CI: 0.33-1.44), non Asian patients (HR=1.14, 95%CI: 0.77-1.70), patients' number > 106 (HR=1.07, 95%CI: 0.67-1.72), publication year after 2003 (HR=1.13, 95%CI: 0.76-1.69), and retrospectively designed study (HR=1.22, 95%CI: 0.89-1.67). Conclusions: Our meta-analysis suggests that HER-2/neu overexpression might not be a significantly prognostic indicator for patients with CRC. Further studies are required to confirm these results.</abstract><oa>free_for_read</oa></addata></record> |
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| title | Lack of Effects of HER-2/neu on Prognosis in Colorectal Cancer: a Meta-analysis |
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