OZONE DIFFERENTIALLY MODULATES AIRWAY RESPONSIVENESS IN ATOPIC VERSUS NONATOPIC GUINEA PIGS

While acute exposures to ozone (O 3) can alter airway responsiveness, effects from long-term exposures at low concentrations are less clear. This study assessed whether such exposures could induce nonspecific hyperresponsiveness in nonatopic (nonsensitized) guinea pigs and/or could exacerbate the pr...

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Published in:Inhalation toxicology 2002-05, Vol.14 (5), p.431-457
Main Authors: Schlesinger, Richard B., Cohen, Mitchell D., Gordon, Terry, Nadziejko, Christine, Zelikoff, Judith T., Sisco, Maureen, Regal, Jean F., Ménache, Margaret G.
Format: Article
Language:English
Subjects:
Airway Resistance - drug effects
Animals
Dose-Response Relationship, Drug
Female
Guinea Pigs
Hypersensitivity, Immediate
Male
Oxidants, Photochemical - adverse effects
Ozone - adverse effects
Sex Factors
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cited_by cdi_FETCH-LOGICAL-c567t-1c58081757939c19a881077b5a1d460e9d0d8a3c3e363e40e9dd883b6f7c0b5b3
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container_end_page 457
container_issue 5
container_start_page 431
container_title Inhalation toxicology
container_volume 14
creator Schlesinger, Richard B.
Cohen, Mitchell D.
Gordon, Terry
Nadziejko, Christine
Zelikoff, Judith T.
Sisco, Maureen
Regal, Jean F.
Ménache, Margaret G.
description While acute exposures to ozone (O 3) can alter airway responsiveness, effects from long-term exposures at low concentrations are less clear. This study assessed whether such exposures could induce nonspecific hyperresponsiveness in nonatopic (nonsensitized) guinea pigs and/or could exacerbate the pre-existing hyperresponsive state in atopic (sensitized) animals, and whether gender was a factor modulating any effect of O 3. Responsiveness was measured during and following exposures to 0.1 and 0.3 ppm O 3 for 4 h/day, 4 days/wk for 24 wk in male and female nonsensitized animals, those sensitized to allergen (ovalbumin) prior to initiation of O 3 exposures, and those sensitized concurrently with exposures. Ozone did not produce hyperresponsiveness in nonsensitized animals, but did exacerbate hyperresponsiveness to both specific and nonspecific bronchoprovocation challenges in sensitized animals, an effect that persisted through at least 4 wk after exposures ended. Gender was not a factor modulating response to O 3. Induced effects on responsiveness were not associated with numbers of eosinophils in the lungs nor with any chronic pulmonary inflammatory response, but were correlated with antigen-specific antibodies in blood. This study supports a role for chronic O 3 exposure in the exacerbation of airways dysfunction in a certain segment of the general population, namely, those demonstrating atopy.
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subjects Airway Resistance - drug effects
Animals
Dose-Response Relationship, Drug
Female
Guinea Pigs
Hypersensitivity, Immediate
Male
Oxidants, Photochemical - adverse effects
Ozone - adverse effects
Sex Factors
title OZONE DIFFERENTIALLY MODULATES AIRWAY RESPONSIVENESS IN ATOPIC VERSUS NONATOPIC GUINEA PIGS
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