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Reduced Maximal Inhibition in Phenotypic Susceptibility Assays Indicates that Viral Strains Resistant to the CCR5 Antagonist Maraviroc Utilize Inhibitor-Bound Receptor for Entry
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| Published in: | Journal of Virology 2007-03, Vol.81 (5), p.2359-2371 |
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| Main Authors: | , , , , , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c469t-bfce596d9e6425b97cee4507c6af0ac1228c2ce6f520c041b5a8af9d251123f83 |
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| cites | cdi_FETCH-LOGICAL-c469t-bfce596d9e6425b97cee4507c6af0ac1228c2ce6f520c041b5a8af9d251123f83 |
| container_end_page | 2371 |
| container_issue | 5 |
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| container_title | Journal of Virology |
| container_volume | 81 |
| creator | WESTBY, Mike SMITH-BURCHNELL, Caroline MORI, Julie LEWIS, Marilyn MOSLEY, Nichael STOCKDALE, Mark DORR, Patrick CIARAMELLA, Giuseppe PERROS, Manos |
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| doi_str_mv | 10.1128/JVI.02006-06 |
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</description><identifier>ISSN: 0022-538X</identifier><identifier>EISSN: 1098-5514</identifier><identifier>DOI: 10.1128/JVI.02006-06</identifier><identifier>PMID: 17182681</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Amino Acid Sequence ; Amino Acid Substitution ; Biological and medical sciences ; CCR5 Receptor Antagonists ; Cell Line ; Cyclohexanes - pharmacology ; Drug Resistance, Viral - genetics ; Fundamental and applied biological sciences. Psychology ; Genes, env ; Genetic Variation ; HIV Envelope Protein gp120 - genetics ; HIV Fusion Inhibitors - pharmacology ; HIV Infections - drug therapy ; HIV Infections - virology ; HIV-1 - drug effects ; HIV-1 - genetics ; HIV-1 - pathogenicity ; HIV-1 - physiology ; Human immunodeficiency virus 1 ; Humans ; In Vitro Techniques ; Lymphocytes - virology ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Mutagenesis, Site-Directed ; Peptide Fragments - genetics ; Phenotype ; Receptors, CXCR4 - antagonists & inhibitors ; Triazoles - pharmacology ; Vaccines and Antiviral Agents ; Virology ; Virus Cultivation ; Virus Replication - genetics</subject><ispartof>Journal of Virology, 2007-03, Vol.81 (5), p.2359-2371</ispartof><rights>2007 INIST-CNRS</rights><rights>Copyright © 2007, American Society for Microbiology 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c469t-bfce596d9e6425b97cee4507c6af0ac1228c2ce6f520c041b5a8af9d251123f83</citedby><cites>FETCH-LOGICAL-c469t-bfce596d9e6425b97cee4507c6af0ac1228c2ce6f520c041b5a8af9d251123f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865946/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1865946/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,315,733,786,790,891,3207,3208,27957,27958,53827,53829</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18533826$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17182681$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>WESTBY, Mike</creatorcontrib><creatorcontrib>SMITH-BURCHNELL, Caroline</creatorcontrib><creatorcontrib>MORI, Julie</creatorcontrib><creatorcontrib>LEWIS, Marilyn</creatorcontrib><creatorcontrib>MOSLEY, Nichael</creatorcontrib><creatorcontrib>STOCKDALE, Mark</creatorcontrib><creatorcontrib>DORR, Patrick</creatorcontrib><creatorcontrib>CIARAMELLA, Giuseppe</creatorcontrib><creatorcontrib>PERROS, Manos</creatorcontrib><title>Reduced Maximal Inhibition in Phenotypic Susceptibility Assays Indicates that Viral Strains Resistant to the CCR5 Antagonist Maraviroc Utilize Inhibitor-Bound Receptor for Entry</title><title>Journal of Virology</title><addtitle>J Virol</addtitle><description>Article Usage Stats
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</description><subject>Amino Acid Sequence</subject><subject>Amino Acid Substitution</subject><subject>Biological and medical sciences</subject><subject>CCR5 Receptor Antagonists</subject><subject>Cell Line</subject><subject>Cyclohexanes - pharmacology</subject><subject>Drug Resistance, Viral - genetics</subject><subject>Fundamental and applied biological sciences. 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Psychology</topic><topic>Genes, env</topic><topic>Genetic Variation</topic><topic>HIV Envelope Protein gp120 - genetics</topic><topic>HIV Fusion Inhibitors - pharmacology</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - drug effects</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - pathogenicity</topic><topic>HIV-1 - physiology</topic><topic>Human immunodeficiency virus 1</topic><topic>Humans</topic><topic>In Vitro Techniques</topic><topic>Lymphocytes - virology</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Mutagenesis, Site-Directed</topic><topic>Peptide Fragments - genetics</topic><topic>Phenotype</topic><topic>Receptors, CXCR4 - antagonists & inhibitors</topic><topic>Triazoles - pharmacology</topic><topic>Vaccines and Antiviral Agents</topic><topic>Virology</topic><topic>Virus Cultivation</topic><topic>Virus Replication - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>WESTBY, Mike</creatorcontrib><creatorcontrib>SMITH-BURCHNELL, Caroline</creatorcontrib><creatorcontrib>MORI, Julie</creatorcontrib><creatorcontrib>LEWIS, Marilyn</creatorcontrib><creatorcontrib>MOSLEY, Nichael</creatorcontrib><creatorcontrib>STOCKDALE, Mark</creatorcontrib><creatorcontrib>DORR, Patrick</creatorcontrib><creatorcontrib>CIARAMELLA, Giuseppe</creatorcontrib><creatorcontrib>PERROS, Manos</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>WESTBY, Mike</au><au>SMITH-BURCHNELL, Caroline</au><au>MORI, Julie</au><au>LEWIS, Marilyn</au><au>MOSLEY, Nichael</au><au>STOCKDALE, Mark</au><au>DORR, Patrick</au><au>CIARAMELLA, Giuseppe</au><au>PERROS, Manos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reduced Maximal Inhibition in Phenotypic Susceptibility Assays Indicates that Viral Strains Resistant to the CCR5 Antagonist Maraviroc Utilize Inhibitor-Bound Receptor for Entry</atitle><jtitle>Journal of Virology</jtitle><addtitle>J Virol</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>81</volume><issue>5</issue><spage>2359</spage><epage>2371</epage><pages>2359-2371</pages><issn>0022-538X</issn><eissn>1098-5514</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Corresponding author. Mailing address: Pfizer Ltd. PGRD, Sandwich Labs, Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom. Phone: 44 (01304) 649876. Fax: 44 (01304) 651819. E-mail: mike.westby@pfizer.com.</notes><abstract>Article Usage Stats
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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>17182681</pmid><doi>10.1128/JVI.02006-06</doi><tpages>13</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Virology, 2007-03, Vol.81 (5), p.2359-2371 |
| issn | 0022-538X 1098-5514 |
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| source | American Society for Microbiology; PubMed Central |
| subjects | Amino Acid Sequence Amino Acid Substitution Biological and medical sciences CCR5 Receptor Antagonists Cell Line Cyclohexanes - pharmacology Drug Resistance, Viral - genetics Fundamental and applied biological sciences. Psychology Genes, env Genetic Variation HIV Envelope Protein gp120 - genetics HIV Fusion Inhibitors - pharmacology HIV Infections - drug therapy HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics HIV-1 - pathogenicity HIV-1 - physiology Human immunodeficiency virus 1 Humans In Vitro Techniques Lymphocytes - virology Microbiology Miscellaneous Molecular Sequence Data Mutagenesis, Site-Directed Peptide Fragments - genetics Phenotype Receptors, CXCR4 - antagonists & inhibitors Triazoles - pharmacology Vaccines and Antiviral Agents Virology Virus Cultivation Virus Replication - genetics |
| title | Reduced Maximal Inhibition in Phenotypic Susceptibility Assays Indicates that Viral Strains Resistant to the CCR5 Antagonist Maraviroc Utilize Inhibitor-Bound Receptor for Entry |
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