Personal exposure to PM2.5 oxidative potential and its association to birth outcomes

BackgroundPrenatal exposure to fine particulate matter (PM2.5) assessed through its mass concentration has been associated with foetal growth restriction in studies based on outdoor levels. Oxidative potential of PM2.5 (OP) is an emerging metric a priori relevant to mechanisms of action of PM on hea...

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Published in:Journal of exposure science & environmental epidemiology 2023-05, Vol.33 (3), p.416-426
Main Authors: Borlaza, Lucille Joanna S., Uzu, Gaëlle, Ouidir, Marion, Lyon-Caen, Sarah, Marsal, Anouk, Weber, Samuël, Siroux, Valérie, Lepeule, Johanna, Boudier, Anne, Jaffrezo, Jean-Luc, Slama, Rémy, Lyon-Caen, S., Siroux, V., Lepeule, J., Philippat, C., Slama, R., Hofmann, P., Hullo, E., Llerena, C., Quentin, J., Pin, I., Eyriey, E., Licinia, A., Vellement, A., Morin, X., Morlot, A.
Format: Article
Language:English
Subjects:
Airborne particulates
Ascorbic acid
Birth
Births
Childbirth & labor
Circumferences
Dithiothreitol
Dosimeters
Environmental Sciences
Exposure
Fetuses
Human exposure
Human health and pathology
Life Sciences
Offspring
Particulate emissions
Particulate matter
Pregnancy
Prenatal development
Prenatal experience
Pulmonology and respiratory tract
Santé publique et épidémiologie
Weight
Weight reduction
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cited_by cdi_FETCH-LOGICAL-c342t-2b7c8ebfa1cf306da3a34d0025107801d01c36795f0865b38f944d89bc7d2da43
cites cdi_FETCH-LOGICAL-c342t-2b7c8ebfa1cf306da3a34d0025107801d01c36795f0865b38f944d89bc7d2da43
container_end_page 426
container_issue 3
container_start_page 416
container_title Journal of exposure science & environmental epidemiology
container_volume 33
creator Borlaza, Lucille Joanna S.
Uzu, Gaëlle
Ouidir, Marion
Lyon-Caen, Sarah
Marsal, Anouk
Weber, Samuël
Siroux, Valérie
Lepeule, Johanna
Boudier, Anne
Jaffrezo, Jean-Luc
Slama, Rémy
Lyon-Caen, S.
Siroux, V.
Lepeule, J.
Philippat, C.
Slama, R.
Hofmann, P.
Hullo, E.
Llerena, C.
Quentin, J.
Pin, I.
Eyriey, E.
Licinia, A.
Vellement, A.
Morin, X.
Morlot, A.
description BackgroundPrenatal exposure to fine particulate matter (PM2.5) assessed through its mass concentration has been associated with foetal growth restriction in studies based on outdoor levels. Oxidative potential of PM2.5 (OP) is an emerging metric a priori relevant to mechanisms of action of PM on health, with very limited evidence to indicate its role on birth outcomes.ObjectivesWe investigated the association of OP with birth outcomes and compared it with that of PM2.5 mass concentration.Methods405 pregnant women from SEPAGES cohort (Grenoble area) carried PM2.5 personal dosimeters for one or two one-week periods. OP was measured using dithiothreitol (DTT) and ascorbic acid (AA) assays from the collected filters. Associations of each exposure metric with offspring weight, height, and head circumference at birth were estimated adjusting for potential confounders.ResultsThe correlation between PM2.5 mass concentration and OPvDTT was 0.7. An interquartile range increase in .. was associated with reduced weight (adjusted change, −64 g, −166 to −11, p = 0.02) and height (−4 mm, −6 to −1, p = 0.01) at birth. PM2.5 mass concentration showed similar associations with weight (−53 g, −99 to −8, p = 0.02) and height (−2 mm, −5 to 0, p = 0.05). In birth height models mutually adjusted for the two exposure metrics, the association with OPvDTT was less attenuated than that with mass concentration, while for weight both effect sizes attenuated similarly. There was no clear evidence of associations with head circumference for any metric, nor for OPvAA with any growth parameter.ImpactPM2.5 pregnancy exposure assessed from personal dosimeters was associated with altered foetal growth. Personal OP exposure was associated with foetal growth restrictions, specifically decreased weight and height at birth, possibly to a larger extent than PM2.5 mass concentration alone. These results support OP assessed from DTT as being a health-relevant metric. Larger scale cohort studies are recommended to support our findings.
doi_str_mv 10.1038/s41370-022-00487-w
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Oxidative potential of PM2.5 (OP) is an emerging metric a priori relevant to mechanisms of action of PM on health, with very limited evidence to indicate its role on birth outcomes.ObjectivesWe investigated the association of OP with birth outcomes and compared it with that of PM2.5 mass concentration.Methods405 pregnant women from SEPAGES cohort (Grenoble area) carried PM2.5 personal dosimeters for one or two one-week periods. OP was measured using dithiothreitol (DTT) and ascorbic acid (AA) assays from the collected filters. Associations of each exposure metric with offspring weight, height, and head circumference at birth were estimated adjusting for potential confounders.ResultsThe correlation between PM2.5 mass concentration and OPvDTT was 0.7. An interquartile range increase in .. was associated with reduced weight (adjusted change, −64 g, −166 to −11, p = 0.02) and height (−4 mm, −6 to −1, p = 0.01) at birth. PM2.5 mass concentration showed similar associations with weight (−53 g, −99 to −8, p = 0.02) and height (−2 mm, −5 to 0, p = 0.05). In birth height models mutually adjusted for the two exposure metrics, the association with OPvDTT was less attenuated than that with mass concentration, while for weight both effect sizes attenuated similarly. There was no clear evidence of associations with head circumference for any metric, nor for OPvAA with any growth parameter.ImpactPM2.5 pregnancy exposure assessed from personal dosimeters was associated with altered foetal growth. Personal OP exposure was associated with foetal growth restrictions, specifically decreased weight and height at birth, possibly to a larger extent than PM2.5 mass concentration alone. These results support OP assessed from DTT as being a health-relevant metric. Larger scale cohort studies are recommended to support our findings.</description><identifier>ISSN: 1559-0631</identifier><identifier>EISSN: 1559-064X</identifier><identifier>DOI: 10.1038/s41370-022-00487-w</identifier><language>eng</language><publisher>Tuxedo: Nature Publishing Group</publisher><subject>Airborne particulates ; Ascorbic acid ; Birth ; Births ; Childbirth &amp; labor ; Circumferences ; Dithiothreitol ; Dosimeters ; Environmental Sciences ; Exposure ; Fetuses ; Human exposure ; Human health and pathology ; Life Sciences ; Offspring ; Particulate emissions ; Particulate matter ; Pregnancy ; Prenatal development ; Prenatal experience ; Pulmonology and respiratory tract ; Santé publique et épidémiologie ; Weight ; Weight reduction</subject><ispartof>Journal of exposure science &amp; environmental epidemiology, 2023-05, Vol.33 (3), p.416-426</ispartof><rights>The Author(s), under exclusive licence to Springer Nature America, Inc. 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-2b7c8ebfa1cf306da3a34d0025107801d01c36795f0865b38f944d89bc7d2da43</citedby><cites>FETCH-LOGICAL-c342t-2b7c8ebfa1cf306da3a34d0025107801d01c36795f0865b38f944d89bc7d2da43</cites><orcidid>0000-0001-8378-1954 ; 0000-0002-7720-0233 ; 0000-0001-6027-1484</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://hal.science/hal-04302731$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Borlaza, Lucille Joanna S.</creatorcontrib><creatorcontrib>Uzu, Gaëlle</creatorcontrib><creatorcontrib>Ouidir, Marion</creatorcontrib><creatorcontrib>Lyon-Caen, Sarah</creatorcontrib><creatorcontrib>Marsal, Anouk</creatorcontrib><creatorcontrib>Weber, Samuël</creatorcontrib><creatorcontrib>Siroux, Valérie</creatorcontrib><creatorcontrib>Lepeule, Johanna</creatorcontrib><creatorcontrib>Boudier, Anne</creatorcontrib><creatorcontrib>Jaffrezo, Jean-Luc</creatorcontrib><creatorcontrib>Slama, Rémy</creatorcontrib><creatorcontrib>Lyon-Caen, S.</creatorcontrib><creatorcontrib>Siroux, V.</creatorcontrib><creatorcontrib>Lepeule, J.</creatorcontrib><creatorcontrib>Philippat, C.</creatorcontrib><creatorcontrib>Slama, R.</creatorcontrib><creatorcontrib>Hofmann, P.</creatorcontrib><creatorcontrib>Hullo, E.</creatorcontrib><creatorcontrib>Llerena, C.</creatorcontrib><creatorcontrib>Quentin, J.</creatorcontrib><creatorcontrib>Pin, I.</creatorcontrib><creatorcontrib>Eyriey, E.</creatorcontrib><creatorcontrib>Licinia, A.</creatorcontrib><creatorcontrib>Vellement, A.</creatorcontrib><creatorcontrib>Morin, X.</creatorcontrib><creatorcontrib>Morlot, A.</creatorcontrib><creatorcontrib>the SEPAGES cohort study group</creatorcontrib><title>Personal exposure to PM2.5 oxidative potential and its association to birth outcomes</title><title>Journal of exposure science &amp; environmental epidemiology</title><description>BackgroundPrenatal exposure to fine particulate matter (PM2.5) assessed through its mass concentration has been associated with foetal growth restriction in studies based on outdoor levels. Oxidative potential of PM2.5 (OP) is an emerging metric a priori relevant to mechanisms of action of PM on health, with very limited evidence to indicate its role on birth outcomes.ObjectivesWe investigated the association of OP with birth outcomes and compared it with that of PM2.5 mass concentration.Methods405 pregnant women from SEPAGES cohort (Grenoble area) carried PM2.5 personal dosimeters for one or two one-week periods. OP was measured using dithiothreitol (DTT) and ascorbic acid (AA) assays from the collected filters. Associations of each exposure metric with offspring weight, height, and head circumference at birth were estimated adjusting for potential confounders.ResultsThe correlation between PM2.5 mass concentration and OPvDTT was 0.7. An interquartile range increase in .. was associated with reduced weight (adjusted change, −64 g, −166 to −11, p = 0.02) and height (−4 mm, −6 to −1, p = 0.01) at birth. PM2.5 mass concentration showed similar associations with weight (−53 g, −99 to −8, p = 0.02) and height (−2 mm, −5 to 0, p = 0.05). In birth height models mutually adjusted for the two exposure metrics, the association with OPvDTT was less attenuated than that with mass concentration, while for weight both effect sizes attenuated similarly. There was no clear evidence of associations with head circumference for any metric, nor for OPvAA with any growth parameter.ImpactPM2.5 pregnancy exposure assessed from personal dosimeters was associated with altered foetal growth. Personal OP exposure was associated with foetal growth restrictions, specifically decreased weight and height at birth, possibly to a larger extent than PM2.5 mass concentration alone. These results support OP assessed from DTT as being a health-relevant metric. 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environmental epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borlaza, Lucille Joanna S.</au><au>Uzu, Gaëlle</au><au>Ouidir, Marion</au><au>Lyon-Caen, Sarah</au><au>Marsal, Anouk</au><au>Weber, Samuël</au><au>Siroux, Valérie</au><au>Lepeule, Johanna</au><au>Boudier, Anne</au><au>Jaffrezo, Jean-Luc</au><au>Slama, Rémy</au><au>Lyon-Caen, S.</au><au>Siroux, V.</au><au>Lepeule, J.</au><au>Philippat, C.</au><au>Slama, R.</au><au>Hofmann, P.</au><au>Hullo, E.</au><au>Llerena, C.</au><au>Quentin, J.</au><au>Pin, I.</au><au>Eyriey, E.</au><au>Licinia, A.</au><au>Vellement, A.</au><au>Morin, X.</au><au>Morlot, A.</au><aucorp>the SEPAGES cohort study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Personal exposure to PM2.5 oxidative potential and its association to birth outcomes</atitle><jtitle>Journal of exposure science &amp; environmental epidemiology</jtitle><date>2023-05-01</date><risdate>2023</risdate><volume>33</volume><issue>3</issue><spage>416</spage><epage>426</epage><pages>416-426</pages><issn>1559-0631</issn><eissn>1559-064X</eissn><abstract>BackgroundPrenatal exposure to fine particulate matter (PM2.5) assessed through its mass concentration has been associated with foetal growth restriction in studies based on outdoor levels. Oxidative potential of PM2.5 (OP) is an emerging metric a priori relevant to mechanisms of action of PM on health, with very limited evidence to indicate its role on birth outcomes.ObjectivesWe investigated the association of OP with birth outcomes and compared it with that of PM2.5 mass concentration.Methods405 pregnant women from SEPAGES cohort (Grenoble area) carried PM2.5 personal dosimeters for one or two one-week periods. OP was measured using dithiothreitol (DTT) and ascorbic acid (AA) assays from the collected filters. Associations of each exposure metric with offspring weight, height, and head circumference at birth were estimated adjusting for potential confounders.ResultsThe correlation between PM2.5 mass concentration and OPvDTT was 0.7. An interquartile range increase in .. was associated with reduced weight (adjusted change, −64 g, −166 to −11, p = 0.02) and height (−4 mm, −6 to −1, p = 0.01) at birth. PM2.5 mass concentration showed similar associations with weight (−53 g, −99 to −8, p = 0.02) and height (−2 mm, −5 to 0, p = 0.05). In birth height models mutually adjusted for the two exposure metrics, the association with OPvDTT was less attenuated than that with mass concentration, while for weight both effect sizes attenuated similarly. There was no clear evidence of associations with head circumference for any metric, nor for OPvAA with any growth parameter.ImpactPM2.5 pregnancy exposure assessed from personal dosimeters was associated with altered foetal growth. Personal OP exposure was associated with foetal growth restrictions, specifically decreased weight and height at birth, possibly to a larger extent than PM2.5 mass concentration alone. These results support OP assessed from DTT as being a health-relevant metric. Larger scale cohort studies are recommended to support our findings.</abstract><cop>Tuxedo</cop><pub>Nature Publishing Group</pub><doi>10.1038/s41370-022-00487-w</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0001-8378-1954</orcidid><orcidid>https://orcid.org/0000-0002-7720-0233</orcidid><orcidid>https://orcid.org/0000-0001-6027-1484</orcidid></addata></record>
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identifier ISSN: 1559-0631
ispartof Journal of exposure science & environmental epidemiology, 2023-05, Vol.33 (3), p.416-426
issn 1559-0631
1559-064X
language eng
recordid cdi_hal_primary_oai_HAL_hal_04302731v1
source Springer Link; Alma/SFX Local Collection
subjects Airborne particulates
Ascorbic acid
Birth
Births
Childbirth & labor
Circumferences
Dithiothreitol
Dosimeters
Environmental Sciences
Exposure
Fetuses
Human exposure
Human health and pathology
Life Sciences
Offspring
Particulate emissions
Particulate matter
Pregnancy
Prenatal development
Prenatal experience
Pulmonology and respiratory tract
Santé publique et épidémiologie
Weight
Weight reduction
title Personal exposure to PM2.5 oxidative potential and its association to birth outcomes
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