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Latrophilin participates in insecticide susceptibility through positively regulating CSP10 and partially compensated by OBPC01 in Tribolium castaneum
Latrophilin (LPH) is an adhesion G protein-coupled receptor (aGPCR) that participates in multiple essential physiological processes. Our previous studies have shown that lph is not only indispensable for the development and reproduction of red flour beetles (Tribolium castaneum), but also for their...
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| Published in: | Pesticide biochemistry and physiology 2019-09, Vol.159, p.107-117 |
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| creator | Xiong, Wenfeng Gao, Shanshan Lu, Yaoyao Wei, Luting Mao, Jinjuan Xie, Jia Cao, Quanquan Liu, Juanjuan Bi, Jingxiu Song, Xiaowen Li, Bin |
| description | Latrophilin (LPH) is an adhesion G protein-coupled receptor (aGPCR) that participates in multiple essential physiological processes. Our previous studies have shown that lph is not only indispensable for the development and reproduction of red flour beetles (Tribolium castaneum), but also for their resistance against dichlorvos or carbofuran insecticides. However, the regulatory mechanism of lph-mediated insecticide susceptibility remains unclear. Here, we revealed that knockdown of lph in beetles resulted in opposing changes in two chemoreception genes, chemosensory protein 10 (CSP10) and odorant-binding protein C01 (OBPC01), in which the expression of TcCSP10 was downregulated, whereas the expression of TcOBPC01 was upregulated. TcCSP10 and TcOBPC01 were expressed at the highest levels in early pupal and late larval stages, respectively. High levels of expression of both these genes were observed in the heads (without antennae) of adults. TcCSP10 and TcOBPC01 were significantly induced by dichlorvos or carbofuran between 12 and 72 h (hrs) after exposure, suggesting that they are likely associated with increasing the binding affinity of insecticides, leading to a decrease in sensitivity to the insecticides. Moreover, once these two genes were knocked down, the susceptibility of the beetles to dichlorvos or carbofuran was enhanced. Additionally, RNA interference (RNAi) targeting of lph followed by exposure to dichlorvos or carbofuran also caused the opposing expression levels of TcCSP10 and TcOBPC01 compared to the expression levels of wild-type larvae treated with insecticides alone. All these results indicate that lph is involved in insecticide susceptibility through positively regulating TcCSP10; and the susceptibility could also further partially compensated for through the negative regulation of TcOBPC01 when lph was knockdown in the red flour beetle. Our studies shed new light on the molecular regulatory mechanisms of lph related to insecticide susceptibility.
lph was involved in insecticide susceptibility through positively regulating TcCSP10, and it could further partially compensate for insecticide susceptibility by negatively regulating TcOBPC01 when lph was knockdown in Tribolium castaneum. [Display omitted]
•TcCSP10 was down-regulated and TcOBPC01 was up-regulated after knockdown of Tclph.•TcCSP10 and TcOBPC01 were significantly induced by insecticides of dichlorvos or carbofuran.•RNAi of TcCSP10 and TcOBPC01 increased the susceptibilities of l |
| doi_str_mv | 10.1016/j.pestbp.2019.06.005 |
| format | article |
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lph was involved in insecticide susceptibility through positively regulating TcCSP10, and it could further partially compensate for insecticide susceptibility by negatively regulating TcOBPC01 when lph was knockdown in Tribolium castaneum. [Display omitted]
•TcCSP10 was down-regulated and TcOBPC01 was up-regulated after knockdown of Tclph.•TcCSP10 and TcOBPC01 were significantly induced by insecticides of dichlorvos or carbofuran.•RNAi of TcCSP10 and TcOBPC01 increased the susceptibilities of larval to insecticides.•Tclph related to insecticide susceptibility via regulating TcCSP10 and partially compensated by TcOBPC01.</description><identifier>ISSN: 0048-3575</identifier><identifier>EISSN: 1095-9939</identifier><identifier>DOI: 10.1016/j.pestbp.2019.06.005</identifier><identifier>PMID: 31400772</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Biodiversity and Ecology ; Carbofuran ; Dichlorvos ; Ecology, environment ; Ecosystems ; Environmental Sciences ; Gene Expression Regulation, Developmental - drug effects ; Gene Expression Regulation, Developmental - genetics ; Insect Proteins - genetics ; Insect Proteins - metabolism ; Insecticide susceptibility ; Insecticides - pharmacology ; Latrophilin ; Life Sciences ; Receptors, Peptide - metabolism ; RNA interference ; Tribolium - drug effects ; Tribolium - metabolism ; Tribolium castaneum</subject><ispartof>Pesticide biochemistry and physiology, 2019-09, Vol.159, p.107-117</ispartof><rights>2019 Elsevier Inc.</rights><rights>Copyright © 2019 Elsevier Inc. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-aa47c17e3ad8f21b52d6594bcd26e3fd9e5105c7b14bdbfa7260821d90685fc33</citedby><cites>FETCH-LOGICAL-c396t-aa47c17e3ad8f21b52d6594bcd26e3fd9e5105c7b14bdbfa7260821d90685fc33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31400772$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02439907$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiong, Wenfeng</creatorcontrib><creatorcontrib>Gao, Shanshan</creatorcontrib><creatorcontrib>Lu, Yaoyao</creatorcontrib><creatorcontrib>Wei, Luting</creatorcontrib><creatorcontrib>Mao, Jinjuan</creatorcontrib><creatorcontrib>Xie, Jia</creatorcontrib><creatorcontrib>Cao, Quanquan</creatorcontrib><creatorcontrib>Liu, Juanjuan</creatorcontrib><creatorcontrib>Bi, Jingxiu</creatorcontrib><creatorcontrib>Song, Xiaowen</creatorcontrib><creatorcontrib>Li, Bin</creatorcontrib><title>Latrophilin participates in insecticide susceptibility through positively regulating CSP10 and partially compensated by OBPC01 in Tribolium castaneum</title><title>Pesticide biochemistry and physiology</title><addtitle>Pestic Biochem Physiol</addtitle><description>Latrophilin (LPH) is an adhesion G protein-coupled receptor (aGPCR) that participates in multiple essential physiological processes. Our previous studies have shown that lph is not only indispensable for the development and reproduction of red flour beetles (Tribolium castaneum), but also for their resistance against dichlorvos or carbofuran insecticides. However, the regulatory mechanism of lph-mediated insecticide susceptibility remains unclear. Here, we revealed that knockdown of lph in beetles resulted in opposing changes in two chemoreception genes, chemosensory protein 10 (CSP10) and odorant-binding protein C01 (OBPC01), in which the expression of TcCSP10 was downregulated, whereas the expression of TcOBPC01 was upregulated. TcCSP10 and TcOBPC01 were expressed at the highest levels in early pupal and late larval stages, respectively. High levels of expression of both these genes were observed in the heads (without antennae) of adults. TcCSP10 and TcOBPC01 were significantly induced by dichlorvos or carbofuran between 12 and 72 h (hrs) after exposure, suggesting that they are likely associated with increasing the binding affinity of insecticides, leading to a decrease in sensitivity to the insecticides. Moreover, once these two genes were knocked down, the susceptibility of the beetles to dichlorvos or carbofuran was enhanced. Additionally, RNA interference (RNAi) targeting of lph followed by exposure to dichlorvos or carbofuran also caused the opposing expression levels of TcCSP10 and TcOBPC01 compared to the expression levels of wild-type larvae treated with insecticides alone. All these results indicate that lph is involved in insecticide susceptibility through positively regulating TcCSP10; and the susceptibility could also further partially compensated for through the negative regulation of TcOBPC01 when lph was knockdown in the red flour beetle. Our studies shed new light on the molecular regulatory mechanisms of lph related to insecticide susceptibility.
lph was involved in insecticide susceptibility through positively regulating TcCSP10, and it could further partially compensate for insecticide susceptibility by negatively regulating TcOBPC01 when lph was knockdown in Tribolium castaneum. [Display omitted]
•TcCSP10 was down-regulated and TcOBPC01 was up-regulated after knockdown of Tclph.•TcCSP10 and TcOBPC01 were significantly induced by insecticides of dichlorvos or carbofuran.•RNAi of TcCSP10 and TcOBPC01 increased the susceptibilities of larval to insecticides.•Tclph related to insecticide susceptibility via regulating TcCSP10 and partially compensated by TcOBPC01.</description><subject>Animals</subject><subject>Biodiversity and Ecology</subject><subject>Carbofuran</subject><subject>Dichlorvos</subject><subject>Ecology, environment</subject><subject>Ecosystems</subject><subject>Environmental Sciences</subject><subject>Gene Expression Regulation, Developmental - drug effects</subject><subject>Gene Expression Regulation, Developmental - genetics</subject><subject>Insect Proteins - genetics</subject><subject>Insect Proteins - metabolism</subject><subject>Insecticide susceptibility</subject><subject>Insecticides - pharmacology</subject><subject>Latrophilin</subject><subject>Life Sciences</subject><subject>Receptors, Peptide - metabolism</subject><subject>RNA interference</subject><subject>Tribolium - drug effects</subject><subject>Tribolium - metabolism</subject><subject>Tribolium castaneum</subject><issn>0048-3575</issn><issn>1095-9939</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1DAUhS0EokPhDRDyEhYJ106cjDdI7Qgo0kitRFlb_suMR0kcbGekeRDeF0cpXbKyfP3dc6xzEHpPoCRAms-ncrIxqamkQHgJTQnAXqANAc4Kziv-Em0A6m1RsZZdoTcxngCA18Bfo6uK1ABtSzfoz16m4Kej692IJxmS026SyUac726MVi8TY3Gco7ZTciqT6YLTMfj5cMSTjy65s-0vONjD3MvkxgPe_XwggOVoVknZ52fth8mOMWsbrC74_vZhB2RxeQxO-d7NA9YyJjnaeXiLXnWyj_bd03mNfn37-ri7K_b333_sbvaFrniTCinrVpPWVtJsO0oUo6ZhvFba0MZWneGWEWC6VaRWRnWypQ1sKTEcmi3rdFVdo0-r7lH2YgpukOEivHTi7mYvlhnQuuIc2jPJ7MeVnYL_PefoxeByJH2ff-znKChtKaWsrpqM1iuqg48x2O5Zm4BYyhMnsZYnlvIENCKXl9c-PDnMarDmeelfWxn4sgI2Z3J2NoionR21NS7kooTx7v8OfwHRB6-n</recordid><startdate>20190901</startdate><enddate>20190901</enddate><creator>Xiong, Wenfeng</creator><creator>Gao, Shanshan</creator><creator>Lu, Yaoyao</creator><creator>Wei, Luting</creator><creator>Mao, Jinjuan</creator><creator>Xie, Jia</creator><creator>Cao, Quanquan</creator><creator>Liu, Juanjuan</creator><creator>Bi, Jingxiu</creator><creator>Song, Xiaowen</creator><creator>Li, Bin</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope></search><sort><creationdate>20190901</creationdate><title>Latrophilin participates in insecticide susceptibility through positively regulating CSP10 and partially compensated by OBPC01 in Tribolium castaneum</title><author>Xiong, Wenfeng ; Gao, Shanshan ; Lu, Yaoyao ; Wei, Luting ; Mao, Jinjuan ; Xie, Jia ; Cao, Quanquan ; Liu, Juanjuan ; Bi, Jingxiu ; Song, Xiaowen ; Li, Bin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-aa47c17e3ad8f21b52d6594bcd26e3fd9e5105c7b14bdbfa7260821d90685fc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Animals</topic><topic>Biodiversity and Ecology</topic><topic>Carbofuran</topic><topic>Dichlorvos</topic><topic>Ecology, environment</topic><topic>Ecosystems</topic><topic>Environmental Sciences</topic><topic>Gene Expression Regulation, Developmental - drug effects</topic><topic>Gene Expression Regulation, Developmental - genetics</topic><topic>Insect Proteins - genetics</topic><topic>Insect Proteins - metabolism</topic><topic>Insecticide susceptibility</topic><topic>Insecticides - pharmacology</topic><topic>Latrophilin</topic><topic>Life Sciences</topic><topic>Receptors, Peptide - metabolism</topic><topic>RNA interference</topic><topic>Tribolium - drug effects</topic><topic>Tribolium - metabolism</topic><topic>Tribolium castaneum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiong, Wenfeng</creatorcontrib><creatorcontrib>Gao, Shanshan</creatorcontrib><creatorcontrib>Lu, Yaoyao</creatorcontrib><creatorcontrib>Wei, Luting</creatorcontrib><creatorcontrib>Mao, Jinjuan</creatorcontrib><creatorcontrib>Xie, Jia</creatorcontrib><creatorcontrib>Cao, Quanquan</creatorcontrib><creatorcontrib>Liu, Juanjuan</creatorcontrib><creatorcontrib>Bi, Jingxiu</creatorcontrib><creatorcontrib>Song, Xiaowen</creatorcontrib><creatorcontrib>Li, Bin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Pesticide biochemistry and physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiong, Wenfeng</au><au>Gao, Shanshan</au><au>Lu, Yaoyao</au><au>Wei, Luting</au><au>Mao, Jinjuan</au><au>Xie, Jia</au><au>Cao, Quanquan</au><au>Liu, Juanjuan</au><au>Bi, Jingxiu</au><au>Song, Xiaowen</au><au>Li, Bin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Latrophilin participates in insecticide susceptibility through positively regulating CSP10 and partially compensated by OBPC01 in Tribolium castaneum</atitle><jtitle>Pesticide biochemistry and physiology</jtitle><addtitle>Pestic Biochem Physiol</addtitle><date>2019-09-01</date><risdate>2019</risdate><volume>159</volume><spage>107</spage><epage>117</epage><pages>107-117</pages><issn>0048-3575</issn><eissn>1095-9939</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Latrophilin (LPH) is an adhesion G protein-coupled receptor (aGPCR) that participates in multiple essential physiological processes. Our previous studies have shown that lph is not only indispensable for the development and reproduction of red flour beetles (Tribolium castaneum), but also for their resistance against dichlorvos or carbofuran insecticides. However, the regulatory mechanism of lph-mediated insecticide susceptibility remains unclear. Here, we revealed that knockdown of lph in beetles resulted in opposing changes in two chemoreception genes, chemosensory protein 10 (CSP10) and odorant-binding protein C01 (OBPC01), in which the expression of TcCSP10 was downregulated, whereas the expression of TcOBPC01 was upregulated. TcCSP10 and TcOBPC01 were expressed at the highest levels in early pupal and late larval stages, respectively. High levels of expression of both these genes were observed in the heads (without antennae) of adults. TcCSP10 and TcOBPC01 were significantly induced by dichlorvos or carbofuran between 12 and 72 h (hrs) after exposure, suggesting that they are likely associated with increasing the binding affinity of insecticides, leading to a decrease in sensitivity to the insecticides. Moreover, once these two genes were knocked down, the susceptibility of the beetles to dichlorvos or carbofuran was enhanced. Additionally, RNA interference (RNAi) targeting of lph followed by exposure to dichlorvos or carbofuran also caused the opposing expression levels of TcCSP10 and TcOBPC01 compared to the expression levels of wild-type larvae treated with insecticides alone. All these results indicate that lph is involved in insecticide susceptibility through positively regulating TcCSP10; and the susceptibility could also further partially compensated for through the negative regulation of TcOBPC01 when lph was knockdown in the red flour beetle. Our studies shed new light on the molecular regulatory mechanisms of lph related to insecticide susceptibility.
lph was involved in insecticide susceptibility through positively regulating TcCSP10, and it could further partially compensate for insecticide susceptibility by negatively regulating TcOBPC01 when lph was knockdown in Tribolium castaneum. [Display omitted]
•TcCSP10 was down-regulated and TcOBPC01 was up-regulated after knockdown of Tclph.•TcCSP10 and TcOBPC01 were significantly induced by insecticides of dichlorvos or carbofuran.•RNAi of TcCSP10 and TcOBPC01 increased the susceptibilities of larval to insecticides.•Tclph related to insecticide susceptibility via regulating TcCSP10 and partially compensated by TcOBPC01.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>31400772</pmid><doi>10.1016/j.pestbp.2019.06.005</doi><tpages>11</tpages></addata></record> |
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| ispartof | Pesticide biochemistry and physiology, 2019-09, Vol.159, p.107-117 |
| issn | 0048-3575 1095-9939 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Animals Biodiversity and Ecology Carbofuran Dichlorvos Ecology, environment Ecosystems Environmental Sciences Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - genetics Insect Proteins - genetics Insect Proteins - metabolism Insecticide susceptibility Insecticides - pharmacology Latrophilin Life Sciences Receptors, Peptide - metabolism RNA interference Tribolium - drug effects Tribolium - metabolism Tribolium castaneum |
| title | Latrophilin participates in insecticide susceptibility through positively regulating CSP10 and partially compensated by OBPC01 in Tribolium castaneum |
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