Loading…
Exploitation vs. exploration—computational temporal and semantic analysis explains semantic verbal fluency impairment in Alzheimer's disease
Impaired Semantic Verbal Fluency (SVF) in dementia due to Alzheimer's Disease (AD) and its precursor Mild Cognitive Impairment (MCI) is well known. Yet, it remains open whether this impairment mirrors the breakdown of semantic memory retrieval processes or executive control processes. Therefore...
Saved in:
Published in: | Neuropsychologia 2019-08, Vol.131, p.53-61 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | cdi_FETCH-LOGICAL-c426t-1436fb7f0f96751c21d83a1d413e501aa9719f93ad3205a9a71fec641e574a683 |
---|---|
cites | cdi_FETCH-LOGICAL-c426t-1436fb7f0f96751c21d83a1d413e501aa9719f93ad3205a9a71fec641e574a683 |
container_end_page | 61 |
container_issue | |
container_start_page | 53 |
container_title | Neuropsychologia |
container_volume | 131 |
creator | Tröger, Johannes Linz, Nicklas König, Alexandra Robert, Philippe Alexandersson, Jan Peter, Jessica Kray, Jutta |
description | Impaired Semantic Verbal Fluency (SVF) in dementia due to Alzheimer's Disease (AD) and its precursor Mild Cognitive Impairment (MCI) is well known. Yet, it remains open whether this impairment mirrors the breakdown of semantic memory retrieval processes or executive control processes. Therefore, qualitative analysis of the SVF has been proposed but is limited in terms of methodology and feasibility in clinical practice. Consequently, research draws no conclusive picture which of these afore-mentioned processes drives the SVF impairment in AD and MCI. This study uses a qualitative computational approach—combining temporal and semantic information—to investigate exploitation and exploration patterns as indicators for semantic memory retrieval and executive control processes. Audio SVF recordings of 20 controls (C, 66–81 years), 55 MCI (57–94 years) and 20 AD subjects (66–82 years) were assessed while groups were matched according to age and education. All groups produced, on average, the same amount of semantically related items in rapid succession within word clusters. Conversely, towards AD, there was a clear decline in semantic as well as temporal exploration patterns between clusters. Results strongly point towards preserved exploitation—semantic memory retrieval processes—and hampered exploration—executive control processes—in AD and potentially in MCI.
•AD patients show no impairment in semantic memory exploitation patterns in the SVF.•AD and MCI patients show impairments in exploration of semantic memory in the SVF.•AD patients show impairment in executive control but preserved semantic memory.•Novel temporal and semantic computational information are fused to analyze the SVF. |
doi_str_mv | 10.1016/j.neuropsychologia.2019.05.007 |
format | article |
fullrecord | <record><control><sourceid>proquest_hal_p</sourceid><recordid>TN_cdi_hal_primary_oai_HAL_hal_02339134v1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0028393218305116</els_id><sourcerecordid>2232130940</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-1436fb7f0f96751c21d83a1d413e501aa9719f93ad3205a9a71fec641e574a683</originalsourceid><addsrcrecordid>eNqNkU2O1DAQhS0EYpqBK6Cs-FkkuGznb4PUGg00UktsYG1VOxXaLScOdtKaZsUJWHFCTkJ6MgwSK1alqvfVK6keYy-AZ8CheHPIepqCH-LJ7L3zXyxmgkOd8TzjvHzAVlCVMpU5qIdsxbmoUllLccGexHjgnKtcVI_ZhQQQAJVasR_XN4PzdsTR-j45xiyh8yDc9r--_zS-G6ZFRZeM1A2z5hLsmyRSh_1ozdygO0Ubb1fR9vGvdKSwm_HWTdSbU2K7AW3oqB8T2ydr921PtqPwMiaNjYSRnrJHLbpIz-7qJfv87vrT1Sbdfnz_4Wq9TY0SxZiCkkW7K1ve1kWZgxHQVBKhUSAp54BYl1C3tcRGCp5jjSW0ZAoFlJcKi0pesteL7x6dHoLtMJy0R6s3660-z7iQsgapjjCzrxZ2CP7rRHHUnY2GnMOe_BS1EFKA5LXiM_p2QU3wMQZq772B63N--qD_zU-f89M813N-s8Hzu1vTrqPmfv1PYDOwWQCav3O0FHQ0dv4tNTaQGXXj7f_e-g39L7r5</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2232130940</pqid></control><display><type>article</type><title>Exploitation vs. exploration—computational temporal and semantic analysis explains semantic verbal fluency impairment in Alzheimer's disease</title><source>ScienceDirect Freedom Collection</source><creator>Tröger, Johannes ; Linz, Nicklas ; König, Alexandra ; Robert, Philippe ; Alexandersson, Jan ; Peter, Jessica ; Kray, Jutta</creator><creatorcontrib>Tröger, Johannes ; Linz, Nicklas ; König, Alexandra ; Robert, Philippe ; Alexandersson, Jan ; Peter, Jessica ; Kray, Jutta</creatorcontrib><description>Impaired Semantic Verbal Fluency (SVF) in dementia due to Alzheimer's Disease (AD) and its precursor Mild Cognitive Impairment (MCI) is well known. Yet, it remains open whether this impairment mirrors the breakdown of semantic memory retrieval processes or executive control processes. Therefore, qualitative analysis of the SVF has been proposed but is limited in terms of methodology and feasibility in clinical practice. Consequently, research draws no conclusive picture which of these afore-mentioned processes drives the SVF impairment in AD and MCI. This study uses a qualitative computational approach—combining temporal and semantic information—to investigate exploitation and exploration patterns as indicators for semantic memory retrieval and executive control processes. Audio SVF recordings of 20 controls (C, 66–81 years), 55 MCI (57–94 years) and 20 AD subjects (66–82 years) were assessed while groups were matched according to age and education. All groups produced, on average, the same amount of semantically related items in rapid succession within word clusters. Conversely, towards AD, there was a clear decline in semantic as well as temporal exploration patterns between clusters. Results strongly point towards preserved exploitation—semantic memory retrieval processes—and hampered exploration—executive control processes—in AD and potentially in MCI.
•AD patients show no impairment in semantic memory exploitation patterns in the SVF.•AD and MCI patients show impairments in exploration of semantic memory in the SVF.•AD patients show impairment in executive control but preserved semantic memory.•Novel temporal and semantic computational information are fused to analyze the SVF.</description><identifier>ISSN: 0028-3932</identifier><identifier>EISSN: 1873-3514</identifier><identifier>DOI: 10.1016/j.neuropsychologia.2019.05.007</identifier><identifier>PMID: 31121184</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Alzheimer's disease ; Cognitive science ; MCI (mild cognitive impairment) ; Semantic speech analysis ; Temporal analysis</subject><ispartof>Neuropsychologia, 2019-08, Vol.131, p.53-61</ispartof><rights>2019 Elsevier Ltd</rights><rights>Copyright © 2019 Elsevier Ltd. All rights reserved.</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-1436fb7f0f96751c21d83a1d413e501aa9719f93ad3205a9a71fec641e574a683</citedby><cites>FETCH-LOGICAL-c426t-1436fb7f0f96751c21d83a1d413e501aa9719f93ad3205a9a71fec641e574a683</cites><orcidid>0000-0001-5178-3234 ; 0000-0001-9960-9657</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,315,786,790,891,27957,27958</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/31121184$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-02339134$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Tröger, Johannes</creatorcontrib><creatorcontrib>Linz, Nicklas</creatorcontrib><creatorcontrib>König, Alexandra</creatorcontrib><creatorcontrib>Robert, Philippe</creatorcontrib><creatorcontrib>Alexandersson, Jan</creatorcontrib><creatorcontrib>Peter, Jessica</creatorcontrib><creatorcontrib>Kray, Jutta</creatorcontrib><title>Exploitation vs. exploration—computational temporal and semantic analysis explains semantic verbal fluency impairment in Alzheimer's disease</title><title>Neuropsychologia</title><addtitle>Neuropsychologia</addtitle><description>Impaired Semantic Verbal Fluency (SVF) in dementia due to Alzheimer's Disease (AD) and its precursor Mild Cognitive Impairment (MCI) is well known. Yet, it remains open whether this impairment mirrors the breakdown of semantic memory retrieval processes or executive control processes. Therefore, qualitative analysis of the SVF has been proposed but is limited in terms of methodology and feasibility in clinical practice. Consequently, research draws no conclusive picture which of these afore-mentioned processes drives the SVF impairment in AD and MCI. This study uses a qualitative computational approach—combining temporal and semantic information—to investigate exploitation and exploration patterns as indicators for semantic memory retrieval and executive control processes. Audio SVF recordings of 20 controls (C, 66–81 years), 55 MCI (57–94 years) and 20 AD subjects (66–82 years) were assessed while groups were matched according to age and education. All groups produced, on average, the same amount of semantically related items in rapid succession within word clusters. Conversely, towards AD, there was a clear decline in semantic as well as temporal exploration patterns between clusters. Results strongly point towards preserved exploitation—semantic memory retrieval processes—and hampered exploration—executive control processes—in AD and potentially in MCI.
•AD patients show no impairment in semantic memory exploitation patterns in the SVF.•AD and MCI patients show impairments in exploration of semantic memory in the SVF.•AD patients show impairment in executive control but preserved semantic memory.•Novel temporal and semantic computational information are fused to analyze the SVF.</description><subject>Alzheimer's disease</subject><subject>Cognitive science</subject><subject>MCI (mild cognitive impairment)</subject><subject>Semantic speech analysis</subject><subject>Temporal analysis</subject><issn>0028-3932</issn><issn>1873-3514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNqNkU2O1DAQhS0EYpqBK6Cs-FkkuGznb4PUGg00UktsYG1VOxXaLScOdtKaZsUJWHFCTkJ6MgwSK1alqvfVK6keYy-AZ8CheHPIepqCH-LJ7L3zXyxmgkOd8TzjvHzAVlCVMpU5qIdsxbmoUllLccGexHjgnKtcVI_ZhQQQAJVasR_XN4PzdsTR-j45xiyh8yDc9r--_zS-G6ZFRZeM1A2z5hLsmyRSh_1ozdygO0Ubb1fR9vGvdKSwm_HWTdSbU2K7AW3oqB8T2ydr921PtqPwMiaNjYSRnrJHLbpIz-7qJfv87vrT1Sbdfnz_4Wq9TY0SxZiCkkW7K1ve1kWZgxHQVBKhUSAp54BYl1C3tcRGCp5jjSW0ZAoFlJcKi0pesteL7x6dHoLtMJy0R6s3660-z7iQsgapjjCzrxZ2CP7rRHHUnY2GnMOe_BS1EFKA5LXiM_p2QU3wMQZq772B63N--qD_zU-f89M813N-s8Hzu1vTrqPmfv1PYDOwWQCav3O0FHQ0dv4tNTaQGXXj7f_e-g39L7r5</recordid><startdate>201908</startdate><enddate>201908</enddate><creator>Tröger, Johannes</creator><creator>Linz, Nicklas</creator><creator>König, Alexandra</creator><creator>Robert, Philippe</creator><creator>Alexandersson, Jan</creator><creator>Peter, Jessica</creator><creator>Kray, Jutta</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><orcidid>https://orcid.org/0000-0001-5178-3234</orcidid><orcidid>https://orcid.org/0000-0001-9960-9657</orcidid></search><sort><creationdate>201908</creationdate><title>Exploitation vs. exploration—computational temporal and semantic analysis explains semantic verbal fluency impairment in Alzheimer's disease</title><author>Tröger, Johannes ; Linz, Nicklas ; König, Alexandra ; Robert, Philippe ; Alexandersson, Jan ; Peter, Jessica ; Kray, Jutta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-1436fb7f0f96751c21d83a1d413e501aa9719f93ad3205a9a71fec641e574a683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Alzheimer's disease</topic><topic>Cognitive science</topic><topic>MCI (mild cognitive impairment)</topic><topic>Semantic speech analysis</topic><topic>Temporal analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tröger, Johannes</creatorcontrib><creatorcontrib>Linz, Nicklas</creatorcontrib><creatorcontrib>König, Alexandra</creatorcontrib><creatorcontrib>Robert, Philippe</creatorcontrib><creatorcontrib>Alexandersson, Jan</creatorcontrib><creatorcontrib>Peter, Jessica</creatorcontrib><creatorcontrib>Kray, Jutta</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><jtitle>Neuropsychologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tröger, Johannes</au><au>Linz, Nicklas</au><au>König, Alexandra</au><au>Robert, Philippe</au><au>Alexandersson, Jan</au><au>Peter, Jessica</au><au>Kray, Jutta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exploitation vs. exploration—computational temporal and semantic analysis explains semantic verbal fluency impairment in Alzheimer's disease</atitle><jtitle>Neuropsychologia</jtitle><addtitle>Neuropsychologia</addtitle><date>2019-08</date><risdate>2019</risdate><volume>131</volume><spage>53</spage><epage>61</epage><pages>53-61</pages><issn>0028-3932</issn><eissn>1873-3514</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><abstract>Impaired Semantic Verbal Fluency (SVF) in dementia due to Alzheimer's Disease (AD) and its precursor Mild Cognitive Impairment (MCI) is well known. Yet, it remains open whether this impairment mirrors the breakdown of semantic memory retrieval processes or executive control processes. Therefore, qualitative analysis of the SVF has been proposed but is limited in terms of methodology and feasibility in clinical practice. Consequently, research draws no conclusive picture which of these afore-mentioned processes drives the SVF impairment in AD and MCI. This study uses a qualitative computational approach—combining temporal and semantic information—to investigate exploitation and exploration patterns as indicators for semantic memory retrieval and executive control processes. Audio SVF recordings of 20 controls (C, 66–81 years), 55 MCI (57–94 years) and 20 AD subjects (66–82 years) were assessed while groups were matched according to age and education. All groups produced, on average, the same amount of semantically related items in rapid succession within word clusters. Conversely, towards AD, there was a clear decline in semantic as well as temporal exploration patterns between clusters. Results strongly point towards preserved exploitation—semantic memory retrieval processes—and hampered exploration—executive control processes—in AD and potentially in MCI.
•AD patients show no impairment in semantic memory exploitation patterns in the SVF.•AD and MCI patients show impairments in exploration of semantic memory in the SVF.•AD patients show impairment in executive control but preserved semantic memory.•Novel temporal and semantic computational information are fused to analyze the SVF.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>31121184</pmid><doi>10.1016/j.neuropsychologia.2019.05.007</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5178-3234</orcidid><orcidid>https://orcid.org/0000-0001-9960-9657</orcidid></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0028-3932 |
ispartof | Neuropsychologia, 2019-08, Vol.131, p.53-61 |
issn | 0028-3932 1873-3514 |
language | eng |
recordid | cdi_hal_primary_oai_HAL_hal_02339134v1 |
source | ScienceDirect Freedom Collection |
subjects | Alzheimer's disease Cognitive science MCI (mild cognitive impairment) Semantic speech analysis Temporal analysis |
title | Exploitation vs. exploration—computational temporal and semantic analysis explains semantic verbal fluency impairment in Alzheimer's disease |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-09-21T11%3A37%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_hal_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Exploitation%20vs.%20exploration%E2%80%94computational%20temporal%20and%20semantic%20analysis%20explains%20semantic%20verbal%20fluency%20impairment%20in%20Alzheimer's%20disease&rft.jtitle=Neuropsychologia&rft.au=Tr%C3%B6ger,%20Johannes&rft.date=2019-08&rft.volume=131&rft.spage=53&rft.epage=61&rft.pages=53-61&rft.issn=0028-3932&rft.eissn=1873-3514&rft_id=info:doi/10.1016/j.neuropsychologia.2019.05.007&rft_dat=%3Cproquest_hal_p%3E2232130940%3C/proquest_hal_p%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c426t-1436fb7f0f96751c21d83a1d413e501aa9719f93ad3205a9a71fec641e574a683%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2232130940&rft_id=info:pmid/31121184&rfr_iscdi=true |