Dental and extra‐oral clinical features in 41 patients with WNT10A gene mutations: A multicentric genotype–phenotype study

WNT10A gene encodes a canonical wingless pathway signaling molecule involved in cell fate specification as well as morphogenetic patterning of the developing ectoderm, nervous system, skeleton, and tooth. In patients, WNT10A mutations are responsible for ectodermal‐derived pathologies including isol...

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Published in:Clinical genetics 2017-11, Vol.92 (5), p.477-486
Main Authors: Tardieu, C., Jung, S., Niederreither, K., Prasad, M., Hadj‐Rabia, S., Philip, N., Mallet, A., Consolino, E., Sfeir, E., Noueiri, B., Chassaing, N., Dollfus, H., Manière, M.C., Bloch‐Zupan, A., Clauss, F.
Format: Article
Language:English
Subjects:
Adolescent
Adult
bone
Cell fate
Child
Cohort Studies
Cone-Beam Computed Tomography
Cysts
dental phenotype
Dysplasia
Ectoderm
Ectoderm - pathology
extra‐ectodermal signs
Genetic Association Studies
Genetics
Genotype & phenotype
Heterozygote
Homozygote
Human genetics
Humans
Life Sciences
Lipid metabolism
Mandible - pathology
Middle Aged
Mutation
Mutation - genetics
Nervous system
Neurogenesis
oligodontia
Patients
Pattern formation
Phenotype
Skeleton
Skin
Teeth
Tooth - diagnostic imaging
Tooth - pathology
Wnt protein
Wnt Proteins - genetics
WNT10A mutation
Young Adult
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cited_by cdi_FETCH-LOGICAL-c3872-77285264c95f1d690a978f943d8775de433216f23ccd682b0b0e9317815a50d13
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container_end_page 486
container_issue 5
container_start_page 477
container_title Clinical genetics
container_volume 92
creator Tardieu, C.
Jung, S.
Niederreither, K.
Prasad, M.
Hadj‐Rabia, S.
Philip, N.
Mallet, A.
Consolino, E.
Sfeir, E.
Noueiri, B.
Chassaing, N.
Dollfus, H.
Manière, M.C.
Bloch‐Zupan, A.
Clauss, F.
description WNT10A gene encodes a canonical wingless pathway signaling molecule involved in cell fate specification as well as morphogenetic patterning of the developing ectoderm, nervous system, skeleton, and tooth. In patients, WNT10A mutations are responsible for ectodermal‐derived pathologies including isolated hypo‐oligodontia, tricho‐odonto‐onycho‐dermal dysplasia and Schöpf‐Schulz‐Passarge syndrome (SSPS). Here we describe the dental, ectodermal, and extra‐ectodermal phenotypic features of a cohort of 41 patients from 32 unrelated families. Correlations with WNT10A molecular status (heterozygous carrier, compound heterozygous, homozygous) and patient's phenotypes were performed. Mild to severe oligodontia was observed in all patients bearing biallelic WNT10A mutations. However, patients with compound heterozygous mutations presented no significant difference in phenotypes compared with homozygous individuals. Anomalies in tooth morphology were frequently observed with heterozygous patients displaying hypodontia. No signs of SSPS, especially eyelids cysts, were detected in our cohort. Interestingly, extra‐ectodermal signs consisted of skeletal, neurological and vascular anomalies, the latter suggesting a wider phenotypic spectrum associated with WNT10A mutations. Indeed, the Wnt pathway plays a crucial role in skeletal development, lipid metabolism, and neurogenesis, potentially explaining patient's clinical manifestations.
doi_str_mv 10.1111/cge.12972
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Interestingly, extra‐ectodermal signs consisted of skeletal, neurological and vascular anomalies, the latter suggesting a wider phenotypic spectrum associated with WNT10A mutations. 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In patients, WNT10A mutations are responsible for ectodermal‐derived pathologies including isolated hypo‐oligodontia, tricho‐odonto‐onycho‐dermal dysplasia and Schöpf‐Schulz‐Passarge syndrome (SSPS). Here we describe the dental, ectodermal, and extra‐ectodermal phenotypic features of a cohort of 41 patients from 32 unrelated families. Correlations with WNT10A molecular status (heterozygous carrier, compound heterozygous, homozygous) and patient's phenotypes were performed. Mild to severe oligodontia was observed in all patients bearing biallelic WNT10A mutations. However, patients with compound heterozygous mutations presented no significant difference in phenotypes compared with homozygous individuals. Anomalies in tooth morphology were frequently observed with heterozygous patients displaying hypodontia. No signs of SSPS, especially eyelids cysts, were detected in our cohort. Interestingly, extra‐ectodermal signs consisted of skeletal, neurological and vascular anomalies, the latter suggesting a wider phenotypic spectrum associated with WNT10A mutations. Indeed, the Wnt pathway plays a crucial role in skeletal development, lipid metabolism, and neurogenesis, potentially explaining patient's clinical manifestations.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>28105635</pmid><doi>10.1111/cge.12972</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-8078-2406</orcidid></addata></record>
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source Wiley-Blackwell Journals
subjects Adolescent
Adult
bone
Cell fate
Child
Cohort Studies
Cone-Beam Computed Tomography
Cysts
dental phenotype
Dysplasia
Ectoderm
Ectoderm - pathology
extra‐ectodermal signs
Genetic Association Studies
Genetics
Genotype & phenotype
Heterozygote
Homozygote
Human genetics
Humans
Life Sciences
Lipid metabolism
Mandible - pathology
Middle Aged
Mutation
Mutation - genetics
Nervous system
Neurogenesis
oligodontia
Patients
Pattern formation
Phenotype
Skeleton
Skin
Teeth
Tooth - diagnostic imaging
Tooth - pathology
Wnt protein
Wnt Proteins - genetics
WNT10A mutation
Young Adult
title Dental and extra‐oral clinical features in 41 patients with WNT10A gene mutations: A multicentric genotype–phenotype study
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