A switchable dual organocatalytic system and the enantioselective total synthesis of the quadrane sesquiterpene suberosanone

A switchable dual organocatalytic system and the enantioselective total synthesis of the quadrane sesquiterpene suberosanone

The combination of aminocatalysis with N-heterocyclic carbene catalysis has been extended to a switchable dual catalytic system, which allowed a direct enantioselective entry to bridged bicyclo[3.n.1] ring systems and the total synthesis of the natural product (1R)-suberosanone.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (39), p.6565-6568
Main Authors: Ren, Yajun, Presset, Marc, Godemert, Jeremy, Vanthuyne, Nicolas, Naubron, Jean-Valère, Giorgi, Michel, Rodriguez, Jean, Coquerel, Yoann
Format: Article
Language:eng
Subjects:
Carbenes
Catalysis
Catalysts
Chemical Sciences
Natural products
Organic chemistry
Synthesis
Online Access:Request full text
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Description
Summary:The combination of aminocatalysis with N-heterocyclic carbene catalysis has been extended to a switchable dual catalytic system, which allowed a direct enantioselective entry to bridged bicyclo[3.n.1] ring systems and the total synthesis of the natural product (1R)-suberosanone.
ISSN:1359-7345
1364-548X